The lab led an international effort to define the differences between normal Schwann cells and NF1 mutant Schwann cells that may be relevant to neurofibroma formation and to the development of malignant peripheral nerve sheath tumor (MPNST). Our initial approach was to use large-scale microarray analysis to identify deregulated genes, and then to test their effect on tumorigenesis in transgenic mice. This has been extended to screens in collaboration with several outside laboratories using shRNAs, oncolytic viruses and sleeping beauty insertional mutagenesis screen.