Publications

Eicher, AK; Kechele, DO; Sundaram, N; Berns, HM; Poling, HM; Haines, LE; Sanchez, JG; Kishimoto, K; Krishnamurthy, M; Han, L; et al. Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells. Cell Stem Cell. 2022; 29:36-51.e6.

Kasendra, M; Wells, JM. A Window into Your Gut: Biologically Inspired Engineering of Mini-gut Tubes In Vitro. Developmental Cell. 2020; 55:522-524.

McCauley, HA; Matthis, AL; Enriquez, JR; Nichol, JT; Sanchez, JG; Stone, WJ; Sundaram, N; Helmrath, MA; Montrose, MH; Aihara, E; et al. Enteroendocrine cells couple nutrient sensing to nutrient absorption by regulating ion transport. Nature Communications. 2020; 11.

Shacham-Silverberg, V; Wells, JM. Generation of esophageal organoids and organotypic raft cultures from human pluripotent stem cells. . 2020.

Pradhan, S; Karve, SS; Weiss, AA; Hawkins, J; Poling, HM; Helmrath, MA; Wells, JM; McCauley, HA. Tissue Responses to Shiga Toxin in Human Intestinal Organoids. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2020; 10:171-190.

Nowrouzi, A; Sertorio, MG; Akbarpour, M; Knoll, M; Krunic, D; Kuhar, M; Schwager, C; Brons, S; Debus, J; Wells, SI; et al. Personalized Assessment of Normal Tissue Radiosensitivity via Transcriptome Response to Photon, Proton and Carbon Irradiation in Patient-Derived Human Intestinal Organoids. Cancers. 2020; 12.

Nasr, T; Mancini, P; Rankin, SA; Edwards, NA; Agricola, ZN; Kenny, AP; Kinney, JL; Daniels, K; Vardanyan, J; Han, L; et al. Endosome-Mediated Epithelial Remodeling Downstream of Hedgehog-Gli Is Required for Tracheoesophageal Separation. Developmental Cell. 2019; 51:665-674.e6.

Kechele, DO; Wells, JM. Recent advances in deriving human endodermal tissues from pluripotent stem cells. Current Opinion in Cell Biology. 2019; 61:92-100.

Lau, S; Li, Z; Lai, FP-L; Lui, KN-C; Li, P; Munera, JO; Pan, G; Mahe, MM; Hui, C; Wells, JM; et al. Activation of Hedgehog Signaling Promotes Development of Mouse and Human Enteric Neural Crest Cells, Based on Single-Cell Transcriptome Analyses. Gastroenterology. 2019; 157:1556-1571.e5.

Koike, H; Iwasawa, K; Ouchi, R; Maezawa, M; Giesbrecht, K; Saiki, N; Ferguson, A; Kimura, M; Thompson, WL; Wells, JM; et al. Modelling human hepato-biliary-pancreatic organogenesis from the foregut-midgut boundary. Nature. 2019; 574:112-116.

Ouchi, R; Togo, S; Kimura, M; Shinozawa, T; Koido, M; Koike, H; Thompson, W; Karns, RA; Mayhew, CN; McGrath, PS; et al. Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids. Cell Metabolism. 2019; 30:374-384.e6.

Zhang, X; McGrath, PS; Salomone, J; Rahal, M; McCauley, HA; Schweitzer, J; Kovall, R; Gebelein, B; Wells, JM. A Comprehensive Structure-Function Study of Neurogenin3 Disease-Causing Alleles during Human Pancreas and Intestinal Organoid Development. Developmental Cell. 2019; 50:367-380.e7.

Oz-Levi, D; Olender, T; Bar-Joseph, I; Zhu, Y; Marek-Yagel, D; Barozzi, I; Osterwalder, M; Alkelai, A; Ruzzo, EK; Han, Y; et al. Noncoding deletions reveal a gene that is critical for intestinal function. Nature. 2019; 571:107-111.

