Critical Care Medicine Research

Publications

Al Gharaibeh, FN; Kempton, KM; Alder, MN. Olfactomedin-4-Positive Neutrophils in Neonates: Link to Systemic Inflammation and Bronchopulmonary Dysplasia. Neonatology: foetal and neonatal research. 2023; 120:40-48.

Al Gharaibeh, FN; Lahni, P; Alder, MN; Wong, HR. Biomarkers estimating baseline mortality risk for neonatal sepsis: nPERSEVERE: neonate-specific sepsis biomarker risk model. Pediatric Research. 2023; 94:1451-1456.

Atreya, MR; Cvijanovich, NZ; Fitzgerald, JC; Weiss, SL; Bigham, MT; Jain, PN; Schwarz, AJ; Lutfi, R; Nowak, J; Allen, GL; et al. Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1. Critical Care (UK). 2023; 27:250.

Atreya, MR; Cvijanovich, NZ; Fitzgerald, JC; Weiss, SL; Bigham, MT; Jain, PN; Schwarz, AJ; Lutfi, R; Nowak, J; Allen, GL; et al. Prognostic and predictive value of endothelial dysfunction biomarkers in sepsis-associated acute kidney injury: risk-stratified analysis from a prospective observational cohort of pediatric septic shock. Critical Care (UK). 2023; 27:260.

Atreya, MR; Cvijanovich, NZ; Fitzgerald, JC; Weiss, SL; Bigham, MT; Jain, PN; Schwarz, AJ; Lutfi, R; Nowak, J; Thomas, NJ; et al. SERUM SOLUBLE ENDOGLIN IN PEDIATRIC SEPTIC SHOCK-ASSOCIATED MULTIPLE ORGAN DYSFUNCTION SYNDROME. Shock. 2023; 60:379-384.

Atreya, MR; Piraino, G; Cvijanovich, NZ; Fitzgerald, JC; Weiss, SL; Bigham, MT; Jain, PN; Schwarz, AJ; Lutfi, R; Nowak, J; et al. Serum Humanin in Pediatric Septic Shock Associated Multiple Organ Dysfunction Syndrome. Shock. 2023; 61:83-88.

Benscoter, AL; Alten, JA; Atreya, MR; Cooper, DS; Byrnes, JW; Nelson, DP; Ollberding, NJ; Wong, HR. Biomarker-based risk model to predict persistent multiple organ dysfunctions after congenital heart surgery: a prospective observational cohort study. Critical Care (UK). 2023; 27:193.

Bodilly, L; Williamson, L; Howell, K; Alder, MN; Kaplan, JM. OBESE MICE WITH PNEUMONIA HAVE HYPERLEPTINEMIA AND INCREASED PULMONARY SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 ACTIVATION. Shock. 2023; 59:409-416.

Bodilly, L; Williamson, L; Lahni, P; Alder, MN; Haslam, DB; Kaplan, JM. Obesity Alters cytokine signaling and gut microbiome in septic mice. Innate Immunity. 2023; 29:161-170.

Brown, S; Frazier, M; Roberts, J; Wolfe, H; Tegtmeyer, K; Sutton, R; Dewan, M. 35: EXTRACORPOREAL LIFE SUPPORT AFTER SUCCESSFUL RESUSCITATION FROM PEDIATRIC IN-HOSPITAL CARDIAC ARREST. Critical Care Medicine. 2023; 51:18.

Brown, SR; Frazier, M; Roberts, J; Wolfe, H; Tegtmeyer, K; Sutton, R; Dewan, M. CPR quality and outcomes after extracorporeal life support for pediatric In-Hospital cardiac arrest. Resuscitation. 2023; 189:109874.

Cervantes, FC; Mizuno, T; Dong, M; Tang, P; Arbough, T; Vinks, AA; Kaplan, JM; Girdwood, SC T. Ceftriaxone Pharmacokinetics and Pharmacodynamics in 2 Pediatric Patients on Extracorporeal Membrane Oxygenation Therapy. Therapeutic Drug Monitoring. 2023; 45:832-836.

