My interest in pediatric medicine began with the idea that diseases can be prevented and managed in childhood to avoid complications as adults. My career and research now focus on the complications of obesity in children and adolescents. Type 2 diabetes, cholesterol issues and blood pressure problems, once thought to be adult diseases, are also seen more and more often in young people with obesity.

Currently, my research focuses on obesity and Type 2 diabetes and their long-term health consequences. With my work, I try to determine how the complications of diabetes, including cardiovascular disease, start, and how diabetes increases the risk for cardiovascular disease. I hope to understand how to prevent Type 2 diabetes in adolescents and reduce health problems in the future.

I serve as the director of the Adolescent Type 2 Diabetes Program at Cincinnati Children’s Hospital Medical Center. In this setting, my colleagues and I work as a team to discover the best medical treatments for youth with Type 2 diabetes. We have a comprehensive clinical team that includes gastroenterologists to assess for fatty liver disease, psychologists, nutritionists, certified diabetes educators and social workers. We also work with the bariatric surgery team to understand how bariatric surgery effects youth-onset Type 2 diabetes and its complications.

I have received several awards and honors, including:

  • 2014 Young Investigator Award, The International Society of Pediatric and Adolescent Diabetes
  • 2015 and 2016 Young Investigator Award, The National Lipid Association
  • 2016 Young Physician Scientist Award, The American Society of Clinical Investigation
  • 2016 Early Career Development Award, The Central Society for Clinical and Translational Research
  • 2020 Nominated as a Fellow of the National Lipid Association

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Association between triglycerides, known risk SNVs and conserved rare variation in SLC25A40 in a multi-ancestry cohort. Rosenthal, EA; Crosslin, DR; Gordon, AS; Carrell, DS; Stanaway, IB; Larson, EB; Grafton, J; Wei, WQ; Denny, JC; Feng, QP; et al. BMC Medical Genomics. 2021; 14.

A cross sectional study to compare cardiac structure and diastolic function in adolescents and young adults with youth-onset type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth Study. Shah, AS; Isom, S; Dabelea, D; D’Agostino, R; Dolan, LM; Wagenknecht, L; Imperatore, G; Saydah, S; Liese, AD; Lawrence, JM; et al. Cardiovascular Diabetology. 2021; 20.

Case Studies in Pediatric Lipid Disorders and Their Management. Ashraf, AP; Sunil, B; Bamba, V; Breidbart, E; Brar, PC; Chung, S; Gupta, A; Khokhar, A; Kumar, S; Lightbourne, M; et al. Journal of Clinical Endocrinology and Metabolism. 2021; 106:3605-3620.

Demographic Correlates of Short-Term Mortality Among Youth and Young Adults With Youth-Onset Diabetes Diagnosed From 2002 to 2015: The SEARCH for Diabetes in Youth Study. Lawrence, JM; Reynolds, K; Saydah, SH; Mottl, A; Pihoker, C; Dabelea, D; Dolan, L; Henkin, L; Liese, AD; Isom, S; et al. Diabetes Care. 2021; 44:2691-2698.

Glycemic control is associated with dyslipidemia over time in youth with type 2 diabetes: The SEARCH for diabetes in youth study. Brady, RP; Shah, AS; Jensen, ET; Stafford, JM; D'Agostino, RB; Dolan, LM; Knight, L; Imperatore, G; Turley, CB; Liese, AD; et al. Pediatric Diabetes. 2021; 22:951-959.

Genome-wide Association Study of Lipid Traits in Youth With Type 2 Diabetes. Santoro, N; Chen, L; Todd, J; Divers, J; Shah, AS; Gidding, SS; Burke, B; Haymond, M; Lange, L; Marcovina, S; et al. Journal of the Endocrine Society. 2021; 5.

Disparities in Hemoglobin A1c Testing During the Transition to Adulthood and Association With Diabetes Outcomes in Youth-Onset Type 1 and Type 2 Diabetes: The SEARCH for Diabetes in Youth Study. Sauder, KA; Stafford, JM; Ehrlich, S; Lawrence, JM; Liese, AD; Marcovina, S; Mottl, AK; Pihoker, C; Saydah, S; Shah, AS; et al. Diabetes Care. 2021.

Longitudinal changes in vascular stiffness and heart rate variability among young adults with youth-onset type 2 diabetes: results from the follow-up observational treatment options for type 2 diabetes in adolescents and youth (TODAY) study. Shah, AS; El ghormli, L; Gidding, SS; Hughan, KS; Levitt Katz, LE; Koren, D; Tryggestad, JB; Bacha, F; Braffett, BH; Arslanian, S; et al. Acta Diabetologica. 2021.

Study protocol: a prospective controlled clinical trial to assess surgical or medical treatment for paediatric type 2 diabetes (ST2OMP). Shah, AS; Helmrath, MA; Inge, TH; Xanthakos, SA; Kelsey, MM; Jenkins, T; Trout, AT; Browne, L; Nadeau, KJ. BMJ Open. 2021; 11.

Associations of Genetically Predicted Lp(a) (Lipoprotein [a]) Levels With Cardiovascular Traits in Individuals of European and African Ancestry. Satterfield, BA; Dikilitas, O; Safarova, MS; Clarke, SL; Tcheandjieu, C; Zhu, X; Bastarache, L; Larson, EB; Justice, AE; Shang, N; et al. Circulation: Genomic and Precision Medicine. 2021; 14.

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