Liu Lab
Publications

Publications

Research in the Liu Lab focuses on developing therapeutic strategies to stimulate CM proliferation, reversing cardiac remodeling, reducing cardiac fibrosis and improving cardiac function. Learn more about this research and our published findings.

Morikawa, Y; Kim, JH; Li, RG; Liu, L; Liu, S; Deshmukh, V; Hill, MC; Martin, JF. YAP Overcomes Mechanical Barriers to Induce Mitotic Rounding and Adult Cardiomyocyte Division. Circulation. 2025; 151:76-93.

Liu, S; Deshmukh, V; Meng, F; Wang, Y; Morikawa, Y; Steimle, JD; Li, RG; Wang, J; Martin, JF. Microtubules Sequester Acetylated YAP in the Cytoplasm and Inhibit Heart Regeneration. Circulation. 2025; 151:59-75.

Liu, S; Deshmukh, V; Wang, F; Liang, J; Cusick, J; Li, X; Martin, JF. Myocardial Infarction Suppresses Protein Synthesis and Causes Decoupling of Transcription and Translation. JACC: Basic to Translational Science. 2024; 9:792-807.

Zhang, S; Liu, S; Leach, JP; Li, K; Perin, EC; Martin, JF. Gene Therapy Knockdown of Hippo Signaling Resolves Arrhythmic Events in Pigs After Myocardial Infarction. Circulation. 2022; 146:1558-1560.

Liu, S; Li, RG; Martin, JF. The cell-autonomous and non-cell-autonomous roles of the Hippo pathway in heart regeneration. Journal of Molecular and Cellular Cardiology. 2022; 168:98-106.

Liu, S; Tang, L; Zhao, X; Nguyen, B; Heallen, TR; Li, M; Wang, J; Wang, J; Martin, JF. Yap Promotes Noncanonical Wnt Signals From Cardiomyocytes for Heart Regeneration. Circulation Research. 2021; 129:782-797.

Liu, S; Li, K; Wagner Florencio, L; Tang, L; Heallen, TR; Leach, JP; Wang, Y; Grisanti, F; Willerson, JT; Perin, EC; Zhang, S; Martin, JF. Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction. Science Translational Medicine. 2021; 13:eabd6892.

Wang, J; Liu, S; Heallen, T; Martin, JF. The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration. Nature Reviews. Cardiology. 2018; 15:672-684.

Li, R; Li, X; Morikawa, Y; Grisanti, F; Meng, F; Tsai, C; Zhao, Y; Liu, L; Kim, J; Xie, B; Klysik, E; Liu, S; Samee, MA H; Martin, J. YAP Induces a Neonatal Like Pro-Renewal Niche in the Adult Heart. Journal of Molecular and Cellular Cardiology Plus. 2025; 12:100304.

Morikawa, Y; Kim, JH; Li, RG; Liu, L; Liu, S; Deshmukh, V; Hill, MC; Martin, JF. YAP Overcomes Mechanical Barriers to Induce Mitotic Rounding and Adult Cardiomyocyte Division. Circulation. 2025; 151:76-93.

Liu, S; Deshmukh, V; Meng, F; Wang, Y; Morikawa, Y; Steimle, JD; Li, RG; Wang, J; Martin, JF. Microtubules Sequester Acetylated YAP in the Cytoplasm and Inhibit Heart Regeneration. Circulation. 2025; 151:59-75.

Liu, S; Deshmukh, V; Wang, F; Liang, J; Cusick, J; Li, X; Martin, JF. Myocardial Infarction Suppresses Protein Synthesis and Causes Decoupling of Transcription and Translation. JACC: Basic to Translational Science. 2024; 9:792-807.

Li, RG; Li, X; Morikawa, Y; Grisanti-Canozo, FJ; Meng, F; Tsai, C; Zhao, Y; Liu, L; Kim, J; Xie, B; Klysik, E; Liu, S; Samee, MA H; Martin, JF. YAP induces a neonatal-like pro-renewal niche in the adult heart. Nature Cardiovascular Research. 2024; 3:283-300.

Franklin, DA; Liu, S; Jin, A; Cui, P; Guo, Z; Arend, KC; Moorman, NJ; He, S; Wang, GG; Wan, YY; Zhang, Y. Ribosomal protein RPL11 haploinsufficiency causes anemia in mice via activation of the RP-MDM2-p53 pathway. The Journal of biological chemistry. 2023; 299:102739.

Zhang, S; Liu, S; Leach, JP; Li, K; Perin, EC; Martin, JF. Gene Therapy Knockdown of Hippo Signaling Resolves Arrhythmic Events in Pigs After Myocardial Infarction. Circulation. 2022; 146:1558-1560.

Liu, S; Li, RG; Martin, JF. The cell-autonomous and non-cell-autonomous roles of the Hippo pathway in heart regeneration. Journal of Molecular and Cellular Cardiology. 2022; 168:98-106.

Liu, S; Martin, JF. RNA splicing to cytoskeleton: A new path to cardiomyocyte ploidy and division?. Developmental Cell. 2022; 57:945-946.

Liu, S; Tang, L; Zhao, X; Nguyen, B; Heallen, TR; Li, M; Wang, J; Wang, J; Martin, JF. Yap Promotes Noncanonical Wnt Signals From Cardiomyocytes for Heart Regeneration. Circulation Research. 2021; 129:782-797.

Liu, S; Li, K; Wagner Florencio, L; Tang, L; Heallen, TR; Leach, JP; Wang, Y; Grisanti, F; Willerson, JT; Perin, EC; Zhang, S; Martin, JF. Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction. Science Translational Medicine. 2021; 13:eabd6892.

Liu, Q; Pan, S; Liu, S; Zhang, S; Willerson, JT; Martin, JF; Dixon, RA F. Suppressing Hippo signaling in the stem cell niche promotes skeletal muscle regeneration. Stem Cells. 2021; 39:737-749.

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