Publications

Duvall, K; Crist, L; Perl, AJ; Pode Shakked, N; Chaturvedi, P; Kopan, R. Revisiting the role of Notch in nephron segmentation confirms a role for proximal fate selection during mouse and human nephrogenesis. Development (Cambridge). 2022; 149.

Murrison, LB; Ren, X; Preusse, K; He, H; Kroner, J; Chen, X; Jenkins, S; Johansson, E; Biagini, JM; Weirauch, MT; et al. TSLP disease-associated genetic variants combined with airway TSLP expression influence asthma risk. Journal of Allergy and Clinical Immunology. 2022; 149:79-88.

Jarmas, AE; Brunskill, EW; Chaturvedi, P; Salomonis, N; Kopan, R. Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis. Nature Communications. 2021; 12.

Kuang, Y; Pyo, A; Eafergan, N; Cain, B; Gutzwiller, LM; Axelrod, O; Gagliani, EK; Weirauch, MT; Kopan, R; Kovall, RA; et al. Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor. PLoS Genetics. 2021; 17.

Makayes, Y; Resnick, E; Hinden, L; Aizenshtein, E; Shlomi, T; Kopan, R; Nechama, M; Volovelsky, O. Increasing mTORC1 Pathway Activity or Methionine Supplementation during Pregnancy Reverses the Negative Effect of Maternal Malnutrition on the Developing Kidney. Journal of the American Society of Nephrology : JASN. 2021; 32:1898-1912.

Hass, MR; Brissette, D; Parameswaran, S; Pujato, M; Donmez, O; Kottyan, LC; Weirauch, MT; Kopan, R. Runx1 shapes the chromatin landscape via a cascade of direct and indirect targets. PLoS Genetics. 2021; 17.

Schuh, MP; Alkhudairy, L; Potter, A; Potter, SS; Chetal, K; Thakkar, K; Salomonis, N; Kopan, R. The Rhesus Macaque Serves As a Model for Human Lateral Branch Nephrogenesis. Journal of the American Society of Nephrology : JASN. 2021; 32:1097-1112.

Kobia, FM; Preusse, K; Dai, Q; Weaver, N; Hass, MR; Chaturvedi, P; Stein, SJ; Pear, WS; Yuan, Z; Kovall, RA; et al. Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation. PLoS Biology. 2020; 18.

Mukherjeel, M; Ratnayake, I; Janga, M; Fogarty, E; Scheidt, S; Grassmeyer, J; DeRiso, J; Chandrasekar, I; Ahrenkiel, SP; Kopan, R; et al. Notch signaling regulates Akap12 expression and primary cilia length during renal tubule morphogenesis. FASEB Journal. 2020; 34:9512-9530.

Kuang, Y; Golan, O; Preusse, K; Cain, B; Christensen, CJ; Salomone, J; Campbell, I; Okwubido-Williams, FV; Hass, MR; Yuan, Z; et al. Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism. eLife. 2020; 9.

Seymour, PA; Collin, CA; Egeskov-Madsen, AL R; Jorgensen, MC; Shimojo, H; Imayoshi, I; de Lichtenberg, KH; Kopan, R; Kageyama, R; Serup, P. Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors. Developmental Cell. 2020; 52:731-747.e8.

Volovelsky, O; Nguyen, T; Jarmas, AE; Combes, AN; Wilson, SB; Little, MH; Witte, DP; Brunskill, EW; Kopan, R. Hamartin regulates cessation of mouse nephrogenesis independently of Mtor. Proceedings of the National Academy of Sciences of the United States of America. 2018; 115:5998-6003.

Farber, G; Hurtado, R; Loh, S; Monette, S; Mtui, J; Kopan, R; Quaggin, S; Meyer-Schwesinger, C; Herzlinger, D; Scott, RP; et al. Glomerular endothelial cell maturation depends on ADAM10, a key regulator of Notch signaling. Angiogenesis. 2018; 21:335-347.

Combes, AN; Wilson, S; Phipson, B; Binnie, BB; Ju, A; Lawlor, KT; Cebrian, C; Walton, SL; Smyth, IM; Moritz, KM; et al. Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number. Kidney International. 2018; 93:589-598.

Lander, JM; Supp, DM; He, H; Martin, LJ; Chen, X; Weirauch, MT; Boyce, ST; Kopan, R. Analysis of chromatin accessibility in human epidermis identifies putative barrier dysfunction-sensing enhancers. PLoS ONE. 2017; 12.

Contact Us

A photo of Raphael Kopan.

Raphael Kopan, PhD
William K. Schubert Professor of Pediatrics, University of Cincinnati College of Medicine

Director of the Division of Developmental Biology, Cincinnati Children's Hospital Medical Center

Mailing Address:
3333 Burnet Avenue, MLC 7029
Cincinnati, OH 45229-3039

Phone: 513-636-2090
Fax: 513-636-4317
Email: raphael.kopan@cchmc.org