A photo of Frank Biro.

Professor, UC Department of Pediatrics



Board Certified

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My Biography & Research


I was inspired by the work of Dr. Robert Masland Jr. at Harvard Medical School and Dr. James Tanner at Oxford University to pursue my career in research studying pubertal maturation. I analyze factors that impact the onset of pubertal maturation and how changes during puberty can impact adult morbidity and mortality.

Youth are maturing at an earlier age. My research studies evaluate the effects that endocrine disruptors, such as household chemicals and personal care products, can exert on growth and development. I'm also studying risk markers for breast cancer. I examine additional factors, such as body mass index (BMI) and how elevations in BMI may be associated with the development of breast cancer.

My research is funded by the National Institutes of Health (NIH). I am board-certified in Internal Medicine (1983), Pediatrics (1986) and Adolescent Medicine (1995). I received the Clinical Care Achievement award from Cincinnati Children’s in 2017.

Clinical Interests

Complex medical problems of adolescence; growth; puberty

Academic Affiliation

Professor, UC Department of Pediatrics

Clinical Divisions

Adolescent Medicine

Research Divisions

Adolescent Medicine

Blog Posts

My Education

MD: Harvard Medical School, Boston, MA, 1979.

Certification: Internal Medicine, September 1983; Pediatrics, November 1986; Adolescent Medicine, February 1995.

My Publications

Onset of Puberty: Mother Knows Best. Biro, FM; Huang, B; Pinney, SM. Journal of Pediatric and Adolescent Gynecology. 2020; 33:455-458.

Pubertal development: What's normal/what's not. Smith, CE; Biro, FM. Clinical Obstetrics and Gynecology. 2020; 63:491-503.

Worldwide Secular Trends in Age at Pubertal Onset Assessed by Breast Development among Girls: A Systematic Review and Meta-analysis. Eckert-Lind, C; Busch, AS; Petersen, JH; Biro, FM; Butler, G; Brauner, EV; Juul, A. JAMA Pediatrics. 2020; 174:e195881-e195881.

Sex Hormone Phenotypes in Young Girls and the Age at Pubertal Milestones. Fassler, CS; Gutmark-Little, I; Xie, C; Giannini, CM; Chandler, DW; Biro, FM; Pinney, SM. Journal of Clinical Endocrinology and Metabolism. 2019; 104:6079-6089.

Environmental exposures during windows of susceptibility for breast cancer: a framework for prevention research. Michels, KB; Brody, JG; Jerry, DJ; Malecki, KM C; Miller, RL; Neuhausen, SL; Silk, K; Trentham-Dietz, A; Berry, MP; Bird, J; et al. Breast Cancer Research. 2019; 21:96-111.

Longitudinal study of age of menarche in association with childhood concentrations of persistent organic pollutants. Attfield, KR; Pinney, SM; Sjödin, A; Voss, RW; Greenspan, LC; Biro, FM; Hiatt, RA; Kushi, LH; Windham, GC. Environmental Research. 2019; 176:108551-108558.

Complex relationships between perfluorooctanoate, body mass index, insulin resistance and serum lipids in young girls. Fassler, CS; Pinney, SE; Xie, C; Biro, FM; Pinney, SM. Environmental Research. 2019; 176:108558-108558.

Perfluorooctanoate and changes in anthropometric parameters with age in young girls in the Greater Cincinnati and San Francisco Bay Area. Pinney, SM; Windham, GC; Xie, C; Herrick, RL; Calafat, AM; McWhorter, K; Fassler, CS; Hiatt, RA; Kushi, LH; Biro, FM; et al. International Journal of Hygiene and Environmental Health. 2019; 222:1038-1046.

Impact of Pubertal Maturation and Chronologic Age on Sex Steroids in Peripubertal Girls. Biro, FM; Huang, B; Chandler, DW; Fassler, CL; Pinney, SM. Journal of Clinical Endocrinology and Metabolism. 2019; 104:2971-2977.

"Complementary Medicine ": Complementary and Alternative Health Approaches in Pediatric and Adolescent Gynecology. Biro, FM; Bloemer, NL. Journal of Pediatric and Adolescent Gynecology. 2019; 32:3-6.