Our laboratory has shown that youth with type 2 diabetes are deplete of a specific population of large HDL subspecies. Furthermore, we have shown that depletion of these subspecies is directly related to arterial stiffness, measured non-invasively as pulse wave velocity. Our current work aims to understand how diabetes alters HDL subspecies composition and function. We use size exclusion chromatography and mass spectrometry to identify lipid subspecies and their associated proteins.
K23 Career Development Award