Endocrinology

Clinical

Pediatric endocrinology; diabetes mellitus

Research

Epidemiology of obesity; insulin resistance; abnormal carbohydrate metabolism; diabetes and their relationships to the development and progression of cardiovascular disease

Biography

Lawrence M. Dolan, MD, is board-certified in pediatrics and pediatric endocrinology. He has been on the faculty of Cincinnati Children's Hospital Medical Center within the Department of Pediatrics for the University of Cincinnati College of Medicine since 1983.

Dr. Dolan is a professor of pediatrics in the Division of Endocrinology within the UC College of Medicine. His research focuses on the epidemiology and genetics of obesity, insulin resistance, abnormal carbohydrate metabolism, diabetes and their relationships to the development and progression of cardiovascular disease.

Dr. Dolan received his Bachelor of Science degree from the University of San Francisco. He received his Doctor of Medicine degree from the University of California at Los Angeles.

Dr. Dolan completed his pediatric internship and residency at the University of Minnesota. He also served as chief resident. He obtained fellowship training in pediatric endocrinology at the University of Virginia.

BS: University of San Francisco, San Francisco, CA, 1971.

MD: University of California at Los Angeles, Los Angeles, CA, 1976.

Residency: University of Minnesota, Minneapolis, MN, 1976 to 1979.

Chief Resident: 1979.

Fellowship: University of Virginia, Charlottesville, VA.

Certification: Pediatrics, 1982; Pediatric Endocrinology, 1983.

Mayer-Davis EJ, Lawrence JM, Dabelea D, Divers J, Isom S, Dolan L, Imperatore G, Linder B, Marcovina S, Pettitt DJ, Pihoker C, Saydah S, Wagenknecht L; SEARCH for Diabetes in Youth Study. Incidence Trends of Type 1 and Type 2 Diabetes among Youths, 2002-2012. N Engl J Med. 2017 Apr 13;376(15):1419-1429.

Gupta R, Khoury J, Altaye M, Dolan L, Szczesniak RD. Glycemic Excursions in Type 1 Diabetes in Pregnancy: A Semiparametric Statistical Approach to Identify Sensitive Time Points during Gestation. J Diabetes Res. 2017;2017:2852913.

Dabelea D, Stafford JM, Mayer-Davis EJ, D'Agostino R Jr, Dolan L, Imperatore G, Linder B, Lawrence JM, Marcovina SM, Mottl AK, Black MH, Pop-Busui R, Saydah S, Hamman RF, Pihoker C; SEARCH for Diabetes in Youth Research Group. Association of Type 1 Diabetes vs Type 2 Diabetes Diagnosed During Childhood and Adolescence with Complications During Teenage Years and Young Adulthood. JAMA. 2017 Feb 28;317(8):825-835.

Shah AS, Maahs DM, Stafford JM, Dolan LM, Lang W, Imperatore G, Bell RA, Liese AD, Reynolds K, Pihoker C, Marcovina S, D'Agostino RB Jr, Dabelea D. Predictors of Dyslipidemia Over Time in Youth with Type 1 Diabetes: For the SEARCH for Diabetes in Youth Study. Diabetes Care. 2017 Apr;40(4):607-613.

Shah AS, Maahs DM, Stafford JM, Dolan LM, Lang W, Imperatore G, Bell RA, Liese AD, Reynolds K, Pihoker C, Marcovina S, D'Agostino RB Jr, Dabelea D. Predictors of Dyslipidemia Over Time in Youth With Type 1 Diabetes: For the SEARCH for Diabetes in Youth Study. Diabetes Care. 2017 Jan 26.

Levenson AE, Shah AS, Khoury PR, Kimball TR, Urbina EM, de Ferranti SD, Maahs DM, Dolan LM, Wadwa RP, Biddinger SB. Obesity and type 2 diabetes are associated with elevated PCSK9 levels in young women. Pediatr Diabetes. 2017 Jan 17.

Patton SR, Noser AE, Clements MA, Dolan LM, Powers SW. Reexamining the Hypoglycemia Fear Survey for Parents of Young Children in a Sample of Children Using Insulin Pumps. Diabetes Technol Ther. 2017 Feb;19(2):103-108.

Couch SC, Crandell J, King I, Peairs A, Shah AS, Dolan LM, Tooze J, Crume T, Mayer-Davis E. Associations between long chain polyunsaturated fatty acids and cardiovascular lipid risk factors in youth with type 1 diabetes: SEARCH Nutrition Ancillary Study. J Diabetes Complications. 2016 Oct 5.

Corathers SD, Kichler JC, Fino NF, Lang W, Lawrence JM, Raymond JK, Yi-Frazier JP, Dabelea D, Liese AD, Saydah SH, Seid M, Dolan LM. High Health Satisfaction Among Emerging Adults With Diabetes: Factors Predicting Resilience. Health Psychol. 2016 Oct 13.

Grants

SEARCH for Diabetes in Youth Registry Study, Phase 4: Ohio Center. Principal Investigator. Center for Disease Control and National Institutes of Health. Sep 2015-Sep 2020. U18DP006134.

SEARCH for Diabetes in Youth 4: Cohort Study. Principal Investigator for the Ohio Site. Center for Disease Control and National Institutes of Health. Sep 2015-Sep 2020. UC4DK108173.

Self-management of type 1 diabetes during adolescence. Co-investigator. National Institutes of Health. Jul 2013–Jun 2018. R01DK069486-06.

Faculty

Philippe F. Backeljauw, MD Fellowship Program Director, Division of Endocrinology

Within the Division of Endocrinology, Dr. Backeljauw's research emphasis relates to children with growth disorders and Turner syndrome. Ongoing studies focus on IGF-I therapy in GH resistance syndromes, as well as assessment and treatment of Turner syndrome co-morbidities. His research efforts have resulted in more than 100 publications, including peer-reviewed original manuscripts, abstracts and textbook chapters.

513-636-8444 philippe.backeljauw@cchmc.org

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Philippe F. Backeljauw, MD

Fellowship Program Director, Division of Endocrinology

Clinical Director, Cincinnati Growth Center

Director, Turner Syndrome Center of Cincinnati

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-8444

Fax 513-636-7486

Email philippe.backeljauw@cchmc.org

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Clinical

Pediatric endocrinology; growth disorders; Turner syndrome

Research

Growth disorders; Turner syndrome

Biography

Dr. Backeljauw's research has focused on clinical trials evaluating the efficacy and safety of recombinant human IGF-I in patients with growth hormone insensitivity syndrome. These studies have led to the USFDA approval of IGF-I as a treatment for growth failure associated with primary IGF-I deficiency. The studies ended in 2012, and results have been published. He has also been involved in other multicenter studies of IGF-I therapy or combined growth hormone plus IGF-I therapy for idiopathic short stature. In collaboration with Dr. Meilan Rutter, they recently finished a comprehensive study looking at the efficacy and safety of IGF-I therapy in patients with Duchenne muscular dystrophy.

Another area of research for Dr. Backeljauw, during the last five years, is related to activities in the Turner Syndrome Center. We now have conducted several clinical research projects evaluating the cardiovascular pathology, hypertension, attention deficit disorder status, gonadectomy surgery outcomes, and, in particular, vasculopathy prevalence in our large cohort of patients with Turner syndrome.

MD: University of Ghent, Belgium.

Residency: Pediatric and Adolescent Medicine, Cleveland Clinic Foundation Children's Hospital, Cleveland, OH.

Fellowship: Pediatric Endocrinology, University of North Carolina, Chapel Hill, NC.

Certification: Pediatrics, 1992; recertified, 1999, 2007; Pediatric Endocrinology, 1995; recertified, 2003, 2013.

Gravholt CH, Backeljauw P. New international Turner syndrome guideline – a multi-society. European Journal of Endocrinology. 2017.

Gravholt CH, Andersen NH, Conway GS, Dekkers OM, Geffner ME, Klein KO, Lin AE, Mauras N, Quigley CA, Rubin K, Sandberg DE, Sas TCJ, Silberbach M, Söderström-Anttila V, Stochholm K, van Alfen-van derVelden JA, Woelfle J, Backeljauw PF. Clinical practice guidelines for the care of girls and women with Turner syndrome. European Journal of Endocrinology. 2017;177:G1–G70.

Kelley JC, Gutmark-Little I, Backeljauw P, Bamba V. Increased Non-High-Density Lipoprotein Cholesterol in Children and Young Adults with Turner Syndrome Is Not Explained By BMI Alone. Horm Res Paediatr. 2017 Aug 2.

Cabrera-Salcedo C, Shah AS, Andrew M, Tyzinski L, Hwa V, Gutmark-Little I, Backeljauw P, Dauber A. Isolated Growth Hormone Deficiency due to R183H Mutation in GH1: Clinical Analysis of a Four-Generation Family. Clin Endocrinol (Oxf). 2017 Jun 19.

Gonzales Ballesteros LF, Ma NS, Gordon RJ, Ward L, Backeljauw P, Wasserman H, Weber DR, DiMeglio LA, Gagne J, Stein S, Cody D, Simmons K, Zimakas P, Topor LS, Agrawal S, Calabiria A, Tebben P, Faircloth R, Imel EA, Casey L, Carpenter TO. Hypophosphatemia and Bone Disease associated with Elemental Formula Use in Infants and Children. Bone. 2017.

Subramaniam DR, Stoddard WA, Mortensen KR, Ringgaard S, Trolle C, Gravholt CH, Gutmark EJ, Mylavarapu G, Backeljauw PF, Gutmark-Little I. Continuous measurement of aortic dimensions in Turner syndrome: a cardiovascular magnetic resonance study. JCMR. 2017.

Ocaranza P, Golekoh MC, Andrew SF, Guo MH, Kaplowitz P, Saal H, Rosenfeld RG, Dauber A, Cassorla F, Backeljauw PF, Hwa V. Expanding Genetic and Functional Diagnoses of IGF1R Haploinsufficiencies. Horm Res Paediatr. 2017 Apr 10.

Vairamani K, Merjaneh L, Casano-Sancho P, Emecen Sanli M, David A, Metherell LA, Savage MO, del Pozo S, Backeljauw PF, Rosenfeld RG, Aisenberg J, Dauber A, Hwa V. Novel Dominant-Negative GH Receptor Mutations Expands the Spectrum of GHI and IGF-I Deficiency. J Endocr. 2017;1(4):345-358.

van den hoven AT, Duijnhouwer AL, Eicken A, Aboulhosn J, deBruin C, Backeljauw PF, Demulier L, Chessa M, Uebing A, Veldtman GR, Armstrong A, van den Bosch AE, Witsenburg M, Roos-Hesselink JW. Adverse outcome of coarctation stenting in patients with Turner syndrome. Catheter Cardiovasc Interv. 2016 Sep 15.

