Sudhansu K. Dey, PhD

Biography & Affiliation Education Publications

Lova Riekert Chair, Cancer and Cell Biology

Director, Division of Reproductive Sciences

Professor, UC Department of Pediatrics

sk.dey@cchmc.org

513-803-1158

513-803-1160

Visit the Dey Lab

Biography & Affiliation

Biography

Dr. Dey received his PhD from The University of Calcutta College of Sciences in 1972, after which he received postdoctoral training at the University of Kansas Medical Center from 1973-1977, followed by his faculty appointment in 1977 where he rose to the rank of University Distinguished Professor. He moved to Vanderbilt University as Dorothy Overall Wells professor of pediatrics, cell and developmental biology and pharmacology in 2002. In both places he directed NIH-funded reproductive biology training grants. In 2008, Dr. Dey moved to Cincinnati Children’s Hospital Medical Center as Lova Riekert Chair and professor of pediatrics within the University of Cincinnati College of Medicine to start a new Division of Reproductive Sciences. He has published over 300 original articles and has been funded by two MERIT Awards, RO1 grants and a Program Project Grants from NIH, and grants from the Bill and Melinda Gates Foundation and March of Dimes Foundation. His research mission has been to define the molecular road map to embryo-uterine interactions during pregnancy. His recent work published in Developmental Cell, Nat Med, PNAS and JCI provides novel information in the context of cell polarity in implantation, ectopic pregnancy, progesterone resistance to pregnancy failure and premature decidual senescence in preterm delivery. In 2008, Dr. Dey received Carl G. Hartman Award, the highest honor of the Society for the Study of Reproduction. In 2009, he received IVI Award sponsored by Schering-Plough for best contribution in reproductive medicine.

He has graduated seven PhD students and mentored over 40 postdoctoral fellows, 20 of whom are currently independent faculty members, and most others are investigators in major research institutions. His laboratory currently consists of one junior faculty, four postdoctoral fellows, one MD/PhD student, and two research assistants.

Research Interests

Prostaglandin-nuclear receptor-angiogenic signaling axis during embryo implantation with special emphasis to cPLA2α-Cox2-PPARδ-Vegf network in the uterus; cytokine-growth factor-homeobox-morphogen signaling axis in implantation involving Lif-Hb-Egf-Hoxa10/Msx1-Ihh/Bmp/Wnt network in the uterus; immunophilin/cochaperone-nuclear signaling in the mouse uterus during implantation involving Fkbp52-PR; ligand-receptor signaling with endocannabinoids during the periimplantation events in mice in the context of anandamide interacting with G-protein coupled receptors, CB1 and CB2; molecular and genetic basis of epithelial ovarian cancer with special reference to prostaglandin-PPAR signaling; miRNA and Cox-2 regulation in uterine biology and cancer; Pten and uterine carcinoma: conditionally gene deleted mouse models

Academic Affiliation

Professor, UC Department of Pediatrics

Departments

Reproductive Sciences, Developmental Biology

Science Blog

Potential New Target Emerges for Preventing Preterm Birth

SK Dey, PhD7/3/2019

Study Links Marijuana to Preeclampsia

SK Dey, PhD6/26/2019

Education

BSc: Presidency College, Calcutta, India, 1965.

MSc: University of Calcutta, India, 1967.

PhD: University of Calcutta, India, 1972.

Publications

Endothelial Cells in the Decidual Bed Are Potential Therapeutic Targets for Preterm Birth Prevention. Deng, W; Yuan, J; Cha, J; Sun, X; Bartos, A; Yagita, H; Hirota, Y; Dey, SK. Cell Reports. 2019; 27:1755-1768.e4.

Mice Missing Cnr1 and Cnr2 Show Implantation Defects. Li, Y; Bian, F; Sun, X; Dey, SK. Endocrinology. 2019; 160:938-946.

Tridimensional visualization reveals direct communication between the embryo and glands critical for implantation. Yuan, J; Deng, W; Cha, J; Sun, X; Borg, J; Dey, SK. Nature Communications. 2018; 9.

The uterine epithelial loss of Pten is inefficient to induce endometrial cancer with intact stromal Pten. Liang, X; Daikoku, T; Terakawa, J; Ogawa, Y; Joshi, AR; Ellenson, LH; Sun, X; Dey, SK. PLoS Genetics. 2018; 14:e1007630-e1007630.

Crosstalk between PKC alpha and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium. Hsu, AH; Lum, MA; Shim, K; Frederick, PJ; Morrison, CD; Chen, B; Lele, SM; Sheinin, YM; Daikoku, T; Dey, SK; et al. Cell Reports. 2018; 24:655-669.

Quantitative Mass Spectrometry Imaging of Prostaglandins as Silver Ion Adducts with Nanospray Desorption Electrospray Ionization. Duncan, KD; Fang, R; Yuan, J; Chu, RK; Dey, SK; Burnum-Johnson, KE; Lanekoff, I. Analytical Chemistry. 2018; 90:7246-7252.

Metformin attenuates susceptibility to inflammation-induced preterm birth in mice with higher endocannabinoid levels. Sun, X; Tavenier, A; Deng, W; Leishman, E; Bradshaw, HB; Dey, SK. Biology of Reproduction. 2018; 98:208-217.

An interview with Dr Sudhansu K. Dey. Nowak, RA; Dey, SK. Biology of Reproduction. 2018; 98:1-3.

Cannabinoid receptor 1/2 double-knockout mice develop epilepsy. Rowley, S; Sun, X; Lima, IV; Tavenier, A; Pinheiro de Oliveira, AC; Dey, SK; Danzer, SC. Epilepsia. 2017; 58:e162-e166.

Preterm labor in the absence of acute histologic chorioamnionitis is characterized by cellular senescence of the chorioamniotic membranes. Gomez-Lopez, N; Romero, R; Plazyo, O; Schwenkel, G; Garcia-Flores, V; Unkel, R; Xu, Y; Leng, Y; Hassan, SS; Panaitescu, B; et al. American Journal of Obstetrics and Gynecology. 2017; 217:592.e1-592.e17.