Shah Lab

Shah, AS; Gidding, SS; El ghormli, L; Tryggestad, JB; Nadeau, KJ; Bacha, F; Levitt Katz, LE; Willi, SM; Lima, J; Urbina, EM. Relationship between Arterial Stiffness and Subsequent Cardiac Structure and Function in Young Adults with Youth-Onset Type 2 Diabetes: Results from the TODAY Study. Journal of the American Society of Echocardiography. 2022.

Muffly, BT; O'Shaughnessy, MA; Fazal, FZ; Riley, SA; Shah, AS; Cornwall, R; Burke, CS. Rare Presentation of Pediatric Multiple Enchondromatosis Limited to Single Ray or Single Nerve Distribution in the Hand: A Multicenter Case Series. Journal of Pediatric Orthopaedics. 2022.

Kelsey, MM; Zeitler, PS; Nadeau, KJ; Shah, AS. Type 2 diabetes in youth: Rationale for use of off-label antidiabetic agents. Pediatric Diabetes. 2022.

Damen, MS M A; Alarcon, PC; Shah, AS; Divanovic, S. Greasing the inflammatory pathogenesis of viral pneumonias in diabetes. Obesity Reviews. 2022; 23.

Redel, JM; DiFrancesco, M; Lee, GR; Ziv, A; Dolan, LM; Brady, CC; Shah, AS. Cerebral blood flow is lower in youth with type 2 diabetes compared to obese controls: A pilot study. Pediatric Diabetes. 2022; 23:291-300.

Bedi, S; Morris, J; Shah, A; Hart, RC; Gray Jerome, W; Aller, SG; Tang, C; Vaisar, T; Bornfeldt, KE; Segrest, JP; et al. Conformational flexibility of apolipoprotein A-I amino- and carboxy-termini is necessary for lipid binding but not cholesterol efflux. Journal of Lipid Research. 2022; 63.

Shah, AS; El ghormli, L; Gidding, SS; Hughan, KS; Levitt Katz, LE; Koren, D; Tryggestad, JB; Bacha, F; Braffett, BH; Arslanian, S; et al. Longitudinal changes in vascular stiffness and heart rate variability among young adults with youth-onset type 2 diabetes: results from the follow-up observational treatment options for type 2 diabetes in adolescents and youth (TODAY) study. Acta Diabetologica. 2022; 59:197-205.

Davidson, WS; Shah, AS; Sexmith, H; Gordon, SM. The HDL Proteome Watch: Compilation of studies leads to new insights on HDL function. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 2022; 1867.

Malik, FS; Sauder, KA; Isom, S; Reboussin, BA; Dabelea, D; Lawrence, JM; Roberts, A; Mayer-Davis, EJ; Marcovina, S; Dolan, L; et al. Trends in Glycemic Control Among Youth and Young Adults With Diabetes: The SEARCH for Diabetes in Youth Study. Diabetes Care. 2022; 45:285-294.

Shah, AS; Sadayappan, S; Urbina, EM. Lipids: a Potential Molecular Pathway Towards Diastolic Dysfunction in Youth-Onset Type 2 Diabetes. Current Atherosclerosis Reports. 2022; 24:109-117.

Shah, AS; Nadeau, KJ; Dabelea, D; Redondo, MJ. Spectrum of Phenotypes and Causes of Type 2 Diabetes in Children. Annual Review of Medicine. 2022; 73:501-515.

Rosenthal, EA; Crosslin, DR; Gordon, AS; Carrell, DS; Stanaway, IB; Larson, EB; Grafton, J; Wei, WQ; Denny, JC; Feng, QP; et al. Association between triglycerides, known risk SNVs and conserved rare variation in SLC25A40 in a multi-ancestry cohort. BMC Medical Genomics. 2021; 14.

Shah, AS; Isom, S; Dabelea, D; D’Agostino, R; Dolan, LM; Wagenknecht, L; Imperatore, G; Saydah, S; Liese, AD; Lawrence, JM; et al. A cross sectional study to compare cardiac structure and diastolic function in adolescents and young adults with youth-onset type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth Study. Cardiovascular Diabetology. 2021; 20.