Wasserman H, Ikomi C, Hafberg ET, Miethke AG, Bove KE, Backeljauw PF. Two Case Reports of FGF23-Induced Hypophosphatemia in Childhood Biliary Atresia. Pediatrics. 2016 Aug;138(2).

Grants

Long-acting GH in GH deficient children (3 studies). Principal Investigator. Versartis, Novo Nordisk, Opko. Ongoing.

IGF-I therapy in PAPP-A2 patients. Co-Principal Investigator. Ipsen. Ongoing.

Janet Chuang, MD

513-636-4744 janet.chuang@cchmc.org

Janet Chuang, MD

Academic Affiliations

Assistant Professor, UC Department of Internal Medicine

Phone 513-636-4744

Email janet.chuang@cchmc.org

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Clinical Interests

Pediatric endocrinology; thyroid nodules/cancer; endocrine complications of childhood cancer treatment

MD: Ohio State University, Columbus, OH, 2007.

Residency: Pediatrics, Rainbow Babies Children's Hospital, Cleveland, OH.

Certification: Pediatrics, 2010.

Fellowship: Pediatric endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Certification: Pediatric endocrinology, 2013.

Chuang J, Fehr K, Ievers-Landis C, et al. Associations of sleep duration and regularity with level of obesity among youth in a weight loss program. Translational Issues in
Psychological Science. 2015;1(1):45-56.

Chuang J, Vallerie A, Breech L, et al. Complexities of gender assignment in 17ß-hydroxysteroid dehydrogenase type 3 deficiency: Is there a role for early orchiectomy? Int J Pediatr Endocrinol. 2013 Sep 12;2013(1):15.

Chuang J, Zeller MH, Inge T, et al. Bariatric Surgery for Severe Obesity in Two Adolescents with Type 1 Diabetes. Pediatrics. 2013 Oct;132(4):e1031-4.

Book Chapter

Chuang J, Gutmark-Little I, Rose S. Fanaroff & Martin's Neonatal-Perinatal Medicine, 10th Ed. Chapter 49.3 Thyroid. September 2014.

Sarah D. Corathers, MD Director, Diabetes Transition Program, Division of Endocrinology

Sarah D. Corathers, MD, investigates psychosocial contributors to clinical outcomes for adolescents with type 1 diabetes with a special interest in factors predicting successful transition between pediatric and adult care.

513-636-4744 sarah.corathers@cchmc.org

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Sarah D. Corathers, MD

Director, Diabetes Transition Program, Division of Endocrinology

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

UC Department of Internal Medicine

Phone 513-636-4744

Email sarah.corathers@cchmc.org

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Clinical

Adult and pediatric endocrinology including type 1 diabetes, transgender, Turner syndrome, and hereditary endocrine conditions; effective transition between pediatric and adult care; quality improvement

Research

Transition between pediatric and adult care; psychosocial contributors to clinical and patient reported outcomes in type 1 diabetes

Biography

Sarah Corathers, MD, completed residency training in internal medicine and pediatrics followed by a combined fellowship in adult and pediatric endocrinology. Her clinical training provides a unique a background in management of diabetes and endocrine conditions across the lifespan. She has a special interest in psychosocial aspects of diabetes care for adolescents and young adults including depression and resilience. She is the director of the diabetes transition program with the aim of preparing pediatric patients for successful transition to adult care. Additional clinical and research interests include Turner syndrome, transgender health, hereditary endocrine conditions and quality improvement in health care.

MD: Wright State University, Dayton, OH, 2002.

Residency: Internal Medicine and Pediatrics, University of Cincinnati and Cincinnati Children’s Hospital Medical Center, 2002-2006.

Fellowship: Endocrinology, University of Cincinnati and Cincinnati Children's Hospital Medical Center, 2009-2013.

Certification: Pediatrics, 2006; Internal Medicine, 2007; Pediatric Endocrinology, 2013; Adult Endocrinology, 2013.

Gravholt et al (contributing author of International Turner Consensus Group). Clinical Practice Guidelines for the care of girls and women with Turner Syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting. European Journal of Endocrinology. 2017.

Matlock K, Yayah Jones N, Kichler J, Corathers S. Clinical and psychosocial factors associated with suicidal ideation in adolescents with type 1 diabetes mellitus. Journal Adolescent Health. 2017.

Corathers S, Kichler J, Mara C. Psychosocial Patient-Reported Outcomes in Pediatric and Adolescent Diabetes: A Review and Case Example. Curr Diab Rep. 2017 Jul;17(7):45.

Corathers S. Kichler J, Fino N, Lang W, Lawrence J, Raymond J, Yi-Frazier J, Dabelea D, Liese A, Saydah S, Seid M, Dolan L. High health satisfaction among emerging adults with diabetes: factors predicting resilience. Health Psychology. 2017 Mar;36(3):206-214.

Garvey KC, Foster NC, Agarwal S, DiMeglio LA, Anderson BJ, Corathers SD, Desimone ME, Libman IM, Lyons SK, Peters AL, Raymond JK, Laffel LM. Health care transition preparation and experiences in a US national sample of young adults with type 1 diabetes. Diabetes Care. 2017 Mar;40(3):317-324.

Beal S, Riddle I, Kichler J, Duncan A, Houchen A, Casnellie L, Woodward J, Corathers S. Transition readiness across different clinic populations: The association of chronic condition type and individual characteristics with transition readiness. Academic Pediatrics. 2016 Sept-Oct;16(7):660-7.

Corathers S, Schoettker P, Clements M, List B, Mullen D, Ohmer A, Shah A, Lee J. Health-System-Based Interventions to Improve Care in Pediatric and Adolescent Type 1 Diabetes. Curr Diab Rep. 2015 Sept;15:91.

Powell P, Corathers S, Raymond J, Streisand R. New Approaches to Providing Individualized Diabetes Care in the 21st Century. Curr Diabetes Rev. 2015 Apr 21.

Corathers S, Kichler J, Jones N, Houchen A, Jolly M, Morwessel N, Dolan L, Hood K. Improving Depression Screening for Adolescents with Diabetes. Pediatrics. 2013;132(5):e1395-402.

Lotstein D, Seid M, Klingensmith G, Case D, Lawrence J, Pihoker C, Dabelea D, Mayer-Davis E, Gilliam L, Corathers S, Imperatore G, Dolan L, Anderson A, Bell R, Waitzfelder B for the SEARCH for Diabetes in Youth Study Group. Transition from Childhood to Adult Care for Youth with Type 1 Diabetes in Adolescence. Pediatrics. 2013 Apr;131(4):e1062-70.

Grants

T1DX quality improvement learning collaborative pilot. Faculty leader. Unitio/Helmsley Charitable Trust. March 2016-2018.

Nancy A. Crimmins, MD

Nancy A. Crimmins, MD, is interested in genetic and environmental factors of early-onset obesity. She also is interested in studying the effects of comorbid celiac disease in patients with type 1 diabetes. Dr. Crimmins is the local PI of TrialNet, a natural history study which focuses on the development of type 1 diabetes.

513-636-4744 nancy.crimmins@cchmc.org

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Nancy A. Crimmins, MD

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-4744

Fax 513-636-7486

Email nancy.crimmins@cchmc.org

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Clinical

Early-onset obesity; diabetes and Celiac disease

Research

Early-onset obesity; effects of comorbid celiac disease in pediatric patients with type 1 diabetes

MD: Indiana University School of Medicine, 2000.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, 2003.

Fellowship: Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center, 2006.

Smego A*, Woo JG*, Klein J, Bansal D, Bolling C, Daniels SR, Crimmins NA. High BMI in Infancy Can Predict Severe Obesity in Early Childhood. J Peds. 2017 Apr;183:87-93.

Brady C, Thaker V, Lingren T, Woo JG, Kennebeck SS, Namjou-Khales B, Roach A, Bickel JP, Patibandla N, Savova GK, Solti I, Holm IA, Harley JB, Kohane IS, Crimmins NA. Suboptimal Clinical Documentation in Young Children with Severe Obesity at Tertiary Care Centers. Int J Pediatr. 2016;2016:4068582.

Newton KP, Hou J, Crimmins NA, Lavine JE, Barlow SE, Xanthakos SA, Africa J, Behling C, Donithan M, Clark JM, Schwimmer JB; Nonalcoholic Steatohepatitis Clinical Research Network. Prevalence of Prediabetes and Type 2 Diabetes in Children With Nonalcoholic Fatty Liver Disease. JAMA Pediatr. 2016 Aug.

Chuang J, Zellar MH, Inge T, Crimmins NA. Bariatric Surgery for Severe Obesity in Two Adolescents with Type 1 Diabetes. Pediatrics. 2013 Oct;132(4):e1031-4.

Andrew Dauber, MD, MMSc Program Director and Director of Translational Research, Cincinnati Center for Growth Disorders

Andrew Dauber, MD, MMSc, investigates the genetic etiology of growth disorders and other pediatric endocrine conditions. His research employs the latest in genomic technologies to discover novel genetic causes of growth disorders in patients with previously undiagnosed conditions. Further laboratory investigations are then performed to understand the underlying perturbations to growth biology.
Visit the Dauber-Hwa Lab.

513-636-4744 andrew.dauber@cchmc.org

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Andrew Dauber, MD, MMSc

Program Director and Director of Translational Research, Cincinnati Center for Growth Disorders

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-4744

Email andrew.dauber@cchmc.org

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Visit the Dauber - Hwa Lab.

MD: Harvard Medical School, Boston, MA, 2000.

MS: Clinical Investigation, Harvard Medical School, Boston, MA, 2008.

Residency: Pediatrics, Boston Combined Residency Program in Pediatrics, Boston Children's Hospital and Boston Medical Center, Boston, MA.

Chief Resident: Pediatrics, Boston Children's Hospital, Boston, MA, 2004-2005.

Fellowship: Pediatric Endocrinology, Boston Children's Hospital, Boston, MA.

Certification: Pediatrics, Pediatric Endocrinology.

