Waggoner Lab

Publications

Ochayon, DE; DeVore, SB; Chang, WC; Krishnamurthy, D; Seelamneni, H; Grashel, B; Spagna, D; Andorf, S; Martin, LJ; Biagini, JM; Waggoner, SN; Khurana Hershey, GK. Progressive accumulation of hyperinflammatory NKG2Dlow NK cells in early childhood severe atopic dermatitis. Science immunology. 2024; 9:eadd3085.

Cox, A; Cevik, H; Feldman, HA; Canaday, LM; Lakes, N; Waggoner, SN. Targeting natural killer cells to enhance vaccine responses. Trends in Pharmacological Sciences. 2021; 42:789-801.

Reighard, SD; Krishnamurthy, D; Cevik, H; Ochayon, DE; Ali, A; Seelamneni, H; Brunner, HI; Waggoner, SN. Immunomodulatory effects of cytokine-induced expansion of cytotoxic lymphocytes in a mouse model of lupus-like disease. Cytotherapy (Informa). 2021; 23:37-45.

Rajaram, S; Canaday, LM; Ochayon, DE; Rangel, KM; Ali, A; Gyurova, IE; Krishnamurthy, D; Fletcher, JS; Reighard, SD; Cox, A; Deshmukh, H; Zacharias, WJ; Borchers, MT; Waggoner, SN. The Promise and Peril of Natural Killer Cell Therapies in Pulmonary Infection. Immunity. 2020; 52:887-889.

Reighard, SD; Cranert, SA; Rangel, KM; Ali, A; Gyurova, IE; de la Cruz-Lynch, AT; Tuazon, JA; Khodoun, MV; Kottyan, LC; Smith, DF; Brunner, HI; Waggoner, SN. Therapeutic Targeting of Follicular T Cells with Chimeric Antigen Receptor-Expressing Natural Killer Cells. Cell Reports Medicine. 2020; 1:100003.

Ochayon, DE; Ali, A; Alarcon, PC; Krishnamurthy, D; Kottyan, LC; Borchers, MT; Waggoner, SN. IL-33 promotes type 1 cytokine expression via p38 MAPK in human NK cells. Journal of Leukocyte Biology. 2020; 107:663-671.

Gyurova, IE; Schlums, H; Sucharew, H; Ambroggio, L; Ochayon, DE; Win, HT; Bryceson, YT; Bernsteins, DI; Waggoner, SN. Dynamic Changes in Natural Killer Cell Subset Frequencies in the Absence of Cytomegalovirus Infection. Frontiers in Immunology. 2019; 10:2728.

Pokrovskii, M; Hall, JA; Ochayon, DE; Yi, R; Chaimowitz, NS; Seelamneni, H; Carriero, N; Watters, A; Waggoner, SN; Littman, DR; Bonneau, R; Miraldi, ER. Characterization of Transcriptional Regulatory Networks that Promote and Restrict Identities and Functions of Intestinal Innate Lymphoid Cells. Immunity. 2019; 51:185-197.e6.

Rydyznski, CE; Cranert, SA; Zhou, JQ; Xu, H; Kleinstein, SH; Singh, H; Waggoner, SN. Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal Centers. Cell Reports. 2018; 24:3367-3373.e4.

Rydyznski, C; Daniels, KA; Karmele, EP; Brooks, TR; Mahl, SE; Moran, MT; Li, C; Sutiwisesak, R; Welsh, RM; Waggoner, SN. Generation of cellular immune memory and B-cell immunity is impaired by natural killer cells. Nature Communications. 2015; 6:6375.

Cantrell, R; Alex Feldman, H; Rosenfeldt, L; Ali, A; Gourley, B; Sprague, C; Leino, D; Crosby, J; Revenko, A; Monia, B; Waggoner, SN; Palumbo, JS. Prothrombin prevents fatal T cell-dependent anemia during chronic virus infection of mice. JCI insight. 2025; 10:e181063.

Wallach, I; Bernard, D; Nguyen, K; Ho, G; Morrison, A; Stecula, A; Rosnik, A; O’Sullivan, AM; Davtyan, A; Samudio, B; Lam, A; Cuddihy, AR; White, A; Taglialatela, A. AI is a viable alternative to high throughput screening: a 318-target study. Scientific Reports. 2024; 14:7526.

