Liu Lab
Publications

Publications

Research in the Liu Lab focuses on developing therapeutic strategies to stimulate CM proliferation, reversing cardiac remodeling, reducing cardiac fibrosis and improving cardiac function. Learn more about this research and our published findings.

Liu, S; Deshmukh, V; Meng, F; Wang, Y; Morikawa, Y; Steimle, JD; Li, RG; Wang, J; Martin, JF. Microtubules Sequester Acetylated YAP in the Cytoplasm and Inhibit Heart Regeneration. Circulation. 2025; 151(1):59-75.

Morikawa, Y; Kim, JH; Li, RG; Liu, L; Liu, S; Deshmukh, V; Hill, MC; Martin, JF. YAP Overcomes Mechanical Barriers to Induce Mitotic Rounding and Adult Cardiomyocyte Division. Circulation. 2025; 151(1):76-93.

Liu, S; Deshmukh, V; Wang, F; Liang, J; Cusick, J; Li, X; Martin, JF. Myocardial Infarction Suppresses Protein Synthesis and Causes Decoupling of Transcription and Translation. JACC: Basic to Translational Science. 2024; 9(6):792-807.

Zhang, S; Liu, S; Leach, JP; Li, K; Perin, EC; Martin, JF. Gene Therapy Knockdown of Hippo Signaling Resolves Arrhythmic Events in Pigs After Myocardial Infarction. Circulation. 2022; 146(20):1558-1560.

Liu, S; Li, RG; Martin, JF. The cell-autonomous and non-cell-autonomous roles of the Hippo pathway in heart regeneration. Journal of Molecular and Cellular Cardiology. 2022; 168:98-106.

Liu, S; Tang, L; Zhao, X; Nguyen, B; Heallen, TR; Li, M; Wang, J; Wang, J; Martin, JF. Yap Promotes Noncanonical Wnt Signals From Cardiomyocytes for Heart Regeneration. Circulation Research. 2021; 129(8):782-797.

Liu, S; Li, K; Wagner Florencio, L; Tang, L; Heallen, TR; Leach, JP; Wang, Y; Grisanti, F; Willerson, JT; Perin, EC; Zhang, S; Martin, JF. Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction. Science Translational Medicine. 2021; 13(600).

Wang, J; Liu, S; Heallen, T; Martin, JF. The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration. Nature Reviews Cardiology. 2018; 15(11):672-684.

Zhang, F; Cusick, JK; Liang, J; Wang, F; Fernandes, AT; Gafranek, JT; Waxman, JS; Chen, Z; Yutzey, KE; Liu, S. YAP Promotes Microtubule Growth to Facilitate Sarcomere Disassembly in Adult Cardiomyocytes. Circulation. 2026.

Liu, S; Gammon, ST; Tan, L; Gao, Y; Kim, K; Elbatreek, MH; Arrieta, A; Williamson, IK; Salazar, RL; Pham, J; Taegtmeyer, H; Piwnica-Worms, D; Martin, JF; Karlstaedt, A. Loss of ATP-Dependent Citrate Lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling. Circulation. 2026; 154(3):223-239.

Rojas, A; Dahlen, S; Zhang, F; Liu, S. The Cytoskeletal Structure in Cardiomyocyte Maturation and Proliferation. Cells. 2025; 14(19).

Meng, F; Kim, JH; Tsai, C-R; Steimle, JD; Wang, J; Shi, Y; Li, RG; Xie, B; Deshmukh, V; Liu, S; Li, X; Martin, JF. SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling. eLife. 2025; 13.

Meng, F; Kim, JH; Tsai, C-R; Steimle, JD; Wang, J; Shi, Y; Li, RG; Xie, B; Deshmukh, V; Liu, S; Li, X; Martin, JF. SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling. eLife. 2025; 13.

Zhang, F; Rojas, A; Cusick, J; Wang, F; Liang, J; Liu, S. Abstract Or305: The microtubule network is required for YAP-induced sarcomere breakdown in adult cardiomyocytes. Circulation Research. 2025; 137(Suppl_1).

