VanDussen Lab
Publications

Publications

Selected Publications

Ojo, BA; Vandussen, KL; Rosen, MJ. The Promise of Patient-Derived Colon Organoids to Model Ulcerative Colitis. Inflammatory Bowel Diseases. 2022; 28(2):299-308.

Liu, T-C; Kern, JT; Jain, U; Sonnek, NM; Xiong, S; Simpson, KF; Vandussen, KL; Winkler, ES; Haritunians, T; Malique, A; Diamond, MS; Head, RD; Mcgovern, DPB; Stappenbeck, TS. Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation. Cell Host and Microbe. 2021; 29(6):988-1001.e6.

Osterman, MT; Vandussen, KL; Gordon, IO; Davis, EM; Li, K; Simpson, K; Ciorba, M; Glover, SC; Abraham, B; Guo, X; Claggett, B; Shen, B; Stappenbeck, TS; Liu, JJ. Epithelial Cell Biomarkers Are Predictive of Response to Biologic Agents in Crohn's Disease. Inflammatory Bowel Diseases. 2021; 27(5):677-685.

Vandussen, KL; Funkhouser-Jones, LJ; Akey, ME; Schaefer, DA; Ackman, K; Riggs, MW; Stappenbeck, TS; Sibley, LD. Neonatal Mouse Gut Metabolites Influence Cryptosporidium parvum Infection in Intestinal Epithelial Cells. mBio. 2020; 11(6).

Vandussen, KL; Sonnek, NM; Stappenbeck, TS. L-WRN conditioned medium for gastrointestinal epithelial stem cell culture shows replicable batch-to-batch activity levels across multiple research teams. Stem Cell Research. 2019; 37:101430.

Vandussen, KL; Stojmirović, A; Li, K; Liu, T-C; Kimes, PK; Muegge, BD; Simpson, KF; Ciorba, MA; Perrigoue, JG; Friedman, JR; Towne, JE; Head, RD; Stappenbeck, TS. Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn's Disease. Gastroenterology. 2018; 155(3):815-828.

Miyoshi, H; Vandussen, KL; Malvin, NP; Ryu, SH; Wang, Y; Sonnek, NM; Lai, C-W; Stappenbeck, TS. Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium. EMBO Journal. 2017; 36(1):5-24.

Vandussen, KL; Marinshaw, JM; Shaikh, N; Miyoshi, H; Moon, C; Tarr, PI; Ciorba, MA; Stappenbeck, TS. Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays. Gut. 2015; 64(6):911-920.

Vandussen, KL; Liu, T-C; Li, D; Towfic, F; Modiano, N; Winter, R; Haritunians, T; Taylor, KD; Dhall, D; Targan, SR; Xavier, RJ; Mcgovern, DPB; Stappenbeck, TS. Genetic variants synthesize to produce paneth cell phenotypes that define subtypes of Crohn's disease. Gastroenterology. 2014; 146(1):200-209.

Vandussen, KL; Carulli, AJ; Keeley, TM; Patel, SR; Puthoff, BJ; Magness, ST; Tran, IT; Maillard, I; Siebel, C; Kolterud, A; Ernst, SA; Tsai, Y-H; Dempsey, PJ; Samuelson, LC. Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells. Development. 2012; 139(3):488-497.

Abbas-Egbariya, H; Elwahidi, L; Levy, DJ; Braun, T; Levhar, N; Hadar, R; Efroni, G; Granot, M; Leichtmann-Bardogoo, Y; Maoz, BM; Ben-Horin, S; Vandussen, KL; Amir, A; Haberman, Y. Supplementation with endogenous healthy gut metabolites reverses the disruptions of in vitro and ex vivo epithelial functions induced by fecal content from IBD patients. Gut Microbes. 2025; 17(1):2597568.

Haberman, Y; Braun, T; Karns, R; Bartel, CA; Bonkowski, E; Simpson, KF; Walters, TD; Hyams, JS; Liu, T-C; Kugathasan, S; Denson, LA; Vandussen, KL. Short Ileal Microvillus Length Phenotype Associates with Progression from Inflammatory to Complicated Disease Behavior in Pediatric Crohn's Disease. Inflammatory Bowel Diseases. 2025.