Ashraf, AP; Sunil, B; Bamba, V; Breidbart, E; Brar, PC; Chung, S; Gupta, A; Khokhar, A; Kumar, S; Lightbourne, M; et al. Case Studies in Pediatric Lipid Disorders and Their Management. Journal of Clinical Endocrinology and Metabolism. 2021; 106:3605-3620.

Lawrence, JM; Reynolds, K; Saydah, SH; Mottl, A; Pihoker, C; Dabelea, D; Dolan, L; Henkin, L; Liese, AD; Isom, S; et al. Demographic Correlates of Short-Term Mortality Among Youth and Young Adults With Youth-Onset Diabetes Diagnosed From 2002 to 2015: The SEARCH for Diabetes in Youth Study. Diabetes Care. 2021; 44:2691-2698.

Brady, RP; Shah, AS; Jensen, ET; Stafford, JM; D'Agostino, RB; Dolan, LM; Knight, L; Imperatore, G; Turley, CB; Liese, AD; et al. Glycemic control is associated with dyslipidemia over time in youth with type 2 diabetes: The SEARCH for diabetes in youth study. Pediatric Diabetes. 2021; 22:951-959.

Santoro, N; Chen, L; Todd, J; Divers, J; Shah, AS; Gidding, SS; Burke, B; Haymond, M; Lange, L; Marcovina, S; et al. Genome-wide Association Study of Lipid Traits in Youth With Type 2 Diabetes. Journal of the Endocrine Society. 2021; 5.

Sauder, KA; Stafford, JM; Ehrlich, S; Lawrence, JM; Liese, AD; Marcovina, S; Mottl, AK; Pihoker, C; Saydah, S; Shah, AS; et al. Disparities in Hemoglobin A1c Testing During the Transition to Adulthood and Association With Diabetes Outcomes in Youth-Onset Type 1 and Type 2 Diabetes: The SEARCH for Diabetes in Youth Study. Diabetes Care. 2021.

Shah, AS; Helmrath, MA; Inge, TH; Xanthakos, SA; Kelsey, MM; Jenkins, T; Trout, AT; Browne, L; Nadeau, KJ. Study protocol: a prospective controlled clinical trial to assess surgical or medical treatment for paediatric type 2 diabetes (ST2OMP). BMJ Open. 2021; 11.

Satterfield, BA; Dikilitas, O; Safarova, MS; Clarke, SL; Tcheandjieu, C; Zhu, X; Bastarache, L; Larson, EB; Justice, AE; Shang, N; et al. Associations of Genetically Predicted Lp(a) (Lipoprotein [a]) Levels With Cardiovascular Traits in Individuals of European and African Ancestry. Circulation: Genomic and Precision Medicine. 2021; 14.

Melchior, JT; Street, SE; Vaisar, T; Hart, R; Jerome, J; Kuklenyik, Z; Clouet-Foraison, N; Thornock, C; Bedi, S; Shah, AS; et al. Apolipoprotein A-I modulates HDL particle size in the absence of apolipoprotein A-II. Journal of Lipid Research. 2021; 62.

Robertson, CC; Inshaw, JR J; Onengut-Gumuscu, S; Chen, WM; Santa Cruz, DF; Yang, H; Cutler, AJ; Crouch, DJ M; Farber, E; Bridges, SL; et al. Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes. Nature Genetics. 2021; 53:962-971.

Acharya, K; Leuthner, SR; Zaniletti, I; Niehaus, JZ; Bishop, CE; Coghill, CH; Datta, A; Dereddy, N; DiGeronimo, R; Jackson, L; et al. Medical and surgical interventions and outcomes for infants with trisomy 18 (T18) or trisomy 13 (T13) at children's hospitals neonatal intensive care units (NICUs). Journal of Perinatology. 2021; 41:1745-1754.

Davidson, WS; Cooke, AL; Swertfeger, DK; Shah, AS. The Difference Between High Density Lipoprotein Subfractions and Subspecies: an Evolving Model in Cardiovascular Disease and Diabetes. Current Atherosclerosis Reports. 2021; 23.

