Oligodendrocytes myelinate axons in the CNS, providing an increased conductivity for the electrical nerve impulses traveling through the axons. Some of the non-tumor problems of NF1 patients, such as learning disabilities, hydrocephaly and T2 hyper-intensities identified by MRIs (thought to represent areas of abnormal-myelin), led us to study oligodendrocyte development and function in NF1 mouse models. Examining how oligodendrocytes are altered may provide potential therapeutic avenues.