Quattrocelli Lab

Publications

Akinborewa, O; Quattrocelli, M. Glucocorticoid receptor epigenetic activity in the heart. Epigenetics. 2025; 20(1):2468113.

Quattrocelli, M. OR29-07 The Rs6190 Polymorphism Unveils Unprecedented Mechanisms Of Cardiovascular Health Elicited By The Glucocorticoid Receptor In Humans And Mice. Journal of the Endocrine Society. 2025; 9(Supplement_1):bvaf149.1857.

Calvo, C; Swoboda, CO; Montecino-Morales, F; Nagar, S; Petrany, MJ; Sun, C; Bindu Durumutla, H; Quattrocelli, M; Millay, DP. The multimodal transcriptional response of denervated skeletal muscle involves regulation of Gramd1 genes impacting muscle size. Proceedings of the National Academy of Sciences of the United States of America. 2025; 122(39):e2424246122.

Durumutla, HB; Haller, A; Noble, G; Prabakaran, AD; Mcfarland, K; Latimer, H; Rajput, A; Akinborewa, O; Namjou-Khales, B; Hui, DY; Quattrocelli, M. The human glucocorticoid receptor variant rs6190 increases blood cholesterol and promotes atherosclerosis. Journal of Clinical Investigation. 2025; 135(17).

Akinborewa, O; Pragasam, ADP; Durumutla, HB; Latimer, H; Mcfarland, K; Quattrocelli, M. Abstract Wed122: LRRC14B is Essential for Cardiac Function via Sarcomeric Protein Quality Control. Circulation Research. 2025; 137(Suppl_1).

Quattrocelli, M. Abstract Thu090: Glucocorticoids activate cardiac ketolysis across heart failure contexts through the clock factor RORα. Circulation Research. 2025; 137(Suppl_1).

Prabakaran, AD; Montecino-Morales, F; Mcfarland, K; Govindarajan, T; Durumutla, HB; Latimer, H; Akinborewa, O; Villa, C; Millay, DP; Quattrocelli, M. The human genetic variant rs6190 unveils Foxc1 and Arid5a as novel prometabolic targets of the glucocorticoid receptor in muscle. Science Advances. 2025; 11(28):eadw2593.

Prabakaran, AD; Quattrocelli, M. The human glucocorticoid receptor variant rs6190 protects the heart from metabolic stress. Journal of Molecular and Cellular Cardiology Plus. 2025; 12:100306.

Chaikin, CA; Thakkar, AV; Steffeck, AWT; Pfrender, EM; Hung, K; Zhu, P; Waldeck, NJ; Nozawa, R; Song, W; Futtner, CR; Quattrocelli, M; Bass, J; Ben-Sahra, I; Peek, CB. Control of circadian muscle glucose metabolism through the BMAL1-HIF axis in obesity. Proceedings of the National Academy of Sciences of the United States of America. 2025; 122(13):e2424046122.

Peach, T; Quattrocelli, M. The muscle stem cell case of Benjamin Button: rejuvenating muscle regenerative capacity through nutraceuticals. Journal of Clinical Investigation. 2024; 134(24).

Durumutla, HB; Prabakaran, AD; El Abdellaoui Soussi, F; Akinborewa, O; Latimer, H; Mcfarland, K; Piczer, K; Werbrich, C; Jain, MK; Haldar, SM; Quattrocelli, M. Glucocorticoid chronopharmacology promotes glucose metabolism in heart through a cardiomyocyte-autonomous transactivation program. JCI Insight. 2024; 9(22).

Prabakaran, AD; Mcfarland, K; Miz, K; Durumutla, HB; Piczer, K; El Abdellaoui Soussi, F; Latimer, H; Werbrich, C; Chung, H-J; Blair, NS; Millay, DP; Morris, AJ; Prideaux, B; Finck, BN; Quattrocelli, M. Intermittent glucocorticoid treatment improves muscle metabolism via the PGC1α/Lipin1 axis in an aging-related sarcopenia model. Journal of Clinical Investigation. 2024; 134(11).

