Critical Care Medicine Research

Publications

Al Gharaibeh, FN; Huang, M; Wynn, JL; Kamaleswaran, R; Atreya, MR. Transcriptomic mortality signature defines high-risk neonatal sepsis endotype. Frontiers in Immunology. 2025; 16:1601316.

Andrist, E; Firn, JI; Kirschen, MP; Sederstrom, NO; Kon, AA; Fowler, JC; Wolfe, AH J; McIlroy, ME; Kiragu, A; Morrison, WE; McGowan, N; Leber, SM; Carroll, CL; Flori, HR. Themes in the Management of Pediatric Brain Death Contestation: Exploratory Qualitative Work From Multidisciplinary Health Professionals in the United States. Pediatric Critical Care Medicine. 2025; 26:e846-e854.

Atreya, MR; Lanziotti, VS. Biomarkers for early identification of severe febrile illness among children in community settings: spot on?. The Lancet Child and Adolescent Health. 2025; 9:615-617.

Aubert, O; Amonkar, GM; Varelas, X; Tilston-Lunel, A; Lerou, PH; Zalieckas, JM; Buchmiller, TL; Varisco, B; Marotta, M; Peiro, JL; Ai, X. YAP Deficiency Drives NF-κB Hyperactivation to Disrupt Airway Epithelium Differentiation in Congenital Diaphragmatic Hernia. American Journal of Respiratory Cell and Molecular Biology. 2025; 72:112-115.

Aubert, O; Miyake, Y; Amonkar, GM; Dinwoodie, OM; Varisco, BM; Marotta, M; Zhao, C; Wagner, R; Chen, YW; Moscatello, A; Lerou, PH; Peiro, JL; Keijzer, R; Ai, X. Fetal Tracheal Occlusion Correlates with Normalized YAP Expression and Alveolar Epithelial Differentiation in Congenital Diaphragmatic Hernia. American Journal of Respiratory Cell and Molecular Biology. 2025; 72:688-697.

Basalely, A; Gist, KM; Stanski, NL; Fuhrman, DY; Seo, JD; Ollberding, NJ; Strong, A; Damian, M; Morgan, C; Reynaud, S; Brown, CL; Burrell, A; Dash, A; Ehrlich, JL. Thrombocytopenia in Children and Young Adults Undergoing Continuous Renal Replacement Therapy: A WE-ROCK Study. Blood Purification. 2025; 54:322-333.

Biniazan, S; Zackoff, M; Stalets, E; Mecoli, M; Lautz, A. 1374: DOCUMENTATION OF ULTRASOUND GUIDANCE DURING CENTRAL VENOUS CATHETER INSERTION. Critical Care Medicine. 2025; 53.

Blackburn, C; Steller, A; Meisman, A; Real, FJ; Rosen, BL. A scoping review of pediatric healthcare provider HPV vaccine communication trainings and implementation outcomes: A critical analysis and recommendations for improvement. Preventive Medicine. 2025; 196:108308.

Clover-Brown, I; Stanski, NL. PRoMPTing Practice Change in Pediatric Sepsis: Is There a Role for Acute Kidney Injury Biomarkers in Early Fluid Resuscitation?. Pediatric Critical Care Medicine. 2025; 26:e839-e841.

Devine, AJ; Smith, NJ; Joshi, R; Brooks-Patton, B; Dunham, J; Varisco, AN; Goodman, EM; Fan, Q; Zingarelli, B; Varisco, BM. KF4 Anti-Chymotrypsin-like Elastase 1 Antibody and Purified Alpha-1 Antitrypsin Have Similar but Not Additive Efficacy in Preventing Emphysema in Murine Alpha-1 Antitrypsin Deficiency. Chronic obstructive pulmonary diseases (Miami, Fla.). 2025; 12:12-22.

Donville, B; Wolfe, H; Tegtmeyer, K; Zackoff, M; Frazier, M; Loeb, D; Lautz, A; O’Halloran, A; Dewan, M. Characteristics of Hot and Cold Debriefs for In-hospital Cardiac Arrest in the Pediatric Intensive Care Unit: A Mixed-methods Analysis. Pediatric Quality and Safety. 2025; 10:e812.

