Xiang Lab

Xiang Research Lab

The Magnetoencephalography (MEG) Center at Cincinnati Children’s conducts collaborative research aimed at tapping the full clinical potential for this advanced imaging technology. Many of our research projects focus on signal processing and presurgical functional mapping, which could lead to safer, less invasive neurosurgical procedures for patients with epilepsy.

One of our areas of focus investigates high-frequency neuromagnetic signals (HFNS) associated with electric high-frequency oscillations (HFOs, ripple or fast ripple). Our preliminary data indicate that high-frequency brain signals are a new window for functional analysis of the brain activity. In addition, high-frequency neuromagnetic signals may provide unique information about brain maturation and development. Our research is some of the first to investigate these signals in children and adolescents.

We also aim to develop new techniques to noninvasively localize seizure onset regions and ultimately avoid lengthy, costly and risky invasive intracranial recordings (or ECoG) to find the abnormal epileptic regions requiring surgical removal. From the clinical point of view, MEG can localize active areas of the brain targeted for surgical removal and provide more accurate spatial localization of functional areas of the brain that should be preserved. Our research can directly translate into safer, more reliable neurosurgery to treat children with severe epileptic seizures.


Xiang, J; Yu, X; Bonnette, S; Anand, M; Riehm, CD; Schlink, B; Diekfuss, JA; Myer, GD; Jiang, Y. Improved Biomagnetic Signal-To-Noise Ratio and Source Localization Using Optically Pumped Magnetometers with Synthetic Gradiometers. Brain Sciences. 2023; 13:663.

Chen, D; Liu, K; Guo, J; Bi, L; Xiang, J. Editorial: Brain-computer interface and its applications. Frontiers in Neurorobotics. 2023; 17:1140508.

Zhang, F; Han, JH; Samy, R; Xiang, J. Editorial: Changes in the auditory brain following deafness, cochlear implantation, and auditory training, volume II. Frontiers in Human Neuroscience. 2023; 17:1124304.

Li, Y; Chen, J; Sun, J; Jiang, P; Xiang, J; Chen, Q; Hu, Z; Wang, X. Changes in functional connectivity in newly diagnosed self-limited epilepsy with centrotemporal spikes and cognitive impairment: An MEG study. Brain and Behavior. 2022; 12:e2830.

Ren, J; Yao, Q; Tian, M; Li, F; Chen, Y; Chen, Q; Xiang, J; Shi, J. Altered effective connectivity in migraine patients during emotional stimuli: a multi-frequency magnetoencephalography study. The Journal of Headache and Pain. 2022; 23:6.

Zhang, J; Xiang, J; Luo, L; Shui, R. Editorial: EEG/MEG based diagnosis for psychiatric disorders. Frontiers in Human Neuroscience. 2022; 16:1061176.

Xiang, J; Tong, H; Jiang, Y; Barnes-Davis, ME. Spatial and Frequency Specific Artifact Reduction in Optically Pumped Magnetometer Recordings. Journal of Integrative Neuroscience. 2022; 21:145.

Guo, Y; Jiao, M; Wan, G; Xiang, J; Wang, S; Liu, F. (2022) EEG Source Imaging using GANs with Deep Image Prior. Institute of Electrical and Electronics Engineers (IEEE). 2022:572-575.

Jiao, M; Wan, G; Guo, Y; Wang, D; Liu, H; Xiang, J; Liu, F. A Graph Fourier Transform Based Bidirectional Long Short-Term Memory Neural Network for Electrophysiological Source Imaging. Frontiers in Neuroscience. 2022; 16:867466.

Xiang, J; Ishii, R; Yang, X. Editorial: High Frequency Brain Signals: From Basic Research to Clinical Application. Frontiers in Human Neuroscience. 2022; 16:872478.

Jiang, W; Sun, J; Xiang, J; Sun, Y; Tang, L; Zhang, K; Chen, Q; Wang, X. Altered Neuromagnetic Activity in Persistent Postural-Perceptual Dizziness: A Multifrequency Magnetoencephalography Study. Frontiers in Human Neuroscience. 2022; 16:759103.

Guo, J; Xiao, N; Li, H; He, L; Li, Q; Wu, T; He, X; Chen, P; Chen, D; Xiang, J; et al. Transformer-Based High-Frequency Oscillation Signal Detection on Magnetoencephalography From Epileptic Patients. Frontiers in Molecular Biosciences. 2022; 9:822810.

Jiao, M; Liu, F; Asan, O; Nilchiani, R; Ju, X; Xiang, J. Brain Source Reconstruction Solution Quality Assessment with Spatial Graph Frequency Features. Brain Informatics. : Springer Nature; Springer Nature; 2022.

Miao, A; Shi, Y; Xiang, J; Wang, X; Ge, J; Chen, Q; Yu, Y; Yu, C; Wu, D. Using EEG and MEG to characterize extreme delta brush in a patient with anti-NMDA receptor encephalitis. BMC Neurology. 2021; 21:134.