Harrington, KM; Nguyen, XT; Song, RJ; Hannagan, K; Quaden, R; Gagnon, DR; Cho, K; Deen, JE; Muralidhar, S; O'Leary, TJ; et al. Gender Differences in Demographic and Health Characteristics of the Million Veteran Program Cohort. Women's Health Issues. 2019; 29 Suppl 1:S56-S66.

Takebe, T; Wells, JM. Organoids by design. Science. 2019; 364:956-959.

Liu, R; Moriggl, R; Zhang, D; Li, H; Karns, R; Ruan, H; Niu, H; Mayhew, C; Watson, C; Bangar, H; et al. Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control Clostridium difficile colitis. Life Science Alliance. 2019; 2.

Holokai, L; Chakrabarti, J; Broda, T; Chang, J; Hawkins, JA; Sundaram, N; Wroblewski, LE; Jr, PR M; Wang, J; Helmrath, M; et al. Increased Programmed Death-Ligand 1 is an Early Epithelial Cell Response to Helicobacter pylori Infection. PLoS Pathogens. 2019; 15.

Broda, TR; McCracken, KW; Wells, JM. Generation of human antral and fundic gastric organoids from pluripotent stem cells. Nature Protocols. 2019; 14:28-50.

Lee, KK; McCauley, HA; Broda, TR; Kofron, MJ; Wells, JM; Hong, CI. Human stomach-on-a-chip with luminal flow and peristaltic-like motility. Lab on a Chip - Miniaturisation for Chemistry and Biology. 2018; 18:3079-3085.

Trisno, SL; Philo, KE D; McCracken, KW; Cata, EM; Ruiz-Torres, S; Rankin, SA; Han, L; Nasr, T; Chaturvedi, P; Rothenberg, ME; et al. Esophageal Organoids from Human Pluripotent Stem Cells Delineate Sox2 Functions during Esophageal Specification. Cell Stem Cell. 2018; 23:501-515.e7.

Sinagoga, KL; McCauley, HA; Munera, JO; Reynolds, NA; Enriquez, JR; Watson, C; Yang, H; Helmrath, MA; Wells, JM. Deriving functional human enteroendocrine cells from pluripotent stem cells. Development (Cambridge). 2018; 145.

Poling, HM; Wu, D; Brown, N; Baker, M; Hausfeld, TA; Huynh, N; Chaffron, S; Dunn, JC Y; Hogan, SP; Wells, JM; et al. Mechanically induced development and maturation of human intestinal organoids in vivo. Nature Biomedical Engineering. 2018; 2:429-442.

Takebe, T; Wells, JM; Helmrath, MA; Zorn, AM. Organoid Center Strategies for Accelerating Clinical Translation. Cell Stem Cell. 2018; 22:806-809.

Wells, JM; Watt, FM. Diverse mechanisms for endogenous regeneration and repair in mammalian organs. Nature. 2018; 557:322-328.

Eicher, AK; Berns, HM; Wells, JM. Translating Developmental Principles to Generate Human Gastric Organoids. CMGH Cellular and Molecular Gastroenterology and Hepatology. 2018; 5:353-363.

Rankin, SA; McCracken, KW; Luedeke, DM; Han, L; Wells, JM; Shannon, JM; Zorn, AM. Timing is everything: Reiterative Wnt, BMP and RA signaling regulate developmental competence during endoderm organogenesis. Developmental Biology. 2018; 434:121-132.

Trisno, SL; Philo, KE D; McCracken, KW; Cata, EM; Rankin, SA; Han, L; Nasr, T; Chatuvedi, P; Mandegar, MA; Zorn, AM; et al. Generation of Esophageal Organoids from Human Pluripotent Stem Cells and Their Use to Study Human Development. 2018.

Munera, JO; Sundaram, N; Rankin, SA; Hill, D; Watson, C; Mahe, M; Vallance, JE; Shroyer, NF; Sinagoga, KL; Zarzoso-Lacoste, A; et al. Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling. Cell Stem Cell. 2017; 21:51-64.e6.

Sinagoga, KL; Stone, WJ; Schiesser, JV; Schweitzer, JI; Sampson, L; Zheng, Y; Wells, JM. Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets. Development (Cambridge). 2017; 144:2402-2414.