Critical Care

Critical care; sepsis
Visit the Wong Lab.

MD: University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ, 1989.

Residency: Department of Pediatrics, George Washington University School of Medicine, Children's National Medical Center, Washington, DC, 1990 to 1992.

Fellowship: Clinical Fellow, Department of Anesthesiology, Division of Pediatric Critical Care Medicine, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, Pittsburgh, PA, 1992 to 1995; Research Fellow, Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 1992 to 1995.

Certification: National Board of Medical Examiners, 1990; Diplomate, American Board of Pediatrics, 1993; American Board of Pediatrics: Sub-Board of Pediatric Critical Care Medicine, 1996.

Solan PD, Dunsmore KE, Denenberg AG, Odoms K, Zingarelli B, Wong HR. A novel role for matrix metalloproeinase-8 in sepsis. Crit Care Med. . 2011.

Wong HR, Wheeler DS, Tegtmeyer K, Poynter SE, Kaplan JM, Chima RS, Stalets E, Basu RK, Doughty LA. Toward a clinically feasible gene expression-based subclassification strategy for septic shock: proof of concept. Crit Care Med. 2010 Oct;38(10):1955-61.

Wong HR, Cvijanovich N, Lin R, Allen GL, Thomas NJ, Willson DF, Freishtat RJ, Anas N, Meyer K, Checchia PA, Monaco M, Odom K, Shanley TP. Identification of pediatric septic shock subclasses based on genome-wide expression profiling. BMC Med. 2009 Jul 22;7:34.

Wong HR, Cvijanovich N, Allen GL, Lin R, Anas N, Meyer K, Freishtat RJ, Monaco M, Odoms K, Sakthivel B, Shanley TP; Genomics of Pediatric SIRS/Septic Shock Investigators. Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum. Crit Care Med. 2009 May;37(5):1558-66.

Wong HR, Cvijanovich N, Wheeler DS, Bigham MT, Monaco M, Odoms K, Macias WL, Williams MD. Interleukin-8 as a stratification tool for interventional trials involving pediatric septic shock. Am J Respir Crit Care Med. 2008 Aug 1;178(3):276-82.

Cvijanovich N, Shanley TP, Lin R, Allen GL, Thomas NJ, Checchia P, Anas N, Freishtat RJ, Monaco M, Odoms K, Sakthivel B, Wong HR; Genomics of Pediatric SIRS/Septic Shock Investigators. Validating the genomic signature of pediatric septic shock. Physiol Genomics. 2008 Jun 12;34(1):127-34.

Shanley TP, Cvijanovich N, Lin R, Allen GL, Thomas NJ, Doctor A, Kalyanaraman M, Tofil NM, Penfil S, Monaco M, Odoms K, Barnes M, Sakthivel B, Aronow BJ, Wong HR. Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock. Mol Med. 2007 Sep-Oct;13(9-10):495-508.

Wong HR, Shanley TP, Sakthivel B, Cvijanovich N, Lin R, Allen GL, Thomas NJ, Doctor A, Kalyanaraman M, Tofil NM, Penfil S, Monaco M, Tagavilla MA, Odoms K, Dunsmore K, Barnes M, Aronow BJ; Genomics of Pediatric SIRS/Septic Shock Investigators. Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome. Physiol Genomics. 2007 Jul 18;30(2):146-55.

Aneja R, Odoms K, Dunsmore K, Shanley TP, Wong HR. Extracellular heat shock protein-70 induces endotoxin tolerance in THP-1 cells. J Immunol. 2006 Nov 15;177(10):7184-92.

Wong HR, Ryan M, Wispé JR. Stress response decreases NF-kB nuclear translocation and increases I-kBα expression in A549 cells. J Clin Invest. 1997;99:2423-2428.

Clinical Director

Erika L. Stalets, MD Medical Director, Pediatric Intensive Care Unit

Erika L. Stalets, MD, is a clinical intensivist interested in quality improvement and patient safety. She is a Quality Scholar and working toward her MS in clinical and translational research. Her interests include decreasing and eliminating hospital acquired infections and the reliable delivery of evidenced-based care to pediatric patients with septic shock.

513-636-4259 erika.stalets@cchmc.org

Faculty

Matthew N. Alder, MD, PhD

Matthew N. Alder, MD, PhD, studies the function of the immune system in patients with sepsis and septic shock. We use patient samples and animal models to better understand how we can treat patients with sepsis.

513-636-4259 matthew.alder@cchmc.org

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Matthew N. Alder, MD, PhD

Academic Affiliations

Instructor, UC Department of Pediatrics

Phone 513-636-4259

Email matthew.alder@cchmc.org

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Clinical

Pediatric critical care

Research

Immunology; sepsis

BA: Mandarin Chinese, University of Utah, Salt Lake City, UT, 2002.

MD, PhD: Microbiology and Immunology, University of Alabama, Birmingham, AL, 2009.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2012.

Fellowship: Critical Care, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2015.

Alder MN, Lindsell CJ, Wong HR. The pediatric sepsis biomarker risk model: potential implications for sepsis therapy and biology. Expert Rev Anti Infect Ther. 2014 Jul;12(7):809-16.