Chiotos, K; Blumenthal, J; Boguniewicz, J; Palazzi, DL; Stalets, EL; Rubens, JH; Tamma, PD; Cabler, SS; Newland, J; Crandall, H; et al. Antibiotic Indications and Appropriateness in the Pediatric Intensive Care Unit: A 10-Center Point Prevalence Study. Clinical Infectious Diseases. 2023; 76:e1021-e1030.

Davis, X; Williamson, L; Stuck, J; Howell, K; Lahni, P; Piraino, G; Wolfe, V; Mukherjee, R; Sanchez-Gurmaches, J; Zingarelli, B; et al. SEX-DEPENDENT EFFECTS OF ADIPOCYTE STAT3 INHIBITION ON THE INFLAMMATORY RESPONSE DURING SEVERE SEPSIS. Shock. 2023; 59:779-790.

Dean, P; Geis, G; Hoehn, EF; Lautz, AJ; Edmunds, K; Shah, A; Zhang, Y; Frey, M; Boyd, S; Nagler, J; et al. High-risk criteria for the physiologically difficult paediatric airway: A multicenter, observational study to generate validity evidence. Resuscitation. 2023; 190:109875.

Devine, AJ; Smith, NJ; Joshi, R; Fan, Q; Borchers, MT; Clair, GC; Adkins, JN; Varisco, BM. Chymotrypsin-like Elastase-1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency. Chronic obstructive pulmonary diseases (Miami, Fla.). 2023; 10:380-391.

Devine, AJ; Smith, NJ; Joshi, R; Fan, Q; Borchers, MT; Clair, GC; Adkins, JN; Varisco, BM. CELA1 Mediates Progressive Emphysema in Alpha-1 Antitrypsin Deficiency. 2023; 4:rs.3.rs-2617812.

Dewan, M; Tegtmeyer, K; Stalets, EL. Through the Looking-Glass Door. Pediatric Critical Care Medicine. 2023; 24:425-426.

Frazier, M; Brown, S; O’Halloran, A; Raymond, T; Kleinman, M; Sutton, R; Roberts, J; Tegtmeyer, K; Wolfe, H; Nadkarni, V; et al. 1165: RISK FACTOR AND OUTCOMES FOR RECURRENT PEDIATRIC IN-HOSPITAL CARDIAC ARREST. Critical Care Medicine. 2023; 51:581.

Frazier, M; Webster, K; Dewan, M; Hutson, T; Collins, K; Fettig, T; Grooms, T; Cordray, M; Tegtmeyer, K. Improving Usability of the Pediatric Code Cart by Combining Lean and Human Factors Principles. Pediatric Quality and Safety. 2023; 8:e676.

Gertz, S; Bhalla, A; Chima, R; Emeriaud, G; Fitzgerald, J; Hsing, D; Jeyapalan, A; Sallee, C; Thomas, N; Yehya, N; et al. 961: IMMUNOCOMPROMISE-ASSOCIATED PEDIATRIC ACUTE RESPIRATORY DISTRESS SYNDROME (IPARDS): A NEW PHENOTYPE. Critical Care Medicine. 2023; 51:473.

Gifford, A; Butcher, B; Chima, RS; Moore, L; Brady, PW; Zackoff, MW; Dewan, M. Use of design thinking and human factors approach to improve situation awareness in the pediatric intensive care unit. Journal of hospital medicine (Online). 2023; 18:978-985.

Girdwood, ST; Hasson, D; Caldwell, JT; Slagle, C; Dong, S; Fei, L; Tang, P; Vinks, AA; Kaplan, J; Goldstein, SL. Relationship between piperacillin concentrations, clinical factors and piperacillin/tazobactam-associated acute kidney injury. Journal of Antimicrobial Chemotherapy. 2023; 78:478-487.

Goldstein, SL; Krallman, KA; Roy, JP; Collins, M; Chima, RS; Basu, RK; Chawla, L; Fei, L. Real-Time Acute Kidney Injury Risk Stratification-Biomarker Directed Fluid Management Improves Outcomes in Critically Ill Children and Young Adults. Kidney International Reports. 2023; 8:2690-2700.