Shapiro, AL B; Dabelea, D; Stafford, JM; D'Agostino, R; Pihoker, C; Liese, AD; Shah, AS; Bellatorre, A; Lawrence, JM; Henkin, L; et al. Cognitive Function in Adolescents and Young Adults With Youth-Onset Type 1 Versus Type 2 Diabetes: The SEARCH for Diabetes in Youth Study. Diabetes Care. 2021; 44:1273-1280.

Moreno-Fernandez, ME; Giles, DA; Oates, JR; Chan, CC; Damen, MS M A; Doll, JR; Stankiewicz, TE; Chen, X; Chetal, K; Karns, R; et al. PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease. Cell Metabolism. 2021; 33:1187-1204.e9.

SAUDER, KA; STAFFORD, JM; EHRLICH, SR; LIESE, AD; MARCOVINA, SM; MOTTL, AK; PIHOKER, C; SAYDAH, S; SHAH, AS; DAGOSTINO, R; et al. 1078-P: Disparities in HbA1c Testing and Diabetes Outcomes: SEARCH for Diabetes in Youth. Diabetes. 2021; 70.

Blunden, CE; Urbina, EM; Lawson, SA; Gutmark-Little, I; Shah, AS; Khoury, PR; Backeljauw, PF. Progression of Vasculopathy in Young Individuals with Turner Syndrome. Pediatric Cardiology. 2021; 42:481-491.

Semova, I; Levenson, AE; Krawczyk, J; Bullock, K; Williams, KA; Wadwa, RP; Khoury, PR; Kimball, TR; Urbina, EM; de Ferranti, SD; et al. Markers of cholesterol synthesis are elevated in adolescents and young adults with type 2 diabetes. Pediatric Diabetes. 2020; 21:1126-1131.

Sauder, KA; Stafford, JM; The, NS; Mayer-Davis, EJ; Thomas, J; Lawrence, JM; Kim, G; Siegel, KR; Jensen, ET; Shah, AS; et al. Dietary strategies to manage diabetes and glycemic control in youth and young adults with youth-onset type 1 and type 2 diabetes: The SEARCH for diabetes in youth study. Pediatric Diabetes. 2020; 21:1093-1101.

Shah, AS; Jaiswal, M; Dabelea, D; Divers, J; Isom, S; Liese, AD; Lawrence, JM; Kim, G; Urbina, EM. Cardiovascular risk and heart rate variability in young adults with type 2 diabetes and arterial stiffness: The SEARCH for Diabetes in Youth Study. Journal of Diabetes and its Complications. 2020; 34.

Atreya, MR; Whitacre, BE; Cvijanovich, NZ; Bigham, MT; Thomas, NJ; Schwarz, AJ; Weiss, SL; Fitzgerald, JC; Allen, GL; Lutfi, R; et al. Proprotein Convertase Subtilisin/Kexin Type 9 Loss-of-Function Is Detrimental to the Juvenile Host With Septic Shock. Critical Care Medicine. 2020; 48:1513-1520.

Logan, K; Lloyd, RS; Schafer-Kalkhoff, T; Khoury, JC; Ehrlich, S; Dolan, LM; Shah, AS; Myer, GD. Youth sports participation and health status in early adulthood: A 12-year follow-up. Preventive Medicine Reports. 2020; 19.

Tryggestad, JB; Shah, RD; Braffett, BH; Bacha, F; Gidding, SS; Gubitosi-Klug, RA; Shah, AS; Urbina, EM; Katz, LE L; Grp, TO D A Y S. Circulating adhesion molecules and associations with HbA1c, hypertension, nephropathy, and retinopathy in the Treatment Options for type 2 Diabetes in Adolescent and Youth study. Pediatric Diabetes. 2020; 21:923-931.

Gourgari, E; Stafford, JM; Jr, DR; Dolan, LM; Lawrence, JM; Marcovina, S; Merjaneh, L; Mottl, AK; Shah, AS; Dabelea, D. The association of low-density lipoprotein cholesterol with elevated arterial stiffness in adolescents and young adults with type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth study. Pediatric Diabetes. 2020; 21:863-870.

REDEL, JM; DIFRANCESCO, MW; LEE, GR; DOLAN, LM; SHAH, AS. 55-OR: Cerebral Blood Flow Is Lower in Youth with Type 2 Diabetes Compared with Obese Controls. Diabetes. 2020; 69.

