Our laboratory conducts both basic science and clinical research. We study type 2 diabetes in teens and young adults. We are interested in why diabetes develops in kids and how type 2 diabetes will impact long term health for teens. Our long term goal is to improve current therapies to prevent and limit early onset complications.

Basic Research Studies

We study how specific lipids (lipoproteins) are altered as a result of obesity and type 2 diabetes. Specific projects focus on:

  1. Characterizing LDL and HDL subspecies and understanding how obesity, insulin resistance and diabetes alter LDL and HDL composition and function.
  2. Understanding how reversal of metabolic diseases through weight loss (bariatric) surgery influences LDL and HDL subspecies composition and function
  3. Developing novel assays to study how LDL and HDL subspecies’ contribute to or protect against cardiovascular disease, respectively.

We work closely with the Davidson Laboratory at the University of Cincinnati.

Clinical Research Studies

We study effects of type 2 diabetes on the heart, blood vessels and brain. We are also interested in the impact of newer medications and weight loss surgery on type 2 diabetes. Specific projects include:

  1. Surgical or Medical Treatment for Pediatric Type 2 Diabetes- ST2OMP. This is a clinical trial with Children’s Hospital Colorado to compare medical therapy to bariatric surgery in teens with type 2 diabetes.
  2. The Effects of Type 2 Diabetes on the Brain. We are currently investigating the effects of type 2 diabetes on the brain blood vessels and cognitive function in adolescents.
  3. The Effects of Type 2 Diabetes on the Heart and Peripheral Vasculature. Through collaborations with the SEARCH for Diabetes in Youth Study and the Treatment options for type 2 diabetes in adolescents and youth (TODAY) study we study the impact of type 2 diabetes on heart and blood vessels.

Clinical Trials

We also partner with industry to bring new drug treatments to adolescents. Ongoing trials include the use of already approved adult drugs to treat high LDL cholesterol, high triglycerides, and type 2 diabetes.

Dr. Shah is also the director of the Adolescent Type 2 Diabetes Program at Cincinnati Children’s Hospital. If your child has been diagnosed with type 2 diabetes, learn more about our multidisciplinary clinic.

For more information regarding clinical care or our research, please contact us at amy.shah@cchmc.org.