A photo of Jing Xiang.

Jing Xiang, MD, PhD


  • Director of MEG Research, Division of Neurology
  • Associate Professor, UC Department of Pediatrics

About

Biography

Neurological conditions, such as epilepsy and migraines, affect hundreds of millions of patients worldwide. Globally, more than 50 million people have epilepsy, while more than 45 million individuals live with dementia. Since neurological disorders impact many patients, families and caregivers, it is vital to pursue neurological scientific research.

My research areas include epilepsy, migraines and magnetoencephalography (MEG). My colleagues and I are working to develop innovative bio-magnetic technology to correctly localize epileptogenic zones or pathological brain regions for advancing successful therapeutic results for epilepsy, migraines and other neurological conditions.

When I learned about risky and invasive conventional therapy for epilepsy surgery, I became interested in magnetoencephalography and bio-magnetic technology. The conventional method for treating epilepsy is a type of surgery in which electrodes are placed directly into or on the brain, which is more prone to error and more costly. In my research, colleagues and I found that spotting magnetic signals is better than spotting electrical signals since magnetic signals can move through the skin and skull without alteration.

Our hope is that using bio-magnetic signals for detection, such as magnetoencephalography (MEG) and magnetocardiography (MCG), will eventually substitute using bioelectric signals, such as electroencephalography (EEG) and electrocardiography (ECG), for detection.

One notable discovery in my research was finding that MEG could noninvasively and correctly localize epileptogenic zones for pediatric epilepsy surgery for improved medical outcomes. My colleagues and I also discovered that the human brain produces high-frequency neuromagnetic signals, which unlocks an entirely new avenue for research and clinical applications.

Some recognitions and honors I have achieved include:

  • Becoming a reviewer for the National Institutes of Health (NIH) Biological Measures for Prognosing and Monitoring of Persistent Concussive Symptoms in Early and Middle Adolescents: Center without Walls (PCS-EMA CWOW)
  • Being an editor of Frontier in Human Neuroscience
  • Being a member of the Data Sharing Committee in MEG North America

I have more than 20 years of expertise in my field and began working at Cincinnati Children’s Hospital Medical Center in 2006. My research has been published in Frontiers in Human Neuroscience, The Journal of Headache and Pain and World Neurosurgery.

Publications

A Graph Fourier Transform Based Bidirectional Long Short-Term Memory Neural Network for Electrophysiological Source Imaging. Jiao, M; Wan, G; Guo, Y; Wang, D; Liu, H; Xiang, J; Liu, F. Frontiers in Neuroscience. 2022; 16.

Editorial: High Frequency Brain Signals: From Basic Research to Clinical Application. Xiang, J; Ishii, R; Yang, X. Frontiers in Human Neuroscience. 2022; 16.

Altered Neuromagnetic Activity in Persistent Postural-Perceptual Dizziness: A Multifrequency Magnetoencephalography Study. Jiang, W; Sun, J; Xiang, J; Sun, Y; Tang, L; Zhang, K; Chen, Q; Wang, X. Frontiers in Human Neuroscience. 2022; 16.

Transformer-Based High-Frequency Oscillation Signal Detection on Magnetoencephalography From Epileptic Patients. Guo, J; Xiao, N; Li, H; He, L; Li, Q; Wu, T; He, X; Chen, P; Chen, D; Xiang, J; et al. Frontiers in Molecular Biosciences. 2022; 9.

Using EEG and MEG to characterize extreme delta brush in a patient with anti-NMDA receptor encephalitis. Miao, A; Shi, Y; Xiang, J; Wang, X; Ge, J; Chen, Q; Yu, Y; Yu, C; Wu, D. BMC Neurology. 2021; 21.

Altered functional connectivity in newly diagnosed benign epilepsy with unilateral or bilateral centrotemporal spikes: A multi-frequency MEG study. Wang, P; Li, Y; Sun, Y; Sun, J; Niu, K; Zhang, K; Xiang, J; Chen, Q; Hu, Z; Wang, X. Epilepsy and Behavior. 2021; 124.

Frequency-Dependent Dynamics of Functional Connectivity Networks During Seizure Termination in Childhood Absence Epilepsy: A Magnetoencephalography Study. Sun, J; Li, Y; Zhang, K; Sun, Y; Wang, Y; Miao, A; Xiang, J; Wang, X. Frontiers in Neurology. 2021; 12.

Functional reorganization of brain regions into a network in childhood absence epilepsy: A magnetoencephalography study. Sun, Y; Li, Y; Sun, J; Zhang, K; Tang, L; Wu, C; Gao, Y; Liu, H; Huang, S; Hu, Z; et al. Epilepsy and Behavior. 2021; 122.

Effect of gap junction blockers on hippocampal ripple energy expression in rats with status epilepticus. Yi, YJ; Ran, X; Xiang, J; Li, XY; Jiang, L; Chen, HS; Hu, Y. Chinese Journal of Contemporary Pediatrics. 2021; 23:848-853.

Neuromagnetic high frequency spikes are a new and noninvasive biomarker for localization of epileptogenic zones. Xiang, J; Maue, E; Tong, H; Mangano, FT; Greiner, H; Tenney, J. Seizure : the journal of the British Epilepsy Association. 2021; 89:30-37.