Dauber A, Cunha-Silva M, Macedo DB, Brito VN, Abreu AP, Roberts SA, Montenegro LR, Andrew M, Kirby A, Weirauch MT, Labilloy G, Bessa DS, Carroll RS, Jacobs DC, Chappell PE, Mendonca BB, Haig D, Kaiser UB, Latronico AC. Paternally Inherited DLK1 Deletion Associated with Familial Central Precocious Puberty. Journal of Clinical Endocrinology and Metabolism. 2017 May;102(5):1557-1567.

Gkourogianni A, Andrew M, Tyzinski L, Crocker M, Douglas J, Dunbar N, Fairchild J, Funari MFA, Heath KE, Jorge AAL, Kurtzman T, LaFranchi S, Lalani S, Lebl J, Lin Y, Los E, Newbern D, Nowak C, Olson M, Popovic J, Pruhova S, Elblova L, Quinto JB, Segerlund E, Sentchordi L, Shinawi M, Stattin EL, Swartz J, Ariadna GA, Sinhue DC, Hosono H, Sanchez-Lara PA, Hwa V, Baron J, Nilsson O, Dauber A. Clinical characterization of patients with autosomal dominant short stature due to Aggrecan mutation. Journal of Clinical Endocrinology and Metabolism. 2017 Feb;102(2):460-469.

Dauber A, Munoz-Calvo MT, Barrios V, Domene HM, Kloverpris S, Serra-Juhe C, Desikan V, Pozo J, Muzumdar R, Martos-Moreno GA, Hawkins F, Jasper HG, Conover CA, Frystyk J, Yakar S, Hwa V, Chowen JA, Oxvig C, Rosenfeld RG, Perez-Jurado LA, Argente J. Mutations in pregnancy-associated protein A2 cause short stature due to low IGF-I availability. EMBO Molecular Medicine. 2016 Mar;8(4):363-74.

de Bruin C, Dauber A. Insights from exome sequencing for endocrine disorders. Nature Reviews Endocrinology. 2015 Aug;11(8):455-64.

de Bruin C, Mericq V, Andrew SF, van Duyvenvoorde HA, Verkaik NS, Losekoot M, Porollo A, Garcia H, Kuang Y, Hanson D, Clayton P, van Gent DC, Wit JM, Hwa V, Dauber A. An XRCC4 splice mutation associated with severe short stature, gonadal failure, and early-onset metabolic syndrome. The Journal of Clinical Endocrinology and Metabolism. 2015 May;100(5):E789-98.

Dauber A, Rosenfeld RG, Hirschhorn JN. Genetic Evaluation of Short Stature. J Clin Endocrinol Metab. 2014 Sep;99(9):3080-92.

Kerns SL, Guevara-Aguirre J, Andrew S, Geng J, Guevara C, Guevara-Aguirre M, Guo M, Oddoux C, Shen Y, Zurita A, Rosenfeld RG, Ostrer H, Hwa V, Dauber A. A novel variant in CDKN1C is associated with intrauterine growth restriction, short stature, and early-adulthood onset diabetes. Clin Endocrinol Metab. 2014 Oct;99(10):E2117-22

Dauber A, Ercan A, Lee J, James P, Jacobs PP, Ashline DJ, Wang SR, Miller T, Hirschhorn JN, Nigrovic PA, Sackstein R. Congenital disorder of fucosylation type 2c (LADII) presenting with short stature and developmental delay with minimal adhesion defect. Hum Mol Genet. 2014 Jun 1;23(11):2880-7.

Wang SR, Carmichael H, Andrew SF, Miller TC, Moon JE, Derr MA, Hwa V, Hirschhorn JN, Dauber A. Large-scale pooled next-generation sequencing of 1077 genes to identify genetic causes of short stature. J Clin Endocrinol Metab. 2013 Aug;98(8):E1428-37.

Abreu AP, Dauber A, Macedo DB, Noel SD, Brito VN, Gill JC, Cukier P, Thompson IR, Navarro VM, Gagliardi PC, Rodrigues T, Kochi C, Longui CA, Beckers D, de Zegher F, Montenegro LR, Mendonca BB, Carroll RS, Hirschhorn JN, Latronico AC, Kaiser UB. Central precocious puberty caused by mutations in the imprinted gene MKRN3. N Engl J Med. 2013 Jun 27;368(26):2467-75.

Deborah A. Elder, MD Endocrinology Director, Pancreas Care Center

Dr. Elder’s current research focus is beta-cell function and glucose tolerance in different diabetes types. Specifically, she follows glucose tolerance in the cystic fibrosis population and abnormalities found in those with chronic pancreatitis. Dr. Elder is also a key member of the Pancreatic Center and Lung Transplantation Center at Cincinnati Children's. These new divisions will have mechanisms to track patient clinical data and clinical outcomes.

513-636-4744 deborah.elder@cchmc.org

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Deborah A. Elder, MD

Endocrinology Director, Pancreas Care Center

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-4744

Fax 513-803-1174

Email deborah.elder@cchmc.org

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Clinical

Type 1 diabetes; type 2 diabetes; cystic-fibrosis-related diabetes; assessment of beta-cell function in the evaluation of total pancreatectomy and islet autotransplantation (TPAIT) in children with chronic pancreatitis; growth disorders; precocious puberty; pancreatic center member; cystic fibrosis and endocrine combined clinic; lung transplantation center member.

Research

Beta-cell function and glucose tolerance in a variety of different diabetes conditions.

BS: Michigan State University, 1991.

MD: University of Kentucky College of Medicine, Lexington, KY, 1995.

Residency: Indiana University Riley Hospital For Children, Indianapolis, IN, 1998.

Fellowship: University of North Carolina at Chapel Hill, Chapel Hill, NC, 2001.

Certification: Pediatric endocrinology.

Auble B, Elder D, Gross A, Hillman JB. Differences in the Management of Adolescents with Polycystic Ovary Syndrome across Pediatric Specialties. J Pediatr Adolesc Gynecol. 2013 May 28.

Elder DA, Herbers P, Weis T, Standiford D, Woo JG, D’Alessio DA. Beta-cell function in adolescent and adults with newly diagnosed type 2 diabetes mellitus. J Pediatr. June 2012;160(6):904-10.

Elder DA, Woo JG, D’Alessio DA. Impaired beta-cell sensitivity to glucose and maximal insulin secretory capacity in adolescents with type 2 diabetes. Ped Diabetes. 2010; 11(5):314-21.

Elder DA, D’Alessio DA, Eyal O, Mueller R, Smith FO, Kansra AR, Rose SR. Abnormalities in Glucose Tolerance Are Common in Children with Fanconi Anemia and Associated with Impaired Insulin Secretion. Pediatric Blood & Cancer. 2008; 51(2):256-60.

Elder DA, Wooldridge JL, Dolan LM, D’Alessio DA. Glucose Tolerance in Children and Adolescents with Cystic Fibrosis and No Prior History of Diabetes. J Pediatr. 2007;151(6):653-8.

Elder DA, Prigeon RL, Wadwa RP, Dolan LM, D’Alessio DA. Beta-cell Function, Insulin Sensitivity and Glucose Tolerance in Obese Diabetic and Nondiabetic Adolescents and Young Adults. J Clin Endocrinol Metab. 2006;91(1):185-91.

Eyal O, Naffaa LN, Elder DA. A Case of Macroprolactinoma and Elevated Insulin-Like Growth Factor-I in a Young Boy. Acta Paediatr. 2005;94(12):1852-6.

Elder DA, Roper MG, Henderson RC, Davenport ML. Kyphosis in a Turner Syndrome Population. Pediatrics. 2002;109(6):e93.

Elder DA, Kaiser-Rogers K, Aylsworth AS, Calikoglu AS. Type 1 diabetes mellitus in a patient with chromosome 22q11.2 deletion syndrome. American Journal of Medical Genetics. 2001; 101(1):17-9.

Elder DA, Karayal AF, D’Ercole AJ, Calikoglu AS. Effects of hypothyroidism on insulin-like growth factor-I expression during brain development in mice. Neuroscience Letters. 2000; 293(2):99-102.

Catherine M. Gordon, MD, MSc Director, Division of Adolescent and Transition Medicine

Catherine M. Gordon, MD, MSc, investigates the effects of malnutrition on bone loss, including early osteoporosis seen in adolescents with anorexia nervosa, cystic fibrosis and inflammatory bowel disease. She has interest in the management of children with progeria and adolescents with primary ovarian insufficiency(POI). Her goal is to identify modifiable factors during adolescence that impact bone health and during the adult years.
Visit the Gordon Lab.

513-636-8602 catherine.gordon@cchmc.org

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Catherine M. Gordon, MD, MSc

Director, Division of Adolescent and Transition Medicine

Rauh Chair of Adolescent Medicine

Director, Procter Scholars Program

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-8602

Email catherine.gordon@cchmc.org

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Clinical

Pediatric and adolescent bone health; eating disorders; reproductive endocrinology (including menstrual disorders, polycystic ovary syndrome, primary ovarian insufficiency (POI), and delayed puberty)

Research

Bone health in young women with eating disorders and/or stress fractures; bone density in cystic fibrosis and inflammatory bowel disease; the skeletal phenotype in Progeria; pediatric and adolescent vitamin D deficiency

Visit the Gordon Lab.

Biography

Catherine Gordon, MD, MS, is a pediatric endocrinologist and adolescent health specialist, whose research has focused on how nutrition influences bone health, with a particular interest in the adolescence and young adulthood. Her research has been funded by the National Institutes of Health, Department of Defense, and private foundations.

In 2005, she received a Presidential Early Career Award for Scientists and Engineers for her studies examining bone loss in adolescent girls with eating disorders. Dr. Gordon founded and directed the Boston Children's Bone Health Program from 2000-2012. She served as chief of adolescent medicine and professor of pediatrics at Hasbro Children's Hospital and the Alpert Brown Medical School from 2012-2015. During that time, she also served as vice-chair of Clinical Research in the Department of Pediatrics. She joined the medical staff at Cincinnati Children's in 2015 as director of the Division of Adolescent and Transition Medicine and professor of pediatrics at the University of Cincinnati College of Medicine.

She enjoys collaborations across many divisions and departments across the UC health system who share her interest in bone health and reproductive endocrinology. She also has a long-time interest in mentoring. She directs the American Pediatric Society/Society for Pediatric Student Research Program, a national research program for medical students, and the Procter Scholar Program at Cincinnati Children’s for junior faculty members who have an interest in clinical/translational research.