Nakahara H, Herrin BR, Alder MN, Catera R, Yan XJ, Chiorazzi N, Cooper MD. Chronic lymphocytic leukemia monitoring with a Lamprey idiotope-specific antibody. Cancer Immunol Res. 2013 Oct;1(4):223-8.

Yu C, Ehrhardt GR, Alder MN, Cooper MD, Xu A. Inhibitory signaling potential of a TCR-like molecule in lamprey. Eur J Immunol. 2009 Feb;39(2):571-9.

Alder MN, Herrin BR, Sadlonova A, Stockard CR, Grizzle WE, Gartland LA, Gartland GL, Boydston JA, Turnbough CL Jr, Cooper MD. Antibody responses of variable lymphocyte receptors in the lamprey. Nat Immunol. 2008 Mar;9(3):319-27.

Herrin BR, Alder MN, Roux KH, Sina C, Ehrhardt GR, Boydston JA, Turnbough CL Jr, Cooper MD. Structure and specificity of lamprey monoclonal antibodies. Proc Natl Acad Sci USA. 2008 Feb 12;105(6):2040-5.

Cooper MD, Alder MN. The evolution of adaptive immune systems. Cell. 2006 Feb 24;124(4):815-22.

Alder MN, Rogozin IB, Iyer LM, Glazko GV, Cooper MD, Pancer Z. Diversity and function of adaptive immune receptors in a jawless vertebrate. Science. 2005 Dec 23;310(5756):1970-3.

Alder MN, Dames S, Gaudet J, Mango SE. Gene silencing in Caenorhabditis elegans by transitive RNA interference. RNA. 2003 Jan;9(1):25-32.

Ranjit S. Chima, MD, FAAP

is a clinical assistant professor within the UC Department of Pediatrics with an interest in critically ill stem cell transplant recipients. His research is focused on predicting and improving outcomes for critically ill stem cell transplant recipients. This work is done in close collaboration with the Division of Bone Marrow Transplantation and Immunodeficiency.

513-636-4259 ranjit.chima@cchmc.org

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Ranjit S. Chima, MD, FAAP

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-4259

Fax 513-636-4267

Email ranjit.chima@cchmc.org

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Critical Illness following stem cell transplantation; extracorporeal life support; venous thromboembolism; critical Illness hyperglycemia

MBBS: Grant Medical College, Mumbai, India, 1996.

MD: Pediatrics, University of Mumbai, Mumbai, India, 1999.

Residency: Pediatrics, University of Mumbai, Mumbai, India, 1996-1999; Pediatrics, Children's Hospital of Michigan, Detroit, MI, 2001-2004.

Fellowship: Pediatric Critical Care Medicine, Cincinnati Children's Hospital Medical Center, 2004-2007.

Certification: Pediatrics, 2004, 2014; Pediatric Critical Care Medicine, 2008.

Jacobs L, Chima RS. Intensive Care Outcomes for Hematopoietic Stem Cell Transplant Recipients: More of the Same. Pediatr Crit Care Med. 2016 Mar;17(3):272-3.

Dandoy CE, Linscott LL, Davies SM, Leach JL, Myers KC, El-Bietar J, Chima RS, Pate A, Nelson A, Wallace G, Wong HR, Jodele S. Clinical Utility of Computed Tomography and Magnetic Resonance Imaging for Diagnosis of Posterior Reversible Encephalopathy Syndrome after Stem Cell Transplantation in Children and Adolescents. Biol Blood Marrow Transplant. 2015 Nov;21(11):2028-32.

Pate A, Rotz S, Warren M, Hirsch R, Cash M, Myers KC, El-Bietar J, Nelson A, Wallace G, Filipovich AH, Bleesing J, Chima RS, Davies SM, Jodele S, Dandoy CE. Pulmonary hypertension associated with bronchiolitis obliterans after hematopoietic stem cell transplantation. Bone Marrow Transplant. 2015 Oct 19. [Epub ahead of print].

Meier K, Clark E, Tarango C, Chima RS, Shaughnessey E. Venous Thromboembolism in Hospitalized Adolescents: an Approach to Risk Assessment and Prophylaxis. Hosp Pediatr. 2015 Jan;5(1):44-51.

Dandoy C, Davies SM, Hirsch R, Chima RS, Paff Z, Cash M, Ryan T, Lane A, El-Bietar J, Myers K, Jodele S. Abnormal echocardiography seven days after transplant may be an early indicator of thrombotic microangiopathy. Biol Blood Marrow Transplant. 2015 Jan; 21(1):113-8.

Jodele S, Davies SM, Lane A, Khoury J, Dandoy C, Goebel J, Myers K, Grimley M, Bleesing J, El-Bietar J, Wallace G, Chima RS, Paff Z, Laskin BL. Refined diagnostic and risk criteria for HSCT-associated thrombotic microangiopathy: a prospective study in children and young adults. Blood. 2014 Jul 24;124 (4): 645-53.

Dandoy C, Hirsch R, Chima R, Davies SM, Jodele S. Pulmonary Hypertension after Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2013 Nov;19(11):1546-56.