Goswami, S; Gist, KM; Bjornstad, P; Ciccia, E; Deep, A; Gelbart, B; Menon, S; Marinari, E; Ollberding, NJ; Qutob, D; Alobaidi, R; Alhamoud, I; Arikan, AA; Ahern, E. Hyperglycemia and kidney outcomes in critically ill children and young adults on continuous kidney replacement therapy. Pediatric Nephrology. 2025; 40:2957-2966.

Hapstack, M; Tezel, O; Ripberger, S; Atreya, M. 1575: A SINGLE NUCLEOTIDE VARIANT OF TMEM100 IS LINKED TO HIGHER ODDS OF PEDIATRIC SEPTIC SHOCK MORTALITY. Critical Care Medicine. 2025; 53.

Herbst, R; Meisman, A; Real, FJ. The Current State of Behavioral Health Training for Pediatric Residents. Academic Pediatrics. 2025; 25:102859.

Hochheiser, H; Klug, J; Mathie, T; Pollard, TJ; Raffa, JD; Ballard, SL; Conrad, EA; Edakalavan, S; Joseph, A; Alnomasy, N; Rooney, SR; Woeltje, M; Celi, LA; Horvat, CM. Raising awareness of potential biases in medical machine learning: Experience from a Datathon. Editor, Cheungpasitporn W. PLOS Digital Health. 2025; 4:e0000932.

Jo, S; Arroyo, R; Marks, K; Higano, NS; Bates, A; von Allenmen, D; Woods, JC; Kingma, PS. Evaluation of Magnetic Resonance Imaging (MRI) Anatomic Risk Factors to Predict Outcomes in Patients With Esophageal Atresia (EA). American Journal of Respiratory and Critical Care Medicine. 2025; 211:a2299.

Johns, A; Knapke, J; Ryan, P; Mendell, A; Kingsley, E; Buccigross, S; Phillips, K; Kues, J; Wakefield, D; Gomaa, D; Marcum, M; Kurtzweil, N; Harris, N; Blackard, J. 188 Undergraduate outreach to foster student interest in clinical and translational science career pathways: Creation of a certificate and CTS Roadshow programming. Journal of Clinical and Translational Science. 2025; 9:57-58.

Joseph, AM; Minturn, JS; Kurland, KS; Davis, BS; Kahn, JM. Development and Evaluation of Pediatric Acute Care Hospital Referral Regions in Eight States. The Journal of Pediatrics. 2025; 276:114371.

Lin, K; Marks, KT; Demehri, FR; Perez, JM. Case 2: Subacute Respiratory Distress in a 3-Year-Old Boy. Pediatrics in review / American Academy of Pediatrics. 2025; 46:321-325.

March, M; Zackoff, M; Fleck, J; Meisman, A; Humphrey, K; MacDougall, MC; Ehrlich, S; Griggs, C; Sacks, C; Masiakos, P; Klein, M; Real, F. A Randomized Trial of Virtual Reality Training to Improve Firearm Safety Counseling Skills. Academic Pediatrics. 2025; 25:102560.

Melink, KF; Stanski, NL; Gorrell, E; Alten, JA; Pettit, KA; Goldstein, SL; Zang, H; Ollberding, NJ; Basu, RK; Menon, S; SooHoo, M; Gist, KM. Modification of the Cardiac Renal Angina Index for Predicting Adverse Kidney Events After Pediatric Cardiac Surgery. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease. 2025; e042941.

Menon, S; Starr, MC; Zang, H; Collins, M; Damian, MA; Fuhrman, D; Krallman, K; Soranno, DE; Webb, TN; Slagle, C; Dolan, KJ; Ding, KL; Deep, A; DeAbreu, G. Characteristics and outcomes of children ≤ 10 kg receiving continuous kidney replacement therapy: a WE-ROCK study. Pediatric Nephrology. 2025; 40:253-264.