MD: University of North Carolina at Chapel Hill, NC, 1991.

MSc: Clinical Investigation, Harvard Medical School, Boston, MA.

Residency: Pediatric, Boston Children's Hospital, Boston, MA, 1991-1994.

Fellowship: Adolescent Medicine and Endocrinology, Boston Children's Hospital, Boston, MA, 1994-1998.

Certification (ABP): Pediatric Endocrinology; Adolescent Medicine.

Havens PL, Stephensen CB, Van Loan MD, Schuster GU, Woodhouse LR, Flynn PM, Gordon CM, Pan CG, Rutledge B, Liu N, Wilson CM, Hazra R, Hosek SG, Anderson PL, Seifert SM, Kapogiannis BG, Mulligan K; Adolescent Medicine Trials Network for HIV/AIDS Interventions 117 Study Team. Decline in bone mass with tenofovir disoproxil fumarate/emtricitabine is associated with hormonal changes in the absence of renal impairment when used by HIV-uninfected adolescent boys and young men for HIV preexposure prophylaxis. Clin Infect Dis. 2017;64(3):317-325.

Wasserman H, O’Donnell JM, Gordon CM. Use of dual energy X-ray absorptiometry in pediatric patients. Bone. 2016;S8756-3282(16)30370-30372.

Hall A, Ofei-Tenkorang NA, Machan JT, Gordon CM. Use of yoga in outpatient eating disorder treatment: a pilot study. J Eat Disord. 2016;9;4:38.

DiVasta AD, Feldman HA, O’Donnell JM, Long J, Leonard MB, Gordon CM. Effect of exercise and antidepressants on skeletal outcomes in adolescent girls with anorexia nervosa. J Adolesc Health. 2017;60(2):229-232.

Gordon CM, Zemel BS, Wren TA, Leonard MB, Bachrach LK, Rauch F, Gilsanz V, Rosen CJ, Winer KK. The determinants of peak bone mass. J Pediatr. 2017;180:261-269.

Bachrach LK, Gordon CM; Section on Endocrinology. Bone densitometry in children and adolescents. Pediatrics. 2016;138(4):e20162398.

Gordon LB, Kleinman ME, Massaro J, D’Agostino RB Sr, Shappell H, Gerhard-Herman M, Smoot LB, Gordon CM, Cleveland RH, Nazarian A, Snyder BD, Ullrich NJ, Silvera VM, Liang MG, Quinn N, Miller DT, Huh SY, Dowton AA, Littlefield K, Greer MM, Kieran MW. Clinical trial of the protein farnesylation inhibitors lonafarnib, pravastatin, and zoledronic acid in children with Hutchinson-Gilford Progeria Syndrome. Circulation. 2016;134(2):114-125.

DiVasta AD, Feldman HA, O’Donnell JM, Long J, Leonard MB, Gordon CM. Skeletal outcomes by peripheral quantitative computed tomography and dual-energy X-ray absorptiometry in adolescent girls with anorexia nervosa. Osteoporos Int. 2016;27(12):3549-3558.

Lewiecki EM, Binkley N, Morgan SL, Shuhart CR, Camargos BM, Carey JJ, Gordon CM, Jankowski LG, Lee JK, Leslie WD; International Society for Clinical Densitometry. Best practices for dual-energy X-ray absorptiometry measurement and reporting: International Society for Clinical Densitometry guidance. J Clin Densitom. 2016;19(2):127-140.

Putman MS, Greenblatt LB, Sicilian L, Uluer A, Lapey A, Sawicki G, Gordon CM, Bouxsein ML, Finkelstein JS. Young adults with cystic fibrosis have altered trabecular microstructure by ITS-based morphological analysis. Osteoporos Int. 2016;27(8):2497-2505.

Grants

Contracts

Progeria Research Foundation.

Society for Pediatric Research

Iris Gutmark-Little, MD

Iris Gutmark-Little, MD, currently conducts research in an interdisciplinary project along with engineering, radiology, cardiology, and pulmonology. The first involves a study of the TS airway, imaged using MRI, then virtually reconstructed, and analyzed to measure air flow features. The overall aim is to assess the cause of airway disease and specific treatments for this poorly described problem in the TS patient group. Similarly, a second project is ongoing and involves modeling aortic blood flow properties from TS patients who have undergone MRI for clinical purposes. The overall aim of this project is to elucidate the cause and progression of aortic disease in TS women.

513-636-4744 iris.little@cchmc.org

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Iris Gutmark-Little, MD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4744

Email iris.little@cchmc.org

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Clinical

Turner syndrome; general pediatric endocrinology; growth; puberty; hypopituitarism

Research

Cardiovascular disease in Turner syndrome

Biography

Iris Gutmark-Little, MD, is board-certified in pediatrics and board-eligible in pediatric endocrinology. She has been on the faculty of Cincinnati Children's Hospital Medical Center within the University of Cincinnati College of Medicine Department of Pediatrics since 2010.

Dr. Gutmark-Little is an assistant professor in the Division of Endocrinology at Cincinnati Children's within the UC Department of Pediatrics. Her research focuses on the airway and great vessel anatomy and diseases in the Turner syndrome population.

Dr. Gutmark-Little received her Bachelor of Science in microbiology and chemistry from Louisiana State University. She received her Doctor of Medicine from the Johns Hopkins University School of Medicine.

Dr. Gutmark-Little completed her pediatric internship and residency at Cincinnati Children’s Hospital Medical Center. She obtained fellowship training in pediatric endocrinology at Cincinnati Children’s.

BS: Louisiana State University, Baton Rouge, LA, 2000.

MD: Johns Hopkins University School of Medicine, Baltimore, MD, 2004.

Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2007.

Fellowship: Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2010.

Certification: General Pediatrics, American Board of Pediatrics, 2008; Pediatric Endocrinology, American Board of Pediatrics, pending 2011.

Subramaniam DR, Stoddard WA, Mortensen KH, Ringgaard S, Trolle C, Gravholt CH, Gutmark EJ, Mylavarapu G, Backeljauw PF, Gutmark-Little I. Continuous measurement of aortic dimensions in Turner syndrome: a cardiovascular magnetic resonance study. J Cardiovasc Magn Reson. 2017 Feb 24;19(1):20.

Viuff MH, Trolle C, Wen J, Jensen JM, Nørgaard BL, Gutmark EJ, Gutmark-Little I, Mortensen KH, Gravholt CH, Andersen NH. Coronary artery anomalies in Turner Syndrome. J Cardiovasc Comput Tomogr. 2016 Nov - Dec;10(6):480-484.

Smego AR, Backeljauw P, Gutmark-Little I. Buccally Administered Intranasal Desmopressin Acetate for the Treatment of Neurogenic Diabetes Insipidus in Infancy. J Clin Endocrinol Metab. 2016 May;101(5):2084-8.

Prahl Wittberg L, van Wyk S, Fuchs L, Gutmark E, Backeljauw P, Gutmark-Little I. Effects of aortic irregularities on blood flow. Biomech Model Mechanobiol. 2016 Apr;15(2):345-60.

Kanakatti Shankar R, Inge TH, Gutmark-Little I, Backeljauw PF. Oophorectomy versus salpingo-oophorectomy in Turner syndrome patients with Y-chromosome material: clinical experience and current practice patterns assessment. J Pediatr Surg. 2014 Nov;49(11):1585-8.

Lawson SA, Urbina EM, Gutmark-Little I, Khoury PR, Gao Z, Backeljauw PF. Vasculopathy in the young Turner syndrome population. J Clin Endocrinol Metab. 2014 Oct;99(10):E2039-45.

Chen J, Gutmark EJ, Mylavarapu G, Backeljauw PF, Gutmark-Little I. Numerical investigation of blood flow through deformed aortae. J Biomech. 2014 Jan 22;47(2):544-52.

Gutmark-Little I, Backeljauw PF. Cardiac magnetic resonance imaging in Turner syndrome. Clin Endocrinol (Oxf). 2012 May;78(5):646-58.

Gutmark-Little I, Hor KN, Cnota J, Gottliebson WM, Backeljauw PF. Partial anomalous pulmonary venous return is common in Turner syndrome. J Pediatr Endocrinol Metab. 2012;25(5-6):435-40.

Kim HK, Gottliebson W, Hor K, Backeljauw P, Gutmark-Little I, Salisbury SR, Racadio JM, Helton-Skally K, Fleck R. Cardiovascular anomalies in Turner syndrome: spectrum, prevalence, and cardiac MRI findings in a pediatric and young adult population. AJR Am J Roentgenol. 2011 Feb;196(2):454-60.

Jonathan C. Howell, MD, PhD

Jonathan C. Howell, MD, PhD, is a clinical endocrinologist who is interested in the study of endocrine defects among patients with hematological disorders and cancer. He studies inherent endocrine deficiencies in patients with congenital anemias and the late endocrine effects of chemotherapy, radiation, chronic transfusions, and chronic steroid therapy with the aim of improving outcomes of patients who have anemia disorders or who are cancer survivors.

513-636-4744 jonathan.howell@cchmc.org

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Jonathan C. Howell, MD, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4744

Email jonathan.howell@cchmc.org

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Specialties

Type 1 and type 2 diabetes mellitus; endocrinopathy in bone marrow failure syndromes; growth disorders; thyroid disorders

Biography

Jonathan C. Howell, MD, PhD, is board certified in both pediatrics and pediatric endocrinology. He has been on the faculty of Cincinnati Children’s Hospital Medical Center within the Department of Pediatrics of the University of Cincinnati College of Medicine since 2012.

Dr. Howell is an assistant professor of pediatrics in the Division of Endocrinology within the UC Department of Pediatrics. His main clinical focus is diabetes as well as providing care for patients with endocrine disorders, including growth, thyroid, pituitary, pubertal, and adrenal dysfunction. Dr. Howell’s research focuses on the effects of congenital anemias and cancer on the endocrine system and the outcomes of chemotherapy, radiation, transfusions, and chronic steroid therapy on endocrine hormone function.

Dr. Howell received his Bachelor of Arts degree from Hanover College. He received his PhD from Indiana University and his MD from Indiana University School of Medicine.

Dr. Howell completed his pediatric internship and residency at Cincinnati Children’s Hospital Medical Center, where he also served as chief resident. He also obtained his fellowship training from Cincinnati Children’s.

BA: Hanover College, Hanover, IN, 1997.

