Our laboratory has shown that youth with type 2 diabetes are deplete of a specific population of large HDL subspecies. Furthermore, we have shown that depletion of these subspecies is directly related to arterial stiffness, measured non-invasively as pulse wave velocity. Our current work aims to understand how diabetes alters HDL subspecies composition and function. We use size exclusion chromatography and mass spectrometry to identify lipid subspecies and their associated proteins.
Grant Funding
K23 Career Development Award
Publications from this Study
Davidson WS, Heink A, Sexmith H, Dolan LM, Gordon SM, Otvos JM. Melchior
JT, Elder DA, Khoury J, Geh E, Shah AS. Obesity is associated with an
altered HDL subspecies profile among adolescents with metabolic disease.
J Lipid Res. 2017 Sep;58(9):1916-1923.
Gordon SM, Davidson WS, Urbina EM, Dolan LM, Heink A, Zang H, Lu LJ, Shah AS. The effects of type 2 diabetes onlipoprotein composition and arterial stiffness in male youth. Diabetes.2013 Aug;62(8):2958-67.
***With commentary published by von Eckardstein A, Nofer JR. Frail HDLs and stiff arteries in type 2 diabetes in juveniles. Diabetes August 2013 62:2662-2664.