I joined the Cincinnati Children’s Hospital Medical Center team in 2008 as the Lova Reikert Chair and professor of pediatrics within the University of Cincinnati College of Medicine. During this time, I started the new Division of Reproductive Sciences.
Prior to my appointment at Cincinnati Children’s, I received my postdoctoral training at the University of Kansas Medical Center. Following that training, I was appointed to the faculty and rose to the rank of University Distinguished Professor. In 2002, I moved to Vanderbilt University as a Dorothy Overall Wells professor of pediatrics, cell and developmental biology and pharmacology. At both institutions, I directed National Institutes of Health (NIH)-funded reproductive biology training grants.
Throughout my career, my focus has been to help define the molecular road map to embryo-uterine interactions during pregnancy. The quality of pregnancy helps determine how each child grows and develops throughout their lifetime. Better understanding these interactions during pregnancy can help improve the health of both mother and child while also preventing complications like preterm birth.
My research spans various aspects of reproduction, including:
- Aspects of preterm birth and its prevention
- How progressive aging leads to term birth
- The regulation of miRNA and Cox-2 in uterine biology and cancer
- The molecular and genetic basis of epithelial ovarian cancer with special reference to prostaglandin-PPAR signaling
- The relationship between phosphatase and tensin homolog (Pten) and uterine carcinoma
- The role of endocannabinoid signaling during early pregnancy
- Understanding how defective embryo implantation creates adverse effects that ripple throughout pregnancy and compromise pregnancy success
In 2008, I received the lifetime achievement award from the Society of Study of Reproduction (SSR). I have also received the International IVI Congress award for best contribution to reproductive medicine. I was elected as an American Association for the Advancement of Science (AAAS) fellow, and I have simultaneously received two NIH MERIT awards.
I have published over 450 papers, including numerous book chapters. Currently, I serve on several editorial boards and NIH Study Sections and advisory committees. I have also helped organize, been honored at, and lectured at many national and international meetings and symposia.
Prostaglandin-nuclear receptor-angiogenic signaling axis during embryo implantation with special emphasis to cPLA2α-Cox2-PPARδ-Vegf network in the uterus; cytokine-growth factor-homeobox-morphogen signaling axis in implantation involving Lif-Hb-Egf-Hoxa10/Msx1-Ihh/Bmp/Wnt network in the uterus; immunophilin/cochaperone-nuclear signaling in the mouse uterus during implantation involving Fkbp52-PR; ligand-receptor signaling with endocannabinoids during the periimplantation events in mice in the context of anandamide interacting with G-protein coupled receptors, CB1 and CB2; molecular and genetic basis of epithelial ovarian cancer with special reference to prostaglandin-PPAR signaling; miRNA and Cox-2 regulation in uterine biology and cancer; Pten and uterine carcinoma: conditionally gene deleted mouse models
Professor, UC Department of Pediatrics
Reproductive Sciences, Developmental Biology