Mersha Lab


Gautam, Y; Afanador, Y; Abebe, T; Lopez, JE; Mersha, TB. Genome-wide analysis revealed sex-specific gene expression in asthmatics. Human Molecular Genetics. 2019; 28:2600-2614.

Proper, SP; Dwyer, AT; Appiagyei, A; Felton, JM; Ben-Baruch Morgenstern, N; Marlman, JM; Kotliar, M; Barski, A; Troutman, TD; Rothenberg, ME; et al. Aryl hydrocarbon receptor and IL-13 signaling crosstalk in human keratinocytes and atopic dermatitis. Frontiers in Allergy. 2024; 5:1323405.

Hardy, DS; Garvin, JT; Mersha, TB. Ancestry Specific Polygenic Risk Score, Dietary Patterns, Physical Activity, and Cardiovascular Disease. 2023; 4:2023.12.05.23299548.

Dessie, EY; Gautam, Y; Ding, L; Altaye, M; Beyene, J; Mersha, TB. Development and validation of asthma risk prediction models using co-expression gene modules and machine learning methods. Scientific Reports. 2023; 13:11279.

Ghosh, D; Mersha, TB. Atopic dermatitis and ocular allergy: common mechanisms and uncommon questions. Current Opinion in Allergy and Clinical Immunology. 2023; 23:383-389.

Phelan, KJ; Dill-McFarland, KA; Kothari, A; Segnitz, RM; Burkle, J; Grashel, B; Jenkins, S; Spagna, D; Martin, LJ; Haslam, DB; et al. Airway transcriptome networks identify susceptibility to frequent asthma exacerbations in children. Journal of Allergy and Clinical Immunology. 2023; 152:73-83.

Correa-Agudelo, E; Beck, AF; Mersha, TB. Racial differences in emergency encounters related to pediatric allergic diseases during the COVID-19 pandemic. Journal of Allergy and Clinical Immunology: In Practice. 2023; 11:2232-2234.e1.

Correa-Agudelo, E; Ding, L; Beck, AF; Mendy, A; Mersha, TB. Multilevel Analysis of Racial and Ethnic Disparities in COVID-19 Hospitalization among Children with Allergies. Annals of the American Thoracic Society. 2023; 20:843-853.

Hardy, DS; Garvin, JT; Mersha, TB. Analysis of ancestry-specific polygenic risk score and diet composition in type 2 diabetes. Editor, Zirlik A. PloS one. 2023; 18:e0285827.

Devonshire, A; Gautam, Y; Johansson, E; Mersha, TB. Multi-omics profiling approach in food allergy. World Allergy Organization Journal. 2023; 16:100777.

Gautam, Y; Caldwell, J; Kottyan, L; Chehade, M; Dellon, ES; Rothenberg, ME; Mersha, TB; Wechsler, J; Davis, C; Furuta, G; et al. Genome-wide admixture and association analysis identifies African ancestry-specific risk loci of eosinophilic esophagitis in African Americans. Journal of Allergy and Clinical Immunology. 2023; 151:1337-1350.

Linder, JE; Allworth, A; Bland, HT; Caraballo, PJ; Chisholm, RL; Clayton, EW; Crosslin, DR; Dikilitas, O; DiVietro, A; Esplin, ED; et al. Returning integrated genomic risk and clinical recommendations: The eMERGE study. Genetics in Medicine. 2023; 25:100006.

Gautam, Y; Mersha, TB. Leveraging genetic ancestry to study severe asthma exacerbations in an admixed population. Thorax. 2023; 78:220-221.

Pennington, J; Rasnick, E; Martin, LJ; Biagini, JM; Mersha, TB; Parsons, A; Khurana Hershey, GK; Ryan, P; Brokamp, C. Racial Fairness in Precision Medicine: Pediatric Asthma Prediction Algorithms. American Journal of Health Promotion. 2023; 37:239-242.

Dessie, E; Mersha, T; Gautam, Y. Comprehensive analysis of epigenome and transcriptome-based correlation network analysis in severe asthma risk prediction. Journal of Allergy and Clinical Immunology. 2023; 151:ab125.

Phelan, K; Dill-McFarland, K; Kothari, A; daniel spagna, ; seth jenkins, ; Grashel, B; Burkle, J; Martin, L; david haslam, ; Biagini, J; et al. Airway transcriptome networks identify susceptibility to frequent asthma exacerbations in children. Journal of Allergy and Clinical Immunology. 2023; 151:ab73.

Mendy, A; Burcham, S; Merianos, AL; Mersha, TB; Mahabee-Gittens, EM; Chen, A; Yolton, K. Urinary volatile organic compound metabolites and reduced lung function in U.S. adults. Respiratory Medicine. 2022; 205:107053.

Correa-Agudelo, E; Ding, L; Beck, AF; Brokamp, C; Altaye, M; Kahn, RS; Mersha, TB. Understanding racial disparities in childhood asthma using individual- and neighborhood-level risk factors. Journal of Allergy and Clinical Immunology. 2022; 150:1427-1436.e5.