Jodele S, Hirsch R, Laskin B, Davies S, Witte D, Chima R. Pulmonary arterial hypertension in pediatric patients with hematopoietic stem cell transplant-associated thrombotic microangiopathy. Biol Blood Marrow Transplant. 2013 Feb;19(2):202-7.

Chima RS, Daniels RC, Kim MO, Li D, Wheeler DS, Davies SM, Jodele S. Improved outcomes for Stem Cell Transplant Recipients Requiring Pediatric Intensive Care. Ped Crit Care Med. 2012 Nov. 13 (6):e336-42.

Raake J, Johnson B, Seger B, Manning PB, Eghtesady P, Boesch P, Rutter M, Woodard A, Chima RS. Tracheal Dehiscence following Slide Tracheoplasty: Use of ECMO, Prolonged Extubation and Lung Recruitment Maneuvers to Optimize Patient Outcomes. Respir Care. 2011 Aug;56(8):1198-202.

Grants

Heart and Lung Failure-Pediatric Insulin Titration Trial. Site Principal Investigator. National Institutes of Health (NIH), National Heart, Lung and Blood Institute (NHLBI). 2012-present.

Coagulation and Fibrinolysis in Pediatric Insulin Titration Trial (CAF-PINT). Site Principal Investigator. National Institutes of Health (NIH), National Heart, Lung and Blood Institute (NHLBI). 2014-present.

Approaches and Decisions in Acute Pediatric TBI Trial (ADAPT). Site Principal Investigator. National Institutes of Health (NIH) / National Institute of Neurological Disorders and Stroke. 2013-present.

Life After Pediatric Sepsis (LAPSE). Site Principal Investigator. National Institutes of Health (NIH) / National Institute of Child Health and Human Development (NICHD). 2015-present.

Maya Dewan, MD, MPH Attending Physician, Division of Critical Care Medicine

513-636-4259 maya.dewan@cchmc.org

Lesley A. Doughty, MD Physician, Division of Critical Care Medicine

is a clinician scientist whose basic science research program focuses on the molecular mechanisms underlying the inflammatory synergy observed during viral and bacterial co-infection. Specific areas of focus include the impact of influenza and antiviral cytokines on TLR signaling.

513-636-4259 lesley.doughty@cchmc.org

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Lesley A. Doughty, MD

Physician, Division of Critical Care Medicine

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-4259

Fax 513-636-4267

Email lesley.doughty@cchmc.org

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Clinical Interests

Sepsis; multiple organ failure; viral immunomodulation

MD: Dartmouth Medical School.

Residency: Tripler Army Medical Center.

Fellowship: Children's Hospital of Pittsburgh.

Goodman DM, Winkler MK, Fiser RT, Abd-Allah S, Mathur M, Rivero N, Weiss IK, Peterson B, Cornfield DN, Mink R, Nozik Grayck E, McCabe ME, Schuette J, Nares MA, Totapally B, Petrillo-Albarano T, Wolfson RK, Moreland JG, Potter KE, Fackler J, Garber N, Burns JP, Shanley TP, Lieh-Lai MW, Steiner M, Tieves KS, Goldsmith M, Asuncion A, Ross SL, Howell JD, Biagas K, Ognibene K, Joshi P, Rubenstein JS, Kocis KC, Cheifetz IM, Turner DA, Doughty L, Hall MW, Mason K, Penfil S, Morrison W, Hoehn KS, Watson RS, Garcia RL, Storgion SA, Fleming GM, Castillo L, Tcharmtchi MH, Taylor RP, Ul Haque I, Crain N, Baden HP, Lee KJ. The Accreditation Council for Graduate Medical Education proposed work hour regulations. Pediatr Crit Care Med. 2011 Jan;12(1):120-121.

Giuliano JS Jr, Lahni PM, Harmon K, Wong HR, Doughty LA, Carcillo JA, Zingarelli B, Sukhatme VP, Parikh SM, Wheeler DS. Admission angiopoietin levels in children with septic shock. Shock. 2007 Dec;28(6):650-654.

Wheeler DS, Lahni P, Odoms K, Jacobs BR, Carcillo JA, Doughty LA, Wong HR. Extracellular heat shock protein 60 (Hsp60) levels in children with septic shock. Inflamm Res. 2007 May;56(5):216-9.

Han YY, Doughty LA, Kofos D, Sasser H, Carcillo JA. Persistently Increased Procalcitonin Is Associated with Poor Outcome among Children with Bacterial Sepsis. Crit Care Med. 2003;4:21-25.

Ayala A, Chung CS, Lomas J, Song GY, Doughty LA, Gregory SH, Cioffi WG, LeBlanc BW, Reichner J, Simms HH, Grutkoski P. Shock Induced Neutrophil Mediated Priming for Acute Lung Injury in Mice: Divergent Effects of TLR 4 and TLR 4 / FasL Deficiency. AJP. 2003;161:2283-2294.

Lomas JL, Chung CS, Grutkoski pS, LeBlanc BW, Lavigne L, Reichner J, Gregory SH, Doughty LA, Cioffi WG, Ayala A. Differential Effects of MIP-2 and KC on Hemorrhage Induced Neutrophil Priming for Lung Inflammation: Assessment by Adoptive Cells. Shock. 2003;19(4):358-365.

