A photo of Mohammed Azam.

Member, Division of Experimental Hematology & Cancer Biology

Associate Professor, UC Department of Pediatrics

513-803-1413

513-636-3768

Biography & Affiliation

Clinical Interests

Leukemia

Research Interests

Structure and function analysis of tyrosine kinases involved in the pathogenesis of leukemia; molecular basis of “oncogene addiction”; modeling of human leukemia in mice using ES and patient derived iPS cells

Academic Affiliation

Associate Professor, UC Department of Pediatrics

Research Divisions

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases

Education

PhD: Jawaharlal Nehru University, India.

Post-doc:
Whitehead Institute for Biomedical Research at MIT, 2001-2003.

Instructor:
Children’s Hospital of Boston and Harvard Medical School, 2006-2009.

Publications

Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition. Fan, C; Zhao, C; Zhang, F; Kesarwani, M; Tu, Z; Cai, X; Davis, AK; Xu, L; Hochstetler, CL; Chen, X; et al. Proceedings of the National Academy of Sciences of the United States of America. 2021; 118.

SWATH-Proteomics of Ibrutinib's Action in Myeloid Leukemia Initiating Mutated G-CSFR Signaling. Dwivedi, P; Chutipongtanate, S; Muench, DE; Azam, M; Grimes, HL; Greis, KD. Proteomics - Clinical Applications. 2020; 14.

Phospho serine and threonine analysis of normal and mutated granulocyte colony stimulating factor receptors. Dwivedi, P; Muench, DE; Wagner, M; Azam, M; Grimes, HL; Greis, KD. Scientific data. 2019; 6.

Targeted Inhibition of the Dual Specificity Phosphatases DUSP1 and DUSP6 Suppress MPNST Growth via JNK. Ramkissoon, A; Chaney, KE; Milewski, D; Williams, KB; Williams, RL; Choi, K; Miller, A; Kalin, TV; Pressey, JG; Szabo, S; et al. Clinical Cancer Research. 2019; 25:4117-4127.

The high NRF2 expression confers chemotherapy resistance partly through up-regulated DUSP1 in myelodysplastic syndromes. Lin, P; Ren, Y; Yan, X; Luo, Y; Zhang, H; Kesarwani, M; Bu, J; Zhan, D; Zhou, Y; Tang, Y; et al. Haematologica. 2019; 104:485-496.

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence. Kesarwani, M; Kincaid, Z; Azam, M. Journal of Visualized Experiments. 2019.

Time resolved quantitative phospho-tyrosine analysis reveals Bruton's Tyrosine kinase mediated signaling downstream of the mutated granulocyte-colony stimulating factor receptors. Dwivedi, P; Muench, DE; Wagner, M; Azam, M; Grimes, HL; Greis, KD. Leukemia. 2019; 33:75-87.

Expansion of EPOR-negative macrophages besides erythroblasts by elevated EPOR signaling in erythrocytosis mouse models. Wang, J; Hayashi, Y; Yokota, A; Xu, Z; Zhang, Y; Huang, R; Yan, X; Liu, H; Ma, L; Azam, M; et al. Haematologica. 2018; 103:40-50.

MEK/ERK addiction in CNL/aCML. Kesarwani, M; Kincaid, Z; Azam, M. Oncotarget. 2017; 8:99215-99216.

AP1 dependent transcriptional regulation in normal and leukemic hematopoiesis. Azam, M. Experimental Hematology. 2017; 53.