A photo of Lee Grimes.

Director, Cancer Pathology Program, Division of Experimental Hematology & Division of Pathology

Co-Leader, Program in Hematologic Malignancies of Cincinnati Children's Hospital Medical Center, Cancer and Blood Diseases Institute

Professor, UC Department of Pediatrics

513-636-6089

513-636-5355

Biography & Affiliation

Biography

Dr. Grimes has a broad background in hematopoiesis, molecular biology, and molecular oncology including modeling of hematopoiesis, myelopoiesis and leukemia. His work on the Growth factor independent-1 (Gfi1) transcriptional repressor protein has spanned the initial identification of Gfi1 in a model of leukemia and the role of Gfi1 in normal myeloid biology, to the identification of GFI1 mutations in patients with severe congenital neutropenia (SCN) and non-immune chronic idiopathic neutropenia of adults (NI-CINA). His work utilizes Gfi1 as a molecular probe to understand both normal myeloid development and innate immune action, as well as marrow failure and transformation.

Research Interests

Acute myelogenous leukemia; T-cell acute lymphoblastic leukemia; severe congenital neutropenia; hematopoiesis; myelopoiesis; lineage decision; transcription factor

Academic Affiliation

Professor, UC Department of Pediatrics

Divisions

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases, Immunobiology

Science Blog

Perspective on Single-Cell Analyses of Genetic Disease Models

Tools for Science

Perspective on Single-Cell Analyses of Genetic Disease Models

H. Leighton (Lee) Grimes, PhD4/23/2020

Finding Genetic Ripple Effects in a Single-Cell Environment

Genomics and Development

Finding Genetic Ripple Effects in a Single-Cell Environment

Nathan Salomonis, PhD, H. Leighton (Lee) Grimes, PhD4/22/2020

Bold Findings About Blood Cell Formation Stir the Scientific Pot

Autoimmune Disorders

Bold Findings About Blood Cell Formation Stir the Scientific Pot

H. Leighton (Lee) Grimes, PhD, Nathan Salomonis, PhD6/30/2019

Education

PhD: Immunology and Molecular Pathology, University of Florida, Gainesville, FL.

Postdoctoral Fellow: Fox Chase Cancer Center.

Publications

Selected Publication

Single-cell analysis of mixed-lineage states leading to a binary cell fate choice. Olsson, A; Venkatasubramanian, M; Chaudhri, VK; Aronow, BJ; Salomonis, N; Singh, H; Grimes, HL. Nature. 2016; 537:698-702.

Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition. Hinge, A; He, J; Bartram, J; Javier, J; Xu, J; Fjellman, E; Sesaki, H; Li, T; Yu, J; Wunderlich, M; et al. Cell Stem Cell. 2020; 26:420-430.e6.

HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms. Yue, L; Sharma, V; Horvat, NP; Akuffo, AA; Beatty, MS; Murdun, C; Colin, C; Billington, JM R; Goodheart, WE; Sahakian, E; et al. Blood. 2020; 135:191-207.

Unraveling bone marrow architecture. Lucas, D; Salomonis, N; Grimes, HL. Nature Cell Biology. 2020; 22:5-6.

cellHarmony: cell-level matching and holistic comparison of single-cell transcriptomes. DePasquale, EA K; Schnell, D; Dexheimer, P; Ferchen, K; Hay, S; Chetal, K; Valiente-Alandi, I; Blaxall, BC; Grimes, HL; Salomonis, N. Nucleic Acids Research. 2019; 47:e138-e138.

Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma. Lee, C; Rudneva, VA; Erkek, S; Zapatka, M; Chau, LQ; Tacheva-Grigorova, SK; Garancher, A; Rusert, JM; Aksoy, O; Lea, R; et al. Nature Communications. 2019; 10.

Phospho serine and threonine analysis of normal and mutated granulocyte colony stimulating factor receptors. Dwivedi, P; Muench, DE; Wagner, M; Azam, M; Grimes, HL; Greis, KD. Scientific Data. 2019; 6.

DoubletDecon: Deconvoluting Doublets from Single-Cell RNA-Sequencing Data. DePasquale, EA K; Schnell, DJ; Van Camp, P; Valiente-Alandi, I; Blaxall, BC; Grimes, HL; Singh, H; Salomonis, N. Cell Reports. 2019; 29:1718-1727.e8.

Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia. Adelman, ER; Huang, HT; Roisman, A; Olsson, A; Colaprico, A; Qin, T; Lindsley, RC; Bejar, R; Salomonis, N; Grimes, HL; et al. Cancer Discovery. 2019; 9:1080-1101.

Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML. Duy, C; Teater, M; Garrett-Bakelman, FE; Lee, TC; Meydan, C; Glass, JL; Li, M; Hellmuth, JC; Mohammad, HP; Smitheman, KN; et al. Cancer Discovery. 2019; 9:872-889.