Carcillo JA, Doughty L, Kofos D, Frye RF, Kaplan SS, Sasser H, Burckart GJ. Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure. Intensive Care Medicine. 2003;29:980-984.

Durbin J, Doughty L, Nguyen K, Caliguri M, Van Deusen J, Biron C. The role of STAT1 in viral sensitization to LPS. J Endotoxin Res. 2003;9:313-316.

Doughty LA. Modulation of the immune response in critical illness / injury. Immunology and Infectious Disease. Eds. Doughty L. and Linden P. Kluwer Academic Publishers, Norwell, MA, 2003.

Jennifer M. Kaplan, MD, MS

Jennifer M. Kaplan, MD, MS, is an attending physician in the PICU who has basic and translational research programs. Her laboratory focuses on understanding the inflammatory responses in sepsis, with a specific interest in the role of the nuclear receptor PPAR gamma. Dr. Kaplan is conducting a Phase 1 clinical trial to evaluate the pharmacokinetic characteristics, safety profile, and effect on inflammatory markers of pioglitazone in patients with severe sepsis and septic shock. Pioglitazone belongs to a class of drugs called thiazolidinediones (TZDs), which are commonly used in patients with type 2 diabetes and ligands for PPAR gamma. Her laboratory also focuses on the increased susceptibility of diet-induced obesity to sepsis. She focuses on the critical links between the inflammatory pathways in sepsis and obesity.
Visit the Kaplan Lab.

513-636-4259 jennifer.kaplan@cchmc.org

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Jennifer M. Kaplan, MD, MS

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-4259

Email jennifer.kaplan@cchmc.org

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Intensive care; respiratory failure; multi-organ failure; sepsis; trauma; inflammation; obesity; PPARg

Visit the Kaplan Lab.

Biography

Dr. Kaplan's long-term career goal is to improve the outcomes of critically ill children. She began her research career in fellowship studying sepsis, driven by the realization that there are few clinical therapies that improve outcomes in critically ill children with severe infections. She focused on the nuclear receptor PPARg as a potential target to alter the sepsis-induced inflammatory state. PPARg is a nuclear receptor with effects on lipid and glucose metabolism, atherosclerosis and inflammation. She elected to extend her fellowship a fourth year to complete training in molecular epidemiology and the Master of Science program at the University of Cincinnati Academic Health Center. She received grant funding from the Translational Research Initiative and the NIH K12 Child Health Research Career Development Award at Cincinnati Children's to investigate the alteration of PPARg in peripheral blood cells from children with sepsis. she is a recipient of an NIH Mentored Clinical Scientist Research Career Development Award (K08).

MS: Epidemiology, University of Cincinnati College of Medicine, Cincinnati, OH.

MD: University of Cincinnati, Cincinnati, OH, 1999.

BA: Washington University in St. Louis, St. Louis, Missouri.

Fellowship: Pediatric Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Residency: Pediatrics, Orlando Regional Healthcare, Orlando, FL.

Certification: Pediatric Critical Care Medicine, Pediatrics.

Wong HR, Cvijanovich N, Allen G, Thomas N, Freishtat R, Anas N, Meyer K, Checchia P, Lin R, Shanley T, Bigham M, Wheeler DS, Doughty LA Tegtmeyer K, Poynter SE, Kaplan JM, Chima RS, Stalets E, Basu RK, Varisco B, Barr F. Validation of a gene expression-based subclassification strategy for pediatric septic shock. Crit Care Med. 2011 Nov;39(11):2511-7.

Kaplan JM, Zingarelli B. Novel therapeutic agents in pediatric sepsis: peroxisome proliferator receptor g (PPARg). The Open Inflammation Journal. 2011; 4:117-121.

Kaplan JM, Wong HR. Biomarker discovery and development in pediatric critical care medicine. Pediatr Crit Care Med. 2011; 12: 165-173.

Sherwin CMT, Ding L, Kaplan J, Spigarelli MG, Vinks AA. Optimal design for a single dose, sparse sampling, pharmacokinetic study in pediatrics subpopulations: A proposed study of pioglitazone in septic pediatric patients.Journal of Pharmacokinetics and Pharmacodynamics. 2011; 38:433-447.

Kaplan JM, Hake P, Denenberg A, Nowell M, Piraino G, Zingarelli B. Phosphorylation of Extracellular Signal-Regulated Kinase (ERK)-1/2 is Associated with the Downregulation of Peroxisome Proliferator Activated Receptor (PPAR)-g During Polymicrobial Sepsis. Mol Med. 2010 Nov-Dec; 16(11-12): 491-7.

Kaplan JM, Denenberg A, Monaco M, Nowell M, Wong H, Zingarelli B. Changes in Peroxisome Proliferator Activated Receptor-gamma Activity in Children with Septic Shock. Intensive Care Med. 2010 Jan; 36(1): 123-130.

Kaplan JM, O’Connor M, Zingarelli B. Peroxisome Proliferator Activated Receptor-g is Required for the Inhibitory Effect of Ciglitazone but not 15-Deoxy-Δ^12,14-Prostaglandin J₂ on the NF-kB Pathway in Human Endothelial Cells. Shock. 2007 Dec; 28(6): 722-726.