Wang, P; Li, Y; Sun, Y; Sun, J; Niu, K; Zhang, K; Xiang, J; Chen, Q; Hu, Z; Wang, X. Altered functional connectivity in newly diagnosed benign epilepsy with unilateral or bilateral centrotemporal spikes: A multi-frequency MEG study. Epilepsy and Behavior. 2021; 124:108276.

Sun, J; Li, Y; Zhang, K; Sun, Y; Wang, Y; Miao, A; Xiang, J; Wang, X. Frequency-Dependent Dynamics of Functional Connectivity Networks During Seizure Termination in Childhood Absence Epilepsy: A Magnetoencephalography Study. Frontiers in Neurology. 2021; 12:744749.

Sun, Y; Li, Y; Sun, J; Zhang, K; Tang, L; Wu, C; Gao, Y; Liu, H; Huang, S; Hu, Z; et al. Functional reorganization of brain regions into a network in childhood absence epilepsy: A magnetoencephalography study. Epilepsy and Behavior. 2021; 122:108117.

Yi, YJ; Ran, X; Xiang, J; Li, XY; Jiang, L; Chen, HS; Hu, Y. Effect of gap junction blockers on hippocampal ripple energy expression in rats with status epilepticus. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. 2021; 23:848-853.

Xiang, J; Maue, E; Tong, H; Mangano, FT; Greiner, H; Tenney, J. Neuromagnetic high frequency spikes are a new and noninvasive biomarker for localization of epileptogenic zones. Seizure-European Journal of Epilepsy. 2021; 89:30-37.

Xiang, J; Maue, E; Fujiwara, H; Mangano, FT; Greiner, H; Tenney, J. Delineation of epileptogenic zones with high frequency magnetic source imaging based on kurtosis and skewness. Epilepsy Research. 2021; 172:106602.

Sun, K; Yu, T; Yang, D; Ren, Z; Qiao, L; Ni, D; Wang, X; Zhao, Y; Chen, X; Xiang, J; et al. Fluid and White Matter Suppression Imaging and Voxel-Based Morphometric Analysis in Conventional Magnetic Resonance Imaging-Negative Epilepsy. Frontiers in Neurology. 2021; 12:651592.

Feng, Y; Xiao, W; Wu, T; Zhang, J; Xiang, J; Guo, H. An Automatic Identification Method for the Blink Artifacts in the Magnetoencephalography with Machine Learning. Applied Sciences-Basel. 2021; 11:2415.

Feng, Y; Xiao, W; Wu, T; Zhang, J; Xiang, J; Guo, H. A New Recognition Method for the Auditory Evoked Magnetic Fields. Editor, Versaci M. Computational Intelligence and Neuroscience. 2021; 2021:6645270.

Hsiao, F; Xiang, J; Chen, W. Magnetoencephalography. Neurophysiology of the Migraine Brain. : Springer Nature; Springer Nature; 2021.

Guo, J; Li, H; Sun, X; Qi, L; Qiao, H; Pan, Y; Xiang, J; Ji, R. Detecting High Frequency Oscillations for Stereoelectroencephalography in Epilepsy via Hypergraph Learning. IEEE Transactions on Neural Systems and Rehabilitation Engineering. 2021; 29:587-596.

Li, Y; Sun, Y; Zhang, T; Shi, Q; Sun, J; Xiang, J; Chen, Q; Hu, Z; Wang, X. The relationship between epilepsy and cognitive function in benign childhood epilepsy with centrotemporal spikes. Brain and Behavior. 2020; 10:e01854.

Wang, Y; Zhou, D; Yang, X; Xu, X; Ren, L; Yu, T; Zhou, W; Shao, X; Yang, Z; Wang, S; et al. Expert consensus on clinical applications of high-frequency oscillations in epilepsy. Acta Epileptologica. 2020; 2:8.

Sun, Y; Li, Y; Shi, Q; Wu, C; Sun, J; Chen, Q; Hu, Z; Xiang, J; Wang, X. Changes of Ictal-Onset Epileptic Network Synchronicity in Childhood Absence Epilepsy: A Magnetoencephalography Study. Frontiers in Neurology. 2020; 11:583267.

Li, Y; Sun, Y; Niu, K; Wang, P; Xiang, J; Chen, Q; Hu, Z; Wang, X. The relationship between neuromagnetic activity and cognitive function in benign childhood epilepsy with centrotemporal spikes. Epilepsy and Behavior. 2020; 112:107363.

Liu, J; Sun, S; Liu, Y; Guo, J; Li, H; Gao, Y; Sun, J; Xiang, J. A Novel MEGNet for Classification of High-Frequency Oscillations in Magnetoencephalography of Epileptic Patients. Complexity. 2020; 2020:1-9.

