Wells Lab

Publications

Múnera, JO; Kechele, DO; Bouffi, C; Qu, N; Jing, R; Maity, P; Enriquez, JR; Han, L; Campbell, I; Mahe, MM; et al. Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon. Cell Stem Cell. 2023; 30:1434-1451.e9.

Rosselot, AE; Park, M; Kim, M; Matsu-Ura, T; Wu, G; Flores, DE; Subramanian, KR; Lee, S; Sundaram, N; Broda, TR; et al. Ontogeny and function of the circadian clock in intestinal organoids. The EMBO Journal. 2022; 41:e106973.

Enriquez, JR; McCauley, HA; Zhang, KX; Sanchez, JG; Kalin, GT; Lang, RA; Wells, JM. A dietary change to a high-fat diet initiates a rapid adaptation of the intestine. Cell Reports. 2022; 41:111641.

Jurickova, I; Bonkowski, E; Angerman, E; Novak, E; Huron, A; Akers, G; Iwasawa, K; Braun, T; Hadar, R; Hooker, M; et al. Eicosatetraynoic Acid and Butyrate Regulate Human Intestinal Organoid Mitochondrial and Extracellular Matrix Pathways Implicated in Crohn's Disease Strictures. Inflammatory Bowel Diseases. 2022; 28:988-1003.

Sanchez, JG; Enriquez, JR; Wells, JM. Enteroendocrine cell differentiation and function in the intestine. Current Opinion in Endocrinology, Diabetes and Obesity. 2022; 29:169-176.

Eicher, AK; Kechele, DO; Sundaram, N; Berns, HM; Poling, HM; Haines, LE; Sanchez, JG; Kishimoto, K; Krishnamurthy, M; Han, L; et al. Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells. Cell Stem Cell. 2022; 29:36-51.e6.

Edwards, NA; Shacham-Silverberg, V; Weitz, L; Kingma, PS; Shen, Y; Wells, JM; Chung, WK; Zorn, AM. Developmental basis of trachea-esophageal birth defects. Developmental Biology. 2021; 477:85-97.

Trisno, SL; Higano, NS; Kechele, D; Nasr, T; Chung, W; Zorn, AM; Woods, JC; Wells, JM; Kingma, PS. Case Report: Esophageal Bronchus in a Neonate, With Image, Histological, and Molecular Analysis. Frontiers in Pediatrics. 2021; 9:707822.

Wells, JZ; Kumar, R; Kumar, M. (2021) Application of Interacting Multiple Model for Future State Prediction of Small Unmanned Aerial Systems. Institute of Electrical and Electronics Engineers (IEEE). 00:3755-3760.

Lewis, PL; Wells, JM. Engineering-inspired approaches to study β-cell function and diabetes. Stem Cells. 2021; 39:522-535.

Nasr, T; Holderbaum, AM; Chaturvedi, P; Agarwal, K; Kinney, JL; Daniels, K; Trisno, SL; Ustiyan, V; Shannon, JM; Wells, JM; et al. Disruption of a hedgehog-foxf1-rspo2 signaling axis leads to tracheomalacia and a loss of sox9+ tracheal chondrocytes. DMM Disease Models and Mechanisms. 2021; 14:dmm046573.

Kumar, R; Deshpande, AM; Wells, JZ; Kumar, M. (2021) Flight Control of Sliding Arm Quadcopter with Dynamic Structural Parameters. Institute of Electrical and Electronics Engineers (IEEE). 00:1358-1363.

Wells, JZ; Kumar, R; Kumar, M. (2021) Implementation of Multiple Model: Simulation and Experimentation for Future State Prediction on Different Classes of Small Unmanned Aerial Systems. American Institute of Aeronautics and Astronautics (AIAA). 1-15.

Lee, KK P; Matsu-Ura, T; Rosselot, AE; Broda, TR; Wells, JM; Hong, CI. An integrated microfluidic bubble pocket for long-term perfused three-dimensional intestine-on-a-chip model. Biomicrofluidics. 2021; 15:014110.

Kasendra, M; Wells, JM. A Window into Your Gut: Biologically Inspired Engineering of Mini-gut Tubes In Vitro. Developmental Cell. 2020; 55:522-524.

Han, L; Chaturvedi, P; Kishimoto, K; Koike, H; Nasr, T; Iwasawa, K; Giesbrecht, K; Witcher, PC; Eicher, A; Haines, L; et al. Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis. Nature Communications. 2020; 11:4158.

McCauley, HA; Matthis, AL; Enriquez, JR; Nichol, JT; Sanchez, JG; Stone, WJ; Sundaram, N; Helmrath, MA; Montrose, MH; Aihara, E; et al. Enteroendocrine cells couple nutrient sensing to nutrient absorption by regulating ion transport. Nature Communications. 2020; 11:4791.