Kaplan JM, Ancheta R, Jacobs BR. Inpatient Verbal Orders and the Impact of Computerized Provider Order Entry. J Pediatr. 2006 Oct; 149(4): 461-467.

Kaplan JM, Cook JA, Hake PW, O’Connor M, Burroughs TJ, Zingarelli B. 15-Deoxy-Δ^12,14-Prostaglandin J₂ (15d-PGJ₂), A Peroxisome Proliferator Activated Receptor-g Ligand, Reduces Tissue Leukosequestration and Mortality in Endotoxic Shock. Shock. 2005 July; 24(1): 59-65.

Kaplan J, O’Connor M, Hake PW, Zingarelli B. Inhibitors of Poly (ADP-Ribose) Polymerase Ameliorate Myocardial Reperfusion Injury by Modulation of Activator Protein-1 and Neutrophil Infiltration. Shock. 2005 Mar; 23(3):233-238.

Andrew J. Lautz, MD Physician, Division of Critical Care Medicine

Andrew J. Lautz, MD, studies myocardial dysfunction in pediatric critical illness, with a specific interest in alterations in mitochondrial biology. Current areas of focus include septic shock and cardiac arrest.

513-636-4259 andrew.lautz@cchmc.org

Sue E. Poynter, MD, MEd Director, Pediatric Residency Training Program

Sue E. Poynter, MD, MEd, is a co-director of the Pediatric Residency Training Program with an interest in medical education, curriculum development and educational research.

513-636-4906 sue.poynter@cchmc.org

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Sue E. Poynter, MD, MEd

Director, Pediatric Residency Training Program

Medical Director, Division of Respiratory Care

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-4906

Fax 513-636-4259

Email sue.poynter@cchmc.org

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Clinical Interests

Graduate medical education; acute lung injury/ARDS

MD: Indiana University School of Medicine, Indianapolis, IN, 1997.

Residency/Chief Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2001.

Fellowship: Critical Care, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2004.

Certification: General Pediatrics, Pediatric Critical Care.

MEd: University of Cincinnati, Cincinnati, OH, 2014.

Narayan AP, McPhillips HA, Anderson MS, Gardner L, Larrabee J, Poynter S, Mann KJ, Spector ND. Strengthening the associate program director workforce: needs assessment and recommendations. Acad Pediatr. 2014 Jul-Aug;14(4):332-4.

Schumacher DJ, Spector ND, Calaman S, West DC, Cruz M, Frohna JG, Gonzalez Del Rey J, Gustafson KK, Poynter SE, Rosenbluth G, Southgate WM, Vinci RJ, Sectish TC. Putting the Pediatrics Milestones Into Practice: A Consensus Roadmap and Resource Analysis. Pediatrics. 2014 May;133(5):898:906.

Willson DF, Thomas NJ, Tamburro R, Truemper E, Truwit J, Conaway M, Traul C, Egan EE; Pediatric Acute Lung and Sepsis Investigators Network. The relationship of fluid administration to outcome in the pediatric calfactant in acute respiratory distress syndrome trial. Pediatr Crit Care Med. 2013 Sep;14(7):666-72.

Willson DF, Thomas NJ, Tamburro R, Truemper E, Truwit J, Conaway M, Traul C, Egan EE; Pediatric Acute Lung and Sepsis Investigators Network. Pediatric calfactant in acute respiratory distress syndrome trial. Pediatr Crit Care Med. 2013 Sep;14(7):657-65.

Wong HR, Cvijanovich NZ, Allen GL, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Checchia PA, Lin R, Shanley TP, Bigham MT, Wheeler DS, Doughty LA, Tegtmeyer K, Poynter SE, Kaplan JM, Chima RS, Stalets E, Basu RK, Varisco BM, Barr FE. Validation of a gene expression-based subclassification strategy for pediatric septic shock. Crit Care Med. 2011 Nov;39(11):2511-7.

Wheeler DS, Dunsmore KE, Denenberg AG, Muething L, Poynter SE, Wong HR. Biological activity of truncated C-terminus human heat shock protein 72. Immunol Lett. 2011 Mar 30;135(1-2):173-9.

Carley L. Riley, MD, MPP, MHS, FAAP Attending Physician, Division of Critical Care Medicine

Carley L. Riley, MD, MPP, MHS, FAAP, aims to generate actionable knowledge to inform multi-sector interventions to foster creation of high well-being populations. She aims to encourage a paradigm shift in how health and heath creation are viewed, with research in healthcare and non-healthcare investments in health, including social determinants of health as a central feature, with projects from the PICU to the community.

