Kopan Lab

Mukherjeel, M; Ratnayake, I; Janga, M; Fogarty, E; Scheidt, S; Grassmeyer, J; DeRiso, J; Chandrasekar, I; Ahrenkiel, SP; Kopan, R; et al. Notch signaling regulates Akap12 expression and primary cilia length during renal tubule morphogenesis. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020; 34:9512-9530.

Kuang, Y; Golan, O; Preusse, K; Cain, B; Christensen, CJ; Salomone, J; Campbell, I; Okwubido-Williams, FV; Hass, MR; Yuan, Z; et al. Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism. eLife. 2020; 9.

Seymour, PA; Collin, CA; Egeskov-Madsen, AL R; Jorgensen, MC; Shimojo, H; Imayoshi, I; de Lichtenberg, KH; Kopan, R; Kageyama, R; Serup, P. Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors. Developmental Cell. 2020; 52:731-747.e8.

Volovelsky, O; Nguyen, T; Jarmas, AE; Combes, AN; Wilson, SB; Little, MH; Witte, DP; Brunskill, EW; Kopan, R. Hamartin regulates cessation of mouse nephrogenesis independently of Mtor. Proceedings of the National Academy of Sciences of USA. 2018; 115:5998-6003.

Farber, G; Hurtado, R; Loh, S; Monette, S; Mtui, J; Kopan, R; Quaggin, S; Meyer-Schwesinger, C; Herzlinger, D; Scott, RP; et al. Glomerular endothelial cell maturation depends on ADAM10, a key regulator of Notch signaling. Angiogenesis. 2018; 21:335-347.

Combes, AN; Wilson, S; Phipson, B; Binnie, BB; Ju, A; Lawlor, KT; Cebrian, C; Walton, SL; Smyth, IM; Moritz, KM; et al. Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number. Kidney International. 2018; 93:589-598.

Lander, JM; Supp, DM; He, H; Martin, LJ; Chen, X; Weirauch, MT; Boyce, ST; Kopan, R. Analysis of chromatin accessibility in human epidermis identifies putative barrier dysfunction-sensing enhancers. PLoS ONE. 2017; 12:e0184500-e0184500.

Kovall, RA; Gebelein, B; Sprinzak, D; Kopan, R. The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force. Developmental Cell. 2017; 41:228-241.

Cunningham, TJ; Tabacchi, M; Eliane, J; Tuchayi, SM; Manivasagam, S; Mirzaalian, H; Turkoz, A; Kopan, R; Schaffer, A; Saavedra, AP; et al. Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy. Journal of Clinical Investigation. 2017; 127:106-116.

Volovelsky, O; Kopan, R. Making new kidneys: On the road from science fiction to science fact. Current Opinion in Organ Transplantation. 2016; 21:574-580.

Turkoz, M; Townsend, RR; Kopan, R. The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development. Journal of Investigative Dermatology. 2016; 136:1106-1115.

Hayashi, Y; Nishimune, H; Hozumi, K; Saga, Y; Harada, A; Yuzaki, M; Iwatsubo, T; Kopan, R; Tomita, T. A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons. Scientific Reports. 2016; 6.