A photo of Susan Thompson.

Professor, UC Department of Pediatrics



Biography & Affiliation


Susan Thompson, PhD, has research interests that span both genetic and functional genomic studies of juvenile rheumatoid arthritis (JRA) to advance the understanding of the causes and mechanisms of disease pathogenesis. A genome-wide screen for JRA susceptibility traits has been completed and defined several regions for linkage mapping and candidate gene analysis. In addition, complementary approaches that measure global gene expression patterns using DNA microarrays are also being used to understand the molecular basis for disease.

Research Interests

Molecular basis of juvenile rheumatoid arthritis; large-scale integrative analysis of gene expression, polymorphism and other genomic data with clinical data

Academic Affiliation

Professor, UC Department of Pediatrics




PhD: University of Tennessee Center for Health Sciences, Memphis, TN, 1988.

Fellowship: Immunology, St. Jude Children's Research Hospital, Memphis, TN, 1988-1991.

Fellowship: Molecular Genetics, University of Cincinnati, Cincinnati, OH, 1991-1994.


Implications of juvenile idiopathic arthritis genetic risk variants for disease pathogenesis and classification. Nigrovic, PA; Martinez-Bonet, M; Thompson, SD. Current Opinion in Rheumatology. 2019; 31:401-410.

Elevated serum complement levels and higher gene copy number of complement C4B are associated with hypertension and effective response to statin therapy in childhood-onset systemic lupus erythematosus (SLE). Mulvihill, E; Ardoin, S; Thompson, SD; Zhou, B; Yu, GR; King, E; Singer, N; Levy, DM; Brunner, H; Wu, YL; et al. Lupus Science and Medicine. 2019; 6:e000333-e000333.

Association of SLCO1B1 *14 Allele with Poor Response to Methotrexate in Juvenile Idiopathic Arthritis Patients. Ramsey, LB; Moncrieffe, H; Smith, CN; Sudman, M; Marion, MC; Langefeld, CD; Becker, ML; Thompson, SD. Acr Open Rheumatology. 2019; 1:58-62.

Identification of enhanced IFN-gamma signaling in polyarticular juvenile idiopathic arthritis with mass cytometry. Throm, AA; Moncrieffe, H; Orandi, AB; Pingel, JT; Geurs, TL; Miller, HL; Daugherty, AL; Malkova, ON; Lovell, DJ; Thompson, SD; et al. JCI insight. 2018; 3.

The Genetic Profile of Rheumatoid Factor-Positive Polyarticular Juvenile Idiopathic Arthritis Resembles That of Adult Rheumatoid Arthritis. Hinks, A; Marion, MC; Cobb, J; Comeau, ME; Sudman, M; Ainsworth, HC; Bowes, J; Becker, ML; Bohnsack, JF; Haas, J; et al. Arthritis and Rheumatology. 2018; 70:957-962.

Review: Genetics and the Classification of Arthritis in Adults and Children. Nigrovic, PA; Raychaudhuri, S; Thompson, SD. Arthritis and Rheumatology. 2018; 70:7-17.

Transancestral mapping and genetic load in systemic lupus erythematosus. Langefeld, CD; Ainsworth, HC; Graham, DS C; Kelly, JA; Comeau, ME; Marion, MC; Howard, TD; Ramos, PS; Croker, JA; Morris, DL; et al. Nature Communications. 2017; 8.

Genome-Wide Association Meta-Analysis Reveals Novel Juvenile Idiopathic Arthritis Susceptibility Loci. McIntosh, LA; Marion, MC; Sudman, M; Comeau, ME; Becker, ML; Bohnsack, JF; Fingerlin, TE; Griffin, TA; Haas, JP; Lovell, DJ; et al. Arthritis and Rheumatology. 2017; 69:2222-2232.

Transcriptional profiles of JIA patient blood with subsequent poor response to methotrexate. Moncrieffe, H; Bennett, MF; Tsoras, M; Luyrink, LK; Johnson, AL; Xu, H; Dare, J; Becker, ML; Prahalad, S; Rosenkranz, M; et al. Rheumatology. 2017; 56:1542-1551.

Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications. Ombrello, MJ; Arthur, VL; Remmers, EF; Hinks, A; Tachmazidou, I; Grom, AA; Foell, D; Martini, A; Gattorno, M; Ozen, S; et al. Annals of the Rheumatic Diseases. 2017; 76:906-913.