Katherine Yutzey, PhD

Biography & Affiliation Education Publications

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Professor, UC Department of Pediatrics

katherine.yutzey@cchmc.org

513-636-8340

513-636-5958

Biography & Affiliation

Biography

Katherine E. Yutzey, PhD, is a professor who joined the Division of Molecular Cardiovascular Biology at Cincinnati Children's Hospital Medical Center within the University of Cincinnati College of Medicine in 1995.

Dr. Yutzey is the first recipient of the Fifth Third Bank/Charlotte R. Schmidlapp Women Scholars Award and was also a recipient of a Children's Hospital Medical Center Trustee Award. Her work is also supported by grants from National Institutes of Health (NIH) and the American Heart Association.

The focus of Dr. Yutzey's research program is the regulation of normal and abnormal heart development. Congenital heart defects represent one of the most common classes of human birth defects. Increasing evidence exists for a genetic basis of certain instances of congenital heart disease.

Dr. Yutzey’s lab also studies molecular mechanisms of cardiac connective tissue cell lineage development and disease. This work focuses on heart valve development and disease as well as mechanisms of cardiac fibrosis.

Academic Affiliation

Professor, UC Department of Pediatrics

Departments

Molecular Cardiovascular Biology, Heart, Fibrosis

Science Blog

Teaching an Old Dogma New Tricks

Katherine Yutzey, PhD6/30/2019

A New Path to Helping Hearts Heal Themselves

Katherine Yutzey, PhD6/28/2019

Education

BA: Oberlin College, Oberlin, OH, 1986.

PhD: Purdue University, West Lafayette, IN,1992

Fellowship: Cornell University Medical College, New York, NY,1992-1995.

Publications

Cardiac Fibroblasts and the Extracellular Matrix in Regenerative and Nonregenerative Hearts. Hortells, L; Johansen, AK Z; Yutzey, KE. Journal of Cardiovascular Development and Disease. 2019; 6.

Maturation of heart valve cell populations during postnatal remodeling. Hulin, A; Hortells, L; Gomez-Stallons, MV; O'Donnell, A; Chetal, K; Adam, M; Lancellotti, P; Oury, C; Potter, SS; Salomonis, N; et al. Development (Cambridge). 2019; 146.

Endothelial Cell Lineage Analysis Does Not Provide Evidence for EMT in Adult Valve Homeostasis and Disease. Kim, AJ; Alfieri, CM; Yutzey, KE. The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology. 2019; 302:125-135.

At the Heart of the Matter: A Tribute to Roger Markwald. Yutzey, KE. The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology. 2019; 302:12-13.

FOXF1 transcription factor promotes lung morphogenesis by inducing cellular proliferation in fetal lung mesenchyme. Ustiyan, V; Bolte, C; Zhang, Y; Han, L; Xu, Y; Yutzey, KE; Zorn, AM; Kalin, TV; Shannon, JM; Kalinichenko, VV. Developmental Biology. 2018; 443:50-63.

Macrophage Transitions in Heart Valve Development and Myxomatous Valve Disease. Hulin, A; Anstine, LJ; Kim, AJ; Potter, SJ; DeFalco, T; Lincoln, J; Yutzey, KE. Arteriosclerosis, Thrombosis, and Vascular Biology. 2018; 38:636-644.

Hypoxia promotes primitive glycosaminoglycan-rich extracellular matrix composition in developing heart valves. Amofa, D; Hulin, A; Nakada, Y; Sadek, HA; Yutzey, KE. American journal of physiology. Heart and circulatory physiology. 2017; 313:H1143-H1154.

Loss of beta-catenin in resident cardiac fibroblasts attenuates fibrosis induced by pressure overload in mice. Xiang, F; Fang, M; Yutzey, KE. Nature Communications. 2017; 8.

Notch-Tnf signalling is required for development and homeostasis of arterial valves. Wang, Y; Wu, B; Farrar, E; Lui, W; Lu, P; Zhang, D; Alfieri, CM; Mao, K; Chu, M; Yang, D; et al. European Heart Journal (Elsevier). 2017; 38:ehv520-ehv520.

Cardiomyocyte Proliferation Teaching an Old Dogma New Tricks. Yutzey, KE. Circulation Research. 2017; 120:627-629.