A photo of David Ritter.

David M. Ritter, MD, PhD

  • Attending Neurologist, Division of Neurology
  • Director of Clinical Operations, Tuberous Sclerosis Clinic
  • Assistant Professor, UC Department of Pediatrics
Every patient and family deserve an individualized approach. By working together, we can create the best outcome for each child.
David M. Ritter, MD, PhD



As a neurologist, I specialize in treating children and adolescents with neurogenetic diseases that cause autism and epilepsy. I'm interested in tuberous sclerosis complex and phosphatase and tensin homolog (PTEN) hamartoma tumor syndrome. These genetic conditions cause tumors and neurodevelopmental problems.

I was drawn to my field while watching my parents deal with my brother, who had neurologic issues. The positive outcomes and seeing children make even small improvements inspire me. Knowing that we still need to learn much more to get the best outcome for every child drives me to understand further how the nervous system works and what can go wrong.

I see general neurology patients in my practice and am a member of our Tuberous Sclerosis Complex Clinic. Every patient and family deserve an individualized approach. By working together, we can create the best outcome for each child. As a co-director of the Tuberous Sclerosis Clinic, I help lead our team in providing care to patients with tuberous sclerosis complex across their lifespan, from prenatal management to adult complications.

My research focuses on understanding the perinatal time frame of developmental disorders to allow for earlier treatments. My main work looks at understanding the earliest symptoms of tuberous sclerosis complex (cardiac rhabdomyoma) to help us enable early disease management. Additionally, I work on projects understanding the autism phenotype in tuberous sclerosis complex and PTEN hamartoma tumor syndrome. I also participate in clinic trials of new medications and therapies for seizures and behavioral problems.

I am honored to have received the following awards: M. Richard Koenigsberger Award, awarded by the Child Neurology Society to the junior member with the best abstract in neonatal neurology, genetics, HIV or metabolic diseases (2019); the Research Innovation in Support of Excellence Award, a research award given to senior residents at Cincinnati Children's (2019-2020); and the Jefferson MD/PhD Thesis Prize for Innovations In Translation Research, given for the top MD/PhD student thesis (2015).

In my free time, I like playing basketball, hiking and running marathons. My wife and I have biological children and are also foster parents.

MD: Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 2015.

PhD: Thomas Jefferson University, Philadelphia, PA, 2015.

Residency: Child Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2020.


General neurology; tuberous sclerosis; PTEN hamartoma tumor syndrome

Services and Specialties



Tuberous sclerosis complex; PTEN; rhabdomyomas; perinatal care; autism; epilepsy

Research Areas


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Healthcare provider recognition of pregnancy related risks and management considerations in patients with tuberous sclerosis complex. Rose, M; Ritter, D; Gupta, N; Tolusso, L; Horn, P; Wakefield, E; Glass, J. Orphanet Journal of Rare Diseases. 2024; 19:4.


Prevalence of thoracoabdominal imaging findings in tuberous sclerosis complex. Ritter, DM; Fessler, BK; Ebrahimi-Fakhari, D; Wei, J; Franz, DN; Krueger, DA; Trout, AT; Towbin, AJ. Orphanet Journal of Rare Diseases. 2022; 17:124.


In Silico Predictions of KCNQ Variant Pathogenicity in Epilepsy. Ritter, DM; Horn, PS; Holland, KD. Pediatric Neurology. 2021; 118:48-54.


Dysregulation of Kv3.4 channels in dorsal root ganglia following spinal cord injury. Ritter, DM; Zemel, BM; Hala, TJ; O'Leary, ME; Lepore, AC; Covarrubias, M. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015; 35:1260-1273.


Modulation of Kv3.4 channel N-type inactivation by protein kinase C shapes the action potential in dorsal root ganglion neurons. Ritter, DM; Ho, C; O'Leary, ME; Covarrubias, M. The Journal of Physiology. 2012; 590:145-161.

Estradiol- and Progesterone-Associated Changes in microRNA-Induced Silencing and Reduced Antiseizure Efficacy of an Antagomir in Female Mice. Tiwari, D; Rajathi, V; Rymer, JK; Beasley, LN; McGann, AM; Bunk, AT; Parkins, EV; Rice, MF; Smith, KE; Ritter, DM; et al. eNeuro. 2023; 10:eneuro.0047-eneu22.2023.

Diabetes in Individuals With Tuberous Sclerosis Complex Treated With mTOR Inhibitors. Agricola, K; Stires, G; Krueger, DA; Capal, JK; Franz, DN; Ritter, DM. Pediatric Neurology. 2021; 120:7-10.

Acute Ataxia and Paresthesia in a Healthy 5-year-old Girl. Taylor, RJ; Ritter, DM; Frazier, ME; Zackoff, MW. Pediatrics in review / American Academy of Pediatrics. 2021; 42:329-331.

Treatment of SCN4A-induced myotonic crisis. Ritter, DM; Tian, C; Broomall, E. Muscle and Nerve. 2021; 63:E59-E61.

Genetic Testing in Epilepsy. Ritter, DM; Holland, K. Seminars in Neurology. 2020; 40:730-738.

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