Valbon, SF; Lebel, ME; Feldman, HA; Condotta, SA; Dong, M; Giordano, D; Waggoner, SN; Melichar, HJ; Richer, MJ. Type I interferon induced during chronic viral infection favors B-cell development in the thymus. Immunology and Cell Biology. 2024; 102:801-816.

Ochayon, DE; DeVore, SB; Chang, WC; Krishnamurthy, D; Seelamneni, H; Grashel, B; Spagna, D; Andorf, S; Martin, LJ; Biagini, JM; Waggoner, SN; Khurana Hershey, GK. Progressive accumulation of hyperinflammatory NKG2Dlow NK cells in early childhood severe atopic dermatitis. Science immunology. 2024; 9:eadd3085.

Burkes, RM; Bailey, E; Hwalek, T; Osterburg, A; Lach, L; Panos, R; Waggoner, SN; Borchers, MT. Associations of Smoking, Cytomegalovirus Serostatus, and Natural Killer Cell Phenotypes in Smokers With and At Risk for COPD. Chronic obstructive pulmonary diseases (Miami, Fla.). 2023; 10:286-296.

Lakes, N; Canaday, LM; Waggoner, SN. Can't drop the MIC(A/B): Preventing stress-ligand shedding to enhance pan-cancer targeting. Med. 2023; 4:398-400.

Alex Feldman, H; Cevik, H; Waggoner, SN. Negativity begets longevity in T cells. The Journal of Clinical Investigation. 2023; 133:e171027.

Le, H; Spearman, P; Waggoner, SN; Singh, K. Ebola virus protein VP40 stimulates IL-12- and IL-18-dependent activation of human natural killer cells. JCI insight. 2022; 7:e158902.

Rahman, SA; Billingsley, JM; Sharma, AA; Styles, TM; Govindaraj, S; Shanmugasundaram, U; Babu, H; Riberio, SP; Ali, SA; Tharp, GK; Villinger, F; Bosinger, SE; Amara, RR; Velu, V. Lymph node CXCR5+ NK cells associate with control of chronic SHIV infection. JCI insight. 2022; 7:e155601.

Rao, R; Han, R; Ogurek, S; Xue, C; Wu, LM; Zhang, L; Zhang, L; Hu, J; Phoenix, TN; Waggoner, SN; Lu, QR. Glioblastoma genetic drivers dictate the function of tumor-associated macrophages/microglia and responses to CSF1R inhibition. Neuro-Oncology. 2022; 24:584-597.

Tang, Y; Xu, Q; Hu, L; Yan, X; Feng, X; Yokota, A; Wang, W; Zhan, D; Krishnamurthy, D; Ochayon, DE; Vivier, E; Zhou, J; Waggoner, SN; Huang, G. Tumor Microenvironment-Derived R-spondins Enhance Antitumor Immunity to Suppress Tumor Growth and Sensitize for Immune Checkpoint Blockade Therapy. Cancer Discovery. 2021; 11:3142-3157.

Ali, A; Canaday, LM; Feldman, HA; Cevik, H; Moran, MT; Rajaram, S; Lakes, N; Tuazon, JA; Seelamneni, H; Krishnamurthy, D; Blass, E; Barouch, DH; Waggoner, SN. Natural killer cell immunosuppressive function requires CXCR3-dependent redistribution within lymphoid tissues. The Journal of Clinical Investigation. 2021; 131:146686.

Cox, A; Cevik, H; Feldman, HA; Canaday, LM; Lakes, N; Waggoner, SN. Targeting natural killer cells to enhance vaccine responses. Trends in Pharmacological Sciences. 2021; 42:789-801.

Ochayon, DE; Waggoner, SN. The Effect of Unconventional Cytokine Combinations on NK-Cell Responses to Viral Infection. Frontiers in Immunology. 2021; 12:645850.

Reighard, SD; Krishnamurthy, D; Cevik, H; Ochayon, DE; Ali, A; Seelamneni, H; Brunner, HI; Waggoner, SN. Immunomodulatory effects of cytokine-induced expansion of cytotoxic lymphocytes in a mouse model of lupus-like disease. Cytotherapy (Informa). 2021; 23:37-45.