Le Cras Research Lab

Vascular Malformations and Tumors In Children

Vascular malformations and tumors in children and infants can have high morbidity and mortality. Definitive diagnosis of these congenital diseases is challenging and usually requires a biopsy that can worsen the disease and precipitate severe complications. Mechanisms driving abnormal vessel growth in vascular anomalies are unclear and therapeutic options are limited and often have deleterious side effects.

Our group is based in the Pulmonary Biology Division but has extensive collaborations with other investigators and physicians in the Hemangioma and Vascular Malformation Center (HVMC) at CCHMC as well as in vascular anomaly centers around the US.

The long-term goals of our laboratory including the following:

  • Identify diagnostic and prognostic biomarkers for patients with vascular malformations and tumors
  • Gain insights into the pathogenesis of these diseases
  • Develop new therapeutic targets for these patients
vascular anomalies chart
Members of the Le Cras Laboratory.

Click to enlarge.

Publications

To view a complete and updated list of publications from the Le Cras Lab, visit Dr. Le Cras' PubMed listing.

Contact Information

Tim D. Le Cras, PhD
Associate Professor
UC Department of Pediatrics

Mailing Address:
Division of Pulmonary Biology
Cincinnati Children's Hospital Medical Center
3333 Burnet Ave.
Cincinnati, OH 45229-3039

Phone: 513-636-8151
Fax: 513-636-7868
Email: tim.lecras@cchmc.org

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