Zhao, B; Socha, J; Toth, A; Fernandes, S; Warheit-Niemi, H; Ruff, B; Khurana Hershey, GK; Vandussen, KL; Swarr, D; Zacharias, WJ. The Homeobox Transcription Factor CUX1 Coordinates Postnatal Epithelial Developmental Timing but Is Dispensable for Lung Organogenesis and Regeneration. American Journal of Respiratory Cell and Molecular Biology. 2025; 72(6):678-687.

Ma, C; Haritunians, T; Gremida, AK; Syal, G; Shah, J; Yang, S; Ramos Del Aguila De Rivers, C; Storer, CE; Chen, L; Mengesha, E; Head, RD; Ciorba, MA; Mcgovern, DPB; Liu, T-C. Ileal Paneth Cell Phenotype is a Cellular Biomarker for Pouch Complications in Ulcerative Colitis. Journal of Crohn's and Colitis. 2024; 18(12):2010-2022.

Funkhouser-Jones, LJ; Xu, R; Wilke, G; Fu, Y; Schriefer, LA; Makimaa, H; Rodgers, R; Kennedy, EA; Vandussen, KL; Stappenbeck, TS; Baldridge, MT; Sibley, LD. Microbiota-produced indole metabolites disrupt mitochondrial function and inhibit Cryptosporidium parvum growth. Cell reports. 2023; 42(7):112680.

Braun, T; Sosnovski, KE; Amir, A; Benshoshan, M; Vandussen, KL; Karns, R; Levhar, N; Abbas-Egbariya, H; Hadar, R; Efroni, G; Ferrer, J; Hyams, JS; Denson, LA; Haberman, Y. Mucosal transcriptomics highlight lncRNAs implicated in ulcerative colitis, Crohn's disease, and celiac disease. JCI Insight. 2023; 8(14).

Sosnovski, KE; Braun, T; Amir, A; Moshel, D; Benshoshan, M; Vandussen, KL; Levhar, N; Abbas-Egbariya, H; Beider, K; Ben-Yishay, R; Ulitsky, I; Hyams, JS; Denson, LA; Haberman, Y. GATA6-AS1 Regulates Intestinal Epithelial Mitochondrial Functions, and its Reduced Expression is Linked to Intestinal Inflammation and Less Favourable Disease Course in Ulcerative Colitis. Journal of Crohn's and Colitis. 2023; 17(6):960-971.

Overcast, GR; Meibers, HE; Eshleman, EM; Saha, I; Waggoner, L; Patel, KN; Jain, VG; Haslam, DB; Alenghat, T; Vandussen, KL; Pasare, C. IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation. Journal of Experimental Medicine (JEM). 2023; 220(6).

Strine, MS; Alfajaro, MM; Graziano, VR; Song, J; Hsieh, LL; Hill, R; Guo, J; Vandussen, KL; Orchard, RC; Baldridge, MT; Lee, S; Wilen, CB. Tuft-cell-intrinsic and -extrinsic mediators of norovirus tropism regulate viral immunity. Cell reports. 2022; 41(6):111593.

Ojo, BA; Vandussen, KL; Rosen, MJ. The Promise of Patient-Derived Colon Organoids to Model Ulcerative Colitis. Inflammatory Bowel Diseases. 2022; 28(2):299-308.

Liu, T-C; Kern, JT; Jain, U; Sonnek, NM; Xiong, S; Simpson, KF; Vandussen, KL; Winkler, ES; Haritunians, T; Malique, A; Diamond, MS; Head, RD; Mcgovern, DPB; Stappenbeck, TS. Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation. Cell Host and Microbe. 2021; 29(6):988-1001.e6.

Osterman, MT; Vandussen, KL; Gordon, IO; Davis, EM; Li, K; Simpson, K; Ciorba, M; Glover, SC; Abraham, B; Guo, X; Claggett, B; Shen, B; Stappenbeck, TS; Liu, JJ. Epithelial Cell Biomarkers Are Predictive of Response to Biologic Agents in Crohn's Disease. Inflammatory Bowel Diseases. 2021; 27(5):677-685.

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