513-636-4259 carley.riley@cchmc.org

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Carley L. Riley, MD, MPP, MHS, FAAP

Attending Physician, Division of Critical Care Medicine

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4259

Email carley.riley@cchmc.org

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Clinical

Pediatric critical care

Research

Well-being; population health; community health; community-based research; multi-sector research; health services research; social determinants of health; violence

Biography

Carley Riley, MD, MPP, MHS, is an assistant professor in the Department of Pediatrics, Division of Critical Care Medicine at Cincinnati Children's Hospital Medical Center within the University of Cincinnati College of Medicine. Dr. Riley received a Bachelor of Arts in English literature and a medical doctorate from Northwestern University, a Master of Public Policy from UCLA, and a Master of Health Science from Yale University. She completed General Pediatric Residency and Chief Residency at Children’s Hospital Los Angeles and pediatric critical care fellowship at Cincinnati Children’s Hospital Medical Center. Dr. Riley was a scholar with the Robert Wood Johnson Foundation Clinical Scholars Program at Yale University from 2013 to 2015.

Dr. Riley is actively involved in multiple national endeavors and organizations. She is a lead investigator within the Well-being Research Team, an academic-industry research collaboration between Yale University Center on Outcomes Research and Evaluation and Healthways, Inc. Within the Institute for Healthcare Improvement, Dr. Riley is currently a member of the 100 Million Healthier Lives Metrics Hub as well as a 100 Million Healthier Lives Measurement Advisor. In her work with the American Academy of Pediatrics (AAP), she serves as chair of the AAP Section on Critical Care Subcommittee on Member Engagement and Mentorship as well as a member of the AAP Measurement Alignment and Strategic Selection (MASS) Work Group. Dr. Riley is also a member of the Society of Critical Care Medicine (SCCM) Impact of Violent Injuries in the ICU Task Force. Locally, Dr. Riley serves on the Cincinnati Children’s Hospital Medical Center World Sepsis Day Committee.

MHS: Yale University, School of Medicine, New Haven, CT, 2015.

Scholar: Robert Wood Johnson Foundation Clinical Scholars Program, Yale University, New Haven, CT, 2013-2015.

Clinical Fellow: Division of Critical Care Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2010-2013.

Chief Resident: Department of General Pediatrics, Children’s Hospital Los Angeles, Los Angeles, CA, 2009-2010.

Resident: Department of General Pediatrics, Children’s Hospital Los Angeles, Los Angeles, CA, 2007-2009.

MPP: UCLA, School of Public Affairs, Los Angeles, CA, 2008.

Intern: Department of General Pediatrics, Children’s Hospital Los Angeles, Los Angeles, CA, 2006-2007.

MD: Northwestern University, Feinberg School of Medicine, Chicago, IL, 2004.

BA: English Literature, Northwestern University, College of Arts & Sciences, Evanston, IL, 1998.

Certifications: Pediatric Critical Care, American Board of Pediatrics, November 2014; General Pediatrics, American Board of Pediatrics, October 2009; Pediatric Advanced Life Support, May 2015.

Riley C, Sarani B, Sullivan JA, Upperman JS, Kane-Gill SL, Bailey H. Critical violent injury in the United States: A review and call to action. Critical Care Medicine. 2015.

Radabaugh CL, Ruch-Ross HS, Riley CL, Stockwell JA, Conway EE, Mink RB, Agus MS, Poss WB, Salerno RA, Vernon DD. Practice patterns in pediatric critical care medicine: results of a workforce survey. Pediatric Critical Care Medicine. 2015 Jul 1.

Riley C, Poss WB, Wheeler DS. The evolving model of pediatric critical care delivery in North America. Pediatric Clinics of North America. 2013 Jun;60(3):545-62.

Riley C, Wheeler DS. Prevention of sepsis in children: a new paradigm for public policy. Critical Care Research and Practice. 2012;2012:437139.

Riley C, Basu RK, Kissoon N, Wheeler DS. Pediatric sepsis: preparing for the future against a global scourge. Current Infectious Disease Reports. 2012 Oct;14(5):503-11.

Steve Standage, MD Attending Physician, Division of Critical Care Medicine

Steve Standage, MD, investigates the molecular underpinnings of organ system failure in sepsis with a goal to elucidate targetable mechanisms with therapeutic potential. His laboratory currently focuses on understanding and manipulating metabolic and functional changes in the heart in sepsis.

513-803-7685 steve.standage@cchmc.org

Ken Tegtmeyer, MD

Ken Tegtmeyer, MD, develops multimedia medical education tools involving video as well as 2- and 3D animations to enhance medical education. Dr. Tegtmeyer is also interested in resuscitation and is in charge of the code and MRT processes.

513-636-4259 ken.tegtmeyer@cchmc.org

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Ken Tegtmeyer, MD

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-4259

Fax 513-636-4267

Email ken.tegtmeyer@cchmc.org

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Clinical

Shock; sepsis; respiratory failure; head trauma; mechanical ventilation

Research

Multimedia medical education

MD: University of Minnesota, Twin Cities, 1992.

Residency: Pediatrics, University of Minnesota, 1995.

Fellowship: Pediatric Critical Care, 1998.

Certification: Pediatrics, 1996; Pediatric Critical Care, 2000, 2007.

Malempati S, Joshi S, Lai S, Braner DA, Tegtmeyer K. Videos in clinical medicine. Bone marrow aspiration and biopsy. N Engl J Med. 2009 Oct 8;361(15):e28.

Anderson J, Leonard D, Braner DA, Lai S, Tegtmeyer K. Videos in clinical medicine. Umbilical vascular catheterization. N Engl J Med. 2008 Oct 9;359(15):e18.