Miley, AE; Patronick, J; Zhang, N; Bode, RL; Fabio, A; Treble-Barna, A; Chima, RS; Adlam, AL R; Bell, MJ; Wisniewski, SR; Walson, K; West, AN; Willyerd, A; Zimmerman, J. Social Environment and Neurobehavioral Outcomes 1 Year After Severe Pediatric TBI in the Intensive Care Unit. The Journal of Head Trauma Rehabilitation. 2025; 40:147-156.

Molloy, E; Loeb, D; Generoso Junior, J; Zackoff, M. 1582: VERBALIZATION VERSUS RECOGNITION OF SEPSIS BY RESIDENTS IN A VIRTUAL REALITY SIMULATION. Critical Care Medicine. 2025; 53.

Molloy, E; Zackoff, M; Tegtmeyer, K. 822: CHARACTERIZING RAPID RESPONSE TEAM ACTIVATIONS AND CONTRIBUTING FACTORS. Critical Care Medicine. 2025; 53.

Moore, A; Zheng, H; Ganesan, A; Hasin-Brumshtein, Y; van der Poll, T; Scicluna, B; Giamarellos-Bourboulis, E; Martin-Loeches, I; Rothman, R; Atreya, M; Meyer, N; Sweeney, T; Rogers, A; Khatri, P. 1055: MULTI-COHORT ANALYSIS IDENTIFIES CONSENSUS SEPSIS CLUSTERS WITH PROGNOSTIC AND THERAPEUTIC RELEVANCE. Critical Care Medicine. 2025; 53.

Moore, AR; Zheng, H; Ganesan, A; Hasin-Brumshtein, Y; Maddali, MV; Levitt, JE; van der Poll, T; Scicluna, B; Giamarellos-Bourboulis, E; Kotsaki, A; Meyer, NJ; Sweeney, TE; Rogers, A; Khatri, P. International Multi-cohort Analysis Identifies Novel Framework for Quantifying Immune Dysregulation in Sepsis. American Journal of Respiratory and Critical Care Medicine. 2025; 211:a7761.

Morales Junior, R; Hambrick, HR; Mizuno, T; Pavia, KE; Paice, KM; Tang, P; Schuler, E; Krallman, KA; Johnson, L; Collins, M; Gibson, A; Curry, C; Kaplan, J; Goldstein, S; Tang Girdwood, S. Population Pharmacokinetics of Cefepime in Critically Ill Children and Young Adults: Model Development and External Validation for Monte Carlo Simulations and Model-Informed Precision Dosing. Clinical Pharmacokinetics. 2025; 64:553-564.

Myers, C; Asp, R; Duan, Q; Beck, A; Riley, C. 13: SNAP PARTICIPATION ASSOCIATED WITH PICU UTILIZATION: A POTENTIAL INDICATOR OF FOOD INSECURITY RISK. Critical Care Medicine. 2025; 53.

Myers, CN; Rao, M; Bandi, R; Densley, S; Diaz, D; Knecht, M; Sacca, L. Funding the future: safeguarding pediatric health equity through CMS and CHIP. Frontiers in Public Health. 2025; 13:1611720.

Pavia, K; Girdwood, ST; Kaplan, J. Complexity in assessing acute kidney injury and cefepime exposure in critically ill patients. Pediatric Nephrology. 2025; 40:2101-2102.

Pavia, K; Girdwood, ST; Paice, K; Dong, M; Mizuno, T; Tang, P; Mangeot, C; Vinks, AA; Kaplan, J. Acute kidney injury is associated with abnormal cefepime exposure among critically ill children and young adults. Pediatric Nephrology. 2025; 40:513-521.

Pettit, KA; Melink, KF; Alten, JA; Goldstein, SL; Ollberding, N; SooHoo, M; Sullivan, E; Zang, H; Stanski, NL; Gist, KM. Biomarker-based acute kidney injury sub-phenotypes refine risk assessment in children undergoing cardiac surgery. Pediatric Nephrology. 2025; 40:523-531.

