VanDussen Lab

Publications

Ojo, BA; Vandussen, KL; Rosen, MJ. The Promise of Patient-Derived Colon Organoids to Model Ulcerative Colitis. Inflammatory Bowel Diseases. 2022; 28:299-308.

Liu, TC; Kern, JT; Jain, U; Sonnek, NM; Xiong, S; Simpson, KF; VanDussen, KL; Winkler, ES; Haritunians, T; Malique, A; et al. Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation. Cell Host and Microbe. 2021; 29:988-1001.e6.

Osterman, MT; Vandussen, KL; Gordon, IO; Davis, EM; Li, K; Simpson, K; Ciorba, M; Glover, SC; Abraham, B; Guo, X; et al. Epithelial Cell Biomarkers Are Predictive of Response to Biologic Agents in Crohn's Disease. Inflammatory Bowel Diseases. 2021; 27:677-685.

Vandussen, KL; Funkhouser-Jones, LJ; Akey, ME; Schaefer, DA; Ackman, K; Riggs, MW; Stappenbeck, TS; David Sibley, L. Neonatal Mouse Gut Metabolites Influence Cryptosporidium parvum Infection in Intestinal Epithelial Cells. Editor, Weiss LM. mBio. 2020; 11:e02582-e02520.

VanDussen, KL; Sonnek, NM; Stappenbeck, TS. L-WRN conditioned medium for gastrointestinal epithelial stem cell culture shows replicable batch-to-batch activity levels across multiple research teams. Stem Cell Research. 2019; 37:101430.

VanDussen, KL; Stojmirovic, A; Li, K; Liu, T; Kimes, PK; Muegge, BD; Simpson, KF; Ciorba, MA; Perrigoue, JG; Friedman, JR; et al. Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn's Disease. Gastroenterology. 2018; 155:815-828.

Miyoshi, H; VanDussen, KL; Malvin, NP; Ryu, SH; Wang, Y; Sonnek, NM; Lai, C; Stappenbeck, TS. Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium. The EMBO Journal. 2017; 36:5-24.

VanDussen, KL; Marinshaw, JM; Shaikh, N; Miyoshi, H; Moon, C; Tarr, PI; Ciorba, MA; Stappenbeck, TS. Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays. Gut. 2015; 64:911-920.

VanDussen, KL; Liu, T; Li, D; Towfic, F; Modiano, N; Winter, R; Haritunians, T; Taylor, KD; Dhall, D; Targan, SR; et al. Genetic variants synthesize to produce paneth cell phenotypes that define subtypes of Crohn's disease. Gastroenterology. 2014; 146:200-209.

VanDussen, KL; Carulli, AJ; Keeley, TM; Patel, SR; Puthoff, BJ; Magness, ST; Tran, IT; Maillard, I; Siebel, C; Kolterud, A; et al. Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells. Development (Cambridge). 2012; 139:488-497.

Funkhouser-Jones, LJ; Xu, R; Wilke, G; Fu, Y; Schriefer, LA; Makimaa, H; Rodgers, R; Kennedy, EA; VanDussen, KL; Stappenbeck, TS; et al. Microbiota-produced indole metabolites disrupt mitochondrial function and inhibit Cryptosporidium parvum growth. Cell Reports. 2023; 42:112680.

Braun, T; Sosnovski, KE; Amir, A; BenShoshan, M; VanDussen, KL; Karns, R; Levhar, N; Abbas-Egbariya, H; Hadar, R; Efroni, G; et al. Mucosal transcriptomics highlight lncRNAs implicated in ulcerative colitis, Crohn's disease, and celiac disease. JCI insight. 2023; 8:e170181.

Sosnovski, KE; Braun, T; Amir, A; Moshel, D; Benshoshan, M; Vandussen, KL; Levhar, N; Abbas-Egbariya, H; Beider, K; Ben-Yishay, R; et al. GATA6-AS1 Regulates Intestinal Epithelial Mitochondrial Functions, and its Reduced Expression is Linked to Intestinal Inflammation and Less Favourable Disease Course in Ulcerative Colitis. Journal of Crohn's and Colitis. 2023; 17:960-971.

Overcast, GR; Meibers, HE; Eshleman, EM; Saha, I; Waggoner, L; Patel, KN; Jain, VG; Haslam, DB; Alenghat, T; Vandussen, KL; et al. IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation. The Journal of Experimental Medicine. 2023; 220:e20212523.

Ma, C; Haritunians, T; Mujukian, A; Hanna, M; Li, D; VanDussen, KL; Head, RD; Stappenbeck, TS; Mcgovern, DP B; Liu, T. Sa1862 ABNORMAL PANETH CELL PHENOTYPE IN INFLAMMATORY BOWEL DISEASE PATIENTS IS ASSOCIATED WITH DEFECTS IN SECRETORY GRANULE MATURATION SIGNALING. Gastroenterology. 2023; 164:s-467.

