Publications

Adelman, ER; Huang, HT; Roisman, A; Olsson, A; Colaprico, A; Qin, T; Lindsley, RC; Bejar, R; Salomonis, N; Grimes, HL; et al. Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia. Cancer Discovery. 2019; 9:1080-1101.

Bayram, U; Pestian, J; Santel, D; Minai, AA. (2019) What's in a Word? Detecting Partisan Affiliation from Word Use in Congressional Speeches. IEEE. 2019-July.

Brokamp, C; Beck, AF; Goyal, NK; Ryan, P; Greenberg, JM; Hall, ES. Material community deprivation and hospital utilization during the first year of life: an urban population-based cohort study. Annals of Epidemiology. 2019; 30:37-43.

Chen, J; Xu, H; Jegga, A; Zhang, K; White, PS; Zhang, G. Novel phenotype-disease matching tool for rare genetic diseases. Genetics in Medicine. 2019; 88:341-348.

Denson, LA; Jurickova, I; Karns, R; Shaw, KA; Cutler, DJ; Okou, D; Valencia, CA; Dodd, A; Mondal, K; Aronow, BJ; et al. Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Pediatric Crohn's Disease. Inflammatory Bowel Diseases. 2019; 25:547-560.

Dorn, LE; Lasman, L; Chen, J; Xu, X; Hund, TJ; Medvedovic, M; Hanna, JH; van Berlo, JH; Accornero, F. The N-6-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy. Circulation. 2019; 139:533-545.

Du, Y; Clair, GC; Al Alam, D; Danopoulos, S; Schnell, D; Kitzmiller, JA; Misra, RS; Bhattacharya, S; Warburton, D; Mariani, TJ; et al. Integration of transcriptomic and proteomic data identifies biological functions in cell populations from human infant lung. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2019; 317:L347-L360.

Dwivedi, P; Muench, DE; Wagner, M; Azam, M; Grimes, HL; Greis, KD. Time resolved quantitative phospho-tyrosine analysis reveals Bruton's Tyrosine kinase mediated signaling downstream of the mutated granulocyte-colony stimulating factor receptors. Leukemia. 2019; 33:75-87.

Fletcher, JS; Wu, J; Jessen, WJ; Pundavela, J; Miller, JA; Dombi, E; Kim, M; Rizvi, TA; Chetal, K; Salomonis, N; et al. Cxcr3-expressing leukocytes are necessary for neurofibroma formation in mice. JCI insight. 2019; 4.

Greiner, MV; Beal, SJ; Dexheimer, JW; Divekar, P; Patel, V; Hall, ES. Improving Information Sharing for Youth in Foster Care. Pediatrics. 2019; 144:e20190580-e20190580.

Haberman, Y; Schirmer, M; Dexheimer, PJ; Karns, R; Braun, T; Kim, M; Walters, TD; Baldassano, RN; Noe, JD; Rosh, J; et al. Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis. Mucosal Immunology. 2019; 12:491-502.

Hagedorn, PA; Kirkendall, ES; Spooner, SA; Mohan, V. Inpatient Communication Networks: Leveraging Secure Text-Messaging Platforms to Gain Insight into Inpatient Communication Systems. Applied Clinical Informatics. 2019; 10:471-478.

Hall, ES; McAllister, JM; Wexelblatt, SL. Developmental Disorders and Medical Complications Among Infants with Subclinical Intrauterine Opioid Exposures. Population Health Management. 2019; 22:19-24.

Helbig, I; Lopez-Hernandez, T; Shor, O; Galer, P; Ganesan, S; Pendziwiat, M; Rademacher, A; Ellis, CA; Hümpfer, N; Schwarz, N; et al. A Recurrent Missense Variant in AP2M1 Impairs Clathrin-Mediated Endocytosis and Causes Developmental and Epileptic Encephalopathy. The American Journal of Human Genetics. 2019; 104:1060-1072.

Higashi, AY; Aronow, BJ; Dressler, GR. Expression Profiling of Fibroblasts in Chronic and Acute Disease Models Reveals Novel Pathways in Kidney Fibrosis. Journal of the American Society of Nephrology : JASN. 2019; 30:80-94.

Hripcsak, G; Shang, N; Peissig, PL; Rasmussen, LV; Liu, C; Benoit, B; Carroll, RJ; Carrell, DS; Denny, JC; Dikilitas, O; et al. Facilitating phenotype transfer using a common data model. Journal of Biomedical Informatics. 2019; 96:103253-103253.

