Huppert Lab

Publications

Adams, JM; Huppert, KA; Castro, EC; Lopez, MF; Niknejad, N; Subramanian, S; Zarrin-Khameh, N; Finegold, MJ; Huppert, SS; Jafar-Nejad, H. Sox9 Is a Modifier of the Liver Disease Severity in a Mouse Model of Alagille Syndrome. Hepatology. 2020; 71:1331-1349.

Huppert, SS; Iwafuchi-Doi, M. Molecular regulation of mammalian hepatic architecture. Editor, Wellik DM. Current Topics in Developmental Biology. 2019; 132:91-136.

Schaub, JR; Huppert, KA; Kurial, SN T; Hsu, BY; Cast, AE; Donnelly, B; Karns, RA; Chen, F; Rezvani, M; Luu, HY; Mattis, AN; Rougemont, A; Rosenthal, P; Huppert, SS; Willenbring, H. De novo formation of the biliary system by TGFβ-mediated hepatocyte transdifferentiation. Nature. 2018; 557:247-251.

Broadus, MR; Chen, TW; Neitzel, LR; Ng, VH; Jodoin, JN; Lee, LA; Salic, A; Robbins, DJ; Capobianco, AJ; Patton, JG; Huppert, SS; Lee, E. Identification of a Paralog-Specific Notch1 Intracellular Domain Degron. Cell Reports. 2016; 15:1920-1929.

McDaniel, CG; Fox, D; Pastura, P; Alharbi, S; Huppert, SS; Cras, TD L. Lyve1-Driven NrasQ61R Causes Edema, Enlarged Lymphatic Vessels, and Hepatic Vascular Defects in Embryonic Mice. Pediatric Blood and Cancer. 2025; 72:e31492.

Hellen, DJ; Fay, ME; Lee, DH; Klindt-Morgan, C; Bennett, A; Pachura, KJ; Grakoui, A; Huppert, SS; Dawson, PA; Lam, WA; Karpen, SJ. BiliQML: a supervised machine-learning model to quantify biliary forms from digitized whole slide liver histopathological images. American Journal of Physiology: Gastrointestinal and Liver Physiology. 2024; 327:G1-G15.

Huppert, SS; Balistreri, WF. Morphogenesis of the Liver and Biliary System. Nelson Textbook of Pediatrics: Volume 1-2. 2024.

Niknejad, N; Fox, D; Burwinkel, JL; Zarrin-Khameh, N; Cho, S; Soriano, A; Cast, AE; Lopez, MF; Huppert, KA; Rigo, F; Huppert, SS; Jafar-Nejad, P; Jafar-Nejad, H. ASO silencing of a glycosyltransferase, Poglut1 , improves the liver phenotypes in mouse models of Alagille syndrome. Hepatology. 2023; 78:1337-1351.

Huppert, SS; Schwartz, RE. Multiple Facets of Cellular Homeostasis and Regeneration of the Mammalian Liver. Annual Review of Physiology. 2023; 85:469-493.

Hayashi, H; Osaka, S; Sakabe, K; Fukami, A; Kishimoto, E; Aihara, E; Sabu, Y; Mizutani, A; Kusuhara, H; Naritaka, N; Mayhew, C; Setchell, K; Takebe, T; Asai, A. Modeling Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation. Stem Cell Reports. 2021; 16:309-323.

Adams, JM; Huppert, KA; Castro, EC; Lopez, MF; Niknejad, N; Subramanian, S; Zarrin-Khameh, N; Finegold, MJ; Huppert, SS; Jafar-Nejad, H. Sox9 Is a Modifier of the Liver Disease Severity in a Mouse Model of Alagille Syndrome. Hepatology. 2020; 71:1331-1349.