Braner DA, Lai S, Eman S, Tegtmeyer K. Videos in clinical medicine. Central venous catheterization -- subclavian vein. N Engl J Med. 2007 Dec 13;357(24):e26.

Edelman A, Anderson J, Lai S, Braner DA, Tegtmeyer K. Videos in clinical medicine: Pelvic examination. N Engl J Med. 2007 Jun 28; 356(26):e26.

Graham AS, Ozment C, Tegtmeyer K, Lai S, Braner DA. Videos in clinical medicine: Central venous catheterization. N Engl J Med. 2007 May 24; 356(21):e21.

Ellenby MS, Tegtmeyer K, Lai S, Braner DA. Videos in clinical medicine. Lumbar puncture. N Engl J Med. 2006 Sep 28;355(13):e12.

Tegtmeyer K, Brady G, Lai S, Hodo R, Braner D. Videos in Clinical Medicine. Placement of an arterial line. N Engl J Med. 2006 Apr 13;354(15):e13.

Cornfield DN, Tegtmeyer K, Nelson MD, Milla CE, Sweeney M. Continuous propofol infusion in 142 critically ill children. Pediatrics. 2002 Dec;110(6):1177-81.

Tegtmeyer K, Ibsen L, Goldstein B. Computer-assisted learning in critical care: from ENIAC to HAL. Crit Care Med. 2001 Aug;29(8 Suppl):N177-82.

Brian M. Varisco, MD Clinician Researcher, Division of Critical Care Medicine

Brian M. Varisco, MD, investigates the stretch-dependent mechanisms of lung development, injury, repair, and regeneration.
Visit the Varisco Lab.

513-803-2485 brian.varisco@cchmc.org

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Brian M. Varisco, MD

Clinician Researcher, Division of Critical Care Medicine

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-803-2485

Email brian.varisco@cchmc.org

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Lung development; lung fibroblast biology; chronic lung disease / bronchopulmonary dysplasia.

Visit the Varisco Lab.

MD: Medical College of Georgia, Augusta, GA, 2004.

Residency: Pediatrics, The Children's Hospital, Denver, CO.

Fellowship: Pediatrics, The Children's Hospital, Denver, CO.

Certification: Pediatrics, 2008; Pediatric Critical Care Medicine, 2011.

Joshi R, Heinz A, Fan Q, Guo S, Monia B, Schmelzer CE, Weiss A, Batie M, Parameshwaran H, Varisco BM. Role for Cela1 in Postnatal Lung Remodeling and AAT-Deficient Emphysema. American Journal of Respiratory Cell and Molecular Biology. 2018.

Varisco BM, Sbragia L, Chen J, Scorletti F, Joshi R, Wong HR, Lobes-Figueira R, Oria M, Peiro J. Excessive Reversal of Epidermal Growth Factor Receptor and Ephrin Signaling Following Tracheal Occlusion in Rabbit Model of Congenital Diaphragmatic Hernia. Molecular Medicine. 2016 Jul 19;22.

Joshi R, Liu S, Brown MD, Young SM, Batie M, Kofron JM, Xu Y, Weaver TE, Apsley K, Varisco BM. Stretch Regulates Expression and binding of Chymotrypsin-like Elastase 1 in the Postnatal Lung. FASEB Journal. 2016 Feb;30(2):590-600.

Young SM, Liu S, Joshi R, Batie M, Kofron M, Jinbang G, Woods J, Varisco BM. Localization and Stretch-Dependence of Lung Elastase Activity in Development and Compensatory Growth. Journal of Applied Physiology (1985). 2015 Apr;118(7):921-31.

Liu S, Cimprich J, Varisco BM. Mouse Pneumonectomy Model of Compensatory Lung Growth. Journal of Visualized Experiments. 2014 Dec 17;(94).

Chamberlain A, Varisco BM. The Pharmacology of Acute Respiratory Distress Syndrome. Clinical Pharmacy and Biopharmaceutics. 2014.

Liu S, Young SM, Varisco BM. Dynamic Expression of Chymotrypsin Like Elastase-1 Over the Course of Lung Development. American Journal of Lung Cell and Molecular Physiology. 2014 Jun 15;306(12):L1104-16.

Liu S, Parameswaran H, Young SM, Varisco BM. JNK Suppresses Pulmonary Fibroblast Elastogenesis During Alveolar Development. Respiratory Research. 2014 Mar 25;15:34.

Cornett B, Snowball J, Varisco BM, Lang R, Whitsett J, Sinner D. Wntless Is Required for Peripheral Lung Differentiation And Pulmonary Vascular Development. Developmental Biology. 2013 Jul 1;379(1):38-52.

Varisco BM, Ambalavanan N, Whitsett JA, Hagood JS. Thy-1 Signals through PPARγ to Promote Lipofibroblast Differentiation in the Developing Lung. Am J Resp Cell Mol Biol. 2012 Jun;46(6):765-72.

Derek S. Wheeler, MD, MMM, MBA Chief of Staff

Derek S. Wheeler, MD, MMM, MBA, is a pediatric intensivist who has translational and clinical research interests in the fields of pediatric sepsis and shock. He is also the associate chief of staff. Additional research interests include hospital-acquired infection, quality improvement and patient safety.

