A photo of Jason Woods.

Jason C. Woods, PhD

  • Director, Center for Pulmonary Imaging Research
  • Professor, UC Department of Pediatrics
  • UC Department of Radiology

About

Biography

My interest in pulmonary imaging research was born of a unique background in hyperpolarized gases and atomic physics, combined with an interest in translational applications to surgery and pulmonary medicine.

My primary research areas include pulmonary MRI, regional structure-function relationships, pathophysiology, translational imaging research and clinical trials. The overall goal of this research is to improve outcomes for patients with lung disease through precise imaging and determination of regional structure-function relationships, using a combination of translational techniques and innovative methodologies.

We have pioneered 129Xe MRI in pediatrics and help lead the 129Xe MRI Clinical Trials Consortium. We also have begun to redefine bronchopulmonary dysplasia (BPD) by imaging-phenotypes, which show a direct relationship to outcomes.

Our research team is comprised of experts in hyperpolarized-gas MRI and in the use of this technique to measure regional lung function, physiology and microstructure. Many of the fellows and junior faculty that I have mentored have won awards and recognition from national and international organizations, such as the International Society for Magnetic Resonance in Medicine (ISMRM), the American Thoracic Society (ATS) and the Society for Pediatric Radiology (SPR).

Since my arrival at Cincinnati Children’s in 2013, I’ve served as the director of the Center for Pulmonary Imaging Research (CPIR). Our center offers a multidisciplinary research and training program that combines pulmonary medicine, radiology and neonatology. I also co-lead the Bronchopulmonary Dysplasia Center at Cincinnati Children’s, where imaging research has been rapidly translated into clinical care and improved patient outcomes.

PhD: Washington University, St. Louis, MO, 2002.

Postdoctoral: Washington University, St. Louis, MO, 2004.

Interests

Hyperpolarized gas; pulmonary MRI; translational studies; image-guided pulmonary interventions

Research Areas

Pulmonary Medicine, Imaging, Fibrosis

Publications

Predicting Tracheal Work of Breathing in Neonates Based on Radiological and Pulmonary Measurements. Gunatilaka, CC; Hysinger, EB; Schuh, A; Xiao, Q; Gandhi, DB; Higano, NS; Ignatiuk, DA; Hossain, MM; Fleck, RJ; Woods, JC; et al. Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 2022.

Fetal lung development via quantitative biomarkers from diffusion MRI and histological validation in rhesus macaques. Higano, NS; Cao, X; Guo, J; Wang, X; Kroenke, CD; Filuta, AL; Bridges, JP; Woods, JC. Journal of Perinatology. 2022; 42:866-872.

Tissue-localized immune responses in people with cystic fibrosis and respiratory nontuberculous mycobacteria infection. Hayes, D; Shukla, RK; Cheng, Y; Gecili, E; Merling, MR; Szczesniak, RD; Ziady, AG; Woods, JC; Hall-Stoodley, L; Liyanage, NP M; et al. JCI insight. 2022; 7.

Virtual Bronchoscopy of Neonatal Airway Malacia via High-Resolution, Respiratory-Gated MRI. Higano, NS; Gandhi, DB; Xiao, Q; Gunatilaka, CC; Hysinger, EB; Fleck, RJ; Woods, JC; Bates, AJ. American Journal of Respiratory and Critical Care Medicine. 2022.

Quantitative cardiopulmonary magnetic resonance imaging in neonatal congenital diaphragmatic hernia. Tkach, JA; Higano, NS; Taylor, MD; Moore, RA; Hossain, M; Huang, G; Spielberg, DR; Fain, SB; Kingma, PS; Woods, JC. Pediatric Radiology. 2022.

Tracheostomy prediction model in neonatal bronchopulmonary dysplasia via lung and airway MRI. Adaikalam, SA; Higano, NS; Hysinger, EB; Bates, AJ; Fleck, RJ; Schapiro, AH; House, MA; Nathan, AT; Ahlfeld, SK; Brady, JM; et al. Pediatric Pulmonology. 2022; 57:1042-1050.

Bronchopulmonary dysplasia from chest radiographs to magnetic resonance imaging and computed tomography: adding value. Higano, NS; Bates, AJ; Gunatilaka, CC; Hysinger, EB; Critser, PJ; Hirsch, R; Woods, JC; Fleck, RJ. Pediatric Radiology. 2022; 52:643-660.

Cover Image, Volume 57, Number 4, April 2022. Adaikalam, SA; Higano, NS; Hysinger, EB; Bates, AJ; Fleck, RJ; Schapiro, AH; House, MA; Nathan, AT; Ahlfeld, SK; Brady, JM; et al. Pediatric Pulmonology. 2022; 57:ii-ii.

Maladaptive functional changes in alveolar fibroblasts due to perinatal hyperoxia impair epithelial differentiation. Riccetti, MR; Ushakumary, MG; Waltamath, M; Green, J; Snowball, J; Dautel, SE; Endale, M; Lami, B; Woods, J; Ahlfeld, SK; et al. JCI insight. 2022; 7.

Pediatric 129 Xe Gas-Transfer MRI-Feasibility and Applicability. Willmering, MM; Walkup, LL; Niedbalski, PJ; Wang, H; Wang, Z; Hysinger, EB; Myers, KC; Towe, CT; Driehuys, B; Cleveland, ZI; et al. Journal of Magnetic Resonance Imaging. 2022.