A photo of Andrew Herr.

Director of Admissions, Immunology Graduate Program

Associate Professor, UC Department of Pediatrics

513-803-7490

Biography & Affiliation

Biography

Andrew Herr, PhD, is an associate professor in the Division of Immunobiology and Center for Systems Immunology, with an affiliate appointment in the Division of Infectious Diseases at Cincinnati Children's within the UC Department of Pediatrics. Dr. Herr completed his thesis work in molecular biophysics from Washington University in St. Louis, and completed his postdoctoral work in structural immunology at the California Institute of Technology as a Damon Runyon Research Fellow. He was recruited to the University of Cincinnati College of Medicine as an Ohio Eminent Scholar in Structural Biology before moving to Cincinnati Children’s Hospital.

Dr. Herr solved the first structure of a human IgA1 antibody bound to its cognate Fc receptor while at Caltech, and his lab has continued to study antibodies and immune receptors implicated in autoimmune diseases. In addition, the lab is studying a family of related collagen-specific immune receptors such as glycoprotein VI, which activates platelets upon exposure to fibrous collagen. The Herr lab also studies mechanisms of bacterial pathogenesis. Specifically, they discovered the zinc-dependent mechanism of intercellular adhesion in bacterial biofilms formed by Staphylococcus epidermidis and S. aureus. Biofilms are specialized bacterial colonies that are highly resistant to antibiotics and immune responses, so developing novel therapies to prevent biofilm formation is of high importance.

Before joining the faculty at Cincinnati Children's within the University of Cincinnati College of Medicine, Dr. Herr was an Ohio Eminent Scholar in Structural Biology at the University of Cincinnati College of Medicine and served as an associate director of the Cincinnati Medical Scientist (MD/PhD) Training Program. Dr. Herr received the 2014 Emerging Entrepreneurial Achievement Faculty Award from UC for his work to commercialize a novel anti-infective therapy based on his lab’s research.

Research Interests

Structural biology and biophysics of antibodies; immune receptors; bacterial surface proteins

Academic Affiliation

Associate Professor, UC Department of Pediatrics

Divisions

Immunobiology, Infectious Diseases

Education

BA: Oral Roberts University, Tulsa, OK, 1993.

PhD: Washington University Medical School, St. Louis, MO, 1999.

Postdoc: California Institute of Technology, Pasadena, CA, 2003.

Publications

Selected Publication

Gab3 is required for IL-2-and IL-15-induced NK cell expansion and limits trophoblast invasion during pregnancy. Sliz, A; Locker, KC S; Lampe, K; Godarova, A; Plas, DR; Janssen, EM; Jones, H; Herr, AB; Hoebe, K. Science Immunology. 2019; 4:eaav3866-eaav3866.

Fc alpha RI binding at the IgA1 C(H)2-C(H)3 interface induces long-range conformational changes that are transmitted to the hinge region. Posgai, MT; Tonddast-Navaei, S; Jayasinghe, M; Ibrahim, GM; Stan, G; Herr, AB. Proceedings of the National Academy of Sciences of USA. 2018; 115:E8882-E8891.

Functional consequences of B-repeat sequence variation in the staphylococcal biofilm protein Aap: deciphering the assembly code. Shelton, CL; Conrady, DG; Herr, AB. The Biochemical journal. 2017; 474:427-443.

The Proline/Glycine-Rich Region of the Biofilm Adhesion Protein Aap Forms an Extended Stalk that Resists Compaction. Yarawsky, AE; English, LR; Whitten, ST; Herr, AB. Journal of Molecular Biology. 2017; 429:261-279.

Structural basis for collagen recognition by the immune receptor OSCAR. Zhou, L; Hinerman, JM; Blaszczyk, M; Miller, JL C; Conrady, DG; Barrow, AD; Chirgadze, DY; Bihan, D; Farndale, RW; Herr, AB. Blood. 2016; 127:529-537.

IgG1 protects against renal disease in a mouse model of cryoglobulinaemia. Strait, RT; Posgai, MT; Mahler, A; Barasa, N; Jacob, CO; Koehl, J; Ehlers, M; Stringer, K; Shanmukhappa, SK; Witte, D; et al. Nature. 2015; 517:501-504.

Structural basis for Zn2+-dependent intercellular adhesion in staphylococcal biofilms. Conrady, DG; Wilson, JJ; Herr, AB. Proceedings of the National Academy of Sciences of USA. 2013; 110:E202-E211.

A zinc-dependent adhesion module is responsible for intercellular adhesion in staphylococcal biofilms. Conrady, DG; Brescia, CC; Horii, K; Weiss, AA; Hassett, DJ; Herr, AB. Proceedings of the National Academy of Sciences of USA. 2008; 105:19456-19461.

Structural basis for platelet collagen responses by the immune-type receptor glycoprotein VI. Horii, K; Kahn, ML; Herr, AB. Blood. 2006; 108:936-942.

Insights into IgA-mediated immune responses from the crystal structures of human Fc alpha RI and its complex with IgA1-Fc. Herr, AB; Ballister, ER; Bjorkman, PJ. Nature. 2003; 423:614-620.