Lewkowich Lab
Publications

Publications

Mcalees, JW; Baker, T; Houshel, L; Mcknight, C; Lindsley, A; Strait, RT; Zhang, X; Cannata, A; Biagini, JM; Butsch Kovacic, M; Lewkowich, IP. Increased nasal epithelial cell responsiveness to IL-17A in paediatric asthmatics with low blood neutrophil count, low traffic-related air pollution exposure and good asthma control. Clinical and Experimental Allergy. 2022; 52(4):569-573.

Mcalees, JW; Baker, T; Kaur, D; Mcknight, C; Lindsley, A; Strait, RT; Zhang, X; Biagini Myers, JM; Butsch Kovacic, M; Lewkowich, IP. Age and early maternal smoking contribute to epithelial cell IL-13 responsiveness in a pediatric asthma population. Allergy. European Journal of Allergy and Clinical Immunology. 2019; 74(12):2485-2487.

Kim, D; Mcalees, JW; Bischoff, LJ; Kaur, D; Houshel, LK; Gray, J; Hargis, J; Davis, X; Dudas, PL; Deshmukh, H; Lewkowich, IP. Combined administration of anti-IL-13 and anti-IL-17A at individually sub-therapeutic doses limits asthma-like symptoms in a mouse model of Th2/Th17 high asthma. Clinical and Experimental Allergy. 2019; 49(3):317-330.

Richgels, PK; Yamani, A; Chougnet, CA; Lewkowich, IP. Maternal house dust mite exposure during pregnancy enhances severity of house dust mite-induced asthma in murine offspring. Journal of Allergy and Clinical Immunology. 2017; 140(5):1404-1415.e9.

Hall, SL; Baker, T; Lajoie, S; Richgels, PK; Yang, Y; Mcalees, JW; Van Lier, A; Wills-Karp, M; Sivaprasad, U; Acciani, TH; Lecras, TD; Myers, JB; Kovacic, MB; Lewkowich, IP. IL-17A enhances IL-13 activity by enhancing IL-13-induced signal transducer and activator of transcription 6 activation. Journal of Allergy and Clinical Immunology. 2017; 139(2):462-471.e14.

Mcalees, JW; Lajoie, S; Dienger, K; Sproles, AA; Richgels, PK; Yang, Y; Khodoun, M; Azuma, M; Yagita, H; Fulkerson, PC; Wills-Karp, M; Lewkowich, IP. Differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma. European Journal of Immunology. 2015; 45(4):1019-1029.

Lewkowich, IP; Lajoie, S; Stoffers, SL; Suzuki, Y; Richgels, PK; Dienger, K; Sproles, AA; Yagita, H; Hamid, Q; Wills-Karp, M. PD-L2 modulates asthma severity by directly decreasing dendritic cell IL-12 production. Mucosal Immunology. 2013; 6(4):728-739.

Lajoie, S; Lewkowich, IP; Suzuki, Y; Clark, JR; Sproles, AA; Dienger, K; Budelsky, AL; Wills-Karp, M. Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma. Nature Immunology. 2010; 11(10):928-935.

Lewkowich, IP; Herman, NS; Schleifer, KW; Dance, MP; Chen, BL; Dienger, KM; Sproles, AA; Shah, JS; Köhl, J; Belkaid, Y; Wills-Karp, M. CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function. Journal of Experimental Medicine (JEM). 2005; 202(11):1549-1561.

Allgire, E; Ahlbrand, RA; Nawreen, N; Ajmani, A; Hoover, C; Mcalees, JW; Lewkowich, IP; Sah, R. Altered Fear Behavior in Aeroallergen House Dust Mite Exposed C57Bl/6 Mice: A Model of Th2-skewed Airway Inflammation. Neuroscience. 2023; 528:75-88.