Li, R; Li, X; Morikawa, Y; Grisanti, F; Meng, F; Tsai, C-R; Zhao, Y; Liu, L; Kim, J; Xie, B; Klysik, E; Liu, S; Samee, AH; Martin, J. YAP Induces a Neonatal Like Pro-Renewal Niche in the Adult Heart. Journal of Molecular and Cellular Cardiology Plus. 2025; 12:100304.

Liu, S; Deshmukh, V; Meng, F; Wang, Y; Morikawa, Y; Steimle, JD; Li, RG; Wang, J; Martin, JF. Microtubules Sequester Acetylated YAP in the Cytoplasm and Inhibit Heart Regeneration. Circulation. 2025; 151(1):59-75.

Morikawa, Y; Kim, JH; Li, RG; Liu, L; Liu, S; Deshmukh, V; Hill, MC; Martin, JF. YAP Overcomes Mechanical Barriers to Induce Mitotic Rounding and Adult Cardiomyocyte Division. Circulation. 2025; 151(1):76-93.

Zhang, F; Liang, J; Cusick, J; Wang, F; Li, A; Liu, S. Abstract Or113: Identification of Newly Synthesized Protein in Cardiomyocytes after Myocardial Infarction. Circulation Research. 2024; 135(Suppl_1):aor113-aor113.

Liu, S; Gao, Y; Kim, K; Gammon, S; Tan, L; Pham, J; Khanna, R; Gould, B; Salazar, R; Lien, E; Taegtmeyer, H; Piwnica-Worms, D; Martin, J; Karlstaedt, A. Abstract Mo026: ATP-dependent citrate lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling of the Heart. Circulation Research. 2024; 135(Suppl_1):amo026-amo026.

Liu, S; Deshmukh, V; Wang, F; Liang, J; Cusick, J; Li, X; Martin, JF. Myocardial Infarction Suppresses Protein Synthesis and Causes Decoupling of Transcription and Translation. JACC: Basic to Translational Science. 2024; 9(6):792-807.

Li, RG; Li, X; Morikawa, Y; Grisanti-Canozo, FJ; Meng, F; Tsai, C-R; Zhao, Y; Liu, L; Kim, J; Xie, B; Klysik, E; Liu, S; Samee, MAH; Martin, JF. YAP induces a neonatal-like pro-renewal niche in the adult heart. Nature Cardiovascular Research. 2024; 3(3):283-300.

Liu, S; Kim, K; Gao, Y; Gammon, S; Tan, L; Taegtmeyer, H; Lorenzi, P; Piwnica-Worms, D; Martin, JF; Karlstaedt, A. Abstract 19008: ATP-Dependent Citrate Lyase Drives Cardiac Left Ventricular Dysfunction by Metabolic Remodeling. Circulation. 2023; 148(Suppl_1):a19008-a19008.

Franklin, DA; Liu, S; Jin, A; Cui, P; Guo, Z; Arend, KC; Moorman, NJ; He, S; Wang, GG; Wan, YY; Zhang, Y. Ribosomal protein RPL11 haploinsufficiency causes anemia in mice via activation of the RP-MDM2-p53 pathway. Journal of Biological Chemistry. 2023; 299(1):102739.

Zhang, S; Liu, S; Leach, JP; Li, K; Perin, EC; Martin, JF. Gene Therapy Knockdown of Hippo Signaling Resolves Arrhythmic Events in Pigs After Myocardial Infarction. Circulation. 2022; 146(20):1558-1560.

Liu, S; Gammon, S; Tan, L; Pham, J; Lorenzi, PL; Taegtmeyer, H; Piwnica-Worms, D; Martin, JF; Karlstaedt, A. Abstract OEC103: ATP-dependent Citrate Lyase Drives Metabolic Remodeling In The Heart During Cancer. Circulation Research. 2022; 131(Suppl_1):aoec103-aoec103.

Liu, S; Li, RG; Martin, JF. The cell-autonomous and non-cell-autonomous roles of the Hippo pathway in heart regeneration. Journal of Molecular and Cellular Cardiology. 2022; 168:98-106.

Liu, S; Martin, JF. RNA splicing to cytoskeleton: A new path to cardiomyocyte ploidy and division? Developmental Cell. 2022; 57(8):945-946.

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