Guo, J; Li, H; Pan, Y; Gao, Y; Sun, J; Wu, T; Xiang, J; Luo, X. Automatic and Accurate Epilepsy Ripple and Fast Ripple Detection via Virtual Sample Generation and Attention Neural Networks. IEEE Transactions on Neural Systems and Rehabilitation Engineering. 2020; 28:1710-1719.

Leng, X; Xiang, J; Yang, Y; Yu, T; Qi, X; Zhang, X; Wu, S; Wang, Y. Frequency-specific changes in the default mode network in patients with cingulate gyrus epilepsy. Human Brain Mapping. 2020; 41:2447-2459.

Liang, C; Wenstrup, LH; Samy, RN; Xiang, J; Zhang, F. The Effect of Side of Implantation on the Cortical Processing of Frequency Changes in Adult Cochlear Implant Users. Frontiers in Neuroscience. 2020; 14:368.

Firestone, GM; McGuire, K; Liang, C; Zhang, N; Blankenship, CM; Xiang, J; Zhang, F. A Preliminary Study of the Effects of Attentive Music Listening on Cochlear Implant Users' Speech Perception, Quality of Life, and Behavioral and Objective Measures of Frequency Change Detection. Frontiers in Human Neuroscience. 2020; 14:110.

Yin, C; Zhang, X; Xiang, J; Chen, Z; Li, X; Wu, S; Lv, P; Wang, Y. Altered effective connectivity network in patients with insular epilepsy: A high-frequency oscillations magnetoencephalography study. Clinical Neurophysiology. 2020; 131:377-384.

Shi, Q; Zhang, T; Miao, A; Sun, J; Sun, Y; Chen, Q; Hu, Z; Xiang, J; Wang, X. Differences Between Interictal and Ictal Generalized Spike-Wave Discharges in Childhood Absence Epilepsy: A MEG Study. Frontiers in Neurology. 2020; 10:1359.

Xiang, J; Maue, E; Fan, Y; Qi, L; Mangano, FT; Greiner, H; Tenney, J. Kurtosis and skewness of high-frequency brain signals are altered in paediatric epilepsy. Brain Communications. 2020; 2:fcaa036.

Zhou, ZY; Yu, YW; Wu, D; Liu, HX; Xiang, J; Wu, T; Chen, QQ; Wang, XS. Abnormality of visual neuromagnetic activation in female migraineurs without aura between attacks. The Journal of Headache and Pain. 2019; 20:7.

Ren, J; Xiang, J; Chen, Y; Li, F; Wu, T; Shi, J. Abnormal functional connectivity under somatosensory stimulation in migraine: a multi-frequency magnetoencephalography study. The Journal of Headache and Pain. 2019; 20:3.

Zhang, L; Chen, D; Xiang, J; Wu, T. (2019) MEG High-frequency Oscillations (HFOs) Identification and 3D Reconstruction with MRI based on MEG Processor*. Institute of Electrical and Electronics Engineers (IEEE). 00:1-5.

Jiang, W; Wu, C; Xiang, J; Miao, A; Qiu, W; Tang, L; Huang, S; Chen, Q; Hu, Z; Wang, X. Dynamic Neuromagnetic Network Changes of Seizure Termination in Absence Epilepsy: A Magnetoencephalography Study. Frontiers in Neurology. 2019; 10:703.

Yang, K; Chen, J; Xiang, J; Liu, H; Zou, Y; Kan, W; Liu, Y; Li, L. Histopathologic and Clinical Correlation of Aberrant Neuromagnetic Activities with Low to High Frequency of Gliomas. World Neurosurgery. 2019; 123:e609-e620.

Miao, A; Wang, Y; Xiang, J; Liu, Q; Chen, Q; Qiu, W; Liu, H; Tang, L; Gao, Y; Wu, C; et al. Ictal Source Locations and Cortico-Thalamic Connectivity in Childhood Absence Epilepsy: Associations with Treatment Response. Brain Topography: journal of functional neurophysiology. 2019; 32:178-191.

Korostenskaja, M; Raviprakash, H; Bagci, U; Lee, KH; Chen, PC; Kapeller, C; Salinas, C; Westerveld, M; Ralescu, A; Xiang, J; et al. Gold Standard for Epilepsy/Tumor Surgery Coupled with Deep Learning Offers Independence to a Promising Functional Mapping Modality. Brain-Computer Interface Research. : Springer Nature; Springer Nature; 2019.

275 MEG channels and 128 EEG electrodes. Sampling rate is up to 12 kHz per channel. Supersensitive (superconducting) magnetic detectors record the brain's spontaneous neuromagnetic signals.

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Contact Us

Jing Xiang, MD, PhD

Mailing Address:
MEG Center, Department of Neurology
3333 Burnet Ave.
MLC 2015
Cincinnati, OH 45229

Phone: 513-636-6303
Fax: 513-636-1888