Hulin, A; Hortells, L; Gomez-Stallons, MV; O'Donnell, A; Chetal, K; Adam, M; Lancellotti, P; Oury, C; Potter, SS; Salomonis, N; et al. Maturation of heart valve cell populations during postnatal remodeling. Development (Cambridge). 2019; 146:dev173047-dev173047.

Kasam, RK; Reddy, GB; Jegga, AG; Madala, SK. Dysregulation of Mesenchymal Cell Survival Pathways in Severe Fibrotic Lung Disease: The Effect of Nintedanib Therapy. Frontiers in Pharmacology. 2019; 10.

Kirkendall, ES; Ni, Y; Lingren, T; Leonard, M; Hall, ES; Melton, K. Data Challenges With Real-Time Safety Event Detection And Clinical Decision Support. Journal of Medical Internet Research. 2019; 21:e13047-e13047.

Kozlovski, T; Mitelpunkt, A; Thaler, A; Gurevich, T; Orr-Urtreger, A; Gana-Weisz, M; Shachar, N; Galili, T; Marcus-Kalish, M; Bressman, S; et al. Hierarchical data-driven analysis of clinical symptoms among patients with Parkinson's disease. Frontiers in Neurology. 2019; 10:1-7.

Kurowski, BG; Treble-Barna, A; Pilipenko, V; Wade, SL; Yeates, KO; Taylor, HG; Martin, LJ; Jegga, AG. Genetic Influences on Behavioral Outcomes After Childhood TBI: A Novel Systems Biology-Informed Approach. Frontiers in Genetics. 2019; 10.

Lee, M; Hall, ES; DeFranco, E. Contribution of previable births to infant mortality rate racial disparity in the United States. Journal of Perinatology. 2019; 39:1190-1195.

Lewis, CS; Thomas, HE; Orr-Asman, MA; Green, LC; Boody, RE; Matiash, K; Karve, A; Hisada, YM; Davis, HW; Qi, X; et al. mTOR kinase inhibition reduces tissue factor expression and growth of pancreatic neuroendocrine tumors. Journal of Thrombosis and Haemostasis. 2019; 17:169-182.

Liu, L; Ni, Y; Zhang, N; Pratap, JN. Mining patient-specific and contextual data with machine learning technologies to predict cancellation of children's surgery. International Journal of Medical Informatics. 2019; 129:234-241.

Ljungberg, MC; Sadi, M; Wang, Y; Aronow, BJ; Xu, Y; Kao, RJ; Liu, Y; Gaddis, N; Ardini-Poleske, ME; Umrod, T; et al. Spatial distribution of marker gene activity in the mouse lung during alveolarization. Data in Brief. 2019; 22:365-372.

Mitelpunkt, A; Kramer, U; Hausman Kedem, M; Zilbershot Fink, E; Orbach, R; Chernuha, V; Fattal-Valevski, A; Deutsch, L; Heffetz, D; Sacks, H. The safety, tolerability, and effectiveness of PTL-101, an oral cannabidiol formulation, in pediatric intractable epilepsy: A phase II, open-label, single-center study. Epilepsy and Behavior. 2019; 98:233-237.

Nasimuzzaman, M; Arumugam, PI; Mullins, ES; James, JM; Vanden Heuvel, K; Narciso, MG; Shaw, MA; McGraw, S; Aronow, BJ; Malik, P. Elimination of the fibrinogen integrin aMb2-binding motif improves renal pathology in mice with sickle cell anemia. Blood Advances. 2019; 3:1519-1532.

Nenni, MJ; Fisher, ME; James-Zorn, C; Pells, TJ; Ponferrada, V; Chu, S; Fortriede, JD; Burns, KA; Wang, Y; Lotay, VS; et al. Xenbase: Facilitating the Use of Xenopus to Model Human Disease. Frontiers in Physiology. 2019; 10.

Ni, Y; Bermudez, M; Kennebeck, S; Liddy-Hicks, S; Dexheimer, J. Designing and evaluating a real-time automated patient screening system in an emergency department. Journal of Medical Internet Research. 2019; 7:e14185-e14185.