Ramachandran, K; Futtner, CR; Sommars, MA; Quattrocelli, M; Omura, Y; Fruzyna, E; Wang, JC; Waldeck, NJ; Senagolage, MD; Telles, CG; Arango, D; Bederman, IR; Mcnally, EM; Barish, GD. Transcriptional programming of translation by BCL6 controls skeletal muscle proteostasis. Nature Metabolism. 2024; 6(2):304-322.

Krishna, S; Echevarria, KG; Reed, CH; Eo, H; Wintzinger, M; Quattrocelli, M; Valentine, RJ; Selsby, JT. A fat- and sucrose-enriched diet causes metabolic alterations in mdx mice. American Journal of Physiology. Regulatory Integrative and Comparative Physiology. 2023; 325(6):R692-R711.

Prabakaran, A; Wintzinger, M; Piczer, K; Miz, K; Walton, A; Durumutla, HB; Quattrocelli, M. OR33-04 Mechanistic Dissection Of Circadian-Specific Glucocorticoid Effects On Exercise Tolerance And Muscle Glucose Utilization. Journal of the Endocrine Society. 2023; 7(Supplement_1):bvad114.1772.

Farini, A; Tripodi, L; Villa, C; Strati, F; Facoetti, A; Baselli, G; Troisi, J; Landolfi, A; Lonati, C; Molinaro, D; Caprioli, F; Facciotti, F; Quattrocelli, M; Torrente, Y. Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin-deficient mice. EMBO Molecular Medicine. 2023; 15(3):e16244.

Durumutla, HB; Villa, C; Panta, M; Wintzinger, M; Pragasam, ADP; Miz, K; Quattrocelli, M. Comprehensive Analyses of Muscle Function, Lean and Muscle Mass, and Myofiber Typing in Mice. Bio-protocol. 2023; 13(4):e4617.

Fischer, JA; Monroe, TO; Pesce, LL; Sawicki, KT; Quattrocelli, M; Bauer, R; Kearns, SD; Wolf, MJ; Puckelwartz, MJ; Mcnally, EM. Opposing effects of genetic variation in MTCH2 for obesity versus heart failure. Human Molecular Genetics. 2023; 32(1):15-29.

Wintzinger, M; Miz, K; York, A; Demonbreun, AR; Molkentin, JD; Mcnally, EM; Quattrocelli, M. Effects of Glucocorticoids in Murine Models of Duchenne and Limb-Girdle Muscular Dystrophy. Methods in Molecular Biology. 2023; 2587:467-478.

Kimura, M; Iguchi, T; Iwasawa, K; Dunn, A; Thompson, WL; Yoneyama, Y; Chaturvedi, P; Zorn, AM; Wintzinger, M; Quattrocelli, M; Myers, RP; Subramanian, GM; Hwa, V; Takebe, T. En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH. Cell. 2022; 185(22):4216-4232.e16.

Quattrocelli, M; Wintzinger, M; Miz, K; Panta, M; Durumutla, HB; Prabakaran, AD. Abstract P3035: Time-of-intake Regulates Glucocorticoid Effects On Heart Metabolism And Function Through Cardiomyocyte-autonomous Mechanisms. Circulation Research. 2022; 131(Suppl_1):ap3035-ap3035.

Wintzinger, M; Panta, M; Miz, K; Prabakaran, AD; Durumutla, HB; Sargent, M; Peek, CB; Bass, J; Molkentin, JD; Quattrocelli, M. Impact of circadian time of dosing on cardiomyocyte-autonomous effects of glucocorticoids. Molecular Metabolism. 2022; 62:101528.

Prabakaran, AD; Panta, M; Quattrocelli, M. Commentary for “antagonizing urotensin receptor is a novel therapeutic strategy for glucocorticoid‐induced skeletal muscle atrophy” Clinical and Translational Discovery. 2022; 2(2).