Cao, X; Ding, L; Mersha, TB. Development and validation of an RNA-seq-based transcriptomic risk score for asthma. Scientific Reports. 2022; 12:8643.

Namjou, B; Lape, M; Malolepsza, E; DeVore, SB; Weirauch, MT; Dikilitas, O; Jarvik, GP; Kiryluk, K; Kullo, IJ; Liu, C; et al. Multiancestral polygenic risk score for pediatric asthma. Journal of Allergy and Clinical Immunology. 2022; 150:1086-1096.

Ghosh, D; Mersha, TB. Publicly available cytokine data: Limitations and opportunities. Journal of Allergy and Clinical Immunology. 2022; 150:1053-1056.

Mendy, A; Merianos, AL; Mersha, TB; Mahabee-Gittens, EM. Blood volatile organic compounds associated with non-reversible and reversible airflow obstruction in US adults. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology. 2022; 60:2201185.

Parikh, MN; Brokamp, C; Rasnick, E; Ding, L; Mersha, TB; Bowers, K; Folger, AT. Epigenome-wide association of neonatal methylation and trimester-specific prenatal PM2.5 exposure. Environmental Epidemiology. 2022; 6:e227.

Parikh, M; Brokamp, C; Rasnick, E; Ding, L; Mersha, T; Bowers, K; Folger, A. Epigenome-Wide Association of Neonatal Methylation and Prenatal PM2.5 Exposure Suggests Timing-Specific Effects. ISEE Conference Abstracts. 2022; 2022.

Mendy, A; Mersha, TB. Comorbidities in childhood-onset and adult-onset asthma. Annals of Allergy, Asthma, and Immunology. 2022; 129:327-334.

Cao, X; Ding, L; Mersha, TB. Development and validation of an RNA-seq-based transcriptomic risk score for asthma. Scientific Reports. 2022; 12.

Stevens, ML; Mersha, TB; Zhang, Z; Kothari, A; Khurana Hershey, GK. Skin depletion of Kif3a resembles the pediatric atopic dermatitis transcriptome profile. Human Molecular Genetics. 2022; 31:1588-1598.

Masebo, TM; Fikadu, BK; Mehari, E; Gelaye, B; Habte, A; Mersha, TB; Begna, K. The need for rigour and balance in reporting the health impacts of conflict in Tigray, Ethiopia. BMJ Global Health. 2022; 7:e008263.

Dadi, AF; Mersha, TB. WHO's surveillance system for attacks on health care is failing Ethiopia. The Lancet. 2022; 399:1225-1226.

Roman, YM; McClish, D; Price, ET; Sabo, RT; Woodward, OM; Mersha, TB; Shah, N; Armada, A; Terkeltaub, R. Cardiometabolic genomics and pharmacogenomics investigations in Filipino Americans: Steps towards precision health and reducing health disparities. American Heart Journal Plus. 2022; 15:100136.

Enquobahrie, DA; Tekola-Ayele, F; Mersha, TB. Editorial: Genetic and Epigenetic Insights Into the Developmental Origins of Health and Disease. Frontiers in Genetics. 2022; 12:814126.

Kang, M; Ko, E; Mersha, TB. A roadmap for multi-omics data integration using deep learning. Briefings in Bioinformatics. 2022; 23:bbab454.

Gautam, Y; Johansson, E; Mersha, TB. Multi-Omics Profiling Approach to Asthma: An Evolving Paradigm. Journal of Personalized Medicine. 2022; 12:66.

Adejare, AA; Gautam, Y; Madzia, J; Mersha, TB. Unraveling racial disparities in asthma emergency department visits using electronic healthcare records and machine learning. Journal of Asthma (Informa). 2022; 59:79-93.

Khurana Hershey, GK; Sherenian, MG; Mersha, TB. 2 Precision Medicine. Allergy Essentials. : Elsevier; Elsevier; 2022.

Hardy, DS; Racette, SB; Garvin, JT; Gebrekristos, HT; Mersha, TB. Ancestry specific associations of a genetic risk score, dietary patterns and metabolic syndrome: a longitudinal ARIC study. BMC Medical Genomics. 2021; 14:118.

Mendy, A; Wu, X; Keller, JL; Fassler, CS; Apewokin, S; Mersha, TB; Xie, C; Pinney, SM. Air pollution and the pandemic: Long-term PM2.5 exposure and disease severity in COVID-19 patients. Respirology. 2021; 26:1181-1187.

Mersha, TB; Qin, K; Beck, AF; Ding, L; Huang, B; Kahn, RS. Genetic ancestry differences in pediatric asthma readmission are mediated by socioenvironmental factors. Journal of Allergy and Clinical Immunology. 2021; 148:1210-1218.e4.

Chidambaran, V; Mersha, TB. A step towards understanding disparities - linking race, ancestry, epigenetics and pain. Epigenomics. 2021; 13:1791-1796.

Beyene, J; Harrar, SW; Altaye, M; Astatkie, T; Awoke, T; Shkedy, Z; Mersha, TB. A Roadmap for Building Data Science Capacity for Health Discovery and Innovation in Africa. Frontiers in Public Health. 2021; 9:710961.