Wilburn, AN; Mcalees, JW; Haslam, DB; Graspeuntner, S; Schmudde, I; Laumonnier, Y; Rupp, J; Chougnet, CA; Deshmukh, H; Zacharias, WJ; König, P; Lewkowich, IP. Delayed Microbial Maturation Durably Exacerbates Th17-driven Asthma in Mice. American Journal of Respiratory Cell and Molecular Biology. 2023; 68(5):498-510.

Ghosh, D; Mcalees, J; Bernstein, J; Lewkowich, I. Maternal Exposure To Phthalate Drives Skin Changes Associated With Increased Susceptibility To House Dust Mite Induced Atopic Dermatitis In Offspring. Journal of Allergy and Clinical Immunology. 2023; 151(2):ab150.

Shankar, A; Mcalees, JW; Lewkowich, IP. Modulation of IL-4/IL-13 cytokine signaling in the context of allergic disease. Journal of Allergy and Clinical Immunology. 2022; 150(2):266-276.

Stevens, J; Steinmeyer, S; Bonfield, M; Peterson, L; Wang, T; Gray, J; Lewkowich, I; Xu, Y; Du, Y; Guo, M; Miller, L; Chougnet, C; O'connor, DH; Deshmukh, H. The balance between protective and pathogenic immune responses to pneumonia in the neonatal lung is enforced by gut microbiota. Science Translational Medicine. 2022; 14(649):eabl3981.

Jackson, CM; Demmert, M; Mukherjee, S; Isaacs, T; Thompson, R; Chastain, C; Gray, J; Senthamaraikannan, P; Presicce, P; Chetal, K; Zacharias, WJ; Lewkowich, IP; Deshmukh, H; Chougnet, CA. A potent myeloid response is rapidly activated in the lungs of premature Rhesus macaques exposed to intra-uterine inflammation. Mucosal Immunology. 2022; 15(4):730-744.

Mcalees, JW; Baker, T; Houshel, L; Mcknight, C; Lindsley, A; Strait, RT; Zhang, X; Cannata, A; Biagini, JM; Butsch Kovacic, M; Lewkowich, IP. Increased nasal epithelial cell responsiveness to IL-17A in paediatric asthmatics with low blood neutrophil count, low traffic-related air pollution exposure and good asthma control. Clinical and Experimental Allergy. 2022; 52(4):569-573.

Toth, A; Steinmeyer, S; Kannan, P; Gray, J; Jackson, CM; Mukherjee, S; Demmert, M; Sheak, JR; Benson, D; Kitzmiller, J; Chougnet, CA; Jobe, AH; Deshmukh, H; Zacharias, WJ. Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates. Science Translational Medicine. 2022; 14(638):eabl8574.

Lingel, I; Wilburn, AN; Hargis, J; Mcalees, JW; Laumonnier, Y; Chougnet, CA; Deshmukh, H; König, P; Lewkowich, IP; Schmudde, I. Prenatal antibiotics exposure does not influence experimental allergic asthma in mice. Frontiers in Immunology. 2022; 13:937577.

Allgire, E; Mcalees, JW; Lewkowich, IP; Sah, R. Asthma and posttraumatic stress disorder (PTSD): Emerging links, potential models and mechanisms. Brain, Behavior, and Immunity. 2021; 97:275-285.

Oherle, K; Acker, E; Bonfield, M; Wang, T; Gray, J; Lang, I; Bridges, J; Lewkowich, I; Xu, Y; Ahlfeld, S; Zacharias, W; Alenghat, T; Deshmukh, H. Insulin-like Growth Factor 1 Supports a Pulmonary Niche that Promotes Type 3 Innate Lymphoid Cell Development in Newborn Lungs. Immunity. 2020; 52(2):275-294.e9.

Jackson, CM; Mukherjee, S; Wilburn, AN; Cates, C; Lewkowich, IP; Deshmukh, H; Zacharias, WJ; Chougnet, CA. Pulmonary Consequences of Prenatal Inflammatory Exposures: Clinical Perspective and Review of Basic Immunological Mechanisms. Frontiers in Immunology. 2020; 11:1285.

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