513-803-1422 derek.wheeler@cchmc.org

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Derek S. Wheeler, MD, MMM, MBA

Chief of Staff

Associate Chair, Clinical Affairs

Member, Division of Critical Care Medicine

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-803-1422

Fax 513-636-0333

Email derek.wheeler@cchmc.org

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Quality improvement and patient safety; high reliability organizations; sepsis and acute kidney injury.

MD: Indiana University School of Medicine, Indianapolis, IN, 1994.

Intern: Department of Pediatrics, Naval Medical Center, San Diego, CA, 1994-1995.

Residency: Department of Pediatrics, Naval Medical Center, San Diego, CA, 1995-1997.

Fellowship: Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2000-2003.

Certification: Diplomate, National Board of Medical Examiners, 1995; Diplomate, American Board of Pediatrics, 1997, 2004; Diplomate, American Board of Pediatrics: Sub-Board of Pediatric Critical Care Medicine, 2004.

Masters of Medical Management: Carnegie Mellon University, Pittsburgh, PA, 2013.

MBA: Carl H. Lindner College of Business at the University of Cincinnati, with Post-Graduate Certificate in Health Care Finance, Cincinnati, OH, 2016.

Wheeler DS, Dunsmore KE, Denenberg AG, Muething L, Poynter SE, Wong HR. Biological activity of truncated C-terminus human heat shock protein 72. Immunol Lett. 2011 Mar 30;135(1-2):173-9

Mack EH, Wheeler DS, Hirsch R. Endovascular treatment of near-fatal neonatal superior vena cava syndrome. Pediatr Crit Care Med. 2010 Nov 24.

Basu RK, Devarajan P, Wong H, Wheeler DS. An update and review of acute kidney injury in pediatrics. Pediatr Crit Care Med. 2010 Nov 4.

Istaphanous GK, Wheeler DS, Lisco SJ, Shander A. Red blood cell transfusion in critically ill children: A narrative review. Pediatr Crit Care Med. 2010 May 6.

Nowak JE, Wheeler DS, Harmon KK, Wong HR. Admission chemokine (C-C motif) ligand 4 levels predict survival in pediatric septic shock. Pediatr Crit Care Med. 2010 Mar;11(2):213-6.

Klein JA, Nowak JE, Sutherell JS, Wheeler DS. Nonsurgical management of cardiac missiles. Pediatr Emerg Care. 2010 Jan;26(1):36-8.

Wheeler DS, Chase MA, Senft AP, Poynter SE, Wong HR, Page K. Extracellular Hsp72, an endogenous DAMP, is released by virally infected airway epithelial cells and activates neutrophils via Toll-like receptor (TLR)-4. Respir Res. 2009 Apr 30;10:31.

Wheeler DS. Death to sepsis: targeting apoptosis pathways in sepsis. Crit Care. 2009;13(6):1010.

Mack EH, Wheeler DS, Embi PJ. Clinical decision support systems in the pediatric intensive care unit. Pediatr Crit Care Med. 2009 Jan;10(1):23-8. Review.

Basilia Zingarelli, MD, PhD Director, Basic Science Research

Basilia Zingarelli, MD, PhD, focuses on molecular mechanisms of organ injury during sepsis, trauma and hemorrhage. Her research also involves the identification of age-dependent pathological mechanisms, with special focus on anti-inflammatory nuclear receptors, whose activation may have a clinical therapeutic application in the treatment of critically ill patients.
Visit the Zingarelli Lab.

513-636-8704 basilia.zingarelli@cchmc.org

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Basilia Zingarelli, MD, PhD

Director, Basic Science Research

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-8704

Email basilia.zingarelli@cchmc.org

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Sepsis; trauma; hemorrhagic shock and ischemia and reperfusion injury.
Visit the Zingarelli Lab.

Biography

Basilia Zingarelli, MD, PhD, came to Cincinnati Children's Hospital Medical Center in 1995 as a post-doctoral research fellow in Critical Care Medicine. She joined the faculty of the University of Cincinnati College of Medicine in 1997.

Dr. Zingarelli graduated from the Medical School of the University of Messina in Italy in 1990. She also obtained a doctorate in experimental medicine in 1997 and attended a residency in medical toxicology at the University of Messina from 1990 to 1992.

Dr. Zingarelli now directs the basic science research in the Division of Critical Care Medicine. She directs an NIH-funded research laboratory focused on the pathogenetic mechanisms of organ injury during sepsis, trauma and hemorrhage and coordinates basic science and clinical translational research projects related to other critical care conditions.

Dr. Zingarelli serves on the Executive Council of the Shock Society, a well-established international association of clinical and research scientists in the field of shock and trauma, and serves as associate editor for the journal Shock. She also serves as permanent and ad hoc member on a number of study sections at the National Institutes of Health.

MD: School of Medicine, University of Messina, Italy, 1990.

PhD: Experimental Medicine, School of Medicine, University of Messina, Italy, 1997.

Residency: Medical Toxicology, School of Medicine, University of Messina, Italy, 1990-1992.

Certification: General Medicine (Italian), 1990.