Gray, JM; Raymond, TT; Atkins, DL; Tegtmeyer, K; Niles, DE; Nadkarni, VM; Pandit, SV; Dewan, M; Abulebda, K; Atkins, D; et al. Inappropriate Shock Delivery Is Common During Pediatric In-Hospital Cardiac Arrest. Pediatric Critical Care Medicine. 2023; 24:e390-e396.

Hasson, DC; Zhang, B; Krallman, K; Rose, JE; Kempton, KM; Steele, P; Devarajan, P; Goldstein, SL; Alder, MN. Acute kidney injury biomarker olfactomedin 4 predicts furosemide responsiveness. Pediatric Nephrology. 2023; 38:3153-3161.

Herrmann, LE; Elliott, LE; Sucharew, H; Jerardi, K; Zackoff, MW; Klein, M; Real, FJ. Impact of a Remote Virtual Reality Curriculum Pilot on Clinician Conflict Communication Skills. Hospital Pediatrics. 2023; 13:527-540.

Huang, M; Atreya, MR; Holder, A; Kamaleswaran, R. A MACHINE LEARNING MODEL DERIVED FROM ANALYSIS OF TIME-COURSE GENE-EXPRESSION DATASETS REVEALS TEMPORALLY STABLE GENE MARKERS PREDICTIVE OF SEPSIS MORTALITY. Shock. 2023; 60:671-677.

Ishaque, S; Famularo, S; Saleem, AF; Siddiqui, NU R; Kazi, Z; Parkar, S; Hotwani, A; Thomas, N; Thompson, J; Lahni, P; et al. 28: BIOMARKER-BASED RISK STRATIFICATION IN PEDIATRIC SEPSIS FROM A LOW-MIDDLE-INCOME COUNTRY. Critical Care Medicine. 2023; 51:14.

Ishaque, S; Famularo, ST; Saleem, AF; Siddiqui, NU R; Kazi, Z; Parkar, S; Hotwani, A; Thomas, NJ; Thompson, JM; Lahni, P; et al. Biomarker-Based Risk Stratification in Pediatric Sepsis From a Low-Middle Income Country. Pediatric Critical Care Medicine. 2023; 24:563-573.

Li, P; Wu, Y; Goodwin, AJ; Wolf, B; Halushka, PV; Wang, H; Zingarelli, B; Fan, H. Circulating extracellular vesicles are associated with the clinical outcomes of sepsis. Frontiers in Immunology. 2023; 14:1150564.

Loeb, D; Paice, K; Williams, J; Chima, RS; Lautz, AJ. Rapidly Progressive Respiratory Failure and Shock in a Healthy Teenager. Pediatrics in review / American Academy of Pediatrics. 2023; 44:S77-S80.

Loeb, D; Shoemaker, J; Parsons, A; Schumacher, D; Zackoff, M. How Augmenting Reality Changes the Reality of Simulation: Ethnographic Analysis. JMIR Medical Education. 2023; 9:e45538.

Menon, S; Krallman, KA; Arikan, AA; Fuhrman, DY; Gorga, SM; Mottes, T; Ollberding, N; Ricci, Z; Stanski, NL; Selewski, DT; et al. Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK). Kidney International Reports. 2023; 8:1542-1552.

Merrill, KA; Krallman, KA; Loeb, D; Standage, SW; Mattoon, D; Shan, D; Goldstein, SL; Schuh, MP. First-Time Use of the Seraph® 100 Microbind® Affinity Blood Filter in an Adolescent Patient with Severe COVID-19 Disease: A Case Report. Case Reports in Nephrology and Dialysis. 2023; 13:1-6.

Mitchell, MJ; Riley, C; Crosby, LE. Partnering with Families and Communities to Improve Child Health and Health Equity. Pediatric Clinics of North America. 2023; 70:683-693.

Myers, C; Tegtmeyer, K; Dewan, M. Championing the Spirit of O'hana in the PICU. Pediatric Critical Care Medicine. 2023; 24:1092-1093.

