A photo of Michael Lacagnina.

Michael J. Lacagnina, PhD


  • Member, Department of Anesthesia
  • Assistant Professor, UC Department of Anesthesia

About

PhD: Duke University, Durham, NC, 2016.

Postdoctoral Research: University of Texas MD Anderson Cancer Center, Houston, TX, 2017-2022.

Instructor: University of Texas MD Anderson Cancer Center, Houston, TX, 2022-2023.

Interests

Neuroimmunology; mechanisms of chronic pain; glial biology; autoimmunity

Research Areas

Anesthesia

Publications

The role of cytokines in acute and chronic postsurgical pain after major musculoskeletal surgeries in a quaternary pediatric center. Chidambaran, V; Duan, Q; Pilipenko, V; Glynn, SM; Sproles, A; Martin, LJ; Lacagnina, MJ; King, CD; Ding, L. Brain, Behavior, and Immunity. 2024; 122:596-603.

B cells drive neuropathic pain-related behaviors in mice through IgG-Fc gamma receptor signaling. Lacagnina, MJ; Willcox, KF; Boukelmoune, N; Bavencoffe, A; Sankaranarayanan, I; Barratt, DT; Zuberi, YA; Dayani, D; Chavez, MV; Lu, JT; Heijnen, CJ; Price, TJ; Fiore, NT; Grace, PM. Science Translational Medicine. 2024; 16:eadj1277.

Voluntary wheel running prevents formation of membrane attack complexes and myelin degradation after peripheral nerve injury. Green-Fulgham, SM; Lacagnina, MJ; Willcox, KF; Li, J; Harland, ME; Ciena, AP; Rocha, IR C; Ball, JB; Dreher, RA; Zuberi, YA; Dragavon, JM; Chacur, M; Maier, SF; Watkins, LR; Grace, PM. Brain, Behavior, and Immunity. 2024; 115:419-431.

B Cells Promote Mechanical Allodynia After Peripheral Nerve Injury. Lacagnina, MJ; Willcox, KF; Boukelmoune, N; Heijnen, CJ; Grace, PM. Journal of Pain. 2023; 24:37.

Functionality of a Peripheral Blood Derived Microglia-like Cell System for Drug Discovery to Treat Sickle Cell Related Chronic Pain. Zhang, Y; Kanne, CK; Hernandez, BN; Lacagnina, MJ; Grace, PM; Burish, MJ; Sheehan, VA. Blood. 2022; 140:2498-2499.

Development of a High-Throughput Drug Screening System Based on Human Peripheral Blood Derived Microglia-like Cells from Sickle Cell Patients with Chronic Pain. Zhang, Y; Kanne, CK; Lacagnina, MJ; Grace, PM; Burish, MJ; Sheehan, VA. Blood. 2022; 140:10678-10679.

Preconditioning by voluntary wheel running attenuates later neuropathic pain via nuclear factor E2-related factor 2 antioxidant signaling in rats. Green-Fulgham, SM; Harland, ME; Ball, JB; Li, J; Lacagnina, MJ; D'Angelo, H; Dreher, RA; Willcox, KF; Lorca, SA; Kwilasz, AJ; Maier, SF; Watkins, LR; Grace, PM. PAIN. 2022; 163:1939-1951.

Antibody Receptor Signaling from Spinal Cord Astrocytes Promotes Neuropathic Pain. Lacagnina, MJ; Willcox, K; Li, J; Alfaro, AG; Lorca, S; Grace, PM. Journal of Pain. 2022; 23:10-11.

Microglia Activation Tracking across Brain Regions over the Development of Neuropathic Pain. Cazuza, R; Lacagnina, MJ; Grace, PM. Journal of Pain. 2022; 23:2.

Antibody receptor signaling on spinal cord glial cells promotes neuropathic pain. Lacagnina, MJ; Willcox, K; Li, J; Alfaro, AG; Lorca, S; Grace, PM. Brain, Behavior, and Immunity. 2021; 98:27-28.