About

Biography

I received the prestigious SPR Fellow's Basic Research Award upon completing my pediatric nephrology fellowship. I pursued a career as a physician scientist and continued to investigate the mechanism of proteinuria-induced injury in proximal tubule cells following my fellowship. My laboratory demonstrated an important link between the endocytic adapter protein disabled-2 (Dab2), which binds to the cytoplasmic tail of the albumin receptor megalin, and protein kinase B (Akt). I received an NIH career development-KO8 award to support my studies elucidating the link between albumin endocytosis and cell signaling events.

MD: Ankara University School of Medicine, Ankara, Turkey, 1990

Residency: Pediatrics, Marmara University Hospital, Istanbul, Turkey, 1997

Residency: Pediatrics, Montefiore Medical Center, Albert Einstein School of Medicine, Bronx, NY, 2002

Fellowship: Pediatric Nephrology, Montefiore Medical Center, Albert Einstein School of Medicine, Bronx, NY, 2000

MS: Clinical Research Methods, Montefiore Medical Center, Albert Einstein School of Medicine, Bronx, NY, 2001

Interests

Proteinuria; nephrotic syndrome.

Interests

Proteinuria induced tubular injury; tubular apoptosis; albumin endocytosis.

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Publications

Individualised treatment effects of corticosteroids in IgA nephropathy. Hölscher, DL; Schmitz, NEJ; Niggemeier, L; Pilva, P; Strauch, M; Tesar, V; Barratt, J; Roberts, ISD; Coppo, R; Barisoni, L; Floege, J; Kramann, R; Boor, P; Bülow, RD. EBioMedicine. 2026; 130:106396.

A Pilot Study of Urinary Cubilin Shedding in Type 1 Diabetes Mellitus: A Potential Biomarker to Predict Nephropathy. Ciccia, E; Zhang, B; Costacou, T; Erkan, E. Journal of Diabetes Research. 2026; 2026(1):e2291735.

Downregulation of Akt induces proximal tubule epithelial cell apoptosis via FOXO and BIM pathway in proteinuric States. Chhaing, R; Ma, Q; Schuh, M; Erkan, E. Scientific Reports. 2025; 15(1):37661.

Circulating Lipid Metabolites Exacerbate Progression via Podocyte Injury in FSGS. Humphrey, JA; Wilson, LS; Krallman, KA; Moritz, ML; Zaritsky, J; Erkan, E. Journal of the American Society of Nephrology. 2025; 36(10S):10.1681/asn.2025hymvc5sn.

Defining subgroups of pediatric nephrotic patients with urine proteomics. Cummins, TD; Mariani, LH; Wilkey, DW; Jortani, SA; Helmuth, M; Rane, MJ; Merchant, ML; Kamigaki, Y; Theesfeld, C; Mccown, PJ; Kretzler, M; Sumner, SJ; Smoyer, WE; Klein, JB. Scientific Reports. 2025; 15(1):25064.

Clinical Significance of Immune Deposits and Complement System Activation in FSGS: Findings from the Cure Glomerulonephropathy Network Study. Caliskan, Y; Royal, V; Troyanov, S; Bonnefoy, A; Merlen, C; Schnitzler, M; Edwards, JC; Lentine, KL; Laurin, L-P. Kidney360. 2025; 6(8):1384-1393.

Family History in the Context of CKD. Zanoni, F; Marasa, M; Carlassara, L; Verbitsky, M; Khan, A; Wang, C; Bundy, JD; Canetta, PA; Bomback, AS; Parsa, A; Feldman, HI; Gharavi, AG; Kiryluk, K. Journal of the American Society of Nephrology. 2025; 36(8):1561-1571.

ALONE WE SURVIVE, TOGETHER WE THRIVE: INTERNATIONAL MEDICAL GRADUATE EMPOWERMENT INITIATIVE. Erkan, E; Mohan, S; Bullard-Elias, D; Rodriguez, LR; Leal, JAE. Academic Pediatrics. 2025; 25(1):102690.

Responding to the workforce crisis: consensus recommendations from the Second Workforce Summit of the American Society of Pediatric Nephrology. Soranno, DE; Amaral, S; Ashoor, I; Atkinson, MA; Barletta, G-M; Braun, MC; Carlson, J; Carter, C; Chua, A; Dharnidharka, VR; Verghese, PS; Weidemann, D; Weinstein, A; Smith, J. Pediatric Nephrology. 2024; 39(12):3609-3619.

Urinary Lipid Biomarkers Predict Progression in Focal Segmental Glomerulosclerosis. Humphrey, JA; Armando, AM; Quehenberger, O; Troost, JP; Erkan, E. Journal of the American Society of Nephrology. 2024; 35(10S):10.1681/asn.2024dckvfdtw.

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