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Director, Cancer Pathology Program, Division of Experimental Hematology & Division of Pathology
Co-Leader, Program in Hematologic Malignancies of Cincinnati Children's Hospital Medical Center, Cancer and Blood Diseases Institute
Professor, UC Department of Pediatrics
Dr. Grimes has a broad background in hematopoiesis, molecular biology, and molecular oncology including modeling of hematopoiesis, myelopoiesis and leukemia. His work on the Growth factor independent-1 (Gfi1) transcriptional repressor protein has spanned the initial identification of Gfi1 in a model of leukemia and the role of Gfi1 in normal myeloid biology, to the identification of GFI1 mutations in patients with severe congenital neutropenia (SCN) and non-immune chronic idiopathic neutropenia of adults (NI-CINA). His work utilizes Gfi1 as a molecular probe to understand both normal myeloid development and innate immune action, as well as marrow failure and transformation.
Acute myelogenous leukemia; T-cell acute lymphoblastic leukemia; severe congenital neutropenia; hematopoiesis; myelopoiesis; lineage decision; transcription factor
Experimental Hematology and Cancer Biology, Cancer and Blood Diseases, Immunobiology
H. Leighton (Lee) Grimes, PhD4/23/2020
Nathan Salomonis, PhD, H. Leighton (Lee) Grimes, PhD4/22/2020
H. Leighton (Lee) Grimes, PhD, Nathan Salomonis, PhD6/30/2019
PhD: Immunology and Molecular Pathology, University of Florida, Gainesville, FL.
Postdoctoral Fellow: Fox Chase Cancer Center.
Single-cell analysis of mixed-lineage states leading to a binary cell fate choice.
Olsson, A; Venkatasubramanian, M; Chaudhri, VK; Aronow, BJ; Salomonis, N; Singh, H; Grimes, HL.
Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition.
Hinge, A; He, J; Bartram, J; Javier, J; Xu, J; Fjellman, E; Sesaki, H; Li, T; Yu, J; Wunderlich, M; et al.
Cell Stem Cell.
HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms.
Yue, L; Sharma, V; Horvat, NP; Akuffo, AA; Beatty, MS; Murdun, C; Colin, C; Billington, JM R; Goodheart, WE; Sahakian, E; et al.
Unraveling bone marrow architecture.
Lucas, D; Salomonis, N; Grimes, HL.
Nature Cell Biology.
cellHarmony: cell-level matching and holistic comparison of single-cell transcriptomes.
DePasquale, EA K; Schnell, D; Dexheimer, P; Ferchen, K; Hay, S; Chetal, K; Valiente-Alandi, I; Blaxall, BC; Grimes, HL; Salomonis, N.
Nucleic Acids Research.
Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma.
Lee, C; Rudneva, VA; Erkek, S; Zapatka, M; Chau, LQ; Tacheva-Grigorova, SK; Garancher, A; Rusert, JM; Aksoy, O; Lea, R; et al.
Phospho serine and threonine analysis of normal and mutated granulocyte colony stimulating factor receptors.
Dwivedi, P; Muench, DE; Wagner, M; Azam, M; Grimes, HL; Greis, KD.
DoubletDecon: Deconvoluting Doublets from Single-Cell RNA-Sequencing Data.
DePasquale, EA K; Schnell, DJ; Van Camp, P; Valiente-Alandi, I; Blaxall, BC; Grimes, HL; Singh, H; Salomonis, N.
Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia.
Adelman, ER; Huang, HT; Roisman, A; Olsson, A; Colaprico, A; Qin, T; Lindsley, RC; Bejar, R; Salomonis, N; Grimes, HL; et al.
Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML.
Duy, C; Teater, M; Garrett-Bakelman, FE; Lee, TC; Meydan, C; Glass, JL; Li, M; Hellmuth, JC; Mohammad, HP; Smitheman, KN; et al.