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Assem G. Ziady, PhD

Co-Director of the Imaging and Biomarker RDP Core

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Associate Professor, Case Western Reserve University

Phone 513-803-9094

Email assem.ziady@cchmc.org

Cystic fibrosis; redox mediated inflammatory signaling; nonviral gene transfer to the lung; biomarkers of disease severity and response to therapy.
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Dr. Ziady received his undergraduate education at Boston College in biochemistry in 1993. He completed his graduate studies on cell physiology and received his PhD degree in 1999 from Case Western Reserve University. Following his postdoctoral training at the Department of Pediatrics at Case Western Reserve University, he began a year-long externship at the Cleveland Clinic Proteomic facility in early 2002. In 2003, Dr. Ziady joined the faculty at the Case Western Reserve University Department of Pediatrics as assistant professor. In 2011, Dr. Ziady joined the faculty at the Emory University Department of Pediatrics as an associate professor and served as the associate director of Cystic Fibrosis Basic & Translational Research at Emory University.

In 2014, Dr. Ziady was recruited by the CF program at Cincinnati Children’s Hospital Medical Center, where he joined the faculty as associate professor of pediatrics within the UC College of Medicine in November. Dr. Ziady’s research has been supported by the State of Ohio, the Cystic Fibrosis Foundation, and the National Institutes of Health. His laboratory focuses on the differential regulation of Nrf2 signaling pathways in the inflammatory lung disease observed cystic fibrosis. Dr. Ziady's lab also has unique expertise in developing and characterizing DNA nanoparticles for nonviral gene delivery to the lung, liver, and brain. Finally, Dr. Ziady’s lab has expertise in proteomic analyses for biomarker discovery and the examination of systems biology of various tissues. He is an inventor on five patents (2 USA, 2 EU, and 1 international) pertaining to DNA nanoparticles, and one provisional patent pertaining to modulation of inflammatory signaling. In the past 15 years, he has authored 33 manuscripts and book chapters, has an h-index of 19, and has been invited to present 42 talks on his work at national and international conferences and institutions.

BS: Biochemistry, Boston College, Boston, MA, 1993.

PhD: Cell Physiology, Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, 1999.

Postdoctoral Fellowship: Non-viral gene transfer, Pediatrics, Case Western Reserve University, Cleveland, OH, 2002.

Externship: Proteomic analysis of redox mediated inflammation in CF, Cell Biology, Cleveland Clinic Foundation, Cleveland, OH, 2003.

View PubMed Publications

Ziady AG, Hansen J. Redox balance in Cystic Fibrosis. Int J Biochem Cell Biol. 2014 Jul;52:113-23.

Cheng Y, Doane TL, Chuang CH, Ziady A, Burda C. Near infrared light-triggered drug generation and release from gold nanoparticle carriers for photodynamic therapy. Small. 2014;10(9):1799-1804. (Joint corresponding author with C. Burda).

Ziady AG, Sokolow A, Shank S, Corey D, Myers R, Plafker S, Kelley TJ. Interaction with CREB binding protein modulates the activities of Nrf2 and NF-κB in Cystic Fibrosis Airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2012;302(11):L1221-1231.

Yurek DM, Fletcher AM, McShane M, Kowalczyk TH, Padegimas L, Weatherspoon MR, Kaytor MD, Cooper MJ, Ziady AG. DNA Nanoparticles: Detection of long-term transgene activity in brain using bioluminescence imaging. Mol Imaging. 2011;10(5):327-339.

Lancioni CL, Li Q, Thomas JJ, Ding X, Thiel B, Drage MG, Pecora ND, Ziady AG, Shank S, Harding CV, Boom WH, Rojas RE. Mycobacterium tuberculosis lipoproteins induce human memory CD4+ T cell activation via toll-like receptors 1 and 2. Infect and Immun. 2011;79(2):663-673.

Chen X, Shank S, Davis PB, Ziady AG. Nucleolin-mediated cellular trafficking of DNA nanoparticle is lipid raft and microtubule dependent and can be modulated by glucocorticoid. Molec Ther. 2011;19(1):93-102.

Ziady AG, Kotlarchyk M, Bryant L, McShane M, Lee Z. Bioluminescent imaging of reporter gene expression in the lungs of wildtype and model mice following the administration of PEG-stabilized DNA nanoparticles. Microsc Res Tech. 2010;73(9):918-928.

Nichols DP, Ziady AG, Shank SL, Eastman JF, Davis PB. The Triterpenoid CDDO limits inflammation in preclinical models of Cystic Fibrosis lung disease. Am J Physiol Lung Cell Mol Physiol. 2009;297(5):L828-836.

Yurek DM, Fletcher AM, Smith GM, Seroogy KB, Ziady AG, Molter J, Kowalczyk TH, Padegimas L, Cooper MJ. Long-term transgene expression in the Central Nervous System using DNA nanoparticles. Mol Ther. 2009;17(4):641-650.

Chen J, Kinter M, Shank S, Cotton C, Kelley TJ, Ziady AG. Dysfunction of Nrf-2 in CF epithelia leads to excess intracellular H2O2 and inflammatory cytokine production. PLoS ONE. 2008;3(10):e3367.

Nrf2 dysfunction in CF epithelia. Principal Investigator. National Institutes of Health/National Heart, Lung, and Blood Institute. Jul 2011-Jun 2016. 5R01HL109362.

MR predictors of infection, inflammation, and structural damage in CF. Contract Principal Investigator. National Institutes of Health/National Heart, Lung, and Blood Institute. Sep 2012-Jun 2017. 1R01HL116226.

CFF Cincinnati Children's Hospital Medical Center Research Development Program. Core Director. Cystic Fibrosis Foundation. Jul 2015-Jun 2019.

Gilead Sciences Research Grant. Contract Principal Investigator. Gilead Sciences. Jul 2014-Jun 2016.

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