Koebnick, C; Imperatore, G; Jensen, ET; Stafford, JM; Shah, AS; Mottl, AK; Bell, RA; Dabelea, D; Liese, AD; Marcovina, SM; et al. Progression to hypertension in youth and young adults with type 1 or type 2 diabetes: The SEARCH for Diabetes in Youth Study. Journal of Clinical Hypertension. 2020; 22:888-896.

Shah, AS; Nadeau, KJ. The changing face of paediatric diabetes. Diabetologia. 2020; 63:683-691.

Shah, AS; Nadeau, KJ; Helmrath, MA; Inge, TH; Xanthakos, SA; Kelsey, MM. Metabolic outcomes of surgery in youth with type 2 diabetes. Seminars in Pediatric Surgery. 2020; 29.

Hsia, DS; Shah, AS; Inge, T. Adolescent Metabolic/Bariatric Surgery: Effects on Obesity, Comorbidities, and Insulin Resistance. Insulin Resistance. 2020.

Bjornstad, P; Hughan, K; Kelsey, MM; Shah, AS; Lynch, J; Nehus, E; Mitsnefes, M; Jenkins, T; Xu, P; Xie, C; et al. Effect of Surgical Versus Medical Therapy on Diabetic Kidney Disease Over 5 Years in Severely Obese Adolescents With Type 2 Diabetes. Diabetes Care. 2020; 43:187-195.

Safarova, MS; Satterfield, BA; Fan, X; Austin, EE; Ye, Z; Bastarache, L; Zheng, N; Ritchie, MD; Borthwick, KM; Williams, MS; et al. A phenome-wide association study to discover pleiotropic effects of PCSK9, APOB, and LDLR. npj Genomic Medicine. 2019; 4.

Shah, AS; El Ghormli, L; Vajravelu, ME; Bacha, F; Farrell, RM; Gidding, SS; Katz, LE L; Tryggestad, JB; White, NH; Urbina, EM. Heart Rate Variability and Cardiac Autonomic Dysfunction: Prevalence, Risk Factors, and Relationship to Arterial Stiffness in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study. Diabetes Care. 2019; 42:2143-2150.

Semova, I; Levenson, AE; Krawczyk, J; Bullock, K; Williams, KA; Wadwa, RP; Shah, AS; Khoury, PR; Kimball, TR; Urbina, EM; et al. Type 1 diabetes is associated with an increase in cholesterol absorption markers but a decrease in cholesterol synthesis markers in a young adult population. Journal of Clinical Lipidology. 2019; 13:940-946.

Ruben, MD; Francey, LJ; Guo, Y; Wu, G; Cooper, EB; Shah, AS; Hogenesch, JB; Smith, DF. A large-scale study reveals 24-h operational rhythms in hospital treatment. Proceedings of the National Academy of Sciences of the United States of America. 2019; 116:20953-20958.

Urbina, EM; Bell, RA; Bowlby, DA; Jr, DR; Daniels, SR; Marcovina, SM; Merchant, AT; Shah, AS; Wadwa, RP; Lawrence, JM; et al. Burden of Cardiovascular Risk Factors Over Time and Arterial Stiffness in Youth With Type 1 Diabetes Mellitus: The SEARCH for Diabetes in Youth Study. Journal of the American Heart Association. 2019; 8.

REDEL, JM; DIFRANCESCO, MW; LEE, GR; DOLAN, LM; SHAH, AS. 1334-P: Structural Brain Differences between Adolescents with Type 2 Diabetes and Obese Controls. Diabetes. 2019; 68.

BJORNSTAD, P; HUGHAN, KS; KELSEY, MM; SHAH, AM Y; LYNCH, JL; NEHUS, E; MITSNEFES, M; JENKINS, TM; XU, P; XIE, C; et al. 123-OR: Effect of Surgical vs. Medical Therapy on Diabetic Kidney Disease (DKD) in Severely Obese Adolescents with Type 2 Diabetes (T2D). Diabetes. 2019; 68.