Nguyen, J; Thompson, JM; Balcarcel, DR; Alder, MN; McKeone, DJ; Halstead, ES; Rowan, CM; Lindell, RB; Yehya, N. Immunocompromised Children With Acute Respiratory Distress Syndrome Possess a Distinct Circulating Inflammatory Profile. Critical Care Explorations. 2023; 5:e0844.

Odum, JD; Real, FJ; Rice, J; Meisman, A; Sahay, R; Zhang, B; Zackoff, MW. Virtual Reality to Assess Resident Recognition of Impending Respiratory Failure During COVID-19. Hospital Pediatrics. 2023; 13:e135-e139.

O'Halloran, A; Lockwood, J; Sosa, T; Gawronski, O; Nadkarni, V; Kleinman, M; Dewan, M; Abulebda, K; Atkins, D; Balikai, S; et al. How do we detect and respond to clinical deterioration in hospitalized children? Results of the Pediatric Care BefOre Deterioration Events (CODE) survey. Journal of hospital medicine (Online). 2023; 18:1102-1108.

Paice, K; Girdwood, ST; Pavia, K; Mizuno, T; Tang, P; Curry, C; Gibson, A; Jones, R; Stoneman, E; Yunger, T; et al. 38: CRITICALLY ILL CHILDREN WITH SEVERE SEPSIS OFTEN HAVE SUB-TARGET MEROPENEM LEVELS EARLY IN THERAPY. Critical Care Medicine. 2023; 51:19.

Parsons, A; Harvey, TD; Andrade, SD; Horton, N; Brinkley-Rubenstein, L; Wood, G; Holaday, LW; Riley, C; Spell, VT; Papachristos, AV; et al. "We know what's going on in our community ": A qualitative analysis identifying community assets that deter gun violence. SSM: Qualitative Research in Health. 2023; 3:100258.

Paul, R; Niedner, M; Riggs, R; Richardson, T; DeSouza, HG; Auletta, JJ; Balamuth, F; Campbell, D; Depinet, H; Hueschen, L; et al. Bundled Care to Reduce Sepsis Mortality: The Improving Pediatric Sepsis Outcomes (IPSO) Collaborative. Pediatrics. 2023; 152:e2022059938.

Pavia, K; Girdwood, ST; Paice, K; Jones, R; Curry, C; Stoneman, E; Yunger, T; Gamel, N; Gibson, A; Dong, M; et al. 610: RENAL IMPAIRMENT IS ASSOCIATED WITH HIGH CEFEPIME CONCENTRATIONS IN CRITICALLY ILL CHILDREN. Critical Care Medicine. 2023; 51:294.

Pavia, K; Hambrick, HR; Paice, K; Tang, P; Punt, N; Kaplan, J; Goldstein, SL; Vinks, AA; Mizuno, T; Tang Girdwood, S. Cefepime pharmacokinetics in critically ill children and young adults undergoing continuous kidney replacement therapy. Journal of Antimicrobial Chemotherapy. 2023; 78:2140-2147.

Pode-Shakked, N; Ceschia, G; Rose, JE; Goldstein, SL; Stanski, NL. Increasing angiotensin-converting enzyme concentrations and absent angiotensin-converting enzyme activity are associated with adverse kidney outcomes in pediatric septic shock. Critical Care (UK). 2023; 27:230.

Raab, DL; Ely, K; Donnellan, A; Israel, K; Lin, L; Saupe, J; Klein, M; Zackoff, MW. New Nurse Self-assessed Clinical Competence, Immersion, and Attitudes Following Virtual Reality Training on the Assessment of Pediatric Respiratory Distress. Clinical Simulation in Nursing. 2023; 84:101461.

Real, FJ; Zackoff, MW; Rosen, BL. Using Technology to Overcome Vaccine Hesitancy. Pediatric Clinics of North America. 2023; 70:297-308.

