My interest in pulmonary imaging research was born of a unique background in hyperpolarized gases and atomic physics, combined with an interest in translational applications to surgery and pulmonary medicine.
My primary research areas include pulmonary MRI, regional structure-function relationships, pathophysiology, translational imaging research and clinical trials. The overall goal of this research is to improve outcomes for patients with lung disease through precise imaging and determination of regional structure-function relationships, using a combination of translational techniques and innovative methodologies.
We have pioneered 129Xe MRI in pediatrics and help lead the 129Xe MRI Clinical Trials Consortium. We also have begun to redefine bronchopulmonary dysplasia (BPD) by imaging-phenotypes, which show a direct relationship to outcomes.
Our research team is comprised of experts in hyperpolarized-gas MRI and in the use of this technique to measure regional lung function, physiology and microstructure. Many of the fellows and junior faculty that I have mentored have won awards and recognition from national and international organizations, such as the International Society for Magnetic Resonance in Medicine (ISMRM), the American Thoracic Society (ATS) and the Society for Pediatric Radiology (SPR).
Since my arrival at Cincinnati Children’s in 2013, I’ve served as the director of the Center for Pulmonary Imaging Research (CPIR). Our center offers a multidisciplinary research and training program that combines pulmonary medicine, radiology and neonatology. I also co-lead the Bronchopulmonary Dysplasia Center at Cincinnati Children’s, where imaging research has been rapidly translated into clinical care and improved patient outcomes.
PhD: Washington University, St. Louis, MO, 2002
Postdoctoral: Washington University, St. Louis, MO, 2004
Bronchopulmonary dysplasia
Hyperpolarized gas; pulmonary MRI; translational studies; image-guided pulmonary interventions
Phenotyping bronchopulmonary dysplasia using magnetic resonance imaging. Paediatric Respiratory Reviews. 2026.
Reversible Airway Obstruction on Impulse Oscillometry in Preschool Children with Bronchopulmonary Dysplasia. Journal of Pediatrics. 2026; 293:115013.
Pulmonary vascular growth in bronchopulmonary dysplasia using magnetic resonance imaging. American Journal of Respiratory and Critical Care Medicine. 2026; 212(6):1339-1342.
Hand in glove: New imaging techniques and airway endoscopy. Paediatric Respiratory Reviews. 2026.
Lung mucus burden and treatment response assessed by MRI in the post-modulator era. Journal of Cystic Fibrosis. 2026.
Comparison of Signal- and Volume-Based Ventilation-Weighted Assessment Using 3D FLORET UTE MRI in Patients With Various Pulmonary Disease. Magnetic Resonance in Medicine. 2026; 95(5):2814-2827.
D15-04 MRI Measures Elevated Tracheal Volumes in Infants With Moderate to Severe Bronchopulmonary Dysplasia. American Journal of Respiratory and Critical Care Medicine. 2026; 212(Supplement_1):aamag162.1205.
A62-04 Comparison of Home Spirometry to Office Spirometry in Children and Young Adults Post Hematopoietic Stem Cell Transplant in the Transpire Research Study. American Journal of Respiratory and Critical Care Medicine. 2026; 212(Supplement_1):aamag162.2957.
B101-02 To Bronch or Not to Bronch? - Biologic Markers of Lung Injury in the Bronchoalveolar Lavage Fluid of Pediatric Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation, a Transpire Study. American Journal of Respiratory and Critical Care Medicine. 2026; 212(Supplement_1):aamag162.5393.
C74-09 MCP-1 in Broncho-Alveolar Fluid and Plasma in Children With Lung Injury After Hematopoietic Stem Cell Transplant: A Transpire Study. American Journal of Respiratory and Critical Care Medicine. 2026; 212(Supplement_1):aamag162.5449.