Brain and Spinal Tumors Research Studies

< Back to Young Adult Cancer Research Studies Page

DIPG/High Grade Glioma New Diagnosis

ADVL1217: A Phase 1 Study of AZD1775 (MK-1775) Concurrent With Local Radiation Therapy for the Treatment of Newly Diagnosed Children With Diffuse Intrinsic Pontine Gliomas

PURPOSE: This phase I trial studies the side effects and the best dose of WEE1 inhibitor AZD1775 when given together with local radiation therapy in treating patients with newly diagnosed diffuse intrinsic pontine gliomas. WEE1 inhibitor AZD1775 may stop the growth of tumor cells by blocking some of ...More

BXQ-350 in Children and Young Adults with Recurrent Relapsed Solid Tumors or Recurrent Malignant Brain Tumors or Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG)

  • Ages: 1 to 30 years

The purpose of this study determine the safety and tolerability of the drug BXQ-350 and to establish the maximum tolerated dose that can be taken forward into studies of efficacy. BXQ-350: A Phase 1 Safety Study of BXQ-350 Administered as a Single Agent by Intravenous Infusion in Children and Young ...More

CA209908: Phase Ib /II Clinical Trial of Nivolumab Monotherapy and Nivolumab in Combination With Ipilimumab in Pediatric Subjects With High Grade Primary CNS Malignancies

PURPOSE: The purpose of this study is to determine the safety and effectiveness of nivolumab alone and in combination with ipilimumab in pediatric patients with high grade primary central nervous system (CNS) malignancies.
 PRIMARY OUTCOME MEASURES: Incidence of dose limiting toxicity ( ...More

CONNECT1702: A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma

  • Ages: 36 Months to 21 Years

BRIEF SUMMARY: In this research study the investigators want to learn more about the safety of the study drug, PTC596 has when taken during radiation. The investigators also want to learn about the effects, if any, these drugs have on children and young adults with brain tumors. The investi ...More

LEE RAD17T-MD-1604: A Phase I Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG)

In this research study, we want to learn about the safety of the study drugs, ribociclib and everolimus, when given together at different doses after radiation therapy. We also want to learn about the effects, if any, these drugs have on children and young adults with brain tumors. We are asking peo ...More

ONC201 in Pediatric H3 K27M glioma

  • Ages: 2 Years to 19 Years

We are doing this research to determine the recommended Phase II dose of ONC201 in pediatric glioma patients as a single agent and in combination with radiation. ONC014: ONC201 in Newly Diagnosed Diffuse Intrinsic Pontine Glioma and Recurrent/Refractory Pediatric H3 K27M Gliomas ...More

PBTC-051: Phase I Study to Evaluate the Safety and Tolerability of the CD40 Agonistic Monoclonal Antibody APX005M in Pediatric Subjects With Recurrent/Refractory Brain Tumors and Newly Diagnosed Brain Stem Glioma

PURPOSE: This phase I trial studies the side effects and best dose of APX005M in treating younger patients with primary malignant central nervous system tumor that is growing, spreading, or getting worse (progressive), or newly diagnosed diffuse intrinsic pontine glioma. APX005M can trigger activat ...More