PhD: Indiana University (Edward F. Srour, thesis adviser), Indianapolis, IN, 2003.

MD: Indiana University School of Medicine, Indianapolis, IN, 2005.

Residency: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2005-2008.

Chief Residency: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2008-2009.

Endocrinology Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2009-2012

Certification: Pediatrics, 2008; Pediatric Endocrinology, 2013.

McCracken, Kyle, Jonathan C. Howell, James M. Wells, Jason R. Spence. Generating human intestinal tissue from pluripotent stem cells in vitro. Nature Protocols. 2011;6(12): 1920-1928.

Howell, Jonathan C, James M. Wells. Generating intestinal tissue from stem cells: potential for research and therapy. Regenerative Medicine. 2011;6(6): 743-755.

Howell, Jonathan C, Mandi Cafasso, Philippe F. Backeljauw. Superior mesenteric artery syndrome as a presentation of Graves’ disease in adolescence. EndoTrends. 2011;17(3): 1-3.

Case, Jamie, Tamara L. Horvath, Jonathan C. Howell, Mervin C. Yoder and Edward F. Srour. Clonal multilineage differentiation of murine common pluripotent stem cells isolated from both skeletal muscle and adipose stromal cells. Annals of the New York Academy of Sciences. 2004;1044: 1-18.

Howell, Jonathan C., Wei-Hua Lee, Paul Morrison, Jin Zhong, Mervin C. Yoder, and Edward F. Srour. Pluripotent stem cells identified in multiple murine tissues. Annals of the New York Academy of Sciences. 2003. 996: 158-173.

Howell, Jonathan C, Mervin C. Yoder. Adult Stem Cell Plasticity Defined. NeoReviews. 2003;4(7): 181-186.

Royer, Cassandra L, Jonathan C. Howell, Paul R. Morrison, Edward F. Srour, Mervin C. Yoder. Muscle-derived CD45+Sca-1+c-kit- progenitor cells give rise to skeletal muscle myotubes in vitro. In Vitro Cellular and Developmental Biology -- Animal. 2003;38(9): 512-517.

Howell, Jonathan C, Mervin C. Yoder, Edward F. Srour. Hematopoietic potential of murine skeletal muscle-derived CD45-Sca-1+c-kit- cells. Experimental Hematology. 2002;30(8): 915-924.

Vivian Hwa, PhD Basic Research Director, Cincinnati Center for Growth Disorders

Vivian Hwa, PhD, investigates the functional and cellular impacts of genetic defects identified in children with severe growth failure, who often present with a variety of co-morbidities, including immune deficiencies, insulin insensitivities, intellectual impairment, microcephaly. These pathophysiological mutations provide unique opportunities to delineate molecular mechanism(s) of actions and improve understanding of clinical phenotypes.
Visit the Dauber-Hwa Lab.

513-803-7337 vivian.hwa@cchmc.org

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Vivian Hwa, PhD

Basic Research Director, Cincinnati Center for Growth Disorders

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-803-7337

Email vivian.hwa@cchmc.org

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Visit the Dauber - Hwa Lab.

BS: University of Sydney, Sydney, Australia.

PhD: University of Illinois, Champaign-Urbana, IL.

Kern SL, Guevara-Aguirre J, Andrew S, Geng J, Guevara C, Guevara-Aguirre M, Guo M, Oddoux C, Shen Y, Zurita A, Rosenfeld RG, Ostrer H, Hwa V, Dauber A. A novel variant in CDKN1C is associated with intrauterine growth restriction, short stature, and early-adulthood onset diabetes. J Clin Endocrinol Metab. 2014 Oct;99(10):E2117-22.

Feigerlova E, Swinyard M, Andrew SF, Derr MA, Farnsworth J, Rosenfeld RG, Hwa V. A novel GHR intronic variant c.266+83G>T, activates a cryptic 5’ splice site causing severe GHR deficiency and classical GH insensitivity syndrome. Horm Res Paediatr. 2013;80(6):397-405.

Varco-Merth B, Feigerlová E, Shinde U, Rosenfeld RG, Hwa V, Rotwein P. Severe growth deficiency is associated with STAT5b mutations that disrupt protein folding and activity. Mol Endocrinol. 2013 Jan;27(1):150-61.

Dauber A, LaFranchi SH, Maliga Z, Lui JC, Moon JE, McDeed C, Henke K, Zonana J, Kingman GA, Pers TH, Baron J, Rosenfeld RG, Hirschhorn JN, Harris MP, Hwa V. Novel Microcephalic Primordial Dwarfism Disorder Associated with Variants in the Centrosomal Protein Ninein. J Clin Endocrinol Metab. 2012 Nov;97(11):E2140-51.

Scalia PA, Martinez AS, Feigerlova E, Bezrodnik L, Gaillard MI, Di Giovanni D, Ballerini MG, Jasper HG, Heinrich JJ, Fang P, Domené HM, Rosenfeld RG, Hwa V. A novel missense mutation in the SH2 domain of the STAT5B gene results in a transcriptionally inactive STAT5b associated with severe IGF-I deficiency, immune dysfunction, and lack of pulmonary disease. J Clin Endocrinol Metab. 2012 May;97(5):E830-9.

Derr MA, Aisenberg J, Fang P, Tenenbaum-Rakover Y, Rosenfeld RG, Hwa V. The growth hormone receptor (GHR) c.899dupC mutation functions as a dominant negative: insights into the pathophysiology of intracellular GHR defects. J Clin Endocrinol Metab. 2011 Nov;96(11):E1896-904.

Fang P, Kofoed EM, Little BM, Ross RJM, Frank, SJ, Hwa V, Rosenfeld RG. A mutant STAT5b, associated with growth hormone insensitivity and IGF-I deficiency, cannot function as a signal transducer or transcription factor. J Clin Endocrinol Metab. 2006 Apr; 91(4):1526-34.

Hwa V, Little B, Adiyaman P, Kofoed E, Pratt KL, Ocal G, Berberoglu M, Rosenfeld RG. Severe growth hormone insensitivity resulting from total absence of signal transducer and activator of transcription 5b. J Clin Endocrinol Metab. 2005 Jul;90(7):4260-6.

Hwa V, Little B, Kofoed EM, Rosenfeld RG. Transcriptional regulation of insulin-like growth factor-I (IGF-I) by interferon-gamma (IFN-γ) requires STAT-5b. J Biol Chem. 2004 Jan 23;279(4):2728-36.

Kofoed EM*, Hwa V*, Little B, Woods KA, Buckway CK, Tsubaki J, Pratt KL, Bezrodnik L, Jasper H, Tepper A, Heinrich JJ, Rosenfeld RG. Growth hormone insensitivity associated with a STAT5b mutation. N Engl J Med. 2003 Sep 18:349(12):1139-47. *co-first authors

Jane C. Khoury, PhD

Jane C. Khoury, PhD, is the senior biostatistician for the study of the epidemiology of stroke in Cincinnati, and is principal investigator for the biostatistical core of a Special Program Of Translational Research In Acute Stroke. She holds a joint appointment in the Division of Endocrinology within the UC Department of Pediatrics and works with many of the faculty and fellows on study design and statistical methods in development of their research studies. Her personal research interests involve the effect of intra-uterine exposure to type 1 diabetes on childhood growth, metabolism and cardiac function.

513-636-3690 Jane.Khoury@cchmc.org

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Jane C. Khoury, PhD

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-3690

Fax 513-636-7509

Email Jane.Khoury@cchmc.org

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Specialties

Stroke, diabetes in pregnancy; research design and analysis.

Biography

Dr. Khoury has contributed to over 250 peer-reviewed publications in medical and epidemiological research journals. She obtained internal funding to obtain pilot data to pursue her diabetes research described above; results were presented and published. She continues to pursue outside funding to further this research. Dr. Khoury holds a joint appointment in the Division of Endocrinology within the UC Department of Pediatrics, collaborating with numerous faculty and fellows on studies involving diabetes, Duchene muscular dystrophy, and Turner’s syndrome among others. She is also involved in research with general and community pediatrics (environmental toxin exposure related to childhood neurodevelopment), sports medicine (ACL injury risk) and emergency medicine. She has been funded by over 25 NIH grants as co-investigator and biostatistician. She has served on peer-review panels for grant applications and as a journal reviewer for Stroke, Pediatrics, Journal of Pediatrics, Archives of Pediatrics and Adolescent Medicine, Public Health Reports and American Journal of Epidemiology.

BSc: Bath University, Bath, England, 1973.

MS: University of Cincinnati College of Medicine, Department of Environmental Health, Division of Epidemiology and Biostatistics, Cincinnati, OH, 1989.

PhD: University of Cincinnati College of Medicine, Department of Environmental Health, Division of Epidemiology and Biostatistics, 2006.

Yolton K, Xu Y, Sucharew H, Succop P, Altaye M, Popelar A, Montesano MA, Calafat AM, Khoury JC. Impact of low-level gestational exposure to organophosphate pesticides on neurobehavior in early infancy: a prospective study. Environ Health. 2013 Sep 13;12(1):79.

Sucharew H, Khoury J, Moomaw CJ, Alwell K, Kissela BM, Belagaje S, Adeoye O, Khatri P, Woo D, Flaherty ML, Ferioli S, Heitsch L, Broderick JP, Kleindorfer D. Profiles of the National Institutes of Health Stroke Scale items as a predictor of patient outcome. Stroke. 2013 Aug;44(8):2182-7.

Khoury JC, Kleindorfer D, Alwell K, Moomaw CJ, Woo D, Adeoye O, Flaherty ML, Khatri P, Ferioli S, Broderick JP, Kissela BM. Diabetes Mellitus: a Risk Factor for Ischemic Stroke in a Large Bi-Racial Population. Stroke. 2013. 44(6):1500-1504.

Mahabee-Gittens EM, Xiao Y, Gordon JS, Khoury JC. The dynamic role of parental influences in preventing adolescent smoking initiation. Addict Behav. 2013 Jan 11;38(4):1905-1911.

Khoury JC, Dolan LM, VanDyke R, Rosenn B, Feghali M, Miodovnik M. Fetal development in women with diabetes: imprinting for a life-time?Journal of Maternal-Fetal & Neonatal Medicine. 2012; 25(1), 11-14.

VanDyke R, Ren Y, Sucharew HJ, Miodovnik M, Rosenn B, Khoury JC. Characterizing maternal glycemic control: a more informative approach using semiparametric regression. Journal of Maternal-Fetal & Neonatal Medicine. 2012; 25(1), 15-19.

