High Res

Jason C. Woods, PhD

Director, Center for Pulmonary Imaging Research

Academic Affiliations

Professor, UC Department of Pediatrics

UC Department of Radiology

Phone 513-803-4463

Email jason.woods@cchmc.org

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Research Interests

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Hyperpolarized gas; pulmonary MRI; translational studies; image-guided pulmonary interventions

Visit the Center for Pulmonary Imaging Research Lab.

Biography

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Dr. Woods is one of the world’s experts on hyperpolarized-gas MRI and the use of such gas MRI to measure regional lung function, microstructure and physiology. He began his career in physics, radiology, and the dean's office at Washington University in St Louis, and moved to Cincinnati Children's in 2013 to apply new imaging techniques to pediatric translational research. He leads multiple team projects related to the multidisciplinary study of lung structure, function, biology and physiology. In particular, imaging applications to the study of cystic fibrosis, BPD, rare-lung diseases, and allograft rejection are all active areas of current research.

Dr. Woods directs the Center for Pulmonary Imaging Research at Cincinnati Children’s Hospital Medical Center. The center is a multidisciplinary research and training program at the intersection of pulmonary medicine, radiology, and neonatology.

Education and Training

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PhD: Washington University, St. Louis, MO, 2002.

Postdoctoral: Washington University, St. Louis, MO, 2004.

Publications

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View PubMed Publications

Roach DJ, Crémillieux Y, Fleck RJ, Brody AS, Serai SD, Szczesniak RD, Kerlakian S, Clancy JP, Woods JC. Ultrashort Echo-Time Magnetic Resonance Imaging Is a Sensitive Method for the Evaluation of Early Cystic Fibrosis Lung Disease. Annals ATS. 2016.

Thomen RP, Walkup LL, Roach DJ, Cleveland ZI, Clancy JP, Woods JC. Hyperpolarized 129Xe for investigation of mild cystic fibrosis lung disease in pediatrics. J Cyst Fibr. 2016.

Stein JM, Walkup LL, Brody AS, Fleck RJ, Woods JC. Quantitative CT characterization of pediatric lung development using routine clinical imaging. Pediatric Radiology. 2016.

Roach DJ, Crémillieux Y, Serai SD, Thomen RP, Wang H, Zou Y, Benzaquen S, Szczesniak RD, Woods JC. Morphological and quantitative evaluation of emphysema in COPD patients: a comparative study of MRI with HRCT. J Magn Reson Imag. 2016.

Walkup LL, Thomen RP, Akinyi TG, Watters E, Ruppert K, Clancy JP, Woods JC, Cleveland ZI. Feasibility, tolerability, and safety of pediatric hyperpolarized 129Xe magnetic resonance imaging in healthy volunteers and subjects with cystic fibrosis. Pediatric Radiology. 2016.

Higano NS, Hahn AD, Tkach JA, Cao X, Walkup LL, Thomen RP, Merhar SL, Kingma PS, Fain SB, Woods JC. Retrospective respiratory self-gating and removal of bulk motion in pulmonary UTE MRI of neonates and adults. Magn Reson Med. 2016.

Hahn AD, Higano NS, Walkup LL, Thomen RP, Cao X, Merhar SL, Tkach JA, Woods JC, Fain SB. Pulmonary MRI of neonates in the intensive care unit using 3-D ultrashort echo time and a small footprint MRI system. J Magn Reson Imag. 2016.

Thomen RP, Quirk JD, Roach D, Egan-Rojas T, Ruppert K, Yusen RD, Altes TA, Yablonskiy DA, Woods JC. Direct comparison of 129Xe diffusion measurements with quantitative histology in human lungs. Magn Reson Med. 2016.

Saito A, Nikolaidis NM, Amlal H, Uehara Y, Gardner JC, LaSance K, Pitstick LB, Bridges JP, Wikenheiser-Brokamp KA, McGraw DW, Woods JC, Sabbagh Y, Schiavi SC, Altinişik G, Jakopović M, Inoue Y, McCormack FX. Modeling pulmonary alveolar microlithiasis by lung epithelial deletion of the NPT to be sodium phosphate coat transporter feels novel biomarkers and strategies for treatment. Sci Transl Med. 2015 Nov 11;7(313):313ra181.

Grants

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UTE MRI to monitor CF lung disease and responses to CF TR modulation young children. Principal Investigator. National Heart, Lung, and Blood Institute. June 2016–May 2021.

Pathogenesis-Driven Therapeutic Development for Pulmonary Alveolar Microlithiasis. Investigator. National Heart, Lung, and Blood Institute. Sep 2016–Aug 2021.

Regional Biomarkers of Peripheral Lung Disease in Cystic Fibrosis. Investigator. Cystic Fibrosis Foundation. Apr 2016–Mar 2019.

Severe Asthma Research Program (SARP). Investigator. NHLBI. Aug 2011–Jul 2017.