A photo of Matthew Kofron.

Director, Confocal Imaging Core

Associate Professor, UC Department of Pediatrics

513-803-9055

513-636-4317

Biography & Affiliation

Biography

I chose to become a researcher because of my passion for discovery and innovation. My research interests include developmental biology, germ layer formation, cell signaling, microscopy, immunology, lung biology and digestive disease. I began my work at Cincinnati Children’s in 2000 and have more than 30 years of research experience. I received the Senior Faculty Service award in 2020 from Cincinnati Children’s.

In my early career, I focused on embryonic development and cell-cell signaling. I now facilitate the use of microscopy and advanced imaging for other researchers in the Cincinnati Children’s Research Foundation in the Confocal Imaging Core (CIC). This type of advanced imaging provides a high resolution that allows microscopic visualization down to the subcellular level. In addition to imaging, we have developed tools for analysis and methodologies for image interpretation for quantitative analysis.

My work has been published in various publications, including Nature, Cell Stem Cell, Developmental Cell, Nature Cell Biology, Clinical Cytometry, Genes and Brain Behavior and Hepatology.

Research Interests

Early vertebrate patterning; germ layer formation

Academic Affiliation

Associate Professor, UC Department of Pediatrics

Research Divisions

Developmental Biology, Fibrosis



Blog Posts

Of Mice and Molecules: Our Confocal Imaging Core

Imaging Sciences

Of Mice and Molecules: Our Confocal Imaging Core

J. Matthew Kofron, PhD6/30/2019

Education

PhD: University of Minnesota, Minneapolis, MN, 1999.

Publications

Lipopolysaccharide Reverses Hepatic Stellate Cell Activation Through Modulation of cMyb, Small Mothers Against Decapentaplegic, and CCAAT/Enhancer-Binding Protein C/EBP Transcription Factors. Sharma, A; Verma, AK; Kofron, M; Kudira, R; Miethke, A; Wu, T; Wang, J; Gandhi, CR. Hepatology. 2020; 72:1800-1818.

Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition. Hinge, A; He, J; Bartram, J; Javier, J; Xu, J; Fjellman, E; Sesaki, H; Li, T; Yu, J; Wunderlich, M; et al. Cell Stem Cell. 2020; 26:420-430.e6.

Endosome-Mediated Epithelial Remodeling Downstream of Hedgehog-Gli Is Required for Tracheoesophageal Separation. Nasr, T; Mancini, P; Rankin, SA; Edwards, NA; Agricola, ZN; Kenny, AP; Kinney, JL; Daniels, K; Vardanyan, J; Han, L; et al. Developmental Cell. 2019; 51:665-674.e6.

Human stomach-on-a-chip with luminal flow and peristaltic-like motility. Lee, KK; McCauley, HA; Broda, TR; Kofron, MJ; Wells, JM; Hong, CI. Lab on a Chip: miniaturisation for chemistry, physics, biology, materials science and bioengineering. 2018; 18:3079-3085.

AMP kinase promotes glioblastoma bioenergetics and tumour growth. Chhipa, RR; Fan, Q; Anderson, J; Muraleedharan, R; Huang, Y; Ciraolo, G; Chen, X; Waclaw, R; Chow, LM; Khuchua, Z; et al. Nature Cell Biology. 2018; 20:823-835.

A guide to choosing fluorescent protein combinations for flow cytometric analysis based on spectral overlap. Kleeman, B; Olsson, A; Newkold, T; Kofron, M; DeLay, M; Hildeman, D; Grimes, HL. Cytometry Part B: Clinical Cytometry. 2018; 93A:556-562.

A heterozygous mutation in tubulin, beta 2B (Tubb2b) causes cognitive deficits and hippocampal disorganization. Stottmann, RW; Driver, A; Gutierrez, A; Skelton, MR; Muntifering, M; Stepien, C; Knudson, L; Kofron, M; Vorhees, CV; Williams, MT. Genes, Brain and Behavior. 2017; 16:250-259.

The Dendritic Cell-T Helper 17-Macrophage Axis Controls Cholangiocyte Injury and Disease Progression in Murine and Human Biliary Atresia. Lages, CS; Simmons, J; Maddox, A; Jones, K; Karns, R; Sheridan, R; Shanmukhappa, SK; Mohanty, S; Kofron, M; Russo, P; et al. Hepatology. 2017; 65:174-188.

Airway Epithelial KIF3A Regulates Th2 Responses to Aeroallergens. Giridhar, PV; Bell, SM; Sridharan, A; Rajavelu, P; Kitzmiller, JA; Na, C; Kofron, M; Brandt, EB; Ericksen, M; Naren, AP; et al. Journal of immunology (Baltimore, Md. : 1950). 2016; 197:4228-4239.

Nodal signalling in Xenopus: the role of Xnr5 in left/right asymmetry and heart development. Tadjuidje, E; Kofron, M; Mir, A; Wylie, C; Heasman, J; Cha, S. Open Biology. 2016; 6:150187-150187.