Nielsen, SC A; Roskin, KM; Jackson, KJ L; Joshi, SA; Nejad, P; Lee, J; Wagar, LE; Pham, TD; Hoh, RA; Nguyen, KD; et al. Shaping of infant B cell receptor repertoires by environmental factors and infectious disease. Science Translational Medicine. 2019; 11:eaat2004-eaat2004.

Panmanee, W; Su, S; Schurr, MJ; Lau, GW; Zhu, X; Ren, Z; McDaniel, CT; Lu, LJ; Ohman, DE; Muruve, DA; et al. The anti-sigma factor MucA of Pseudomonas aeruginosa: Dramatic differences of a mucA22 vs. a Delta mucA mutant in anaerobic acidified nitrite sensitivity of planktonic and biofilm bacteria in vitro and during chronic murine lung infection. PLoS ONE. 2019; 14:e0216401-e0216401.

Percy, Z; DeFranco, E; Xu, F; Hall, ES; Haynes, EN; Jones, D; Muglia, LJ; Chen, A. Trimester specific PM2.5 exposure and fetal growth in Ohio, 2007-2010. Environmental Research. 2019; 171:111-118.

Peters, AL; Luo, Z; Li, J; Mourya, R; Wang, Y; Dexheimer, P; Shivakumar, P; Aronow, B; Bezerra, JA. Single cell RNA sequencing reveals regional heterogeneity of hepatobiliary innate lymphoid cells in a tissue-enriched fashion. PLoS ONE. 2019; 14:e0215481-e0215481.

Pogacar, R; Carpenter, TP; Shenk, CE; Kouril, M. Tools and methods for measuring implicit consumer cognition. Handbook of Research Methods in Consumer Psychology. : Routledge; Routledge; 2019.

Porat Rein, A; Kramer, U; Mitelpunkt, A. Development of Ontology for Self-limited Epilepsy with Centrotemporal Spikes and Application of Data Mining Algorithms to Identify New Subtypes. The Israel Medical Association journal : IMAJ. 2019; 21.

Ramsey, LB; Prows, CA; Zhang, K; Saldana, SN; Sorter, MT; Pestian, JP; Wenstrup, RJ; Vinks, AA; Glauser, TA. Implementation of Pharmacogenetics at Cincinnati Children's Hospital Medical Center: Lessons Learned Over 14 Years of Personalizing Medicine. Clinical Pharmacology and Therapeutics. 2019; 105:49-52.

Rossi, RM; Hall, E; DeFranco, EA. Contemporary Trends in Cesarean Delivery Utilization for Live Births Between 22 0/7 and 23 6/7 Weeks of Gestation. Obstetrics and Gynecology. 2019; 133:451-458.

Rossi, RM; Hall, E; Dufendach, K; DeFranco, EA. Predictive Model of Factors Associated With Maternal Intensive Care Unit Admission. Obstetrics and Gynecology. 2019; 134:216-224.

Rossi, RM; Requarth, EW; Warshak, CR; Dufendach, K; Hall, ES; DeFranco, EA. Predictive Model for Failed Induction of Labor Among Obese Women. Obstetrics and Gynecology. 2019; 134:485-493.

Salomonis, N. Investigating cell fate decisions with ICGS analysis of single cells. Methods in molecular biology (Clifton, N.J.). 2019; 1975:251-275.

Shaw, KA; Cutler, DJ; Okou, D; Dodd, A; Aronow, BJ; Haberman, Y; Stevens, C; Walters, TD; Griffiths, A; Baldassano, RN; et al. Genetic variants and pathways implicated in a pediatric inflammatory bowel disease cohort. Genes and Immunity. 2019; 20:131-142.

Smith, MA; Choudhary, GS; Pellagatti, A; Choi, K; Bolanos, LC; Bhagat, TD; Gordon-Mitchell, S; Von Ahrens, D; Pradhan, K; Steeples, V; et al. U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies. Nature Cell Biology. 2019; 21:640-650.

Stemmer, A; Galili, T; Kozlovski, T; Zeevi, Y; Marcus-Kalish, M; Benjamini, Y; Mitelpunkt, A. Current and Potential Approaches for Defining Disease Signatures: a Systematic Review. Journal of Molecular Neuroscience. 2019; 67:550-558.

