VanDussen Lab

Ojo, BA; VanDussen, KL; Rosen, MJ. The Promise of Patient-Derived Colon Organoids to Model Ulcerative Colitis. Inflammatory Bowel Diseases. 2021.

Liu, TC; Kern, JT; Jain, U; Sonnek, NM; Xiong, S; Simpson, KF; VanDussen, KL; Winkler, ES; Haritunians, T; Malique, A; et al. Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation. Cell Host and Microbe. 2021; 29:988-1001.e6.

Osterman, MT; Vandussen, KL; Gordon, IO; Davis, EM; Li, K; Simpson, K; Ciorba, M; Glover, SC; Abraham, B; Guo, X; et al. Epithelial Cell Biomarkers Are Predictive of Response to Biologic Agents in Crohn's Disease. Inflammatory Bowel Diseases. 2021; 27:677-685.

Vandussen, KL; Funkhouser-Jones, LJ; Akey, ME; Schaefer, DA; Ackman, K; Riggs, MW; Stappenbeck, TS; David Sibley, L. Neonatal Mouse Gut Metabolites Influence Cryptosporidium parvum Infection in Intestinal Epithelial Cells. mBio. 2020; 11.

VanDussen, KL; Sonnek, NM; Stappenbeck, TS. L-WRN conditioned medium for gastrointestinal epithelial stem cell culture shows replicable batch-to-batch activity levels across multiple research teams. Stem Cell Research. 2019; 37.

VanDussen, KL; Stojmirovic, A; Li, K; Liu, T; Kimes, PK; Muegge, BD; Simpson, KF; Ciorba, MA; Perrigoue, JG; Friedman, JR; et al. Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn's Disease. Gastroenterology. 2018; 155:815-828.

Miyoshi, H; VanDussen, KL; Malvin, NP; Ryu, SH; Wang, Y; Sonnek, NM; Lai, C; Stappenbeck, TS. Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium. EMBO Journal. 2017; 36:5-24.

VanDussen, KL; Marinshaw, JM; Shaikh, N; Miyoshi, H; Moon, C; Tarr, PI; Ciorba, MA; Stappenbeck, TS. Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays. Gut. 2015; 64:911-920.

VanDussen, KL; Liu, T; Li, D; Towfic, F; Modiano, N; Winter, R; Haritunians, T; Taylor, KD; Dhall, D; Targan, SR; et al. Genetic variants synthesize to produce paneth cell phenotypes that define subtypes of Crohn's disease. Gastroenterology. 2014; 146:200-209.

Ojo, BA; VanDussen, KL; Rosen, MJ. The Promise of Patient-Derived Colon Organoids to Model Ulcerative Colitis. Inflammatory Bowel Diseases. 2021.

Liu, TC; Kern, JT; Jain, U; Sonnek, NM; Xiong, S; Simpson, KF; VanDussen, KL; Winkler, ES; Haritunians, T; Malique, A; et al. Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation. Cell Host and Microbe. 2021; 29:988-1001.e6.

Osterman, MT; Vandussen, KL; Gordon, IO; Davis, EM; Li, K; Simpson, K; Ciorba, M; Glover, SC; Abraham, B; Guo, X; et al. Epithelial Cell Biomarkers Are Predictive of Response to Biologic Agents in Crohn's Disease. Inflammatory Bowel Diseases. 2021; 27:677-685.

Vandussen, KL; Funkhouser-Jones, LJ; Akey, ME; Schaefer, DA; Ackman, K; Riggs, MW; Stappenbeck, TS; David Sibley, L. Neonatal Mouse Gut Metabolites Influence Cryptosporidium parvum Infection in Intestinal Epithelial Cells. mBio. 2020; 11.

Seiler, KM; Bajinting, A; Alvarado, DM; Traore, MA; Binkley, MM; Goo, WH; Lanik, WE; Ou, J; Ismail, U; Iticovici, M; et al. Patient-derived small intestinal myofibroblasts direct perfused, physiologically responsive capillary development in a microfluidic Gut-on-a-Chip Model. Scientific Reports. 2020; 10.

