Holly Depinet, MD, MPH

  • Associate Professor, UC Department of Pediatrics



As a pediatric emergency medicine specialist, I am dedicated to providing thoughtful, compassionate care to children and families during what can sometimes be a stressful time. I enjoy the opportunity to work with patients of all ages and with the varying conditions that we treat in the emergency department — and to bring a combination of evidence-based medical knowledge and family centered care to each visit.

My research interests include quality improvement, ED patient safety and pediatric sepsis. These interests stem from a desire to improve the care and experience for children and families with acute illness. My main focus is on improving processes and systems related to the identification and care of children with sepsis. This work includes efforts here at Cincinnati Children’s, and through involvement with national pediatric sepsis collaboratives.

BA: University of Delaware, Newark, DE, 1997.

MPH: University of South Carolina, Columbia, SC, 1999.

MD: Wake Forest University School of Medicine, Winston-Salem, NC, 2003.

Residency: Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA, 2003-2006.

Fellowship: Pediatric Emergency Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2006-2009;

Diploma Course in Tropical Medicine: University of West Virginia School of Medicine, Morgantown, WV, Summer 2008.

Intermediate Improvement Sciences Seminar: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, Spring 2010.

Services and Specialties

Emergency Medicine

Research Areas

Emergency Medicine


Association Between the First-Hour Intravenous Fluid Volume and Mortality in Pediatric Septic Shock. Eisenberg, MA; Riggs, R; Paul, R; Balamuth, F; Richardson, T; DeSouza, HG; Abbadesa, MK; DeMartini, TK M; Frizzola, M; Lane, R; et al. Annals of Emergency Medicine. 2022; 80:213-224.

Validation of the Pediatric Sequential Organ Failure Assessment Score and Evaluation of Third International Consensus Definitions for Sepsis and Septic Shock Definitions in the Pediatric Emergency Department. Balamuth, F; Scott, HF; Weiss, SL; Webb, M; Chamberlain, JM; Bajaj, L; Depinet, H; Grundmeier, RW; Campos, D; Deakyne Davies, SJ; et al. JAMA Pediatrics. 2022; 176:672-678.

Intravenous Fluid Bolus Rates Associated with Outcomes in Pediatric Sepsis: A Multi-Center Analysis. Mullan, PC; Pruitt, CM; Levasseur, KA; Macias, CG; Paul, R; Depinet, H; Nguyen, AT H; Melendez, E. Open Access Emergency Medicine. 2022; 14:375-384.

Pediatric Septic Shock Collaborative Improves Emergency Department Sepsis Care in Children. Depinet, H; Macias, CG; Balamuth, F; Lane, RD; Luria, J; Melendez, E; Myers, SR; Patel, B; Richardson, T; Zaniletti, I; et al. Pediatrics. 2022; 149.

Patterns of Vasoactive Agent Initiation Among Children With Septic Shock in the Pediatric Emergency Department. Jeffreys, KL; Eckerle, M; Depinet, H. Pediatric Emergency Care. 2022; 38:e205-e208.

Comparison of children receiving emergent sepsis care by mode of arrival. Lloyd, J; Depinet, H; Zhang, Y; Semenova, O; Meinzen-Derr, J; Babcock, L. American Journal of Emergency Medicine. 2021; 47:217-222.

Metric Development for the Multicenter Improving Pediatric Sepsis Outcomes (IPSO) Collaborative. Paul, R; Niedner, M; Brilli, R; Macias, C; Riggs, R; Balamuth, F; Depinet, H; Larsen, G; Huskins, C; Scott, H; et al. Pediatrics. 2021; 147.

Elevated Heart Rate and Risk of Revisit With Admission in Pediatric Emergency Patients. Daymont, C; Balamuth, F; Scott, HF; Bonafide, CP; Brady, PW; Depinet, H; Alpern, ER. Pediatric Emergency Care. 2021; 37:e185-e191.

Early prediction of pediatric acute kidney injury from the emergency department: A pilot study. Hanson, HR; Carlisle, MA; Bensman, RS; Byczkowski, T; Depinet, H; Terrell, TC; Pitner, H; Knox, R; Goldstein, SL; Basu, RK. American Journal of Emergency Medicine. 2021; 40:138-144.

Development of a Quality Improvement Learning Collaborative to Improve Pediatric Sepsis Outcomes. Larsen, GY; Brilli, R; Macias, CG; Niedner, M; Auletta, JJ; Balamuth, F; Campbell, D; Depinet, H; Frizzola, M; Hueschen, L; et al. Pediatrics. 2021; 147.

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