Szczesniak, RD; Brokamp, C; Su, W; Mcphail, GL; Pestian, J; Clancy, JP. Improving Detection of Rapid Cystic Fibrosis Disease Progression-Early Translation of a Predictive Algorithm Into a Point-of-Care Tool. IEEE Journal of Translational Engineering in Health and Medicine-JTEHM. 2019; 7:2800108-8.

Taylor, DM; Aronow, BJ; Tan, K; Bernt, K; Salomonis, N; Greene, CS; Frolova, A; Henrickson, SE; Wells, A; Pei, L; et al. The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution. Developmental Cell. 2019; 49:10-29.

Turnier, JL; Brunner, HI; Bennett, M; Aleed, A; Gulati, G; Haffey, WD; Thornton, S; Wagner, M; Devarajan, P; Witte, D; et al. Discovery of SERPINA3 as a candidate urinary biomarker of lupus nephritis activity. Rheumatology. 2019; 58:321-330.

Van Camp, PJ; Monifa Mahdi, C; Liu, L; Ni, Y; Andrew Spooner, S; Wu, DT Y. Development and preliminary evaluation of a visual annotation tool to rapidly collect expert-annotated weight errors in pediatric growth charts. Studies in Health Technology and Informatics. 2019; 264:853-857.

Venkatasubramanian, M; Chetal, K; Atluri, G; Salomonis, N. Resolving single-cell heterogeneity from hundreds of thousands of cells through sequential hybrid clustering and NMF. 2019.

Walsh, KB; Zhang, X; Zhu, X; Wohleb, E; Woo, D; Lu, L; Adeoye, O. Intracerebral hemorrhage induces monocyte-related gene expression within six hours: Global transcriptional profiling in swine ICH. Metabolic Brain Disease. 2019; 34:763-774.

Walsh, KB; Zhang, X; Zhu, X; Wohleb, E; Woo, D; Lu, L; Adeoye, O. Intracerebral Hemorrhage Induces Inflammatory Gene Expression in Peripheral Blood: Global Transcriptional Profiling in Intracerebral Hemorrhage Patients. DNA and Cell Biology. 2019; 38:660-669.

Wang, Y; Yella, J; Jegga, AG. Transcriptomic Data Mining and Repurposing for Computational Drug Discovery. Methods in molecular biology (Clifton, N.J.). 2019; 1903:73-95.

Wen, T; Aronow, BJ; Rochman, Y; Rochman, M; Kiran, KC; Dexheimer, PJ; Putnam, P; Mukkada, V; Foote, H; Rehn, K; et al. Single-cell RNA sequencing identifies inflammatory tissue T cells in eosinophilic esophagitis. Journal of Clinical Investigation. 2019; 129:2014-2028.

Weng, Q; Wang, J; Wang, J; He, D; Cheng, Z; Zhang, F; Verma, R; Xu, L; Dong, X; Liao, Y; et al. Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis. Cell Stem Cell. 2019; 24:707-723.e8.

Wissel, BD; Greiner, HM; Glauser, TA; Mangano, FT; Santel, D; Pestian, JP; Szczesniak, RD; Dexheimer, JW. Investigation of bias in an epilepsy machine learning algorithm trained on physician notes. Epilepsia. 2019; 60:e93-e98.

Yang, J; Kalim, KW; Li, Y; Duan, X; Nguyen, P; Hershey, GK K; Kroner, J; Ruff, B; Zhang, L; Salomonis, N; et al. Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation. Clinical and Experimental Allergy. 2019; 49:92-107.

Yonekura, A; Kawanaka, H; Prasath, VB S; Aronow, BJ; Tsuruoka, S; IEEE, . (2019) Glioma Subtypes Clustering Method using Histopathological Image Analysis. IEEE. 442-446.

Zouk, H; Venner, E; Muzny, DM; Lennon, NJ; Rehm, HL; Gibbs, RA; Walker, K; Gordon, AS; Bowser, M; Harden, MV; et al. Harmonizing Clinical Sequencing and Interpretation for the eMERGE III Network. The American Journal of Human Genetics. 2019; 105:588-605.

Zusman, E; Sidorov, M; Ayala, A; Chang, J; Singer, E; Chen, M; Desprez, PY; McAllister, S; Salomonis, N; Chetal, K; et al. Tissues harvested using an automated surgical approach confirm molecular heterogeneity of glioblastoma and enhance specimen’s translational research value. Frontiers in Oncology. 2019; 9.