Yolton K, Xu YY, Strauss D, Altaye M, Calafat AM, Khoury J. Prenatal exposure to bisphenol A and phthalates and infant neurobehavior. Neurotoxicology and Teratology. 2011; 33(5), 558-566.

Xu YY, Yolton K, Khoury J. Earliest Appropriate Time for Administering Neurobehavioral Assessment in Newborn Infants. Pediatrics. 2011;127(1), E69-E75.

Bollepalli S, Dolan LM, Miodovnik M, Feghali M, Khoury JC. Asymmetric large-for-gestational-age infants of type 1 diabetic women: Morbidity and abdominal growth. Am J Perinatol. 2010; 27(8), 603-610.

Kleindorfer D, Khoury J, Moomaw CJ, Alwell K, Woo D, Flaherty ML, Khatri P, Adeoye O, Ferioli S, Broderick JP, Kissela BM. Stroke Incidence is Decreasing in Whites, but Not in Blacks: A Population-Based Estimate of Temporal Trends in Stroke Incidence from the Greater Cincinnati/Northern Kentucky Stroke Study. Stroke. 2010;41(7):1326-31.

Grants

Neurobehavioral and Neuroimaging Effects of Traffic Exposure in Children. Co-Investigator. R01 NIH. July 2012-March 2017.

Improving post-discharge outcomes by facilitating family-centered transitions from hospital to home. Co-Investigator. PCORI. July 2014-June 2017.

Sarah Lawson, MD

Sarah Lawson, MD, focuses on the progression of heart disease in the Turner syndrome population, assessing the endocrine needs in children who have received cranial radiation for oncology treatments, and genetics associated with septo-optic dysplasia.

513-636-4744 sarah.lawson@cchmc.org

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Sarah Lawson, MD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4744

Email sarah.lawson@cchmc.org

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Clinical Interests

Turner syndrome; endocrine disease related to oncologic pathology and treatment; septo-optic dysplasia.

Biography

Sarah Lawson, MD, is an assistant professor of pediatrics in the Division of Endocrinology at Cincinnati Children's within the UC Department of Pediatrics. Her research has focused on identifying vascular changes, through non-invasive techniques, in the young Turner syndrome population. This has been possible through the collaboration of Pediatric Endocrinology and Pediatric Cardiology.

Dr. Lawson completed her undergraduate studies in biochemistry and biology with a minor in Bible studies from Lee University, and received her MD from the University of Kentucky. After completion of her pediatric residency at the University of Kentucky, Dr. Lawson began her fellowship in pediatric endocrinology at Cincinnati Children’s Hospital Medical Center.

Dr. Lawson’s clinical interests are in the areas of Turner syndrome, endocrine disease related to oncologic pathology and treatment, and septo-optic dysplasia.

BS: Lee University, Cleveland, TN, 2000.

MD: University of Kentucky, Lexington, KY, 2005.

Residency: Kentucky Children’s Hospital, Lexington, KY, 2005-2008.

Fellowship: Cincinnati Children’s Hospital, Cincinnati, OH.

Takahisa Nakamura, PhD

Takahisa Nakamura, PhD, research goal is to address questions concerning why and how inflammatory responses are initiated, coordinated, and thus involved in the development of obesity-induced metabolic diseases.

Visit the Nakamura Lab.

513-636-4744 takahisa.nakamura@cchmc.org

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Takahisa Nakamura, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4744

Email takahisa.nakamura@cchmc.org

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Specialties

RNA-related inflammation in obesity and metabolic diseases

Visit the Nakamura Lab.

Biography

Dr. Nakamura received his PhD from the University of Tokyo in 2003. He completed postdoctoral training in the laboratory of Dr. Gökhan S. Hotamisligil at Harvard School of Public Health in 2013, followed by his faculty appointment at Cincinnati Children's Hospital Medical Center within the UC Department of Pediatrics in 2013.

PhD: University of Tokyo, 2003.

Postdoctoral Fellow: University of Tokyo, 2003-2006.

Research Fellow: Harvard University, 2006-2010.

Research Associate: Harvard University, 2010-2013.

Nakamura T, Arduini A, Baccaro B, Furuhashi M, Hotamisligil GS. Small molecule inhibitors of PKR improve glucose homeostasis in obese, diabetic mice. Diabetes. 2014 Feb;63(2):526-34.

Lu B, Nakamura T, Inouye K, Li J, Tang Y, Lundbäck P, Valdes-Ferrer SI, Olofsson PS, Kalb T, Roth J, Zou Y, Erlandsson-Harris H, Yang H, Ting JP, Wang H, Andersson U, Antoine DJ, Chavan SS, Hotamisligil GS, Tracey KJ. Novel role of PKR in inflammasome activation and HMGB1 release. Nature. 2012 Aug 20;488(7413):670-4.

Morita M. Oike Y, Nagashima T, Kadomatsu T, Tabata M, Suzuki T, Nakamura T, Yoshida N, Okada M, Yamamoto T. Obesity resistance and increased hepatic expression of catabolism-related mRNAs in Cnot3(+/-) mice. EMBO J. 2011 Sep 6;30(22):4678-4691.

Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ, Hotamisligil GS. Double-stranded RNA-dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis. Cell. 2010 Feb 5;140(3):338-48.

Yoneda M, Suzuki T, Nakamura T, Ajima R, Yoshida Y, Kakuta S, Sudo K, Iwakura Y, Shibutani M, Mitsumori K, Yokota J, Yamamoto T. Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma. Cancer Sci. 2009 Feb;100(2):224-232.

Ajima R, Akiyama T, Usui M, Yoneda M, Yoshida Y, Nakamura T, Minowa O, Noda M, Tanaka S, Noda T, Yamamoto T. Osteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiation. FEBS Lett. 2008 Apr 16;582(9):1313-8.

Morita M, Suzuki T, Nakamura T, Yokoyama K, Miyasaka T, Yamamoto T. Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth. Mol Cell Biol. 2007 Jul;27(13):4980-90.

Nakamura T, Yao R, Ogawa T, Suzuki T, Ito C, Tsunekawa N, Inoue K, Ajima R, Miyasaka T, Yoshida Y, Ogura A, Toshimori K, Noce T, Yamamoto T, Noda T. Oligoasthenoteratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta. Nat Genet. 2004 May;36(5):528-33.

Kimura H*, Nakamura T*, Ogawa T, Tanaka S, Shiota K. Transcription of mouse DNA methyltransferase 1 (Dnmt1) is regulated by both E2F-Rb-HDAC-dependent and -independent pathways. Nucleic Acids Res. 2003 Jun 15;31(12):3101-13. *These authors contributed equally to this work.

Yoshida Y*, Nakamura T*, Komoda M, Satoh H, Suzuki T, Tsuzuku JK, Miyasaka T, Yoshida EH, Umemori H, Kunisaki RK, Tani K, Ishii S, Mori S, Suganuma M, Noda T, Yamamoto T. Mice lacking a transcriptional corepressor Tob are predisposed to cancer. Genes Dev. 2003 May 15;17(10):1201-6. *These authors contributed equally to this work.

Grants

Analysis of pathogenic double-stranded RNA in chronic inflammatory diseases. Principal Investigator. Japan Science and Technology Agency, PRESTO. Feb 2013–Mar 2016.

Meilan M. Rutter, MD Member, Division of Endocrinology

Meilan M. Rutter, MD, is a member of several multidisciplinary clinical teams, including the Neuromuscular Comprehensive Care Center and the Disorders of Sex Development (DSD) Center. Related research interests involve endocrine issues in Duchenne muscular dystrophy, currently focusing on a trial of insulin-like growth factor-I (IGF-I) therapy in this population, and participation in a multicenter trial of parental attitudes from having a child with a DSD.

513-636-4744 meilan.rutter@cchmc.org

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Meilan M. Rutter, MD

Member, Division of Endocrinology

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-4744

Fax 513-636-7486

Email meilan.rutter@cchmc.org

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Clinical

Bone health and calcium metabolism; disorders of growth, puberty and sex development; endocrine function in cancer survivors; endocrine function in neuromuscular disorders

Research

Insulin-like growth factor-1 (IGF-1) therapy in Duchenne muscular dystrophy

Biography

Meilan Rutter is board-certified in pediatrics and pediatric endocrinology. She is an associate professor of pediatrics in the Division of Endocrinology, and joined the faculty of Cincinnati Children's Hospital Medical Center within the UC College of Medicine in 2008. Currently, Dr. Rutter is assistant director of the Pediatric Endocrinology Fellowship Program.

Dr. Rutter received her degrees of Bachelor of Medicine and Bachelor of Surgery (MB, BCh) from the University of Wales College of Medicine. She completed her training in pediatrics in New Zealand, and was admitted to Fellowship of the Royal Australasian College of Physicians (FRACP) in 1995. She underwent fellowship training in pediatric endocrinology at Cincinnati Children's. She completed further pediatric residency training to achieve American Board of Pediatrics specialty and subspecialty board certification.

Dr. Rutter treats children and adolescents with endocrine disorders and diabetes mellitus. She serves as a consultant for the Neuromuscular Comprehensive Care Center and the Neuro-Oncology Program at Cincinnati Children's. Additionally, she is a member of the Disorders of Sex Development Center's interdisciplinary team.

MB, BCh: University of Wales College of Medicine, Cardiff, United Kingdom.

FRACP: Royal Australasian College of Physicians, New Zealand.

Residency: Auckland Children's Hospital and Dunedin Hospital, New Zealand; Cincinnati Children's, Cincinnati, OH.

Fellowship: Pediatric Endocrinology, Cincinnati Children's, Cincinnati, OH.

Certification: General Pediatrics, American Board of Pediatrics, 2002; Pediatric Endocrinology, American Board of Pediatrics, 2003; Pediatrics, Fellowship of the Royal Australasian College of Physicians, 1995.

Rose SR, Rutter MM, Mueller R, Harris M, Hamon B, Fletcher Bulluck A, Smith FO. Bone mineral density is normal in children with Fanconi anemia. Pediatr Blood Cancer. 2011 Dec 1;57(6):1034-8.

Bianchi ML, Biggar D, Bushby K, Rogol AD, Rutter MM, Tseng B. Endocrine aspects of Duchenne Muscular Dystrophy. Neuromuscul Disord. 2011 Apr;21(4):298-303.