Quattrocelli, M; Wintzinger, M; Miz, K; Panta, M; Prabakaran, AD; Barish, GD; Chandel, NS; Mcnally, EM. Intermittent prednisone treatment in mice promotes exercise tolerance in obesity through adiponectin. Journal of Experimental Medicine (JEM). 2022; 219(5).

Salamone, IM; Quattrocelli, M; Barefield, DY; Page, PG; Tahtah, I; Hadhazy, M; Tomar, G; Mcnally, EM. Intermittent glucocorticoid treatment enhances skeletal muscle performance through sexually dimorphic mechanisms. Journal of Clinical Investigation. 2022; 132(6).

Jiang, Z; Elsarrag, SZ; Duan, Q; Lagory, EL; Wang, Z; Alexanian, M; Mcmahon, S; Rulifson, IC; Winchester, S; Wang, Y; Vaisse, C; Brown, JD; Quattrocelli, M; Lin, CY; Haldar, SM. KLF15 cistromes reveal a hepatocyte pathway governing plasma corticosteroid transport and systemic inflammation. Science Advances. 2022; 8(10):eabj2917.

Quattrocelli, M; Wintzinger, M; Miz, K; Levine, DC; Peek, CB; Bass, J; Mcnally, EM. Muscle mitochondrial remodeling by intermittent glucocorticoid drugs requires an intact circadian clock and muscle PGC1α. Science Advances. 2022; 8(7):eabm1189.

Yedigaryan, L; Martínez-Sarrà, E; Giacomazzi, G; Giarratana, N; Van Der Veer, BK; Rotini, A; Querceto, S; Grosemans, H; Cortés-Calabuig, Á; Salucci, S; De Waele, L; Buyse, GM; Derua, R; Sampaolesi, M. Extracellular vesicle-derived miRNAs improve stem cell-based therapeutic approaches in muscle wasting conditions. Frontiers in Immunology. 2022; 13:977617.

Cossu, G; Tonlorenzi, R; Brunelli, S; Sampaolesi, M; Messina, G; Azzoni, E; Benedetti, S; Biressi, S; Bonfanti, C; Bragg, L; Sirabella, D; Tedesco, FS; Torrente, Y; Ugarte, G. Mesoangioblasts at 20: From the embryonic aorta to the patient bed. Frontiers in Genetics. 2022; 13:1056114.

Grassi, F; Falcone, S. Report and Abstracts of the 18th Meeting of the Interuniversity Institute of Myology: Virtual meeting, October 21-24, 2021. European Journal of Translational Myology. 2021; 31(4).

Demonbreun, AR; Fallon, KS; Oosterbaan, CC; Vaught, LA; Reiser, NL; Bogdanovic, E; Velez, MP; Salamone, IM; Page, PGT; Hadhazy, M; Wood, LD; Gonzalez, JP; Morris, C; Mcnally, EM. Anti-latent TGFβ binding protein 4 antibody improves muscle function and reduces muscle fibrosis in muscular dystrophy. Science Translational Medicine. 2021; 13(610):eabf0376.

Ronzoni, FL; Giarratana, N; Crippa, S; Quattrocelli, M; Cassano, M; Ceccarelli, G; Benedetti, L; Van Herck, J; Cusella De Angelis, MG; Vitale, M; Galli, D; Sampaolesi, M. Guide Cells Support Muscle Regeneration and Affect Neuro-Muscular Junction Organization. International Journal of Molecular Sciences. 2021; 22(4).

Quattrocelli, M; Zelikovich, AS; Salamone, IM; Fischer, JA; Mcnally, EM. Mechanisms and Clinical Applications of Glucocorticoid Steroids in Muscular Dystrophy. Journal of Neuromuscular Diseases. 2021; 8(1):39-52.

Giacomazzi, G; Giovannelli, G; Rotini, A; Costamagna, D; Quattrocelli, M; Sampaolesi, M. Isolation of Mammalian Mesoangioblasts: A Subset of Pericytes with Myogenic Potential. Methods in Molecular Biology. 2021; 2235:155-167.