A photo of Rhonda Szczesniak.

Rhonda D. Szczesniak, PhD

  • Professor, UC Department of Pediatrics
  • UC Department of Environmental Health; UC Department of Mathematical Sciences



My research interests include predictive modeling, medical monitoring, lung diseases and disorders, biomarker discovery and longitudinal data analysis. In my research lab, the goals of my team include designing and analyzing medical monitoring investigations as well as incorporating biomarkers for customized, enhanced prediction/early detection of swift disease progression.

Some of the most notable discoveries made at my lab include identifying pediatric phenotypes of rapid lung disease progression using the Cystic Fibrosis Registry and the proteomics-informed prediction modeling of rapid lung disease progression.

I was led to my research interests by witnessing how certain things change over time and determining why things transform. This is why I pursued statistics in my graduate studies at the University of Kentucky.

As my career progressed, I received a recognition for biostatistical contributions to cystic fibrosis research in the Journal of Cystic Fibrosis in April 2019. I have also held reviewer positions on grant award panels and I hold a membership in the Cystic Fibrosis Foundation Patient Registry/Comparative Effectiveness Research Committee. My research has been supported by the National Institutes of Health (NIH) and the Cystic Fibrosis Foundation.

I have more than 12 years of experience in the biostatistics field, and I first started working at the Cincinnati Children’s Hospital Medical Center in 2007. Lastly, my research work has been published in a multitude of journals, including Statistics in Medicine, Journal of Religion and Health, Journal of Cystic Fibrosis, Journal of Diabetes Research, Annals of the American Thoracic Society, and American Journal of Respiratory and Critical Care Medicine.


CellDrift: inferring perturbation responses in temporally sampled single-cell data. Jin, K; Schnell, D; Li, G; Salomonis, N; Prasath, VB S; Szczesniak, R; Aronow, BJ. Briefings in Bioinformatics. 2022; 23.

Projecting the impact of triple CFTR modulator therapy on intravenous antibiotic requirements in cystic fibrosis using patient registry data combined with treatment effects from randomised trials. Keogh, RH; Cosgriff, R; Andrinopoulou, ER; Brownlee, KG; Carr, SB; Diaz-Ordaz, K; Granger, E; Jewell, NP; Lewin, A; Leyrat, C; et al. Thorax. 2022; 77:873-881.

Tissue-localized immune responses in people with cystic fibrosis and respiratory nontuberculous mycobacteria infection. Hayes, D; Shukla, RK; Cheng, Y; Gecili, E; Merling, MR; Szczesniak, RD; Ziady, AG; Woods, JC; Hall-Stoodley, L; Liyanage, NP M; et al. JCI insight. 2022; 7.

Aligning Provider Prescribing With Guidelines for Soft Tissue Infections. Kovaleski, C; Courter, JD; Ghulam, E; Hagedorn, PA; Haslam, DB; Kurowski, EM; Rudloff, J; Szczesniak, R; Dexheimer, JW. Pediatric Emergency Care. 2022; 38:e1063-e1068.

A Joint Model for Unbalanced Nested Repeated Measures with Informative Drop-Out Applied to Ambulatory Blood Pressure Monitoring Data. Ghulam, EM; Khoury, JC; Jandarov, R; Amin, RS; Andrinopoulou, ER; Szczesniak, RD. BioMed Research International. 2022; 2022.

Bayesian regularization for a nonstationary Gaussian linear mixed effects model. Gecili, E; Sivaganesan, S; Asar, O; Clancy, JP; Ziady, A; Szczesniak, RD. Statistics in Medicine. 2022; 41:681-697.

Lung function in children with cystic fibrosis in the USA and UK: a comparative longitudinal analysis of national registry data. Schluter, DK; Ostrenga, JS; Carr, SB; Fink, AK; Faro, A; Szczesniak, RD; Keogh, RH; Charman, SC; Marshall, BC; Goss, CH; et al. Thorax. 2022; 77:136-142.

Sweat metabolomics before and after intravenous antibiotics for pulmonary exacerbation in people with cystic fibrosis. Woodley, FW; Gecili, E; Szczesniak, RD; Shrestha, CL; Nemastil, CJ; Kopp, BT; Hayes, D. Respiratory Medicine. 2022; 191.

Elevated Anthropometric and Metabolic Indicators among Young Adult Offspring of Mothers with Pregestational Diabetes: Early Results from the Transgenerational Effect on Adult Morbidity Study (the TEAM Study). Bowers, K; Ehrlich, S; Dolan, LM; Gupta, R; Altaye, M; Ollberding, NJ; Szczesniak, R; Catalano, P; Smith, E; Khoury, JC. Journal of Diabetes Research. 2021; 2021.

Rapid cystic fibrosis lung-function decline and in-vitro CFTR modulation. Gecili, E; Su, W; Brokamp, C; Andrinopoulou, ER; III, FJ L R; Pestian, T; Clancy, JP; Solomon, GM; Brewington, JJ; Szczesniak, RD. Journal of Cystic Fibrosis. 2021; 20:e69-e71.