Wong BL, Rutter MM, Rose SR, Clark E, Vonderhaar K. Growth hormone therapy in Duchenne Muscular Dystrophy. Best Evidence Statement, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio. 2009.

Rutter MM. What is an endocrinologist and why is endocrine care important for Duchenne? Action Duchenne newsletter. 2009.

Murray R, Rutter MM, Racine M, Rose SR. Report on The Endocrine Society’s 90^th Annual Meeting. Highlights. 2008;16(4):1-36.

Rutter MM, Racine M, Rose SR. Report on The Endocrine Society’s 89^th Annual Meeting. Highlights. 2007;15(3):2-30.

Rutter MM, Rose SR. Long-term endocrine sequelae of childhood cancer. Curr Opin Pediatr. 2007 Aug;19(4):480-7.

Rutter MM, Markoff E, Clayton L, Akeno N, Zhao G, Clemens TL, Chernausek SD. Osteoblast-specific expression of insulin-like growth factor-1 in bone of transgenic mice induces insulin-like growth factor binding protein-5. Bone. 2005 Feb;36(2):224-31.

Rutter MM, Prahalad S, Passo M, Backeljauw PF. Idiopathic hypercalcemia and eosinophilic fasciitis: a novel association. J Pediatr Endocrinol Metab. 2004 Sep;17(9):1251-4.

Rutter MM, Smith EP. Pseudohypoparathyroidism type Ia: late presentation with intact mental development. J Bone Miner Res. 1998 Jul;13(7):1208-9.

Juan Sanchez Gurmaches, PhD

The long-term objective of their research program is to elucidate the developmental and metabolic mechanisms that control adipocyte functions. They are currently working on (1) the developmental and metabolic basis of adipocyte heterogeneity; (2) how metabolic and signaling pathways impact adipose tissue distribution and function; (3) the genetic diversity of lipodystrophy disorders to obtain new insights into adipose tissue biology.

513-636-4001 juan.sanchezgurmaches@cchmc.org

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Juan Sanchez Gurmaches, PhD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4001

Email juan.sanchezgurmaches@cchmc.org

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Adipocytes; brown and white fat; animal models; adipocyte development and heterogeneity; insulin signaling; animal models

BS: University of Barcelona, Catalunya, Spain, 2005.

PhD: University of Barcelona, Catalunya, Spain, 2010.

Sanchez-Gurmaches J, Hung CM, Guertin DA. Emerging Complexities in Adipocyte Origins and Identity. Trends Cell Biol. 2016 May;26(5):313-26.

Tang Y, Wallace M, Sanchez-Gurmaches J, Hsiao WY, Li H, Lee PL, Vernia S, Metallo CM, Guertin DA. Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism. Nat Commun. 2016 Apr 21;7:11365.

Sanchez-Gurmaches J, Hsiao WY, Guertin DA. Highly Selective In Vivo Labeling of Subcutaneous White Adipocyte Precursors with Prx1-Cre. Stem Cell Reports. 2015 Apr 14;4(4):541-50.

Sanchez-Gurmaches J, Guertin DA. mTORC1 gRABs the Golgi. Cancer Cell. 2014 Nov 10;26(5):601-3.

Sanchez-Gurmaches J, Guertin DA. Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed. Nat Commun. 2014 Jun 19;5:4099.

Sanchez-Gurmaches J, Guertin DA. Adipocyte lineages: tracing back the origins of fat. Biochim Biophys Acta. 2014 Mar;1842(3):340-51.

Hung CM, Calejman CM, Sanchez-Gurmaches J, Li H, Clish CB, Hettmer S, Wagers AJ, Guertin DA. Rictor/mTORC2 Loss in the Myf5 Lineage Reprograms Brown Fat Metabolism and Protects Mice against Obesity and Metabolic Disease. Cell Rep. 2014 Jul 10;8(1):256-71.

Sanchez-Gurmaches J, Hung CM, Sparks CA, Tang Y, Li H, Guertin DA. PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors. Cell Metab. 2012 Sep 5;16(3):348-62.

Amy S. Shah, MD, MS

Amy S. Shah, MD, MS's research interests focus on the risk factors that contribute to target organ damage in youth with type 2 diabetes. Ongoing projects focus on 1) understanding the role of lipids and lipoproteins in atherosclerosis development, and 2) understanding the impact of adolescent onset type 2 diabetes on the brain and cognitive function.
Visit the Shah Lab.

513-636-4744 amy.shah@cchmc.org

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Amy S. Shah, MD, MS

Academic Affiliations

Associate Professor, UC Department of Pediatrics

Phone 513-636-4744

Fax 513-636-7486

Email amy.shah@cchmc.org

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Endocrinology; diabetes; lipid disorders

Visit the Shah Lab.

Biography

Dr. Shah is a board-certified pediatric endocrinologist and clinical lipidologist. Dr. Shah has received several prestigious awards including Young Investigator Awards from The International Society of Pediatric and Adolescent Diabetes Young Investigator Award, The National Lipid Association, The American Society of Clinical Investigation and the The Central Society for Clinical and Translational Research.

MD: St. George’s University Medical School, Grenada, West Indies, 2004.

Pediatric Residency: Loyola University Medical Center, Maywood, IL, 2007.

Endocrine Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2010.

Research Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2011.

MS: Clinical Research, The University of Cincinnati, Cincinnati, OH, 2011.

Certifications: The American Board of Pediatrics, Subspeciality Board in Pediatric Endocrinology, Clinical Lipidology.

Shah AS, Jenkins T, Gao Z, Daniels SR, Urbina EM, Kirk S, Siegel R, Inge TH. Lipid Changes 8 Years Post Gastric Bypass in Adolescents with Severe Obesity (FABS-5+ Study). International Journal of Obesity. 2017 Jun 9.

Davidson WS, Inge TH, Sexmith H, Heink A, Elder D, Hui DY, Melchior JT, Kelesidis T, Shah AS. Weight loss surgery in adolescents corrects high density lipoprotein subspecies and their function. International Journal of Obesity. 2017 Jan;41(1):83-89.

Brady CC, Vannest J, Dolan LM, Kadis D, Lee G, Holland S, Khoury J, Shah AS. Obese Adolescents with Type 2 Diabetes Perform Worse than Controls on Cognitive and Behavioral Assessments. Pediatric Diabetes. 2016 Mar;39(3):418-25.

Shah AS, Dabelea D, Fino NF, Dolan LM, Wadwa RP, D’Agostino Jr R, Hamman R, Marcovina S, Daniels SR, Urbina EM. Predictors of Increased Carotid Intima Media Thickness in Youth with Type 1 diabetes: The SEARCH CVD Study. Diabetes Care. 2016 Mar;39(3):418-25.

Shah AS, Dolan LM, Khoury PR, Gai Z, Kimball TR, Urbina EM. Severe Obesity in Adolescents and Young Adults is Associated with Sub-Clinical Cardiac and Vascular Changes. Journal of Endocrinology and Metabolism. 2015 Jul;100(7):2751-7.

Maahs DM, Daniels SR, DeFerranti S, Dichek H, Flynn J, Goldstein BI, Kelly AS, Nadeau KJ, Martyn-Nemeth P, Osganian S, Quinn L, Shah AS, Urbina EM. On behalf of the American Heart Association Atherosclerosis, Hypertension and Obesity in Youth Committee of the Council on Cardiovascular Disease in the Young, Council on Clinical Cardiology, Council of Cardiovascular and Stroke Nursing, Council for High Blood Pressure Research, and Council on Lifestyle and Cardiometabolic Health. Cardiovascular Disease Risk Factors in Youth with Diabetes Mellitus: A Statement from the American Heart Association. Circulation. 2014 Oct 21;130(17):1532-58.

Shah AS, Gao Z, Urbina EM, Kimball TR, Dolan LM. Pre-diabetes: The Effects on Arterial Thickness and Stiffness in Obese Youth. Journal of Clinical Endocrinology and Metabolism. 2 2014 Mar;99(3):1037-43.

Gordon SM, Davidson WS, Urbina EM, Dolan LM, Heink A, Zang H, Lu LJ, Shah AS. The effects of type 2 diabetes on lipoprotein composition and arterial stiffness in male youth. Diabetes. 2013 Aug;62(8):2958-67. ***With commentary published by von Eckardstein A, Nofer JR Diabetes August 2013 62:2662-2664.

Shah AS, Khoury PR, Dolan LM, Ippisch HM, Urbina EM, Daniels SR, Kimball, TR. The Effects of Obesity and Type 2 Diabetes Mellitus on Cardiac Structure and Function in Adolescents and Young Adults. Diabetologia. 2011 Apr; 54 (4):722-30.

Shah AS, Dolan LM, Kimball TR, Gao Z, Khoury PR, Daniels SR, Urbina EM. Influence of Duration of Diabetes, Glycemic Control, and Traditional Cardiovascular Risk Factors on Early Atherosclerotic Vascular Changes in Adolescents and Young Adults with Type 2 Diabetes Mellitus. Journal of Clinical Endocrinology and Metabolism. 2009 Oct; 94(10):3740-5.

Grants

Understanding the Role of HDL Subspecies in Adolescents with Type 2 Diabetes. Principal Investigator. K23 Career Development Award, National Institutes of Health Heart, Lung and Blood. April 2014-March 2019.

Comparisons of Bariatric Surgery Types on High Density Lipoproteins Subspecies and the Functions. Principal Investigator. William Cooper Procter Research Scholar. Jul 2016-Jun 2018.

Long-Term Post-Intervention Follow-Up of the TODAY Clinical Ttrial cohort. Co-Investigator. National Institutes of Health. Apr 2016-Mar 2021.

Exploring the Role of Circulating Small RNAs in Integrative Organ Crosstalk for Glycemic Control. Co-investigator. Pediatric Diabetes and Obesity Center. Jul 2015-Jun 2018.

Nicole M. Sheanon, MD, MS Member, Division of Endocrinology

Nicole M. Sheanon, MD, MS, investigates beta cell function in girls with Turner Syndrome to determine their risk of diabetes. She is also interested in type 1 diabetes treatment and complications specifically diabetic nephropathy.