Sanchez-Pinto, LN; Bennett, TD; Stroup, EK; Luo, Y; Atreya, M; Bubeck Wardenburg, J; Chong, G; Geva, A; Faustino, EV S; Farris, RW; et al. Derivation, Validation, and Clinical Relevance of a Pediatric Sepsis Phenotype With Persistent Hypoxemia, Encephalopathy, and Shock. Pediatric Critical Care Medicine. 2023; 24:795-806.

Sanchez-Pinto, LN; Bhavani, SV; Atreya, MR; Sinha, P. Leveraging Data Science and Novel Technologies to Develop and Implement Precision Medicine Strategies in Critical Care. Critical Care Clinics. 2023; 39:627-646.

Shah, AS; Sobolewski, B; Chon, S; Cruse, B; Glisson, MD; Zackoff, MW; Davis, D; Zhang, Y; Schumacher, DJ; Geis, GL. Just-in-Time, Just-in-Place Virtual Training in the Pediatric Emergency Department: A Novel Approach to Impact the Perfusion Exam. Advances in Medical Education and Practice. 2023; 14:901-911.

Spatz, ES; Roy, B; Riley, C; Witters, D; Herrin, J. Association of Population Well-Being With Cardiovascular Outcomes. JAMA Network Open. 2023; 6:e2321740.

Stanski, NL; Basu, RK; Cvijanovich, NZ; Fitzgerald, JC; Bigham, MT; Jain, PN; Schwarz, AJ; Lutfi, R; Thomas, NJ; Baines, T; et al. External validation of the modified sepsis renal angina index for prediction of severe acute kidney injury in children with septic shock. Critical Care (UK). 2023; 27:463.

Stanski, NL; Krallman, KA; Chima, RS; Goldstein, SL. A risk-stratified assessment of biomarker-based acute kidney injury phenotypes in children. Pediatric Research. 2023; 93:1354-1360.

Stanski, NL; Pode Shakked, N; Zhang, B; Cvijanovich, NZ; Fitzgerald, JC; Jain, PN; Schwarz, AJ; Nowak, J; Weiss, SL; Allen, GL; et al. Serum renin and prorenin concentrations predict severe persistent acute kidney injury and mortality in pediatric septic shock. Pediatric Nephrology. 2023; 38:3099-3108.

Stanski, NL; Rodrigues, CE; Strader, M; Murray, PT; Endre, ZH; Bagshaw, SM. Precision management of acute kidney injury in the intensive care unit: current state of the art. Intensive Care Medicine. 2023; 49:1049-1061.

Sveen, WN; Antommaria, AH M; Gilene, SJ; Stalets, EL. Adverse Events During Apnea Testing for the Determination of Death by Neurologic Criteria: A Single-Center, Retrospective Pediatric Cohort. Pediatric Critical Care Medicine. 2023; 24:399-405.

Tang Girdwood, S; Tang, P; Fenchel, M; Dong, M; Stoneman, E; Jones, R; Ostermeier, A; Curry, C; Forton, M; Hail, T; et al. Pharmacokinetic parameters over time during sepsis and the association of target attainment and outcomes in critically ill children and young adults receiving ceftriaxone. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 2023; 43:609-621.

Taylor, ZL; Poweleit, EA; Paice, K; Somers, KM; Pavia, K; Vinks, AA; Punt, N; Mizuno, T; Girdwood, ST. Tutorial on model selection and validation of model input into precision dosing software for model-informed precision dosing. CPT: Pharmacometrics and Systems Pharmacology. 2023; 12:1827-1845.

Teoh, Z; Danziger-Isakov, L; Courter, JD; Frenck, RW; Grimley, MS; Marsh, RA; Paulsen, GC; Phillips, CL; Spearman, P; Chima, RS; et al. Tocilizumab for Treatment of Children and Young Adults With Severe Acute COVID-19: Experience at a Quaternary-care Children's Hospital. The Pediatric Infectious Disease Journal. 2023; 42:119-121.

Tezel, O; Hutson, TK; Gist, KM; Chima, RS; Goldstein, SL; Stanski, NL. Utilization of Synthetic Human Angiotensin II for Catecholamine-Resistant Vasodilatory Shock in Critically Ill Children: A Single-Center Retrospective Case Series. Critical Care Explorations. 2023; 5:e0978.

