Kim M. Cecil, PhD

Biography & Affiliation Education Publications

Spectroscopist, Imaging Research Center

Professor, UC Department of RadiologyUC Department of Pediatrics

kim.cecil@cchmc.org

513-636-8559

513-636-3754

Biography & Affiliation

Biography

Kim M. Cecil, PhD, received her undergraduate and postgraduate training in chemistry. After a post-doctoral fellowship in magnetic resonance spectroscopy and imaging at the Hospital of the University of Pennsylvania, Dr. Cecil joined the Department of Radiology and the Imaging Research Center at Cincinnati Children’s Hospital Medical Center in 1998. She serves as an imaging research scientist and clinical MR spectroscopist.

In 2000, Kim M. Cecil, PhD, Antonius deGrauw, MD, PhD, and Gajja Salomons, PhD, discovered creatine transporter deficiency syndrome, a genetic disorder caused by mutations in the creatine transporter gene (SLC6A8). Male patients demonstrate a significant reduction or absence of creatine in the brain, as indicated by MR spectroscopy. This is an X-linked intellectual disability disorder thought to be second only to fragile X in prevalence.

Clinical Interests

Magnetic resonance spectroscopy; creatine deficiency syndromes

Research Interests

Magnetic resonance imaging and spectroscopy; inborn errors of metabolism; environmental exposures to lead manganese, air pollution, PBDEs, PFCs; traumatic brain injury including concussion; ADHD; bipolar disorders; breast cancer; non-alcoholic fatty liver disease

Academic Affiliation

Professor, UC Department of RadiologyUC Department of Pediatrics

Departments

Radiology, Imaging

Education

BS: Chemistry & Mathematics (magna cum laude), Kentucky Wesleyan College, 1988.

MS: Chemistry, Vanderbilt University, 1991.

PhD: Chemistry, Vanderbilt University, 1993.

Fellowship: Hospital of the University of Pennsylvania, Philadelphia, PA.

Publications

Clark JF, Cecil KM. Diagnostic methods and recommendations for the cerebral creatine deficiency syndromes. Pediatr Res. 2015;77:398-405.

Maugans TA, Farley C, Altaye M, Leach J, Cecil KM. Pediatric sports-related concussion produces cerebral blood flow alterations. Pediatrics. 2012;129:28-37.

Cecil KM, Dietrich KN, Altaye M, et al. Proton magnetic resonance spectroscopy in adults with childhood lead exposure. Environ Health Perspect. 2011;119:403-8.

Brubaker CJ, Dietrich KN, Lanphear BP, Cecil KM. The influence of age of lead exposure on adult gray matter volume. Neurotoxicology. 2010;31:259-66.

Brubaker CJ, Schmithorst VJ, Haynes EN, et al. Altered myelination and axonal integrity in adults with childhood lead exposure: a diffusion tensor imaging study. Neurotoxicology. 2009;30:867-75.

Yuan W, Holland SK, Cecil KM, et al. The impact of early childhood lead exposure on brain organization: a functional magnetic resonance imaging study of language function. Pediatrics. 2006;118:971-7.

Salomons GS, van Dooren SJ, Verhoeven NM, et al. X-linked creatine-transporter gene (SLC6A8) defect: a new creatine-deficiency syndrome. Am J Hum Genet. 2001;68:1497-500.

Cecil KM, Salomons GS, Ball WS Jr, et al. Irreversible brain creatine deficiency with elevated serum and urine creatine: a creatine transporter defect? Ann Neurol. 2001;49:401-4.

Strakowski SM, DelBello MP, Adler C, Cecil KM, Sax KW. Neuroimaging in bipolar disorder. Bipolar Disord. 2000;2:148-64.

Roebuck JR, Cecil KM, Schnall MD, Lenkinski RE. Human breast lesions: characterization with proton MR spectroscopy. Radiology. 1998;209:269-75.