513-636-4744 nicole.sheanon@cchmc.org

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Nicole M. Sheanon, MD, MS

Member, Division of Endocrinology

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4744

Email nicole.sheanon@cchmc.org

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Clinical

Type 1 diabetes; Turner syndrome; general endocrine disorders

Research

Turner syndrome; diabetes in children

Biography

Nicole Sheanon, MD, MS, is an assistant professor of pediatrics in the Division of Endocrinology at Cincinnati Children's Hospital Medical Center within the UC Department of Pediatrics. Her research has focused on beta cell function in the young Turner syndrome population and complications of type 1 diabetes. Dr. Sheanon's clinical interests are in the areas of Turner syndrome, diabetes in children, adrenal insufficiency, and puberty.

MD: University of Cincinnati, Cincinnati, OH, 2006.

Residency: Pediatrics, University of Massachusetts, Worcester, MA.

Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Certification: Pediatric Endocrinology, 2015.

Sheanon N, Simpson B, Shaughnessy E. Teenager with hip pain and limp. JAMA Pediatr. 2017 Mar 1;171(3):297-298.

Sheanon N, Backeljauw P. Effect of Oxandrolone Therapy on Adult Height in Turner Syndrome Patients Treated with Growth Hormone: A Meta-Analysis. Int J Pediatr Endocrinol. 2015;2015(1):18.

Halley M. Wasserman, MD, MS Member, Division of Endocrinology

Halley Wasserman, MD, MS, investigates pediatric bone health in patients with Turner Syndrome and conditions associated with chronic immobility, aiming to provide insight into the complex relationship of mechanical stimulation, balance, and hormone exposure on bone mass accrual and fracture risk in children. Identifying differences in bone turnover in these populations will help target interventions to manage low bone density and osteoporosis.

513-636-4744 halley.wasserman@cchmc.org

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Halley M. Wasserman, MD, MS

Member, Division of Endocrinology

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4744

Email halley.wasserman@cchmc.org

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Clinical

Pediatric endocrinology; pediatric bone health

Research

Pediatric bone health

MD: Northeastern Ohio Medical University, Rootstown, OH, 2009.

Residency: Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2012.

Fellowship: Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2016.

MS: Clinical and Translational Research, University of Cincinnati, Cincinnati, OH, 2016.

Certification: Pediatrics, 2012; Pediatric Endocrinology, 2015.

Wasserman H, Gordon CM. Fracture Risk Among Children and Adolescents. Journal of Clinical Densitometry. 2017.

Wasserman HM, Hornung LN, Stenger PJ, Rutter MM, Wong BL, Rybalsky I, Khoury JC, Kalkwarf HJ. Low bone mineral density and fractures are highly prevalent in pediatric patients with spinal muscular atrophy regardless of disease severity. Neuromuscul Disord. 2017 Apr;27(4):331-337.

Wasserman H, O’Donnell J, Gordon CM. Use of dual energy X-ray absorptiometry in pediatric patients. Bone. 2016.

Wasserman H, Hufnagel RB, Miraldi Utz V, Zhang K, Valencia CA, Leslie ND, Crimmins NA. Bilateral Cataracts in a 6-year-old with New Onset Diabetes: a novel presentation of a known INS gene mutation. Pediatr Diabetes. 2015 Nov 4.

James M. Wells, PhD Director, Basic Research, Division of Endocrinology

James M. Wells, PhD, researches the molecular mechanisms of endoderm organogenesis in mouse and humans. The goal of this work is to identify the molecular basis of congenital defects affecting the pancreas, liver, and biliary system and to direct the differentiation of pluripotent stem cells (PSCs) into therapeutic cells for replacement therapies, such as transplantable pancreatic beta cells for patients with type-1 diabetes.
Visit the Wells Lab.

513-636-8767 james.wells@cchmc.org

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James M. Wells, PhD

Director, Basic Research, Division of Endocrinology

Director, Pluripotent Stem Cell Center

Academic Affiliations

Professor, UC Department of Pediatrics

Phone 513-636-8767

Fax 513-636-4317

Email james.wells@cchmc.org

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Research

Understanding the development of the pancreas, and gastrointestinal organs; generating 3-dimensional human tissues from pluripotent stem cells and using these as human models of diabetes and digestive disease.

For more information, please visit the Wells lab web page.

Biography

The focus of his teams basic research has been to identify the molecular mechanisms involved in the embryonic development of endocrine cells including pancreatic beta cells and tissues of the gastrointestinal tract. Their translational projects have focused on identifying new approaches to improve child health in several ways: 1. To identify and use embryonic pathways to generate complex, three-dimensional organ tissues from pluripotent stem cells, 2. Use these tissues to develop new in vitro human models for diabetes and digestive disease research and 3. Develop long-term, therapeutic strategies for cell and tissue-replacement therapies.

BS: Biochemistry, Molecular and Cell Biology, University of Maine, Orono, ME, 1987.

PhD: Graduate program in Genetics, SUNY at Stony Brook, New York, 1995.

Postdoctoral Fellow: Harvard University, Cambridge MA, 1996 - 2001.

View Dr. Wells PubMed Publications.

McCracken KW, Catá E, Crawford C, Sinagoga KL, Schumacher M, Mayhew CN, Zavros Y, Wells JM. Modelling human development and disease in pluripotent stem cell-derived gastric organoids. Nature. 2014 Dec 18;516(7531):400-4.

Watson CL, Mahe MM, Howell JC, Munera J, Sundaram N, Schweitzer J, Vallance JE, Shroyer NF, Wells JM, Helmrath MA. An in vivo model of human small intestine using pluripotent stem cells. Nat Med. 2014 Nov;20(11):1310-4.

Ji H, Zhang X, Oh S, Mayhew C, Ulm A, Somineni H, Ericksen M, Wells J, Khurana Hershey GK. Dynamic transcriptional and epigenomic reprogramming from pediatric nasal epithelial cells to induced pluripotent stem cells. J Allergy Clin Immunol. 2014 Oct 14, pii:S0091-6749(14)01262-7.

Chlon TM, Hoskins EE, Mayhew CN, Wikenheiser-Brokamp KA, Davies SM, Mehta P, Myers KC, Wells JM, Wells, SI. High-Risk Human Papillomavirus E6 Protein Promotes Reprogramming of Fanconi Anemia Patient Cells through Repression of p53 but Does Not Allow for Sustained Growth of Induced Pluripotent Stem Cells. J Virol. 2014 Oct 1;88(19)11315-26.

Jonatan D, Spence JR, Method AM, Sinagoga K, Kofron M, Haataja L, Arvan P, Deutsch GH, Wells JM. Sox17 regulates insulin secretion in the normal and pathologic beta cell. PLoS One. 2014 Aug 21;9(8):e104675.

Schiesser JV, Wells JM. Generation of beta cells from human pluripotent stem cells: are we there yet? Ann N Y Acad Sci. 2014 Apr;1311:124-37.

Runck LA, Method A, Bischoff A, Levitt M, Peña A, Collins MH, Gupta A, Shanmukhappa S, Wells JM, Guasch G. Defining the molecular pathologies in cloaca malformation: similarities between mouse and human. Dis Model Mech. 2014 Apr;7(4):483-93.

Wells JM, Spence JR. How to make an intestine. Development. 2014 Feb;141(4):752-60.

Delgiorno KE, Hall JC, Takeuchi KK, Pan FC, Halbrook CJ, Washington MK, Olive KP, Spence JR, Sipos B, Wright CV, Wells JM, Crawford HC. Identification and manipulation of biliary metaplasia in pancreatic tumors. Gastroenterology. 2014 Jan;146(1):233-44.e5.

Suissa Y, Magenheim J, Stolovich-Rain M, Hija A, Collombat P, Mansouri A, Sussel L, Sosa-Pineda B, McCracken K, Wells JM, Heller RS, Dor Y, Glaser B. Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas. PLoS One. 2013 Aug 5;8(8):e70397.

Grants

Investigation of regional identity in human intestinal stem cells. Principal investigator (along with Shroyer NF, PI and Helmrath M, PI). National Institutes of Health. Sep 2014 – Aug 2019. NIH U01DK103117.

Single Cell Dissection of Human Intestine Development. Principal Investigator. National Institutes of Health. Sep 2013 – Aug 2018. NIH 1R01DK098350.

Control of human endocrine cell development. Contact Principal Investigator. National Institutes of Health. Apr 2012 – Mar 2017. NIH 1R01DK092456-01.

Transcriptional Control of Placental Differentiation. Co-Investigator. National Institutes of Health. Feb 2011 – Jan 2016. NIH R01 HD065339.

Nana-Hawa Yayah Jones, MD

Dr. Nana Jones participates in quality improvement projects to improve health care systems navigation for children at risk for adverse outcomes. Projects include preventing loss to follow up in children with congenital hypothyroidism, perioperative management of diabetes patients, and medication reconciliation.

513-636-4744 nana.jones@cchmc.org

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Nana-Hawa Yayah Jones, MD

Academic Affiliations

Assistant Professor, UC Department of Pediatrics

Phone 513-636-4744

Fax 513-636-7486

Email nana.jones@cchmc.org

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Clinical

Pediatric endocrinology; adherence in management of diabetes

Research

Quality improvement

Biography

Nana-Hawa Yayah Jones, MD, is an assistant professor in the Division of Endocrinology. Dr. Yayah Jones arrived in Cincinnati from St. Louis, Missouri where she completed both pediatric residency and endocrinology fellowship at Washington University's St. Louis Children's Hospital (SLCH). An additional year was spent at SLCH as a pediatric chief resident. During all the years of Dr. Yayah Jones's training she was active in fostering diversity among the medical trainees and in fact founded the Washington University Minority Medical Association (WUMMA), a group of medical trainees whose focus was on recruitment, retention and community service.

As a clinician here at CCHMC, she focuses on adherence in children with chronic diseases such as congenital hypothyroidism and insulin dependent diabetes. She is a quality improvement specialist and thus leads developing formal approaches to the systematically improving adherence in the management of congenital hypothyroidism in children as well as addressing the hospital and patient practices of insulin dependent diabetes patients who have surgery at Children's Hospital. Given her passion in adherence, Dr. Jones also works within the healthcare system to improve adherence for children at risk for adverse outcomes, especially in the care of diabetes patients.

MD: University of Louisville School of Medicine, Louisville, KY, 2002.

Residency: Pediatrics, Washington University, St. Louis Children’s Hospital, St. Louis, MO, 2005.

Chief Residency: Pediatrics, Washington University, St. Louis Children’s Hospital, St. Louis, MO, 2006.

Fellowship: Pediatrics, Washington University, St. Louis Children’s Hospital, St. Louis, MO, 2009.