My interest in pulmonary imaging research was born of a unique background in hyperpolarized gases and atomic physics, combined with an interest in translational applications to surgery and pulmonary medicine.
My primary research areas include pulmonary MRI, regional structure-function relationships, pathophysiology, translational imaging research and clinical trials. The overall goal of this research is to improve outcomes for patients with lung disease through precise imaging and determination of regional structure-function relationships, using a combination of translational techniques and innovative methodologies.
We have pioneered 129Xe MRI in pediatrics and help lead the 129Xe MRI Clinical Trials Consortium. We also have begun to redefine bronchopulmonary dysplasia (BPD) by imaging-phenotypes, which show a direct relationship to outcomes.
Our research team is comprised of experts in hyperpolarized-gas MRI and in the use of this technique to measure regional lung function, physiology and microstructure. Many of the fellows and junior faculty that I have mentored have won awards and recognition from national and international organizations, such as the International Society for Magnetic Resonance in Medicine (ISMRM), the American Thoracic Society (ATS) and the Society for Pediatric Radiology (SPR).
Since my arrival at Cincinnati Children’s in 2013, I’ve served as the director of the Center for Pulmonary Imaging Research (CPIR). Our center offers a multidisciplinary research and training program that combines pulmonary medicine, radiology and neonatology. I also co-lead the Bronchopulmonary Dysplasia Center at Cincinnati Children’s, where imaging research has been rapidly translated into clinical care and improved patient outcomes.
PhD: Washington University, St. Louis, MO, 2002.
Postdoctoral: Washington University, St. Louis, MO, 2004.
Hyperpolarized gas; pulmonary MRI; translational studies; image-guided pulmonary interventions
Pulmonary Medicine, Imaging, Fibrosis
Childhood to adulthood: Accounting for age dependence in healthy-reference distributions in 129 Xe gas-exchange MRI. Magnetic Resonance in Medicine. 2023; 89:1117-1133.
Magnetic Resonance Imaging-Based Evaluation of Anatomy and Outcome Prediction in Infants with Esophageal Atresia. Neonatology. 2023; 120:185-195.
Intra- and Inter-visit Repeatability of 129 Xenon Multiple-Breath Washout MRI in Children With Stable Cystic Fibrosis Lung Disease. Journal of Magnetic Resonance Imaging. 2023.
Short-term structural and functional changes after airway clearance therapy in cystic fibrosis. Journal of Cystic Fibrosis. 2023.
Quantitative Imaging Metrics for the Assessment of Pulmonary Pathophysiology: An Official American Thoracic Society and Fleischner Society Joint Workshop Report. Annals of the American Thoracic Society. 2023; 20:161-195.
Seeing Premature Lung Disease: Hyperpolarized Xe Magnetic Resonance Imaging. American Journal of Respiratory and Critical Care Medicine. 2023; 207:15-16.
Quantitative cardiopulmonary magnetic resonance imaging in neonatal congenital diaphragmatic hernia. Pediatric Radiology. 2022; 52:2306-2318.
Pediatric 129 Xe Gas-Transfer MRI-Feasibility and Applicability. Journal of Magnetic Resonance Imaging. 2022; 56:1207-1219.
Predicting tracheal work of breathing in neonates based on radiological and pulmonary measurements. Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 2022; 133:893-901.
Imaging in neonatal respiratory disease. Paediatric Respiratory Reviews. 2022; 43:44-52.