2021; 2021.10.16.464640.
. scTriangulate, a game-theory based framework for optimal solutions of uni- and multimodal single-cell data.Mouse models of neutropenia reveal progenitor-stage-specific defects. Nature. 2020; 582:109-114.
.Single-cell analysis of mixed-lineage states leading to a binary cell fate choice. Nature. 2016; 537:698-702.
.Assay optimization for the objective quantification of human multilineage colony-forming units. Experimental Hematology. 2023; 124:36-44.e3.
.ThPOK is a critical multifaceted regulator of myeloid lineage development. Nature Immunology. 2023; 24:1295-1307.
.MAPK-negative feedback regulation confers dependence to JAK2V617F signaling. Leukemia. 2023; 37:1686-1697.
.pyInfinityFlow: optimized imputation and analysis of high-dimensional flow cytometry data for millions of cells. Editor, Kelso J. Bioinformatics. 2023; 39:btad287.
.2023; 210:250.13.
. High-throughput workflow leveraging spectral flow cytometry and CITE-seq to characterize human bone marrow across race and gender. Journal of immunology (Baltimore, Md. : 1950).2023; 210:65.01.
. Th2 immune responses induced by helminth infection reprogram multilineage progenitors to produce successive waves of neutrophils, basophils, and eosinophils. Journal of immunology (Baltimore, Md. : 1950).2023; 210:65.05.
. Live bacterial ligands universally regulate mTOR activity but are not essential for homeostatic innate immunity. Journal of immunology (Baltimore, Md. : 1950).2022; 140:1981-1982.
. Hematopoietic Flt3+ Multipotent Progenitors Are Organized in Discrete Functionally and Hierarchically Distinct Populations. Blood.2022; 140:9103-9104.
. Metallothionein 1 (MT1) Is Selectively Required for DNMT3A;NPM1 -Mutant Acute Myeloid Leukemia Proliferation. Blood.2022; 140:936-939.
. Sex-Associated Differences in Frequencies and Outcome Prognostication of Recurrent Molecular Features in Adults with Acute Myeloid Leukemia (AML) (AMLCG, CALGB [Alliance]). Blood.2022; 140:2856.
. Identification and Isolation of Hematopoietic Stem Cells and Progenitors with Discrete Developmental Gene Expression Programs. Blood.2022; 140:9759-9760.
. Single-Cell Multiomics Reveal Hypomethylating Agent Partially Restores Hematopoiesis in a LR-MDS Patient at the Cost of Leukemic Transformation. Blood.Erythroblastic islands foster granulopoiesis in parallel to terminal erythropoiesis. Blood. 2022; 140:1621-1634.
.Induced cell-autonomous neutropenia systemically perturbs hematopoiesis in Cebpa enhancer-null mice. Blood Advances. 2022; 6:1406-1419.
.2022; 111:s72.
. 3055 – METALLOTHIONEIN 1 (MT1) AS A TARGETABLE DEPENDENCY IN ACUTE MYELOID LEUKEMIA. Experimental Hematology.2022; 111:s35.
. 2007 – IDENTIFICATION AND ISOLATION OF HEMATOPOIETIC STEM CELLS AND PROGENITORS WITH DISCRETE DEVELOPMENTAL GENE EXPRESSION PROGRAMS. Experimental Hematology.2022; 111:s142.
. 3194 – LIVE BACTERIAL LIGANDS PROGRAM CORE HEMATOPOIETIC GENE EXPRESSION. Experimental Hematology.GM-CSF Programs Hematopoietic Stem and Progenitor Cells During Candida albicans Vaccination for Protection Against Reinfection. Frontiers in Immunology. 2021; 12:790309.
.Why Single-Cell Sequencing Has Promise in MDS. Frontiers in Oncology. 2021; 11:769753.
.2021; 2021.10.16.464640.
. scTriangulate, a game-theory based framework for optimal solutions of uni- and multimodal single-cell data.Isolation of primary immune cells from fibrotic skin, esophageal, and gut tissue. Journal of Immunological Methods. 2021; 497:113107.
.Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4+ T cell identity and function. Nature Immunology. 2021; 22:969-982.
.2021; 10:1-60.
. Systemic inflammation recruits fast-acting anti-inflammatory innate myeloid progenitors from BM into lymphatics. eLife.Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics. eLife. 2021; 10:e66190.
.In situ mapping identifies distinct vascular niches for myelopoiesis. Nature. 2021; 590:457-462.
.The Hepatic Microenvironment Uniquely Protects Leukemia Cells through Induction of Growth and Survival Pathways Mediated by LIPG. Cancer Discovery. 2021; 11:500-519.
.SWATH-Proteomics of Ibrutinib's Action in Myeloid Leukemia Initiating Mutated G-CSFR Signaling. Proteomics: Clinical Applications. 2020; 14:e1900144.
.Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor. Immunity. 2020; 53:303-318.e5.
.Mouse models of neutropenia reveal progenitor-stage-specific defects. Nature. 2020; 582:109-114.
.Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition. Cell Stem Cell. 2020; 26:420-430.e6.
.HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms. Blood. 2020; 135:191-207.
.Unraveling bone marrow architecture. Nature Cell Biology. 2020; 22:5-6.
.cellHarmony: cell-level matching and holistic comparison of single-cell transcriptomes. Nucleic Acids Research. 2019; 47:e138.
.Phospho serine and threonine analysis of normal and mutated granulocyte colony stimulating factor receptors. Scientific Data. 2019; 6:21.
.DoubletDecon: Deconvoluting Doublets from Single-Cell RNA-Sequencing Data. Cell Reports. 2019; 29:1718-1727.e8.
.Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia. Cancer Discovery. 2019; 9:1080-1101.
.Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML. Cancer Discovery. 2019; 9:872-889.
.Clonal hematopoiesis of indeterminate potential and its impact on patient trajectories after stem cell transplantation. Editor, Komarova NL. PLoS Computational Biology. 2019; 15:e1006913.
.Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma. Nature Communications. 2019; 10:332.
.Time resolved quantitative phospho-tyrosine analysis reveals Bruton's Tyrosine kinase mediated signaling downstream of the mutated granulocyte-colony stimulating factor receptors. Leukemia. 2019; 33:75-87.
.