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A photo of Timothy LeCras.

Associate Director of Admissions, Medical Scientist Training Program

Associate Professor, UC Department of Pediatrics

513-636-8151

513-636-7868

Biography & Affiliation

Biography

Timothy Le Cras, PhD, investigates the causes of vascular malformations and biomarkers of these diseases in children. The goal of his laboratory is to use this knowledge to identify new therapeutic targets to treat patients with these congenital vascular malformations. The aim to identify novel biomarkers that can be easily measured is to help develop diagnostic tools that will help with diagnosis of patients and if possible predict the response to treatments.

View Dr. Le Cras's ORCID profile.

Research Interests

Pathogenesis of vascular anomalies; vascular malformations; kaposiform lymphangiomatosis; capillary lymphatic venous malformations; pulmonary hypertension; pulmonary vascular disease; bronchopulmonary dysplasia

Academic Affiliation

Associate Professor, UC Department of Pediatrics

Department

Pulmonary Biology

Education

Postdoctoral fellow: University of Virginia, Charlottesville, VA, 1993-1996.

PhD: University of Cambridge, UK, 1988-1992.

BSc: Biochemistry, Brunel University, London, UK, 1983-1987.

Publications

Signaling pathways and inhibitors of cells from patients with kaposiform lymphangiomatosis. Boscolo, E; Pastura, P; Glaser, K; Goines, J; Hammill, AM; Adams, DM; Dickie, P; Dickie, BH; Le Cras, TD. Pediatric Blood and Cancer. 2019; 66.

Cellular and molecular mechanisms of PIK3CA-related vascular anomalies. Le Cras, TD; Boscolo, E. 2019; 1:H33-H40.

Ponatinib Combined With Rapamycin Causes Regression of Murine Venous Malformation. Li, X; Cai, Y; Goines, J; Pastura, P; Brichta, L; Lane, A; Le Cras, TD; Boscolo, E. Arteriosclerosis, Thrombosis, and Vascular Biology. 2019; 39:496-512.

Hypoxia-induced Pulmonary Hypertension in Different Mouse Strains: Relation to Transcriptome. Ikeda, KT; Hale, PT; Pauciulo, MW; Dasgupta, N; Pastura, PA; Le Cras, TD; Pandey, MK; Nichols, WC. American Journal of Respiratory Cell and Molecular Biology. 2019; 60:106-116.

IL-17A enhances IL-13 activity by enhancing IL-13-induced signal transducer and activator of transcription 6 activation. Hall, SL; Baker, T; Lajoie, S; Richgels, PK; Yang, Y; McAlees, JW; van Lier, A; Wills-Karp, M; Sivaprasad, U; Acciani, TH; et al. Journal of Allergy and Clinical Immunology. 2017; 139:462-471.e14.

Angiopoietins as serum biomarkers for lymphatic anomalies. Le Cras, TD; Mobberley-Schuman, PS; Broering, M; Fei, L; Trenor, CC; Adams, DM. Angiogenesis. 2017; 20:163-173.

Epidermal growth factor receptor signalling regulates granulocyte-macrophage colony-stimulating factor production by airway epithelial cells and established allergic airway disease. Acciani, TH; Suzuki, T; Trapnell, BC; Le Cras, TD. Clinical and Experimental Allergy. 2016; 46:317-328.

Placenta growth factor augments airway hyperresponsiveness via leukotrienes and IL-13. Mpollo, ME M; Brandt, EB; Shanmukhappa, SK; Arumugam, PI; Tiwari, S; Loberg, A; PiIlls, D; Rizvi, T; Lindsey, M; Jonck, B; et al. Journal of Clinical Investigation. 2016; 126:571-584.

Exposure to allergen and diesel exhaust particles potentiates secondary allergen-specific memory responses, promoting asthma susceptibility. Brandt, EB; Myers, JM B; Acciani, TH; Ryan, PH; Sivaprasad, U; Ruff, B; LeMasters, GK; Bernstein, DI; Lockey, JE; LeCras, TD; et al. Journal of Allergy and Clinical Immunology. 2015; 136:295-303.e7.