We proposed a refractory status epilepticus (RSE) registry that will enable us to determine the most effective treatment and monitoring algorithms by establishing a cohort of well-identified RSE patients to identify biomarkers of outcome. Within the pSERG network we will develop a prospective RSE registry among tertiary care hospitals focused on standardized RSE outcome assessment. This will include the expansion of a standardized web-based data entry tool, development of an outcome registry, and determination of illness severity adjusters and outcome predictors in RE as well as analysis of genetic biomarkers.