Wang, Y; Chiang, I; Ohara, TE; Fujii, S; Cheng, J; Muegge, BD; Ver Heul, A; Han, ND; Lu, Q; Xiong, S; et al. Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells. Cell. 2019; 179:1144-1159.e15.

Alvarado, DM; Chen, B; Iticovici, M; Thaker, AI; Dai, N; VanDussen, KL; Shaikh, N; Lim, CK; Guillemin, GJ; Tarr, PI; et al. Epithelial Indoleamine 2,3-Dioxygenase 1 Modulates Aryl Hydrocarbon Receptor and Notch Signaling to Increase Differentiation of Secretory Cells and Alter Mucus-Associated Microbiota. Gastroenterology. 2019; 157:1093-1108.e11.

Potdar, AA; Li, D; Haritunians, T; VanDussen, KL; Fiorino, MF; Liu, T; Stappenbeck, TS; Fleshner, P; Targan, SR; McGovern, DP B; et al. Ileal Gene Expression Data from Crohn's Disease Small Bowel Resections Indicate Distinct Clinical Subgroups. Journal of Crohn's and Colitis. 2019; 13:1055-1066.

Wilke, G; Funkhouser-Jones, LJ; Wang, Y; Ravindran, S; Wang, Q; Beatty, WL; Baldridge, MT; VanDussen, KL; Shen, B; Kuhlenschmidt, MS; et al. A Stem-Cell-Derived Platform Enables Complete Cryptosporidium Development In Vitro and Genetic Tractability. Cell Host and Microbe. 2019; 26:123-134.e8.

VanDussen, KL; Sonnek, NM; Stappenbeck, TS. L-WRN conditioned medium for gastrointestinal epithelial stem cell culture shows replicable batch-to-batch activity levels across multiple research teams. Stem Cell Research. 2019; 37.

Kaiko, GE; Chen, F; Lai, C; Chiang, I; Perrigoue, J; Stojmirovic, A; Li, K; Muegge, BD; Jain, U; VanDussen, KL; et al. PAI-1 augments mucosal damage in colitis. Science Translational Medicine. 2019; 11.

Liu, T; Kern, JT; VanDussen, KL; Xiong, S; Kaiko, GE; Wilen, CB; Rajala, MW; Caruso, R; Holtzman, MJ; Gao, F; et al. Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn's disease. Journal of Clinical Investigation. 2018; 128:5110-5122.

Jain, U; Lai, C; Xiong, S; Goodwin, VM; Lu, Q; Muegge, BD; Christophi, GP; VanDussen, KL; Cummings, BP; Young, E; et al. Temporal Regulation of the Bacterial Metabolite Deoxycholate during Colonic Repair Is Critical for Crypt Regeneration. Cell Host and Microbe. 2018; 24:353-363.e5.

VanDussen, KL; Stojmirovic, A; Li, K; Liu, T; Kimes, PK; Muegge, BD; Simpson, KF; Ciorba, MA; Perrigoue, JG; Friedman, JR; et al. Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn's Disease. Gastroenterology. 2018; 155:815-828.

Wilke, G; Ravindran, S; Funkhouser-Jones, L; Barks, J; Wang, Q; VanDussen, KL; Stappenbeck, TS; Kuhlenschmidt, TB; Kuhlenschmidt, MS; Sibley, LD. Monoclonal Antibodies to Intracellular Stages of Cryptosporidium parvum Define Life Cycle Progression In Vitro. mSphere. 2018; 3.

Liu, T; Naito, T; Liu, Z; VanDussen, KL; Haritunians, T; Li, D; Endo, K; Kawai, Y; Nagasaki, M; Kinouchi, Y; et al. LRRK2 but not ATG16L1 is associated with Paneth cell defect in Japanese Crohn's disease patients. JCI insight. 2017; 2.

Miyoshi, H; VanDussen, KL; Malvin, NP; Ryu, SH; Wang, Y; Sonnek, NM; Lai, C; Stappenbeck, TS. Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium. EMBO Journal. 2017; 36:5-24.