Recent Publications

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Cast AE, Walter TJ, Huppert SS. Vascular patterning sets the stage for macro and micro hepatic architecture. Dev Dyn. 2015 Mar;244(3):497-506.

Walter TJ, Cast AE, Huppert KA, Huppert SS. Epithelial VEGF signaling is required in the mouse liver for proper sinusoid endothelial cell identity and hepatocyte zonation in vivo Am J Physiol Gastrointest Liver Physiol. 2014 May 15;306(10):G849-62.

Walter TJ, Vanderpool C, Cast AE, Huppert SS. Intrahepatic Bile Duct Regeneration in Mice Does Not Require Hnf6 or Notch Signaling through Rbpj. Am J Pathol. 2014 May;184(5):1479-88.

Arasada RR, Amann JM, Rahman MA, Huppert SS, Carbone DP. EGFR blockade enriches for lung cancer stem-like cells through Notch3-dependent signaling. Cancer Res. 2014 Oct 1;74(19):5572-84.

Chen TW, Broadus MR, Huppert SS, Lee E.Reconstitution Of β-catenin degradation in Xenopus egg extract. J Vis Exp. 2014 Jun 17;(88).

Poling HM, Mohanty SK, Tiao GM, Huppert SS. A comprehensive analysis of aquaporin and secretory related gene expression in neonate and adult cholangiocytes. Gene Expr Patterns. 2014 Jul;15(2):96-103.

Miethke AG, Huppert SS. Fishing for biliary atresia susceptibility genes. Gastroenterology. 2013 May;144(5):878-81.

Murphy AJ, de Caestecker C, Pierce J, Boyle SC, Ayers GD, Zhao Z, Libes JM, Correa H, Walter T, Huppert SS, Perantoni AO, de Caestecker MP, Lovvorn HN 3rd. CITED1 expression in liver development and hepatoblastoma. Neoplasia. 2012 Dec;14(12):1153-63. 

Walter TJ, Sparks EE, Huppert SS. 3-dimensional resin casting and imaging of mouse portal vein or intrahepatic bile duct system. J Vis Exp. 2012 Oct 25;(68):e4272.

Hang BI, Thorne CA, Robbins DJ, Huppert SS, Lee LA, Lee E. Screening for small molecule inhibitors of embryonic pathways: sometimes you gotta crack a few eggs. Bioorg Med Chem. 2012 Mar 15;20(6):1869-77.

Humphreys R, Zheng W, Prince LS, Qu X, Brown C, Loomes K, Huppert SS, Baldwin S, Goudy S. Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients. Hum Mol Genet. 2012 Mar 15;21(6):1374-83. Erratum in: Hum Mol Genet. 2012 Jun 15;21(12):2843. 

Vanderpool C, Sparks EE, Huppert KA, Gannon M, Means AL, Huppert SS. Genetic interactions between hepatocyte nuclear factor-6 and Notch signaling regulate mouse intrahepatic bile duct development in vivo. Hepatology. 2012 Jan;55(1):233-43.

Thorne CA, Lafleur B, Lewis M, Hanson AJ, Jernigan KK, Weaver DC, Huppert KA, Chen TW, Wichaidit C, Cselenyi CS, Tahinci E, Meyers KC, Waskow E, Orton D, Salic A, Lee LA, Robbins DJ, Huppert SS, Lee E. A biochemical screen for identification of small-molecule regulators of the Wnt pathway using Xenopus egg extracts. J Biomol Screen. 2011 Oct;16(9):995-1006.

Huppert SSA new set of classifications for ductal plate malformations. Hepatology. 2011 Jun;53(6):1795-7. doi: 10.1002/hep.24404.

Sparks EE, Perrien DS, Huppert KA, Peterson TE, Huppert SS. Defects in hepatic Notch signaling result in disruption of the communicating intrahepatic bile duct network in mice. Dis Model Mech. 2011 May;4(3):359-67.

Sparks EE, Huppert KA, Brown MA, Washington MK, Huppert SSNotch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice. Hepatology. 2010 Apr;51(4):1391-400.

Huppert SS, Magnuson MA. New complexity in differentiating stem cells toward hepatic and pancreatic fates. Sci Signal. 2009 Aug 11;2(83):pe50.

Vooijs M, Ong CT, Hadland B, Huppert S, Liu Z, Korving J, van den Born M, Stappenbeck T, Wu Y, Clevers H, Kopan R. Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development. 2007 Feb;134(3):535-44.

Huppert SS, Ilagan MX, De Strooper B, Kopan R.  Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. Dev Cell. 2005 May;8(5):677-88.

Huppert SS, Le A, Schroeter EH, Mumm JS, Saxena MT, Milner LA, Kopan R. Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. Nature. 2000 Jun 22;405(6789):966-70. Erratum in: Nature 2000 Nov 30;408(6812):616.

Huppert SS, Jacobsen TL, Muskavitch MA. Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis. Development. 1997 Sep;124(17):3283-91.

Contact Us

A photo of Stacey Huppert.

Stacey S. Huppert, PhD
Associate Professor
UC Department of Pediatrics

Division of Gastroenterology, Hepatology & Nutrition, Division of Developmental Biology, Cincinnati Children's Hospital Medical Center

Mailing Address:
Cincinnati Children’s Hospital Medical Center
3333 Burnet Avenue
Cincinnati, Ohio 45229

Office Phone: 513-803-3871
Lab Phone: 513-636-4014