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Elif Erkan, MD, MS

Pediatric Nephrologist, Division of Nephrology

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-4531

Email elif.erkan@cchmc.org

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Clinical & Research Interests

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Clinical

Proteinuria; nephrotic syndrome.

Research

Proteinuria induced tubular injury; tubular apoptosis; albumin endocytosis.

Biography

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Dr. Elif Erkan received the prestigious SPR Fellow's Basic Research Award upon completion of her pediatric nephrology fellowship. She pursued a career as a physician scientist and continued to investigate the mechanism of proteinuria induced injury in proximal tubule cells following her fellowship. Her laboratory demonstrated an important link between endocytic adapter protein disabled-2 (Dab2) that binds to the cytoplasmic tail of albumin receptor megalin and protein kinase B (Akt). She received an NIH career development-KO8 award to support her studies elucidating the link between albumin endocytosis and cell signaling events.

Education and Training

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MD: Ankara University School of Medicine, Ankara, Turkey, 1990.

Residency: Pediatrics, Marmara University Hospital, Istanbul, Turkey, 1992-1997.

Residency: Pediatrics, Montefiore Medical Center, Albert Einstein School of Medicine, Bronx, NY, 2000-2002.

Fellowship: Pediatric Nephrology, Montefiore Medical Center, Albert Einstein School of Medicine, Bronx, NY, 1997-2000.

MS: Clinical Research Methods Montefiore Medical Center, Albert Einstein School of Medicine, Bronx, NY, 1998-2001.

Publications

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View PubMed Publications

Erkan E. Proteinuria: It is time to look beyond the proximal tubule. Am J Physiol Renal Physiol. 2013 Oct:305(8):F1107-8.

Erkan E. Proteinuria and progression of glomerular diseases. Pediatr Nephrol. 2013 Jul;28(7):1049-58.

Koral K, Erkan E. Pkb/Akt partners with Dab2 in albumin endocytosis. Am J Physiol Renal Physiol. 2012 Apr 15;302(8): F1013-24.

Keyel PA, Thieman JR, Roth R, Erkan E, Everett ET, Watkins SC, Heuser JE, Traub LM. The AP-2 adaptor beta2 appendage scaffolds alternate cargo endocytosis. Mol Biol Cell. 2008 Dec;19(12):5309-26.

Erkan E, Devarajan P, Schwartz G. Mitochondria are the major targets in albumin induced apoptosis in proximal tubule cells. J Am Soc Nephrol. 2007 Apr;18(4): 1199-208.

Erkan E, Devarajan P, Schwartz G. Apoptotic responses to albumin overload: proximal vs. distal/collecting tubule cells. Am J Nephrol. 2005 Mar-Apr;25(2):121-31.

Erkan E, Garcia C, Patterson LT, Mishra J, Mitsnefes MM, Kaskel FJ, Devarajan P. Induction of renal tubular cell apoptosis in FSGS: Roles of proteinuria and Fas-dependent pathways. J Am Soc Nephrol. 2005 Feb;16(2): 398-407.

Erkan E, Sakarcan A, Haklar G, Yalcin S. Thyroxine prevents reoxygenation injury in isolated proximal tubule cells. Pediatr Nephrol. 2003 Jul;18(7): 636-43.

Erkan E, Devarajan P, Kaskel F. Role of nitric oxide, endothelin-1, and inflammatory cytokines in blood pressure regulation in hemodialysis patients. Am J Kidney Dis. 2002 Jul;40(1):76-8.1

Erkan E, Moritz M, Kaskel F. Impact of residual renal function in children on hemodialysis. Pediatr Nephrol. 2001 Nov;16(11): 858-61.