A photo of June Goto.

Assistant Professor, UC Department of Neurosurgery


Biography & Affiliation

Academic Affiliation

Assistant Professor, UC Department of Neurosurgery




BS: Tokyo Gakugei University, 2000.

PhD: University of Tokyo, 2006.

Postdoctral training: University of Tokyo, 2007; Brigham and Women’s Hospital, Harvard Medical School, 2012.


Selected Publication

Characterization of a novel rat model of X-linked hydrocephalus by CRISPR-mediated mutation in L1cam. Emmert, AS; Vuong, SM; Shula, C; Lindquist, D; Yuan, W; Hu, Y; Mangano, FT; Goto, J. Journal of Neurosurgery. 2020; 132:945-958.

Impaired neural differentiation and glymphatic CSF flow in the Ccdc39 rat model of neonatal hydrocephalus: Genetic interaction with L1cam. Emmert, AS; Iwasawa, E; Shula, C; Schultz, P; Lindquist, D; Dunn, RS; Fugate, EM; Hu, Y; Mangano, FT; Goto, J. DMM Disease Models and Mechanisms. 2019; 12:dmm040972-dmm040972.

A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal motile cilia development in mice. Abdelhamed, Z; Vuong, SM; Hill, L; Shula, C; Timms, A; Beier, D; Campbell, K; Mangano, FT; Stottmann, RW; Goto, J. Development (Cambridge). 2018; 145:dev154500-dev154500.

Therapeutic value of prenatal rapamycin treatment in a mouse brain model of tuberous sclerosis complex. Anderl, S; Freeland, M; Kwiatkowski, DJ; Goto, J. Human Molecular Genetics. 2011; 20:4597-4604.

Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex. Goto, J; Talos, DM; Klein, P; Qin, W; Chekaluk, YI; Anderl, S; Malinowska, IA; Di Nardo, A; Bronson, RT; Chan, JA; et al. Proceedings of the National Academy of Sciences of USA. 2011; 108:E1070-E1079.

Loss of Fyn tyrosine kinase on the C57BL/6 genetic background causes hydrocephalus with defects in oligodendrocyte development. Goto, J; Tezuka, T; Nakazawa, T; Sagara, H; Yamamoto, T. Molecular and Cellular Neurosciences. 2008; 38:203-212.

Altered gene expression in the adult brain of fyn-deficient mice. Goto, J; Tezuka, T; Nakazawa, T; Tsukamoto, N; Nakamura, T; Ajima, R; Yokoyama, K; Ohta, T; Ohki, M; Yamamoto, T. Cellular and Molecular Neurobiology. 2004; 24:149-159.

Brain-expressed X-linked 2 Is Pivotal for Hyperactive Mechanistic Target of Rapamycin (mTOR)-mediated Tumorigenesis. Hu, Z; Wang, Y; Huang, F; Chen, R; Li, C; Wang, F; Goto, J; Kwiatkowski, DJ; Wdzieczak-Bakala, J; Tu, P; et al. The Journal of biological chemistry. 2015; 290:25756-25765.

Survival benefit and phenotypic improvement by hamartin gene therapy in a tuberous sclerosis mouse brain model. Prabhakar, S; Zhang, X; Goto, J; Han, S; Lai, C; Bronson, R; Sena-Esteves, M; Ramesh, V; Stemmer-Rachamimov, A; Kwiatkowski, DJ; et al. Neurobiology of Disease. 2015; 82:22-31.