Proper, SP; Azouz, NP; Mersha, TB. Achieving Precision Medicine in Allergic Disease: Progress and Challenges. Frontiers in Immunology. 2021; 12:720746.

Johansson, E; Mersha, TB. Genetics of Food Allergy. Immunology and Allergy Clinics of North America. 2021; 41:301-319.

Correa-Agudelo, E; Mersha, TB; Branscum, AJ; Mackinnon, NJ; Cuadros, DF. Identification of Vulnerable Populations and Areas at Higher Risk of COVID-19-Related Mortality during the Early Stage of the Epidemic in the United States. International Journal of Environmental Research and Public Health. 2021; 18:4021.

Mersha, TB; Afanador, Y; Johansson, E; Proper, SP; Bernstein, JA; Rothenberg, ME; Hershey, GK K. Resolving Clinical Phenotypes into Endotypes in Allergy: Molecular and Omics Approaches. Clinical Reviews in Allergy and Immunology. 2021; 60:200-219.

Brandt, EB; Mersha, TB. Environmental Determinants of Coronavirus Disease 2019 (COVID-19). Current Allergy and Asthma Reports. 2021; 21:15.

Jones, DE; Park, JS; Gamby, K; Bigelow, TM; Mersha, TB; Folger, AT. Mental Health Epigenetics: A Primer With Implications for Counselors. Professional counselor. 2021; 11:102-121.

Mendy, A; Wu, X; Keller, JL; Fassler, CS; Apewokin, S; Mersha, TB; Xie, C; Pinney, SM. Long-term exposure to fine particulate matter and hospitalization in COVID-19 patients. Respiratory Medicine. 2021; 178:106313.

Chen, S; Ghandikota, S; Gautam, Y; Mersha, TB. MI-MAAP: marker informativeness for multi-ancestry admixed populations. BMC Bioinformatics. 2020; 21:131.

Ping-I, H; Shu, H; Mersha, TB. Comparing DNA methylation profiles across different tissues associated with the diagnosis of pediatric asthma. Scientific Reports. 2020; 10:151.

Ghosh, D; Jonathan, A; Mersha, TB. COVID-19 pandemic: The African paradox. Journal of Global Health. 2020; 10:020348.

Ghosh, D; Ding, L; Bernstein, JA; Mersha, TB. The Utility of Resolving Asthma Molecular Signatures Using Tissue-Specific Transcriptome Data. G3-Genes Genomes Genetics. 2020; 10:4049-4062.

Gautam, Y; Afanador, Y; Ghandikota, S; Mersha, TB. Comprehensive functional annotation of susceptibility variants associated with asthma. Human Genetics. 2020; 139:1037-1053.

Kiefer, AW; Walker, G; Aamir-Khan, H; Reed, C; Mersha, T; Gubanich, P; Logan, K. Examining the effects of atopic disease on concussion recovery: a preliminary investigation to inform personalized care. Pediatrics. 2020; 146:68-69.

Chen, S; Ghandikota, S; Gautam, Y; Mersha, TB. AllergyGenDB: A literature and functional annotation-based omics database for allergic diseases. Allergy: European Journal of Allergy and Clinical Immunology. 2020; 75:1789-1793.

Brandt, EB; Beck, AF; Mersha, TB. Air pollution, racial disparities, and COVID-19 mortality. Journal of Allergy and Clinical Immunology. 2020; 146:61-63.

Cao, X; Ding, L; Mersha, TB. Joint variable selection and network modeling for detecting eQTLs. Statistical Applications in Genetics and Molecular Biology. 2020; 19:20190032.

Dang, AT; Chundi, PK; Mousa, NA; Beyer, AI; Chansakulporn, S; Venter, C; Mersha, TB; Assa'ad, AH. The effect of age, sex, race/ethnicity, health insurance, and food specific serum immunoglobulin E on outcomes of oral food challenges. World Allergy Organization Journal. 2020; 13:100100.

Mersha, T; Gautam, Y; Caldwell, J; Rothenberg, M. Genome-wide admixture and association analyses identify novel eosinophilic esophagitis-associated loci in African American ancestry. Journal of Allergy and Clinical Immunology. 2020; 145:ab42.

Ghosh, D; Bernstein, J; Mersha, T. The Utility of A Transcriptomic Signature to Assess Atopic Dermatitis Treatment Outcomes. Journal of Allergy and Clinical Immunology. 2020; 145:ab192.

Hardy, DS; Garvin, JT; Mersha, TB; Racette, SB. Ancestry specific associations of FTO gene variant and metabolic syndrome: A longitudinal ARIC study. Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries. 2020; 99:e18820.

Self-reported race / ethnicity in the age of genomic research: its potential impact on understanding health disparities

Various terminologies are used to classify human differences in genomic research including race, ethnicity, and ancestry. Phenotype-based race / ethnicity information and data computed using AIMS often disagree. This review explores the limitations of self-reported race, ethnicity, and genetic ancestry in biomedical research. Read the Highly Accessed Publication