Driving Innovation in Immunology and Vaccine Research
Cincinnati Children’s has a longstanding legacy of leadership in immunology and vaccine research—spanning foundational breakthroughs in polio and rotavirus to today’s cutting-edge studies in immune regulation, inflammation, and vaccine development. Researchers across multiple divisions and centers are advancing our understanding of the immune system in both health and disease, with implications across cancer, infection, autoimmunity, and maternal-fetal medicine.
Our teams investigate how immune cells communicate, adapt, and malfunction—producing insights that inform novel vaccines, immunotherapies, and strategies for managing immune-driven conditions. Active areas of research include innate immune functions, host-microbe interactions, signals that drive inflammation in auto-immune and allergic diseases, cytokine signaling, T cell responses to infections, immunological memory, maternal immunity and impact of early life immune exposures.
Home to the Vaccine Research Center and a growing Immunobiology program, Cincinnati Children’s continues to serve as a national leader in vaccine trials, including efforts to develop longer-lasting flu vaccines, safer immunization protocols for transplant recipients, and next-generation options for RSV, norovirus, and COVID-19.
Through translational partnerships, data-driven tools, and new infrastructure like the Winslow Research Pavilion, our work bridges discovery and clinical application. Explore how Cincinnati Children’s is shaping the future of immunology and vaccine science—driven by collaboration, curiosity, and a commitment to improving lives.