Tjoeng, YL; Myers, C; Irving, SY; Esangbedo, I; Wheeler, D; Musa, N. The Current State of Workforce Diversity and Inclusion in Pediatric Critical Care. Critical Care Clinics. 2023; 39:327-340.

Trinidad, S; Brokamp, C; Sahay, R; Moody, S; Gardner, D; Parsons, AA; Riley, C; Sofer, N; Beck, AF; Falcone, RA; et al. Children from disadvantaged neighborhoods experience disproportionate injury from interpersonal violence. Journal of Pediatric Surgery. 2023; 58:545-551.

Varisco, BM. Nuclear Factor-κB Keeps Basal Cells Undifferentiated in Congenital Diaphragmatic Hernia. American Journal of Respiratory and Critical Care Medicine. 2023; 207:1122-1123.

Varisco, BM; Devaskar, SU; Murray, KO; Cheng, TL; Shah, S; Patel, M; Raphael, J; Keller, D; Chamberlain, L; Cheng, T; et al. The Advanced Research Projects Agency-Health (ARPA-H): a new model for research in child health. Pediatric Research. 2023; 93:451-452.

Wagner, ML; Ammann, A; Piraino, G; Wolfe, V; O'Connor, M; Lahni, P; Ziady, A; Zingarelli, B. PROTECTIVE EFFECTS OF HUMANIN-G IN HEMORRHAGIC SHOCK IN FEMALE MICE VIA AMPKα1-INDEPENDENT MECHANISMS. Shock. 2023; 60:64-74.

Warniment, A; Sauers-Ford, H; Brady, PW; Beck, AF; Callahan, SR; Giambra, BK; Herzog, D; Huang, B; Loechtenfeldt, A; Loechtenfeldt, L; et al. Garnering effective telehealth to help optimize multidisciplinary team engagement (GET2HOME) for children with medical complexity: Protocol for a pragmatic randomized control trial. Journal of hospital medicine (Online). 2023; 18:877-887.

Whitney, J; Varisco, B; Raby, B; Yehya, N. 713: LONGITUDINAL VALIDATION OF A BIOMARKER-BASED RISK STRATIFICATION TOOL FOR PEDIATRIC ARDS. Critical Care Medicine. 2023; 51:347.

Wong, HR. In Response to Reich and Weiner's Recent Article on Leadership in Cardiac Anesthesiology. Journal of Cardiothoracic and Vascular Anesthesia. 2023; 37:840-841.

Wösten-van Asperen, RM; la Roi-Teeuw, HM; van Amstel, RB; Bos, LD; Tissing, WJ; Jordan, I; Dohna-Schwake, C; Bottari, G; Pappachan, J; Crazzolara, R; et al. Distinct clinical phenotypes in paediatric cancer patients with sepsis are associated with different outcomes-an international multicentre retrospective study. EClinicalMedicine. 2023; 65:102252.

Zackoff, MW; Cruse, B; Sahay, RD; Zhang, B; Sosa, T; Schwartz, J; Depinet, H. Interprofessional Immersive Virtual Reality Training on Sepsis Recognition. Pediatric Quality and Safety. 2023; 8:e627.

Zackoff, MW; Rios, M; Davis, D; Boyd, S; Roque, I; Anderson, I; NeCamp, M; Gardner, A; Geis, G; Moore, RA. Immersive Virtual Reality Onboarding using a Digital Twin for a New Clinical Space Expansion: A Novel Approach to Large-Scale Training for Health Care Providers. The Journal of Pediatrics. 2023; 252:7-10.e3.

Zinter, MS; Markovic, D; Asaro, LA; Nadkarni, VM; McQuillen, PS; Sinha, P; Matthay, MA; Jeschke, MG; Agus, MS D; Sapru, A; et al. Tight Glycemic Control, Inflammation, and the ICU: Evidence for Heterogeneous Treatment Effects in Two Randomized Controlled Trials. American Journal of Respiratory and Critical Care Medicine. 2023; 207:945-949.