Pitkowsky, Z; Beck, AF; Brokamp, C; Myers, CN. Association between Air Pollution, Neighborhood Opportunity, and Pediatric Intensive Care Unit Admissions in Acute Respiratory Illness. The Journal of Pediatrics. 2025; 284:114662.

Pitkowsky, Z; Warniment, A; Beck, A; Myers, C. 333: ASSOCIATION BETWEEN LANGUAGE, MEDICAL COMPLEXITY, AND PICU ADMISSION IN ACUTE RESPIRATORY ILLNESS. Critical Care Medicine. 2025; 53.

Rosen, B; Hineline, S; Wilson, K; Holden, C; Garney, W; Meisman, A. Survey Development to Evaluate A Sexual Health Program for Middle School Youth. Journal of Adolescent Health. 2025; 76:s105-s106.

Salloum, S; Lautz, AJ; Statile, C. Evaluating Frequency and Yield of Echocardiography in a Pediatric Intensive Care Unit. The Journal of Pediatrics: X. 2025; 16:200143.

Sanchez-Pinto, LN; Daniels, LA; Atreya, M; Faustino, EV S; Farris, RW D; Geva, A; Khemani, RG; Rogerson, C; Shah, SS; Weiss, SL; Bennett, TD. Phoenix Sepsis Criteria in Critically Ill Children: Retrospective Validation Using a United States Nine-Center Dataset, 2012-2018. Pediatric Critical Care Medicine. 2025; 26:e155-e165.

Stanski, NL; Gist, KM; Fuhrman, DY. The authors reply. Critical Care Medicine. 2025; 53:e517-e518.

Strutz, S; Liang, H; Carey, K; Bashiri, F; Jani, P; Gilbert, E; Fitzgerald, JL; Kuehnel, N; Dewan, M; Sanchez-Pinto, LN; Edelson, D; Afshar, M; Churpek, M; Mayampurath, A. Machine Learning for Predicting Critical Events Among Hospitalized Children. JAMA Network Open. 2025; 8:e2513149.

Taylor, W; Nutman, S; Joseph, A; Rooney, S; Woeltje, M; Conrad, E; Alnomasy, N; Hill, V; Kravchenko, O; Edakalavan, S; Raffa, J; Hochheiser, H; Anthony Celi, L; Horvat, C. 387: RAISING AWARENESS OF POTENTIAL BIASES IN MEDICAL MACHINE LEARNING: EXPERIENCE FROM A DATATHON. Critical Care Medicine. 2025; 53.

Ushpol, A; Je, S; Christoff, A; Nuthall, G; Scholefield, B; Morgan, RW; Nadkarni, V; Gangadharan, S; Abulebda, K; Atkins, D; Tan, G; Pirzadeh, A; Wratney, A; DiMaria, K. Evaluating post-cardiac arrest blood pressure thresholds associated with neurologic outcome in children: Insights from the pediRES-Q database. Resuscitation. 2025; 207:110468.

Williams, J; Varisco, B. 444 scRNA seq analysis of lower respiratory tract immune cells to uncover immuno-endotypes in SA-PARDS. Journal of Clinical and Translational Science. 2025; 9:131-132.

Williams, JG; Whitney, JE; Weiss, SL; Varisco, BM; Yehya, N; Atreya, MR. Derivation and Validation of a Clinical and Endothelial Biomarker Risk Model to Predict Persistent Pediatric Sepsis-Associated Acute Respiratory Dysfunction. 2025; 3:100120.

Zingarelli, B. SHOCK SYNOPSIS FEBRUARY 2025. Shock. 2025; 63:179-181.

Zujkowski, M; Ehrlich, S; Liu, C; Sun, Q; Zackoff, M; Brady, JM; Johnson, BA; Mukthapuram, S. A Needs Assessment of Labor and Delivery Nurses Performing NRP in the Delivery Room. Maternal and Child Health Journal. 2025; 29:23-30.