Singh, A; Poling, HM; Spence, JR; Wells, JM; Helmrath, MA. Gastrointestinal organoids: a next-generation tool for modeling human development. American Journal of Physiology: Gastrointestinal and Liver Physiology. 2020; 319:G375-G381.

Singh, A; Poling, HM; Sundaram, N; Brown, N; Wells, JM; Helmrath, MA. Evaluation of transplantation sites for human intestinal organoids. Editor, Papaccio G. PloS one. 2020; 15:e0237885.

Nowrouzi, A; Sertorio, MG; Akbarpour, M; Knoll, M; Krunic, D; Kuhar, M; Schwager, C; Brons, S; Debus, J; Wells, SI; et al. Personalized Assessment of Normal Tissue Radiosensitivity via Transcriptome Response to Photon, Proton and Carbon Irradiation in Patient-Derived Human Intestinal Organoids. Cancers. 2020; 12:E469.

Pradhan, S; Karve, SS; Weiss, AA; Hawkins, J; Poling, HM; Helmrath, MA; Wells, JM; McCauley, HA. Tissue Responses to Shiga Toxin in Human Intestinal Organoids. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2020; 10:171-190.

Shacham-Silverberg, V; Wells, JM. Generation of esophageal organoids and organotypic raft cultures from human pluripotent stem cells. Methods in Cell Biology. : Elsevier; Elsevier; 2020.

Nasr, T; Mancini, P; Rankin, SA; Edwards, NA; Agricola, ZN; Kenny, AP; Kinney, JL; Daniels, K; Vardanyan, J; Han, L; et al. Endosome-Mediated Epithelial Remodeling Downstream of Hedgehog-Gli Is Required for Tracheoesophageal Separation. Developmental Cell. 2019; 51:665-674.e6.

Kechele, DO; Wells, JM. Recent advances in deriving human endodermal tissues from pluripotent stem cells. Current Opinion in Cell Biology. 2019; 61:92-100.

Lau, S; Li, Z; Lai, FP-L; Lui, KN-C; Li, P; Munera, JO; Pan, G; Mahe, MM; Hui, C; Wells, JM; et al. Activation of Hedgehog Signaling Promotes Development of Mouse and Human Enteric Neural Crest Cells, Based on Single-Cell Transcriptome Analyses. Gastroenterology. 2019; 157:1556-1571.e5.

Koike, H; Iwasawa, K; Ouchi, R; Maezawa, M; Giesbrecht, K; Saiki, N; Ferguson, A; Kimura, M; Thompson, WL; Wells, JM; et al. Modelling human hepato-biliary-pancreatic organogenesis from the foregut-midgut boundary. Nature. 2019; 574:112-116.

Ouchi, R; Togo, S; Kimura, M; Shinozawa, T; Koido, M; Koike, H; Thompson, W; Karns, RA; Mayhew, CN; McGrath, PS; et al. Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids. Cell Metabolism. 2019; 30:374-384.e6.

Zhang, X; McGrath, PS; Salomone, J; Rahal, M; McCauley, HA; Schweitzer, J; Kovall, R; Gebelein, B; Wells, JM. A Comprehensive Structure-Function Study of Neurogenin3 Disease-Causing Alleles during Human Pancreas and Intestinal Organoid Development. Developmental Cell. 2019; 50:367-380.e7.

Oz-Levi, D; Olender, T; Bar-Joseph, I; Zhu, Y; Marek-Yagel, D; Barozzi, I; Osterwalder, M; Alkelai, A; Ruzzo, EK; Han, Y; et al. Noncoding deletions reveal a gene that is critical for intestinal function. Nature. 2019; 571:107-111.

Harrington, KM; Nguyen, XT; Song, RJ; Hannagan, K; Quaden, R; Gagnon, DR; Cho, K; Deen, JE; Muralidhar, S; O'Leary, TJ; et al. Gender Differences in Demographic and Health Characteristics of the Million Veteran Program Cohort. Women's Health Issues. 2019; 29 Suppl 1:S56-S66.

Takebe, T; Wells, JM. Organoids by design. Science. 2019; 364:956-959.

Chakrabarti, J; Steele, N; Holokai, L; Broda, T; Biesiada, J; Pitstick, A; Mayhew, C; Medvedovic, M; Wells, J; Zavros, Y. Induction of CD44 Variant Isoforms is an Early Epithelial Response to Helicobacter pylori Infection. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019; 33:869.28.

Teal, EL; Li, J; Chakrabarti, JL; Broda, T; Steele, N; Rosselot, D; Sundaram, N; Hawkins, J; Hong, C; Helmrath, MA; et al. Expression of Circadian Clock Components PER2 and BMAL1 are Altered During Infection of Helicobacter pylori. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019; 33:869.29.

Liu, R; Moriggl, R; Zhang, D; Li, H; Karns, R; Ruan, H; Niu, H; Mayhew, C; Watson, C; Bangar, H; et al. Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control Clostridium difficile colitis. Life Science Alliance. 2019; 2:e201900296.