A photo of June Goto.

Assistant Professor, UC Department of Neurosurgery

513-803-4582

Biography & Affiliation

Academic Affiliation

Assistant Professor, UC Department of Neurosurgery

Research Divisions

Neurosurgery

Education

BS: Tokyo Gakugei University, 2000.

PhD: University of Tokyo, 2006.

Postdoctral training: University of Tokyo, 2007; Brigham and Women’s Hospital, Harvard Medical School, 2012.

Publications

Selected Publication

Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus. Jin, SC; Dong, W; Kundishora, AJ; Panchagnula, S; Moreno-De-Luca, A; Furey, CG; Allocco, AA; Walker, RL; Nelson-Williams, C; Smith, H; et al. Nature Medicine. 2020; 26:1754-1765.

Neonatal hydrocephalus leads to white matter neuroinflammation and injury in the corpus callosum of Ccdc39 hydrocephalic mice. Goulding, DS; Vogel, RC; Pandya, CD; Shula, C; Gensel, JC; Mangano, FT; Goto, J; Miller, BA. Journal of Neurosurgery: Pediatrics. 2020; 1-8.

Characterization of a novel rat model of X-linked hydrocephalus by CRISPR-mediated mutation in L1cam. Emmert, AS; Vuong, SM; Shula, C; Lindquist, D; Yuan, W; Hu, Y; Mangano, FT; Goto, J. Journal of Neurosurgery. 2020; 132:945-958.

Impaired neural differentiation and glymphatic CSF flow in the Ccdc39 rat model of neonatal hydrocephalus: genetic interaction with L1cam. Emmert, AS; Iwasawa, E; Shula, C; Schultz, P; Lindquist, D; Dunn, RS; Fugate, EM; Hu, Y; Mangano, FT; Goto, J. DMM Disease Models and Mechanisms. 2019; 12.

A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal motile cilia development in mice. Abdelhamed, Z; Vuong, SM; Hill, L; Shula, C; Timms, A; Beier, D; Campbell, K; Mangano, FT; Stottmann, RW; Goto, J. Development (Cambridge). 2018; 145.

Therapeutic value of prenatal rapamycin treatment in a mouse brain model of tuberous sclerosis complex. Anderl, S; Freeland, M; Kwiatkowski, DJ; Goto, J. Human Molecular Genetics. 2011; 20:4597-4604.

Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex. Goto, J; Talos, DM; Klein, P; Qin, W; Chekaluk, YI; Anderl, S; Malinowska, IA; Di Nardo, A; Bronson, RT; Chan, JA; et al. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108:E1070-E1079.

Loss of Fyn tyrosine kinase on the C57BL/6 genetic background causes hydrocephalus with defects in oligodendrocyte development. Goto, J; Tezuka, T; Nakazawa, T; Sagara, H; Yamamoto, T. Molecular and Cellular Neurosciences. 2008; 38:203-212.

Altered gene expression in the adult brain of fyn-deficient mice. Goto, J; Tezuka, T; Nakazawa, T; Tsukamoto, N; Nakamura, T; Ajima, R; Yokoyama, K; Ohta, T; Ohki, M; Yamamoto, T. Cellular and Molecular Neurobiology. 2004; 24:149-159.

Hydrocephalus in mouse B3glct mutants is likely caused by defects in multiple B3GLCT substrates in ependymal cells and subcommissural organ. Neupane, S; Goto, J; Berardinelli, SJ; Ito, A; Haltiwanger, RS; Holdener, BC. Glycobiology. 2021; 31:988-1004.