Allergy and Immunology
Devonshire Lab

Devonshire Research Lab

The Devonshire Lab is investigating for biomarkers of peanut allergy, particularly in the high-risk infant population. Ashley Devonshire, MD, MPH, is passionate about advancing the care of infants with food allergy through clinical practice and research. Her clinical and research interests are focused on early life strategies for food allergy prevention and improving the diagnostic and prognostic approach to patients with food allergy.

The lab is currently examining differential gene expression among infants at high risk for peanut allergy (Devonshire AL, et al. "Differential gene expression among infants at high-risk for peanut allergy." Journal of Allergy and Clinical Immunology. 143: AB83-AB83. 2019). The goal is to identify a biomarker of peanut allergy that may be detectable prior to clinical expression of the disease state. The use of molecular diagnostics to determine a transcriptomic signature of peanut allergy may also provide insight into the mechanisms underlying early loss of tolerance to foods.

Beginning Introduction to Allergens Early (BITE) Clinic

Ashley Devonshire, MD, MPH established the Beginning Introduction to Allergens Early (BITE) Clinic at Cincinnati Children’s, which includes an experimental pipeline for pediatric food allergy research housed within the Center for Autoimmune Genomics and Etiology and the Division of Allergy and Immunology.

About the PI

A photo of Ashley Devonshire.

Ashley Devonshire, MD, MPH

My clinical and research interests focus on food allergy in the infant population. I am particularly interested in early allergenic food introduction and the evaluation of infants at high-risk for food allergy. I hope to identify a biomarker of food allergy and to improve food allergy diagnostic testing.


Kliewer, KL; Murray-Petzold, C; Collins, MH; Abonia, JP; Bolton, SM; DiTommaso, LA; Martin, LJ; Zhang, X; Mukkada, VA; Putnam, PE; et al. Benralizumab for eosinophilic gastritis: a single-site, randomised, double-blind, placebo-controlled, phase 2 trial. The Lancet Gastroenterology and Hepatology. 2023; 8:803-815.

Keet, C; Sicherer, SH; Bunyavanich, S; Visness, C; Fulkerson, PC; Togias, A; Davidson, W; Perry, S; Hamrah, S; Calatroni, A; et al. The SunBEAm birth cohort: Protocol design. 2023; 2:100124.

Devonshire, A; Gautam, Y; Johansson, E; Mersha, TB. Multi-omics profiling approach in food allergy. World Allergy Organization Journal. 2023; 16:100777.

Guarnieri, KM; Saba, NK; Schwartz, JT; Devonshire, AL; Bufford, J; Casale, TB; Rothenberg, ME; Andorf, S. Food Allergy Characteristics Associated With Coexisting Eosinophilic Esophagitis in FARE Registry Participants. Journal of Allergy and Clinical Immunology: In Practice. 2023; 11:1509-1521.e6.

Gill, K; Moore, C; Nwogu, O; Kroner, JW; Chang, W; Stevens, ML; Kyzy, AB; Biagini, JM; Devonshire, AL; Kottyan, L; et al. B cell repertoire in children with skin barrier dysfunction supports altered IgE maturation associated with allergic food sensitization. 2023; 4:2023.02.01.526538.

Cassin, A; Devonshire, A; Ward, S; McNeill, M. Food Allergy. In: Goday PS; Walia C, Ed. Pediatric Nutrition for Dietitians. Boca Raton, FL: CRC Press; 2022.

Eapen, AA; Parameswaran, S; Forney, C; Edsall, LE; Miller, D; Donmez, O; Dunn, K; Lu, X; Granitto, M; Rowden, H; et al. Epigenetic and transcriptional dysregulation in CD4+ T cells in patients with atopic dermatitis. Editor, Absher DM. PLoS Genetics. 2022; 18:e1009973.

Lang, A; Kaur, O; Devonshire, A; Kaat, AJ; Kumar, R. Learning Early About Peanut worries: Evaluation of parental PROMIS-29 anxiety scores during early peanut introduction clinics. Annals of Allergy, Asthma, and Immunology. 2022; 128:472-473.

Devonshire, AL; Fan, H; Pujato, M; Paranjpe, A; Gursel, D; Schipma, M; Dunn, JM; Andorf, S; Pongracic, JA; Kottyan, LC; et al. Whole blood transcriptomics identifies gene expression associated with peanut allergy in infants at high risk. Clinical and Experimental Allergy. 2021; 51:1396-1400.

Devonshire, AL; Lin, AA. Tackling Food Allergy in Infancy. Immunology and Allergy Clinics of North America. 2021; 41:205-219.

Devonshire, AL; Durrani, S; Assa'ad, A. Non-IgE-mediated food allergy during infancy. Current Opinion in Allergy and Clinical Immunology. 2020; 20:292-298.

Devonshire, AL; Kumar, R. Pediatric asthma: Principles and treatment. Allergy and asthma proceedings : the official journal of regional and state allergy societies. 2019; 40:389-392.

Devonshire, AL; Makhija, M. Approach to primary immunodeficiency. Allergy and asthma proceedings : the official journal of regional and state allergy societies. 2019; 40:465-469.

Devonshire, AL; Balmert, LC; Kumar, R. Pediatric posttransplantation food allergy experience at a large US tertiary care center. Annals of Allergy, Asthma, and Immunology. 2019; 123:522-524.e1.