Strine, MS; Alfajaro, MM; Graziano, VR; Song, J; Hsieh, LL; Hill, R; Guo, J; VanDussen, KL; Orchard, RC; Baldridge, MT; et al. Tuft-cell-intrinsic and -extrinsic mediators of norovirus tropism regulate viral immunity. Cell Reports. 2022; 41:111593.

Haberman, Y; Vallance, J; Baverman, J; Liu, T; Kugathasan, S; Denson, L; VanDussen, K. ILEAL ENTEROCYTE BRUSH BORDER ABNORMALITIES ASSOCIATE WITH PROGRESSIVE DISEASE COURSE IN PEDIATRICS CROHN’S DISEASE. Gastroenterology. 2022; 162:s49-s50.

Ojo, BA; Vandussen, KL; Rosen, MJ. The Promise of Patient-Derived Colon Organoids to Model Ulcerative Colitis. Inflammatory Bowel Diseases. 2022; 28:299-308.

Liu, TC; Kern, JT; Jain, U; Sonnek, NM; Xiong, S; Simpson, KF; VanDussen, KL; Winkler, ES; Haritunians, T; Malique, A; et al. Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation. Cell Host and Microbe. 2021; 29:988-1001.e6.

Osterman, MT; Vandussen, KL; Gordon, IO; Davis, EM; Li, K; Simpson, K; Ciorba, M; Glover, SC; Abraham, B; Guo, X; et al. Epithelial Cell Biomarkers Are Predictive of Response to Biologic Agents in Crohn's Disease. Inflammatory Bowel Diseases. 2021; 27:677-685.

Vandussen, KL; Funkhouser-Jones, LJ; Akey, ME; Schaefer, DA; Ackman, K; Riggs, MW; Stappenbeck, TS; David Sibley, L. Neonatal Mouse Gut Metabolites Influence Cryptosporidium parvum Infection in Intestinal Epithelial Cells. Editor, Weiss LM. mBio. 2020; 11:e02582-e02520.

Seiler, KM; Bajinting, A; Alvarado, DM; Traore, MA; Binkley, MM; Goo, WH; Lanik, WE; Ou, J; Ismail, U; Iticovici, M; et al. Patient-derived small intestinal myofibroblasts direct perfused, physiologically responsive capillary development in a microfluidic Gut-on-a-Chip Model. Scientific Reports. 2020; 10:3842.

Wang, Y; Chiang, I; Ohara, TE; Fujii, S; Cheng, J; Muegge, BD; Ver Heul, A; Han, ND; Lu, Q; Xiong, S; et al. Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells. Cell. 2019; 179:1144-1159.e15.

Alvarado, DM; Chen, B; Iticovici, M; Thaker, AI; Dai, N; VanDussen, KL; Shaikh, N; Lim, CK; Guillemin, GJ; Tarr, PI; et al. Epithelial Indoleamine 2,3-Dioxygenase 1 Modulates Aryl Hydrocarbon Receptor and Notch Signaling to Increase Differentiation of Secretory Cells and Alter Mucus-Associated Microbiota. Gastroenterology. 2019; 157:1093-1108.e11.

Potdar, AA; Li, D; Haritunians, T; VanDussen, KL; Fiorino, MF; Liu, T; Stappenbeck, TS; Fleshner, P; Targan, SR; McGovern, DP B; et al. Ileal Gene Expression Data from Crohn's Disease Small Bowel Resections Indicate Distinct Clinical Subgroups. Journal of Crohn's and Colitis. 2019; 13:1055-1066.

Wilke, G; Funkhouser-Jones, LJ; Wang, Y; Ravindran, S; Wang, Q; Beatty, WL; Baldridge, MT; VanDussen, KL; Shen, B; Kuhlenschmidt, MS; et al. A Stem-Cell-Derived Platform Enables Complete Cryptosporidium Development In Vitro and Genetic Tractability. Cell Host and Microbe. 2019; 26:123-134.e8.

VanDussen, KL; Sonnek, NM; Stappenbeck, TS. L-WRN conditioned medium for gastrointestinal epithelial stem cell culture shows replicable batch-to-batch activity levels across multiple research teams. Stem Cell Research. 2019; 37:101430.

Kaiko, GE; Chen, F; Lai, C; Chiang, I; Perrigoue, J; Stojmirovic, A; Li, K; Muegge, BD; Jain, U; VanDussen, KL; et al. PAI-1 augments mucosal damage in colitis. Science Translational Medicine. 2019; 11:eaat0852.

Alvarado, DM; Santhanam, S; Iticovici, M; VanDussen, K; Shaikh, N; Chen, B; Lim, C; Guillemin, G; Tarr, PI; Ciorba, MA. 11 EPITHELIAL IDO1 MODULATES AHR AND NOTCH SIGNALING TO ENHANCE SECRETORY CELL DIFFERENTIATION AND ALTERS MUCUS-ASSOCIATED MICROBIOTA. Inflammatory Bowel Diseases. 2019; 25:s59.