Pathogenesis of Chronic Lung Diseases

Chronic lung diseases are a major cause of long-term disability and death in children and adults. Asthma, pulmonary hypertension, and lung disease in premature babies are the chronic lung diseases that are some of the most common and affect millions of people in the US and worldwide. The underlying causes of these diseases remain poorly understood and current treatments mostly treat the symptoms. Hence, there is a major need for new therapies that better target the disease causing mechanisms of these diseases. This is the focus of our laboratory. Through research using mouse models of these diseases we aim to better understand the causes of these diseases and then target the pathways and genes involved to block the disease process. Our laboratory has extensive experience in lung biology and modeling chronic lung diseases. We work as a team in conjunction with other outstanding groups at Cincinnati Children’s and other institutions around the US and the world.