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Attending Neonatologist, Perinatal Institute
Professor, UC Department of Pediatrics
Dr. Nehal Parikh’s singular goal is to prevent neurodevelopmental disabilities. Following rigorous training in translational research and clinical trials, he embarked on studies of etiology, prediction and prevention of neurodevelopmental disabilities in high-risk newborns. He has led or co-led several cohort studies of advanced brain MRI in very preterm infants, clinical trials of neuroprotective therapies in high-risk newborns, and the development of the NICHD NRN Extremely Preterm Birth Outcomes prognostic calculator and website. Increased survival of extremely preterm infants has contributed to a higher prevalence of survivors with motor, cognitive, and behavioral/psychiatric abnormalities. Accurate diagnosis of these abnormalities takes 2 to 3 years. These early years are when the brain is most active in building its wiring system and optimally receptive to change and healing. Thus, when the diagnosis is delayed by up to 3 years, we are losing precious time. Newer approaches to diagnosis, prediction and prevention of developmental disabilities are urgently needed to improve the long-term quality of life of high-risk newborns.
The Parikh lab employs advanced brain MRI tools such as volumetric, diffusion, and functional MRI for early identification of biomarkers of brain injury/delayed development that are predictive of disabilities in individual high-risk neonates/infants. The lab’s current focus is to understand the nature of the commonly encountered diffuse white matter abnormalities and to develop early prognostic models of motor, cognitive, and behavioral abnormalities in a geographic cohort of 500 very preterm infants. This important step will facilitate risk stratification, soon after birth, to design clinical trials of targeted neuroprotective interventions during the critical window of the first 3 years after birth when brain plasticity is at its peak.
Evidence-based and family-centered care of very premature infants and term infants with asphyxia/neonatal encephalopathy; critically-ill newborns
Early diagnosis of perinatal brain injury/delayed brain development; early detection and prevention of neurodevelopmental disabilities
Perinatal, Neonatology, Newborn Intensive Care NICU, Neonatology, Imaging
Nehal A. Parikh, DO, MS9/17/2019
DO: NY College of Osteopathic Medicine of NY Institute of Technology, Long Island, NY, 1996.
Residency: Pediatrics, Winthrop University Hospital of SUNY Stony Brook, Long Island, NY, 1999.
Fellowship: Neonatology, Thomas Jefferson University of Jefferson Medical College, Philadelphia, PA, 2002.
MS: Translational/Clinical Research, University of Texas Medical School at Houston, Houston, TX, 2007.
Certification: Pediatrics, 1996.
Certification: Neonatology, 2003.
Neonatal Functional and Structural Connectivity Are Associated with Cerebral Palsy at Two Years of Age.
Merhar, SL; Gozdas, E; Tkach, JA; Parikh, NA; Kline-Fath, BM; He, L; Yuan, W; Altaye, M; Leach, JL; Holland, SK.
American Journal of Perinatology: neonatal and maternal-fetal medicine.
Retinopathy of Prematurity and Bronchopulmonary Dysplasia are Independent Antecedents of Cortical Maturational Abnormalities in Very Preterm Infants.
Kline, JE; Illapani, VS P; He, L; Altaye, M; Parikh, NA.
A Multichannel Deep Neural Network Model Analyzing Multiscale Functional Brain Connectome Data for Attention Deficit Hyperactivity Disorder Detection.
Chen, M; Li, H; Wang, J; Dillman, JR; Parikh, NA; He, L.
Developmental Outcomes of Extremely Preterm Infants with a Need for Child Protective Services Supervision.
McGowan, EC; Laptook, AR; Lowe, J; Peralta-Carcelen, M; Chowdhury, D; Higgins, RD; Hintz, SR; Vohr, BR; Polin, RA; Laptook, AR; et al.
The Journal of Pediatrics.
White matter injury and structural anomalies in infants with prenatal opioid exposure.
Merhar, SL; Parikh, NA; Braimah, A; Poindexter, BB; Tkach, J; Kline-Fath, B.
American Journal of Neuroradiology.
Gastrostomy Tube Feeding in Extremely Low Birthweight Infants: Frequency, Associated Comorbidities, and Long-term Outcomes.
Warren, MG; Do, B; Das, A; Smith, PB; Adams-Chapman, I; Jadcherla, S; Jensen, EA; Goldstein, RF; Goldberg, RN; Cotten, CM; et al.
The Journal of Pediatrics.
Early Detection of Cerebral Palsy Using Sensorimotor Tract Biomarkers in Very Preterm Infants.
Parikh, NA; Hershey, A; Altaye, M.
Inadequate oral feeding as a barrier to discharge in moderately preterm infants.
Edwards, L; Cotten, CM; Smith, PB; Goldberg, R; Saha, S; Das, A; Laptook, AR; Stoll, BJ; Bell, EF; Carlo, WA; et al.
Journal of Perinatology.
Objective and Automated Detection of Diffuse White Matter Abnormality in Preterm Infants Using Deep Convolutional Neural Networks.
Li, H; Parikh, NA; Wang, J; Merhar, S; Chen, M; Parikh, M; Holland, S; He, L.
Frontiers in Neuroscience.
Prolonged duration of early antibiotic therapy in extremely premature infants.
Greenberg, RG; Chowdhury, D; Hansen, NI; Smith, PB; Stoll, BJ; Sanchez, PJ; Das, A; Puopolo, KM; Mukhopadhyay, S; Higgins, RD; et al.
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