Le Cras Lab

Publications

Alharbi, S; Wagner, A; Merkle, S; Pastura, P; Mcdaniel, CG; Fox, D; Xu, Y; Cras, TDL. MEK Inhibition Reduces Vascular Malformations and Gene Dysregulation in NRASQ61R Human Endothelial Cells. Pediatric Blood and Cancer. 2026; e70002.

Merkle, S; Lecras, T; Ricci, K; Hammill, A; Engel, E. Use of angiopoietin-2 as a biomarker in vascular anomalies beyond complex lymphatic anomalies. Blood. 2025; 146(Supplement 1):4877.

Fox, DA; Mcdaniel, CG; Pastura, P; Le Cras, TD. Human Lymphatic Endothelial Cells Expressing NRASQ61R Model Characteristics of Kaposiform Lymphangiomatosis. Pediatric Blood and Cancer. 2025; 72(11):e31984.

Mcdaniel, CG; Merkle, S; Lacuna, S; Cooper, S; Courtemanche, R; Nguyen, T; Le Cras, TD. Trametinib Normalizes Angiopoietin-2 Levels and Successfully Treats Kaposiform Lymphangiomatosis. Journal of Vascular Anomalies. 2025; 6(4):e124.

Alharbi, S; Merkle, S; Hammill, AM; Waters, AM; Le Cras, TD. RAS Pathway Mutations and Therapeutics in Vascular Anomalies. Pediatric Blood and Cancer. 2025; 72(5):e31605.

Mcdaniel, CG; Fox, D; Pastura, P; Alharbi, S; Huppert, SS; Cras, TDL. Lyve1-Driven NrasQ61R Causes Edema, Enlarged Lymphatic Vessels, and Hepatic Vascular Defects in Embryonic Mice. Pediatric Blood and Cancer. 2025; 72(3):e31492.

Pastura, P; Mcdaniel, CG; Alharbi, S; Fox, D; Coleman, B; Malik, P; Adams, DM; Le Cras, TD. NRASQ61R mutation drives elevated angiopoietin-2 expression in human endothelial cells and a genetic mouse model. Pediatric Blood and Cancer. 2024; 71(7):e31032.

Engel, ER; Le Cras, TD; Ricci, KW. How we use angiopoietin-2 in the diagnosis and management of vascular anomalies. Pediatric Blood and Cancer. 2024; 71(5):e30921.

Mcdaniel, CG; Adams, DM; Steele, KE; Hammill, AM; Merrow, AC; Crane, JL; Smith, CL; Kozakewich, HPW; Le Cras, TD. Kaposiform lymphangiomatosis: Diagnosis, pathogenesis, and treatment. Pediatric Blood and Cancer. 2023; 70(4):e30219.

Boscolo, E; Pastura, P; Schrenk, S; Goines, J; Kang, R; Pillis, D; Malik, P; Le Cras, TD. NRASQ61R mutation in human endothelial cells causes vascular malformations. Angiogenesis. 2022; 25(3):331-342.