A photo of Jason Woods.

Jason C. Woods, PhD

  • Director, Center for Pulmonary Imaging Research
  • Professor, UC Department of Pediatrics
  • UC Department of Radiology

About

Biography

My interest in pulmonary imaging research was born of a unique background in hyperpolarized gases and atomic physics, combined with an interest in translational applications to surgery and pulmonary medicine.

My primary research areas include pulmonary MRI, regional structure-function relationships, pathophysiology, translational imaging research and clinical trials. The overall goal of this research is to improve outcomes for patients with lung disease through precise imaging and determination of regional structure-function relationships, using a combination of translational techniques and innovative methodologies.

We have pioneered 129Xe MRI in pediatrics and help lead the 129Xe MRI Clinical Trials Consortium. We also have begun to redefine bronchopulmonary dysplasia (BPD) by imaging-phenotypes, which show a direct relationship to outcomes.

Our research team is comprised of experts in hyperpolarized-gas MRI and in the use of this technique to measure regional lung function, physiology and microstructure. Many of the fellows and junior faculty that I have mentored have won awards and recognition from national and international organizations, such as the International Society for Magnetic Resonance in Medicine (ISMRM), the American Thoracic Society (ATS) and the Society for Pediatric Radiology (SPR).

Since my arrival at Cincinnati Children’s in 2013, I’ve served as the director of the Center for Pulmonary Imaging Research (CPIR). Our center offers a multidisciplinary research and training program that combines pulmonary medicine, radiology and neonatology. I also co-lead the Bronchopulmonary Dysplasia Center at Cincinnati Children’s, where imaging research has been rapidly translated into clinical care and improved patient outcomes.

PhD: Washington University, St. Louis, MO, 2002.

Postdoctoral: Washington University, St. Louis, MO, 2004.

Interests

Hyperpolarized gas; pulmonary MRI; translational studies; image-guided pulmonary interventions

Research Areas

Pulmonary Medicine, Imaging, Fibrosis

Publications

Outpatient Respiratory Management of Infants, Children, and Adolescents with Post-Prematurity Respiratory Disease: An Official American Thoracic Society Clinical Practice Guideline. Cristea, AI; Baker, CD; Allen, J; Amin, R; Austin, ED; Cataletto, ME; Collaco, JM; Eldredge, LC; Fleck, RJ; Gelfand, A; et al. American Journal of Respiratory and Critical Care Medicine. 2021; 204:e115-e133.

Neonates With Tracheomalacia Generate Auto-Positive End-Expiratory Pressure via Glottis Closure. Gunatilaka, CC; Hysinger, EB; Schuh, A; Gandhi, DB; Higano, NS; Xiao, Q; Hahn, AD; Fain, SB; Fleck, RJ; Woods, JC; et al. Chest. 2021; 160:2168-2177.

Magnetic Resonance Imaging Assessment of Pulmonary Vascularity in Infants with Congenital Diaphragmatic Hernia: A Novel Tool for Direct Assessment of Severity of Pulmonary Hypertension and Hypoplasia. Mukthapuram, S; Beebe, J; Tkach, JA; Arya, S; Haberman, B; Peiro, J; Lim, FY; Woods, JC; Kingma, PS. Journal of Pediatrics. 2021; 239:89-94.

Protocols for multi-site trials using hyperpolarized 129 Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the 129 Xe MRI clinical trials consortium. Niedbalski, PJ; Hall, CS; Castro, M; Eddy, RL; Rayment, JH; Svenningsen, S; Parraga, G; Zanette, B; Santyr, GE; Thomen, RP; et al. Magnetic Resonance in Medicine. 2021; 86:2966-2986.

Modern Lung Magnetic Resonance Imaging to Screen for Pulmonary Complications in Patients with Dyskeratosis Congenita. Walkup, LL; Myers, KC; Willmering, MM; Mehta, PA; Nelson, AS; Fleck, RJ; Woods, JC; Davies, SM; Towe, CT. American Journal of Respiratory and Critical Care Medicine. 2021; 204:1340-1343.

Improving hyperpolarized 129 Xe ADC mapping in pediatric and adult lungs with uncertainty propagation. Bdaiwi, AS; Niedbalski, PJ; Hossain, MM; Willmering, MM; Walkup, LL; Wang, H; Thomen, RP; Ruppert, K; Woods, JC; Cleveland, ZI. NMR in Biomedicine. 2021.

Fetal lung development via quantitative biomarkers from diffusion MRI and histological validation in rhesus macaques. Higano, NS; Cao, X; Guo, J; Wang, X; Kroenke, CD; Filuta, AL; Bridges, JP; Woods, JC. Journal of Perinatology. 2021.

Oral Positive Expiratory Pressure Device for Excessive Dynamic Airway Collapse Caused by Emphysema. Zafar, MA; Sengupta, R; Bates, A; Woods, JC; Radchenko, C; McCormack, FX; Panos, RJ. Chest. 2021; 160:e333-e337.

Echocardiography-derived septal curvature correlated with invasive hemodynamics in pediatric pulmonary hypertension. Critser, PJ; Evers, PD; Schneider, K; Hirsch, R; Taylor, MD; Woods, JC; Lang, SM. Journal of Echocardiography. 2021.

Human upper-airway respiratory airflow: In vivo comparison of computational fluid dynamics simulations and hyperpolarized 129Xe phase contrast MRI velocimetry. Xiao, Q; Stewart, NJ; Willmering, MM; Gunatilaka, CC; Thomen, RP; Schuh, A; Krishnamoorthy, G; Wang, H; Amin, RS; Dumoulin, CL; et al. PLoS ONE. 2021; 16.