My research areas include developmental biology, gene expression regulation, neural cell-fate specification, mechanisms patterning the early embryo and the mechanisms underlying Notch signaling, with a specific emphasis on modeling the disease alleles of Adams-Oliver syndrome.
The goal of my laboratory is to understand the molecular mechanisms underlying cell-specific transcription. I have always been fascinated with how cells within our body can use the same genome to generate the vast array of cell types needed to form functional organs and tissues.
Some of my groundbreaking discoveries include:
- How Hox transcription factors are integrated with genes regulating segmentation to pattern the early embryo
- How Hox transcription factors are integrated with zinc finger proteins to pattern the nervous system and regulate hematopoiesis
I received the Basil O'Connor Award from the March of Dimes in 2006. I have been a researcher for more than 26 years and began my work at Cincinnati Children's in 2004. My research has been published in respected journals, such as eLife, Nature, Science, Developmental Cell, Genes and Development, Development, Developmental Biology and PLoS Genetics.
Associate Professor, UC Department of Pediatrics