In the Le Cras Lab, our research is centered around studying the mechanisms that regulate and coordinate lung development, and particularly blood vessel development in the lungs. Our work integrates this work with understanding of how these processes get disrupted in premature babies and also children and adults who develop chronic lung diseases and pulmonary hypertension. Our long term goals are to identify new therapeutic targets for lung disease in premature infants (BPD), and pulmonary vascular disease, and pulmonary hypertension in children and adults. In addition, our group also works on identifying mechanisms that cause airway remodeling in asthma (airway smooth muscle thickening and fibrosis). The long-term goal of these studies is to develop new therapeutic targets for chronic lung diseases, including lung disease in premature infants (BPD), pulmonary hypertension (PAH), and asthma. Our group works very closely with a number of other labs at Cincinnati Children's.