Mouzaki, M; Shah, A; Arce-Clachar, AC; Hardy, J; Bramlage, K; Xanthakos, SA. Extremely low levels of low-density lipoprotein potentially suggestive of familial hypobetalipoproteinemia: A separate phenotype of NAFLD?. Journal of Clinical Lipidology. 2019; 13:425-431.

Redel, JM; Dolan, LM; DiFrancesco, M; Vannest, J; Shah, AS. Youth-Onset Type 2 Diabetes and the Developing Brain. Current Diabetes Reports. 2019; 19.

Davidson, WS; Shah, AS. High-Density Lipoprotein Subspecies in Health and Human Disease: Focus on Type 2 Diabetes. Methodist DeBakey cardiovascular journal. 2019; 15:55-61.

Summer, SS; Couch, SC; Shah, AS; McNeill, MP; Peairs, AD. Evaluating a dietary pattern in adolescents with type 1 diabetes mellitus: The dash-d approach. Diabetes Management. 2019; 9:28-38.

Kahkoska, AR; Isom, S; Divers, J; Mayer-Davis, EJ; Dolan, L; Shah, AS; Afkarian, M; Pettitt, DJ; Lawrence, JM; Marcovina, S; et al. The early natural history of albuminuria in young adults with youth-onset type 1 and type 2 diabetes. Journal of Diabetes and its Complications. 2018; 32:1160-1168.

Kim, A; Shah, AS; Nakamura, T. Extracellular Vesicles: A Potential Novel Regulator of Obesity and Its Associated Complications. Children. 2018; 5.

Swertfeger, DK; Rebholz, S; Li, H; Shah, AS; Davidson, WS; Lu, LJ. Feasibility of a plasma bioassay to assess oxidative protection of low-density lipoproteins by high-density lipoproteins. Journal of Clinical Lipidology. 2018; 12:1539-1548.

Shah, AS; El Ghormli, L; Gidding, SS; Bacha, F; Nadeau, KJ; Katz, LE L; Tryggestad, JB; Leibel, N; Hale, DE; Urbina, EM. Prevalence of arterial stiffness in adolescents with type 2 diabetes in the TODAY cohort: Relationships to glycemic control and other risk factors. Journal of Diabetes and its Complications. 2018; 32:740-745.

Cooke, AL; Morris, J; Melchior, JT; Street, SE; Jerome, WG; Huang, R; Herr, AB; Smith, LE; Segrest, JP; Remaley, AT; et al. A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL. Journal of Lipid Research. 2018; 59:1244-1255.

Melchior, JT; Street, SE; Shah, AS; Jerome, WJ; Hart, R; Heinecke, JW; He, Y; Andraski, AB; Furtado, JD; Sacks, FM; et al. Abstract 556: Structural Characterization of Distinct Subparticles of Human High-density Lipoproteins Isolated from Plasma. Arteriosclerosis, Thrombosis, and Vascular Biology. 2018; 38.

Cooke, AL; Morris, JC; Melchior, JT; Jerome, WG; Street, SE; Thompson, TB; Smith, LE; Shah, AS; Herr, A; Segrest, JP; et al. Abstract 026: Apolipoprotein A-I Helical Registry Modulates Lecithin:cholesterol Acyl Transferase Activity. Arteriosclerosis, Thrombosis, and Vascular Biology. 2018; 38.

Redel, JM; DiFrancesco, M; Vannest, J; Altaye, M; Beebe, D; Khoury, J; Dolan, LM; Lee, G; Brunner, H; Holland, S; et al. Brain gray matter volume differences in obese youth with type 2 diabetes: a pilot study. Journal of Pediatric Endocrinology and Metabolism. 2018; 31:261-268.

Zhu, X; Shah, AS; Swertfeger, DK; Li, H; Ren, S; Melchior, JT; Gordon, SM; Davidson, WS; Lu, LJ. High-Density Lipoproteins-Associated Proteins and Subspecies Related to Arterial Stiffness in Young Adults with Type 2 Diabetes Mellitus. Complexity. 2018; 2018:1-14.

Shah, AS; Urbina, EM. Childhood Obesity, Atherogenesis, and Adult Cardiovascular Disease. Pediatric Obesity. 2018.