Timothy D. LeCras, PhD

Associate Director of Admissions, Medical Scientist Training Program

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-8151

Fax 513-636-7868

Email tim.lecras@cchmc.org

Pathogenesis of vascular anomalies; vascular malformations; kaposiform lymphangiomatosis; capillary lymphatic venous malformations; pulmonary hypertension; pulmonary vascular disease; bronchopulmonary dysplasia

Visit the LeCras Lab.

Timothy LeCras, PhD, investigates the causes of vascular malformations and biomarkers of these diseases in children. The goal of his laboratory is to use this knowledge to identify new therapeutic targets to treat patients with these congenital vascular malformations. The aim to identify novel biomarkers that can be easily measured is to help develop diagnostic tools that will help with diagnosis of patients and if possible predict the response to treatments.

View Dr. LeCras's ORCID profile.

Postdoctoral fellow: University of Virginia, Charlottesville, VA, 1993-1996.

PhD: University of Cambridge, UK, 1988-1992.

BSc: Biochemistry, Brunel University, London, UK, 1983-1987.

View PubMed Publications

Ikeda KT, Hale PT, Pauciulo MW, Dasgupta N, Pastura PA, Le Cras TD, Pandey MK, Nichols WC. Hypoxia-Induced Pulmonary Hypertension in Different Mouse Strains - Relation to Transcriptome. Am J Respir Cell Mol Biol. 2018 Aug 22.

Le Cras TD, Mobberley-Schuman PS, Broering M, Fei L, Trenor CC 3rd, Adams DM. Angiopoietins as serum biomarkers for lymphatic anomalies. Angiogenesis. 2017;20(1):163-173. 

Acciani TH, Brandt EB, Khurana Hershey GK, Le Cras TD. (2013) Diesel Exhaust Particle Exposure Exacerbates Allergic Asthma in Young Mice. Clin Exp Allergy. 2013 Dec;43(12):1406-18. *Selected for Editors Choice in December issue 2013 Clin Exp Allergy.

Mushaben EM, Brandt EB, Hershey GKK, Le Cras TD. Differential Effects of Rapamycin and Dexamethasone in Mouse Models of Established Allergic Asthma. PLoS ONE. 2013;8(1):e54426.

Kramer EL, Hardie WD, Mushaben E, Acciani T, Pastura P, Korfhagen T, Khurana Hershey G, Whitsett JA, Le Cras TD. Rapamycin Decreases Airway Remodeling and Hyperreactivity in a Transgenic Model of Noninflammatory Lung Disease.  J Appl Physiol. 2011 Dec;111:1760-7.

Mushaben EM, Kramer EL, Brandt EB, Khurana Hershey G, Le Cras TD. Rapamycin Attenuates Airway Hyperreactivity, IgE, T cells and Mediators of Allergic Asthma. J Immunol. 2011 Dec 1;187(11):5756-63.

Le Cras TD, Acciani TH, Mushaben EM, Kramer EL, Pastura PA, Hardie WD, Korfhagen TR, Sivaprasad U, Ericksen M, Gibson A, Holtzman MJ, Whitsett JA, Khurana Hershey GK. Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic allergic asthma. Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L414-21.

Le Cras TD, Korfhagen TR, Davidson C, Schmidt S, Fenchel M, Ikegami M, Whitsett JA, Hardie WD. Inhibition of PI3K prevents transforming growth factor-alpha induced pulmonary fibrosis. Am J Path. 2010 Feb;176(2):679-86.