LDL has shown to cause atherosclerosis and HDL is thought to prevent against atherosclerosis. Our lab is interested in how LDL gets into the vessel wall and starts the initial steps of atherosclerosis, and how HDL may prevent this. We are also interested in how type 2 diabetes affects these steps. We use in vivo experiments, in vitro assays, and surface plasmon resonance to study these steps.

Shah Pretonomics

Exploring Lipid Subspecies Functions 

Funding

NHLBI R01 Award

Publications from this Study

Cooke AL, Morris J, Melchior JT, Street SE, Jerome WJ, Huang R, Herr A, Smith LE, Segrest JP, Remaley AT, Shah AS, Thompson TB, Davidson WS. A Thumbwheel Mechanism for Modulation of Lecithin:cholesterol Acyl Transferase Activity in HDL. Journal of Lipid Research. 2018 May 17.

Melchior JT, Street SE, Andraski AB, Furtado JD, Sacks FM, Shute RL, Greve EI, Swertfeger DK, Li H, Shah AS, Lu JL, Davidson WS. Apolipoprotein A-II alters the proteome of human lipoproteins and enhances cholesterol efflux from ABCA1. J Lipid Res. 2017 Jul;58(7):1374-1385.

Gordon SM, Li H, Zhu X, Tso P, Reardon CA, Shah AS, Lu JL, Davidson WS. Impact of Genetic Deletion of Platform Apolipoproteins on the Size Distribution of the Murine Lipoproteome. Journal of Proteomics. 2016 Sep 2;146:184-94.

Gordon SM, Li H, Zhu X, Shah AS, Lu LJ, Davidson WS. A Comparison of the Mouse and Human Lipoproteome: Suitability of the Mouse Model for Studies of Human Lipoproteins. Journal of Proteome Research. 2015 Jun 5;14(6):2686-95.  

Heink A, Davidson WS, Swertfeger DK, Lu LJ, Shah AS. A Comparison of Methods To Enhance Protein Detection of Lipoproteins by Mass Spectrometry. J Proteome Res. 2015 Jul 2;14(7):2943-50.

Shah AS, Tan L, Long JL, Davidson WS. Proteomic diversity of high density lipoproteins: our emerging understanding of its importance in lipid transport and beyond. J Lipid Res. 2013 Oct;54(10):2575-85.

Gordon SM, Deng J, Tomann AB, Shah AS, Lu LJ, Davidson WS. Multi-dimensional co-separation analysis reveals protein-protein interactions defining plasma lipoprotein subspeciesMol Cell Proteomics. 2013 Nov;12(11):3123-34.